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Abnormal retinol-binding protein level

MedGen UID:
1387105
•Concept ID:
C4476919
•
Finding
HPO: HP:0031031

Definition

A deviation from normal blood concentration of retinol-binding protein (RBP). The most commonly used indicator of vitamin A status is the serum retinol concentration (retinol is one of the several compounds known as vitamin A). The serum RBP concentration is used as a surrogate measure for serum retinol. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal retinol-binding protein level

Professional guidelines

PubMed

Changes in conjugated linoleic acid and palmitoleic acid are correlated to retinol levels in chronic renal failure in both hemodialysis and conservative treatment patients.
Lucchi L, Banni S, Iannone A, Melis MP, Carta G, Murru E, Cordeddu L, Stipo L, Uggeri S, Gatti V, Malaguti V, Albertazzi A
Artif Organs 2005 May;29(5):413-8. doi: 10.1111/j.1525-1594.2005.29069.x. PMID: 15854218

Recent clinical studies

Etiology

Significance of Plasma Irisin, Adiponectin, and Retinol Binding Protein-4 Levels as Biomarkers for Obstructive Sleep Apnea Syndrome Severity.
Fazlıoğlu N, Uysal P, Durmus S, Yurt S, Gelisgen R, Uzun H
Biomolecules 2023 Sep 24;13(10) doi: 10.3390/biom13101440. PMID: 37892122Free PMC Article
Retinol-binding protein 4 in combination with lipids to predict the regression phenomenon of autism spectrum disorders.
Chen J, Chen J, Xu Y, Cheng P, Yu S, Fu Y, Du Y
Lipids Health Dis 2021 Aug 26;20(1):93. doi: 10.1186/s12944-021-01522-9. PMID: 34446012Free PMC Article
Association of Retinol-Binding Protein 4 with Arteriovenous Fistula Dysfunction in Hemodialysis Patients.
Wu Y, Wang F, Wang T, Zheng Y, You L, Xue J
Blood Purif 2021;50(6):906-913. Epub 2021 Feb 8 doi: 10.1159/000513418. PMID: 33556944
Serum level and polymorphisms of retinol-binding protein-4 and risk for gestational diabetes mellitus: a meta-analysis.
Hu S, Liu Q, Huang X, Tan H
BMC Pregnancy Childbirth 2016 Mar 14;16:52. doi: 10.1186/s12884-016-0838-7. PMID: 26975349Free PMC Article
Pathophysiology of diabetic dyslipidaemia: where are we?
Vergès B
Diabetologia 2015 May;58(5):886-99. Epub 2015 Mar 1 doi: 10.1007/s00125-015-3525-8. PMID: 25725623Free PMC Article

Diagnosis

Significance of Plasma Irisin, Adiponectin, and Retinol Binding Protein-4 Levels as Biomarkers for Obstructive Sleep Apnea Syndrome Severity.
Fazlıoğlu N, Uysal P, Durmus S, Yurt S, Gelisgen R, Uzun H
Biomolecules 2023 Sep 24;13(10) doi: 10.3390/biom13101440. PMID: 37892122Free PMC Article
The role of chemerin in the pathogenesis of cholelithiasis in children and adolescents.
Zdanowicz K, Ryzko J, Bobrus-Chociej A, Wojtkowska M, Lebensztejn DM
J Paediatr Child Health 2021 Mar;57(3):371-375. Epub 2020 Oct 11 doi: 10.1111/jpc.15223. PMID: 33043555
Childhood retinol-binding protein 4 (RBP4) levels predicting the 10-year risk of insulin resistance and metabolic syndrome: the BCAMS study.
Li G, Esangbedo IC, Xu L, Fu J, Li L, Feng D, Han L, Xiao X, Li M, Mi J, Li M, Gao S, Willi SM
Cardiovasc Diabetol 2018 May 14;17(1):69. doi: 10.1186/s12933-018-0707-y. PMID: 29759068Free PMC Article
Serum level and polymorphisms of retinol-binding protein-4 and risk for gestational diabetes mellitus: a meta-analysis.
Hu S, Liu Q, Huang X, Tan H
BMC Pregnancy Childbirth 2016 Mar 14;16:52. doi: 10.1186/s12884-016-0838-7. PMID: 26975349Free PMC Article
The vitamin A-zinc connection: a review.
Smith JC Jr
Ann N Y Acad Sci 1980;355:62-75. doi: 10.1111/j.1749-6632.1980.tb21328.x. PMID: 6786155

