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Non-small cell squamous lung carcinoma

MedGen UID:
1383559
Concept ID:
C4509816
Neoplastic Process
Synonyms: Lung Non-Small Cell Squamous Carcinoma; non-small cell squamous lung cancer; Non-Small Cell Squamous Lung Carcinoma; non-small cell squamous lung carcinoma; Squamous non-small cell lung cancer; Squamous Non-Small Cell Lung Carcinoma; squamous non-small cell lung carcinoma; Squamous NSCLC (non-small cell lung cancer)
SNOMED CT: Squamous non-small cell lung cancer (723301009); Squamous NSCLC (non-small cell lung cancer) (723301009)
 
Monarch Initiative: MONDO:0056806

Definition

A squamous cell carcinoma that arises from the lung. It is characterized by the presence of large malignant cells. It includes the clear cell and papillary variants of squamous cell carcinoma. [from NCI]

Professional guidelines

PubMed

Finall A, Davies G, Jones T, Emlyn G, Huey P, Mullard A
J Clin Pathol 2023 Jun;76(6):391-399. Epub 2022 Jan 18 doi: 10.1136/jclinpath-2021-207987. PMID: 35042754

Recent clinical studies

Etiology

Joon HK, Thalor A, Gupta D
Comput Biol Med 2023 Oct;165:107430. Epub 2023 Aug 29 doi: 10.1016/j.compbiomed.2023.107430. PMID: 37703712
Makharadze T, Gogishvili M, Melkadze T, Baramidze A, Giorgadze D, Penkov K, Laktionov K, Nemsadze G, Nechaeva M, Rozhkova I, Kalinka E, Li S, Li Y, Kaul M, Quek RGW, Pouliot JF, Seebach F, Lowy I, Gullo G, Rietschel P
J Thorac Oncol 2023 Jun;18(6):755-768. Epub 2023 Mar 29 doi: 10.1016/j.jtho.2023.03.008. PMID: 37001859
Shi X, Dong A, Jia X, Zheng G, Wang N, Wang Y, Yang C, Lu J, Yang Y
Front Immunol 2022;13:992990. Epub 2022 Oct 14 doi: 10.3389/fimmu.2022.992990. PMID: 36311764Free PMC Article
Yang M, Lin C, Wang Y, Chen K, Zhang H, Li W
Genome Med 2022 Jul 8;14(1):72. doi: 10.1186/s13073-022-01079-x. PMID: 35799269Free PMC Article
Gettinger SN, Redman MW, Bazhenova L, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Ramalingam SS, Tavernier SS, Yu H, Unger JM, Minichiello K, Highleyman L, Papadimitrakopoulou VA, Kelly K, Gandara DR, Herbst RS
JAMA Oncol 2021 Sep 1;7(9):1368-1377. doi: 10.1001/jamaoncol.2021.2209. PMID: 34264316Free PMC Article

Diagnosis

Joon HK, Thalor A, Gupta D
Comput Biol Med 2023 Oct;165:107430. Epub 2023 Aug 29 doi: 10.1016/j.compbiomed.2023.107430. PMID: 37703712
Lv Y, Liu Z, Xiong K, Duan H, Yang J, Liao P
Autoimmunity 2023 Dec;56(1):2209706. doi: 10.1080/08916934.2023.2209706. PMID: 37165780
Asamura H, Nishimura KK, Giroux DJ, Chansky K, Hoering A, Rusch V, Rami-Porta R; Members of the IASLC Staging and Prognostic Factors Committee and of the Advisory Boards, and Participating Institutions
J Thorac Oncol 2023 May;18(5):564-575. Epub 2023 Feb 10 doi: 10.1016/j.jtho.2023.01.088. PMID: 36773775
Shi X, Dong A, Jia X, Zheng G, Wang N, Wang Y, Yang C, Lu J, Yang Y
Front Immunol 2022;13:992990. Epub 2022 Oct 14 doi: 10.3389/fimmu.2022.992990. PMID: 36311764Free PMC Article
Jain D, Bubendorf L
Cytopathology 2022 Jan;33(1):8-13. Epub 2021 Sep 21 doi: 10.1111/cyt.13056. PMID: 34494327

Therapy

Özgüroğlu M, Kilickap S, Sezer A, Gümüş M, Bondarenko I, Gogishvili M, Nechaeva M, Schenker M, Cicin I, Ho GF, Kulyaba Y, Zyuhal K, Scheusan RI, Garassino MC, He X, Kaul M, Okoye E, Li Y, Li S, Pouliot JF, Seebach F, Lowy I, Gullo G, Rietschel P
Lancet Oncol 2023 Sep;24(9):989-1001. Epub 2023 Aug 14 doi: 10.1016/S1470-2045(23)00329-7. PMID: 37591293
Makharadze T, Gogishvili M, Melkadze T, Baramidze A, Giorgadze D, Penkov K, Laktionov K, Nemsadze G, Nechaeva M, Rozhkova I, Kalinka E, Li S, Li Y, Kaul M, Quek RGW, Pouliot JF, Seebach F, Lowy I, Gullo G, Rietschel P
J Thorac Oncol 2023 Jun;18(6):755-768. Epub 2023 Mar 29 doi: 10.1016/j.jtho.2023.03.008. PMID: 37001859
Gettinger SN, Redman MW, Bazhenova L, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Ramalingam SS, Tavernier SS, Yu H, Unger JM, Minichiello K, Highleyman L, Papadimitrakopoulou VA, Kelly K, Gandara DR, Herbst RS
JAMA Oncol 2021 Sep 1;7(9):1368-1377. doi: 10.1001/jamaoncol.2021.2209. PMID: 34264316Free PMC Article
Chen JW, Dhahbi J
Sci Rep 2021 Jun 25;11(1):13323. doi: 10.1038/s41598-021-92725-8. PMID: 34172784Free PMC Article
National Lung Screening Trial Research Team
J Thorac Oncol 2019 Oct;14(10):1732-1742. Epub 2019 Jun 28 doi: 10.1016/j.jtho.2019.05.044. PMID: 31260833Free PMC Article

