Impaired calcium ionophore-induced platelet aggregation

MedGen UID:: 1386873
•Concept ID:: C4476989
•: Cell or Molecular Dysfunction

Synonyms:	Impaired Ca ionophore-induced platelet aggregation; Impaired Ca2+ ionophore-induced platelet aggregation

HPO:	HP:0031130

Definition

Abnormal response to calcium Ionophore (such as A23187) as manifested by reduced or lacking aggregation of platelets upon addition of the ionophore. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVImpaired calcium ionophore-induced platelet aggregation

Phenotypic abnormality
- Abnormality of blood and blood-forming tissues
  - Abnormality of thrombocytes
    - Abnormal platelet function
      - Abnormal platelet aggregation
        Impaired platelet aggregation
        Impaired calcium ionophore-induced platelet aggregation

Recent clinical studies

Diagnosis

Pathogenetic analysis of three cases with a bleeding disorder characterized by defective platelet aggregation induced by Ca2+ ionophores.

Fuse I, Higuchi W, Uesugi Y, Aizawa Y
Br J Haematol 2001 Mar;112(3):603-8. doi: 10.1046/j.1365-2141.2001.02637.x. PMID: 11260060

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Impaired calcium ionophore-induced platelet aggregation

Definition

Term Hierarchy

Recent clinical studies

Diagnosis

Supplemental Content

Table of contents

Clinical resources

Consumer resources

Reviews

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