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Reduced brain gamma-aminobutyric acid level by MRS

MedGen UID:
1382756
•Concept ID:
C4477080
•
Finding
HPO: HP:0500021

Definition

An decreased level of gamma-aminobutyric acid in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced brain gamma-aminobutyric acid level by MRS

Professional guidelines

PubMed

Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review.
Szulc A, Wiedlocha M, Waszkiewicz N, Galińska-Skok B, Marcinowicz P, Gierus J, Mosiolek A
Psychiatry Res Neuroimaging 2018 Mar 30;273:1-8. Epub 2018 Jan 17 doi: 10.1016/j.pscychresns.2018.01.001. PMID: 29414126
Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype.
Riese F, Gietl A, Zölch N, Henning A, O'Gorman R, Kälin AM, Leh SE, Buck A, Warnock G, Edden RA, Luechinger R, Hock C, Kollias S, Michels L
Neurobiol Aging 2015 Jan;36(1):53-9. Epub 2014 Jul 29 doi: 10.1016/j.neurobiolaging.2014.07.030. PMID: 25169676Free PMC Article

Recent clinical studies

Etiology

Evaluation of Prefrontal γ-Aminobutyric Acid and Glutamate Levels in Individuals With Major Depressive Disorder Using Proton Magnetic Resonance Spectroscopy.
Ritter C, Buchmann A, Müller ST, Volleberg M, Haynes M, Ghisleni C, Noeske R, Tuura R, Hasler G
JAMA Psychiatry 2022 Dec 1;79(12):1209-1216. doi: 10.1001/jamapsychiatry.2022.3384. PMID: 36260322Free PMC Article
Reduced cortical GABA and glutamate in high schizotypy.
Kozhuharova P, Diaconescu AO, Allen P
Psychopharmacology (Berl) 2021 Sep;238(9):2459-2470. Epub 2021 Jun 19 doi: 10.1007/s00213-021-05867-y. PMID: 34146134Free PMC Article
Upper brainstem GABA levels in Parkinson's disease.
Song Y, Gong T, Saleh MG, Mikkelsen M, Wang G, Edden RAE
MAGMA 2021 Oct;34(5):689-696. Epub 2021 Mar 20 doi: 10.1007/s10334-021-00910-7. PMID: 33745095Free PMC Article
Lower cortical gamma-aminobutyric acid level contributes to increased connectivity in sensory-motor regions in progressive MS.
Droby A, Fleysher L, Petracca M, Podranski K, Xu J, Fabian M, Marjańska M, Inglese M
Mult Scler Relat Disord 2020 Aug;43:102183. Epub 2020 May 25 doi: 10.1016/j.msard.2020.102183. PMID: 32480344
Reduced striatal GABA in unmedicated children with ADHD at 7T.
Puts NA, Ryan M, Oeltzschner G, Horska A, Edden RAE, Mahone EM
Psychiatry Res Neuroimaging 2020 Jul 30;301:111082. Epub 2020 May 18 doi: 10.1016/j.pscychresns.2020.111082. PMID: 32438277

Diagnosis

Magnetic Resonance Spectroscopy (MRS) in Alzheimer's Disease.
Sheikh-Bahaei N, Chen M, Pappas I
Methods Mol Biol 2024;2785:115-142. doi: 10.1007/978-1-0716-3774-6_9. PMID: 38427192
Evaluation of Prefrontal γ-Aminobutyric Acid and Glutamate Levels in Individuals With Major Depressive Disorder Using Proton Magnetic Resonance Spectroscopy.
Ritter C, Buchmann A, Müller ST, Volleberg M, Haynes M, Ghisleni C, Noeske R, Tuura R, Hasler G
JAMA Psychiatry 2022 Dec 1;79(12):1209-1216. doi: 10.1001/jamapsychiatry.2022.3384. PMID: 36260322Free PMC Article
Oscillatory, Computational, and Behavioral Evidence for Impaired GABAergic Inhibition in Schizophrenia.
Shaw AD, Knight L, Freeman TCA, Williams GM, Moran RJ, Friston KJ, Walters JTR, Singh KD
Schizophr Bull 2020 Feb 26;46(2):345-353. doi: 10.1093/schbul/sbz066. PMID: 31219602Free PMC Article
Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
Meyerhoff DJ, Mon A, Metzler T, Neylan TC
Sleep 2014 May 1;37(5):893-900. doi: 10.5665/sleep.3654. PMID: 24790267Free PMC Article
Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders.
Chang L, Cloak CC, Ernst T
J Clin Psychiatry 2003;64 Suppl 3:7-14. PMID: 12662128