Prognosis

Zhang H, AbdulJabbar K, Moore DA, Akarca A, Enfield KSS, Jamal-Hanjani M, Raza SEA, Veeriah S, Salgado R, McGranahan N, Le Quesne J, Swanton C, Marafioti T, Yuan Y
Cancer Res 2023 May 2;83(9):1410-1425. doi: 10.1158/0008-5472.CAN-22-2589. PMID: 36853169Free PMC Article
Asamura H, Nishimura KK, Giroux DJ, Chansky K, Hoering A, Rusch V, Rami-Porta R; Members of the IASLC Staging and Prognostic Factors Committee and of the Advisory Boards, and Participating Institutions
J Thorac Oncol 2023 May;18(5):564-575. Epub 2023 Feb 10 doi: 10.1016/j.jtho.2023.01.088. PMID: 36773775
Shi X, Dong A, Jia X, Zheng G, Wang N, Wang Y, Yang C, Lu J, Yang Y
Front Immunol 2022;13:992990. Epub 2022 Oct 14 doi: 10.3389/fimmu.2022.992990. PMID: 36311764Free PMC Article
Chen JW, Dhahbi J
Sci Rep 2021 Jun 25;11(1):13323. doi: 10.1038/s41598-021-92725-8. PMID: 34172784Free PMC Article
National Lung Screening Trial Research Team
J Thorac Oncol 2019 Oct;14(10):1732-1742. Epub 2019 Jun 28 doi: 10.1016/j.jtho.2019.05.044. PMID: 31260833Free PMC Article

Clinical prediction guides

Lv Y, Liu Z, Xiong K, Duan H, Yang J, Liao P
Autoimmunity 2023 Dec;56(1):2209706. doi: 10.1080/08916934.2023.2209706. PMID: 37165780
Zhang H, AbdulJabbar K, Moore DA, Akarca A, Enfield KSS, Jamal-Hanjani M, Raza SEA, Veeriah S, Salgado R, McGranahan N, Le Quesne J, Swanton C, Marafioti T, Yuan Y
Cancer Res 2023 May 2;83(9):1410-1425. doi: 10.1158/0008-5472.CAN-22-2589. PMID: 36853169Free PMC Article
Shi X, Dong A, Jia X, Zheng G, Wang N, Wang Y, Yang C, Lu J, Yang Y
Front Immunol 2022;13:992990. Epub 2022 Oct 14 doi: 10.3389/fimmu.2022.992990. PMID: 36311764Free PMC Article
Yang M, Lin C, Wang Y, Chen K, Zhang H, Li W
Genome Med 2022 Jul 8;14(1):72. doi: 10.1186/s13073-022-01079-x. PMID: 35799269Free PMC Article
Gettinger SN, Redman MW, Bazhenova L, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Ramalingam SS, Tavernier SS, Yu H, Unger JM, Minichiello K, Highleyman L, Papadimitrakopoulou VA, Kelly K, Gandara DR, Herbst RS
JAMA Oncol 2021 Sep 1;7(9):1368-1377. doi: 10.1001/jamaoncol.2021.2209. PMID: 34264316Free PMC Article

Recent systematic reviews

Mazieres J, Vioix H, Pfeiffer BM, Campden RI, Chen Z, Heeg B, Cortot AB
Clin Lung Cancer 2023 Sep;24(6):483-497. Epub 2023 Jun 18 doi: 10.1016/j.cllc.2023.06.008. PMID: 37451931
O'Byrne K, Popoff E, Badin F, Lee A, Yuan Y, Lozano-Ortega G, Eccles LJ, Varol N, Waser N, Penrod JR, Goring S
Lung Cancer 2023 Mar;177:11-20. Epub 2023 Jan 11 doi: 10.1016/j.lungcan.2023.01.006. PMID: 36669321
Siciliano MA, Caridà G, Ciliberto D, d'Apolito M, Pelaia C, Caracciolo D, Riillo C, Correale P, Galvano A, Russo A, Barbieri V, Tassone P, Tagliaferri P
ESMO Open 2022 Jun;7(3):100465. Epub 2022 Apr 12 doi: 10.1016/j.esmoop.2022.100465. PMID: 35427835Free PMC Article
Yang Z, Hackshaw A, Feng Q, Fu X, Zhang Y, Mao C, Tang J
Int J Cancer 2017 Jun 15;140(12):2805-2819. Epub 2017 Mar 27 doi: 10.1002/ijc.30691. PMID: 28295308
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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