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Impaired calcium ionophore-induced platelet aggregation

MedGen UID:
1386873
•Concept ID:
C4476989
•
Cell or Molecular Dysfunction
Synonyms: Impaired Ca ionophore-induced platelet aggregation; Impaired Ca2+ ionophore-induced platelet aggregation
 
HPO: HP:0031130

Definition

Abnormal response to calcium Ionophore (such as A23187) as manifested by reduced or lacking aggregation of platelets upon addition of the ionophore. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired calcium ionophore-induced platelet aggregation

Recent clinical studies

Diagnosis

Pathogenetic analysis of three cases with a bleeding disorder characterized by defective platelet aggregation induced by Ca2+ ionophores.
Fuse I, Higuchi W, Uesugi Y, Aizawa Y
Br J Haematol 2001 Mar;112(3):603-8. doi: 10.1046/j.1365-2141.2001.02637.x. PMID: 11260060

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