Therapy

Effects of High Definition-Transcranial Direct Current Stimulation on Local GABA and Glutamate Levels Among Older Adults with and without Mild Cognitive Impairment: An Exploratory Study.
Lengu K, Ryan S, Peltier SJ, Tyszkowski T, Kairys A, Giordani B, Hampstead BM
J Alzheimers Dis 2021;84(3):1091-1102. doi: 10.3233/JAD-201091. PMID: 34602464Free PMC Article
Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA).
Stivaros S, Garg S, Tziraki M, Cai Y, Thomas O, Mellor J, Morris AA, Jim C, Szumanska-Ryt K, Parkes LM, Haroon HA, Montaldi D, Webb N, Keane J, Castellanos FX, Silva AJ, Huson S, Williams S, Gareth Evans D, Emsley R, Green J; SANTA Consortium
Mol Autism 2018;9:12. Epub 2018 Feb 22 doi: 10.1186/s13229-018-0190-z. PMID: 29484149Free PMC Article
Thalamic GABA predicts fine motor performance in manganese-exposed smelter workers.
Long Z, Li XR, Xu J, Edden RA, Qin WP, Long LL, Murdoch JB, Zheng W, Jiang YM, Dydak U
PLoS One 2014;9(2):e88220. Epub 2014 Feb 4 doi: 10.1371/journal.pone.0088220. PMID: 24505436Free PMC Article
Intravenous ethanol infusion decreases human cortical γ-aminobutyric acid and N-acetylaspartate as measured with proton magnetic resonance spectroscopy at 4 tesla.
Gomez R, Behar KL, Watzl J, Weinzimer SA, Gulanski B, Sanacora G, Koretski J, Guidone E, Jiang L, Petrakis IL, Pittman B, Krystal JH, Mason GF
Biol Psychiatry 2012 Feb 1;71(3):239-46. Epub 2011 Aug 19 doi: 10.1016/j.biopsych.2011.06.026. PMID: 21855054Free PMC Article
Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders.
Chang L, Cloak CC, Ernst T
J Clin Psychiatry 2003;64 Suppl 3:7-14. PMID: 12662128

Prognosis

Magnetic Resonance Spectroscopy (MRS) in Alzheimer's Disease.
Sheikh-Bahaei N, Chen M, Pappas I
Methods Mol Biol 2024;2785:115-142. doi: 10.1007/978-1-0716-3774-6_9. PMID: 38427192
A mean-field model of glutamate and GABA synaptic dynamics for functional MRS.
Lea-Carnall CA, El-Deredy W, Stagg CJ, Williams SR, Trujillo-Barreto NJ
Neuroimage 2023 Feb 1;266:119813. Epub 2022 Dec 14 doi: 10.1016/j.neuroimage.2022.119813. PMID: 36528313Free PMC Article
Oscillatory, Computational, and Behavioral Evidence for Impaired GABAergic Inhibition in Schizophrenia.
Shaw AD, Knight L, Freeman TCA, Williams GM, Moran RJ, Friston KJ, Walters JTR, Singh KD
Schizophr Bull 2020 Feb 26;46(2):345-353. doi: 10.1093/schbul/sbz066. PMID: 31219602Free PMC Article
Reductions in GABA following a tDCS-language intervention for primary progressive aphasia.
Harris AD, Wang Z, Ficek B, Webster K, Edden RA, Tsapkini K
Neurobiol Aging 2019 Jul;79:75-82. Epub 2019 Mar 27 doi: 10.1016/j.neurobiolaging.2019.03.011. PMID: 31029018Free PMC Article
Thalamic GABA predicts fine motor performance in manganese-exposed smelter workers.
Long Z, Li XR, Xu J, Edden RA, Qin WP, Long LL, Murdoch JB, Zheng W, Jiang YM, Dydak U
PLoS One 2014;9(2):e88220. Epub 2014 Feb 4 doi: 10.1371/journal.pone.0088220. PMID: 24505436Free PMC Article

Clinical prediction guides

MRS-assessed brain GABA modulation in response to task performance and learning.
Li H, Rodríguez-Nieto G, Chalavi S, Seer C, Mikkelsen M, Edden RAE, Swinnen SP
Behav Brain Funct 2024 Aug 31;20(1):22. doi: 10.1186/s12993-024-00248-9. PMID: 39217354Free PMC Article
Magnetic Resonance Spectroscopy (MRS) in Alzheimer's Disease.
Sheikh-Bahaei N, Chen M, Pappas I
Methods Mol Biol 2024;2785:115-142. doi: 10.1007/978-1-0716-3774-6_9. PMID: 38427192
Lower cortical gamma-aminobutyric acid level contributes to increased connectivity in sensory-motor regions in progressive MS.
Droby A, Fleysher L, Petracca M, Podranski K, Xu J, Fabian M, Marjańska M, Inglese M
Mult Scler Relat Disord 2020 Aug;43:102183. Epub 2020 May 25 doi: 10.1016/j.msard.2020.102183. PMID: 32480344
Reduced gamma-aminobutyric acid is associated with emotional and behavioral problems in Prader-Willi syndrome.
Rice LJ, Lagopoulos J, Brammer M, Einfeld SL
Am J Med Genet B Neuropsychiatr Genet 2016 Dec;171(8):1041-1048. Epub 2016 Jun 24 doi: 10.1002/ajmg.b.32472. PMID: 27338833
Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
Meyerhoff DJ, Mon A, Metzler T, Neylan TC
Sleep 2014 May 1;37(5):893-900. doi: 10.5665/sleep.3654. PMID: 24790267Free PMC Article

Recent systematic reviews

Neurofunctional correlates of glutamate and GABA imbalance in psychosis: A systematic review.
Zahid U, Onwordi EC, Hedges EP, Wall MB, Modinos G, Murray RM, Egerton A
Neurosci Biobehav Rev 2023 Jan;144:105010. Epub 2022 Dec 19 doi: 10.1016/j.neubiorev.2022.105010. PMID: 36549375
Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review.
Szulc A, Wiedlocha M, Waszkiewicz N, Galińska-Skok B, Marcinowicz P, Gierus J, Mosiolek A
Psychiatry Res Neuroimaging 2018 Mar 30;273:1-8. Epub 2018 Jan 17 doi: 10.1016/j.pscychresns.2018.01.001. PMID: 29414126
Migraine and magnetic resonance spectroscopy: a systematic review.
Younis S, Hougaard A, Vestergaard MB, Larsson HBW, Ashina M
Curr Opin Neurol 2017 Jun;30(3):246-262. doi: 10.1097/WCO.0000000000000436. PMID: 28240609

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