Therapy

Association of Retinol-Binding Protein 4 with Arteriovenous Fistula Dysfunction in Hemodialysis Patients.
Wu Y, Wang F, Wang T, Zheng Y, You L, Xue J
Blood Purif 2021;50(6):906-913. Epub 2021 Feb 8 doi: 10.1159/000513418. PMID: 33556944
Vitamin A and Vision.
Saari JC
Subcell Biochem 2016;81:231-259. doi: 10.1007/978-94-024-0945-1_9. PMID: 27830507
Retinol-binding protein 4 as a risk factor for cholesterol gallstone formation.
Han T, Zhang D, Fu Z, Sun Y, Yang W, Yuan C
Mol Cell Biochem 2013 May;377(1-2):219-27. Epub 2013 Feb 19 doi: 10.1007/s11010-013-1587-9. PMID: 23420326
Association of serum retinol-binding protein 4 with insulin resistance and metabolic parameters during olanzapine therapy.
Faghihi T, Radfar M, Abdoli E, Amini H, Hemami MR, Larijani B
Clin Endocrinol (Oxf) 2012 Feb;76(2):207-11. doi: 10.1111/j.1365-2265.2011.04150.x. PMID: 21711373
New insights into subclinical hypothyroidism and cardiovascular risk.
Duntas LH, Biondi B
Semin Thromb Hemost 2011 Feb;37(1):27-34. Epub 2011 Jan 19 doi: 10.1055/s-0030-1270068. PMID: 21249602

Prognosis

Significance of Plasma Irisin, Adiponectin, and Retinol Binding Protein-4 Levels as Biomarkers for Obstructive Sleep Apnea Syndrome Severity.
Fazlıoğlu N, Uysal P, Durmus S, Yurt S, Gelisgen R, Uzun H
Biomolecules 2023 Sep 24;13(10) doi: 10.3390/biom13101440. PMID: 37892122Free PMC Article
Correlation between Retinol Binding Protein 4 and CT Perfusion Imaging and Prognosis in Patients with Acute Ischemic Stroke Based on Cell Imaging Data Analysis.
Liu C, Gu J, Yao Y, Guo P, Hu H
Contrast Media Mol Imaging 2022;2022:3055712. Epub 2022 Aug 8 doi: 10.1155/2022/3055712. PMID: 36043144Free PMC Article
Retinol-binding protein 4 in combination with lipids to predict the regression phenomenon of autism spectrum disorders.
Chen J, Chen J, Xu Y, Cheng P, Yu S, Fu Y, Du Y
Lipids Health Dis 2021 Aug 26;20(1):93. doi: 10.1186/s12944-021-01522-9. PMID: 34446012Free PMC Article
Association of Retinol-Binding Protein 4 with Arteriovenous Fistula Dysfunction in Hemodialysis Patients.
Wu Y, Wang F, Wang T, Zheng Y, You L, Xue J
Blood Purif 2021;50(6):906-913. Epub 2021 Feb 8 doi: 10.1159/000513418. PMID: 33556944
Serum retinol-binding protein 4 is independently associated with pediatric NAFLD and fasting triglyceride level.
Huang SC, Yang YJ
J Pediatr Gastroenterol Nutr 2013 Feb;56(2):145-50. doi: 10.1097/MPG.0b013e3182722aee. PMID: 22983378

Clinical prediction guides

Significance of Plasma Irisin, Adiponectin, and Retinol Binding Protein-4 Levels as Biomarkers for Obstructive Sleep Apnea Syndrome Severity.
Fazlıoğlu N, Uysal P, Durmus S, Yurt S, Gelisgen R, Uzun H
Biomolecules 2023 Sep 24;13(10) doi: 10.3390/biom13101440. PMID: 37892122Free PMC Article
Association of Retinol-Binding Protein 4 with Arteriovenous Fistula Dysfunction in Hemodialysis Patients.
Wu Y, Wang F, Wang T, Zheng Y, You L, Xue J
Blood Purif 2021;50(6):906-913. Epub 2021 Feb 8 doi: 10.1159/000513418. PMID: 33556944
Serum level and polymorphisms of retinol-binding protein-4 and risk for gestational diabetes mellitus: a meta-analysis.
Hu S, Liu Q, Huang X, Tan H
BMC Pregnancy Childbirth 2016 Mar 14;16:52. doi: 10.1186/s12884-016-0838-7. PMID: 26975349Free PMC Article
Pathophysiology of diabetic dyslipidaemia: where are we?
Vergès B
Diabetologia 2015 May;58(5):886-99. Epub 2015 Mar 1 doi: 10.1007/s00125-015-3525-8. PMID: 25725623Free PMC Article
Embryonic development and pattern formation.
Morriss-Kay GM, Sokolova N
FASEB J 1996 Jul;10(9):961-8. doi: 10.1096/fasebj.10.9.8801178. PMID: 8801178

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