U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Decreased retinol-binding protein level

MedGen UID:
1388725
•Concept ID:
C4476920
•
Finding
HPO: HP:0031032

Definition

A reduced blood concentration of retinol-binding protein. This finding predicts vitamin A deficiency with high sensitivity and specificity. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased retinol-binding protein level

Conditions with this feature

Progressive retinal dystrophy due to retinol transport defect
MedGen UID:
767507
•Concept ID:
C3554593
•
Disease or Syndrome
Progressive retinal dystrophy due to retinol transport defect is a rare, genetic, metabolite absorption and transport disorder characterized by progressive rod-cone dystrophy, usually presenting with impaired night vision in childhood, progressive loss of visual acuity and severe retinol deficiency without keratomalacia. Association with ocular colobomas, severe acne and hypercholesterolemia has been reported.
See: Condition Record
Progressive retinal dystrophy due to retinol transport defect

Professional guidelines

PubMed

Effect of non-surgical periodontal treatment on cytokines/adipocytokines levels among periodontitis patients with or without obesity: a systematic review and meta-analysis.
Zhang Y, Jia R, Zhang Y, Sun X, Mei Y, Zou R, Niu L, Dong S
BMC Oral Health 2023 Oct 5;23(1):717. doi: 10.1186/s12903-023-03383-3. PMID: 37798684Free PMC Article
The significance of anthocyanins in the prevention and treatment of type 2 diabetes.
Różańska D, Regulska-Ilow B
Adv Clin Exp Med 2018 Jan;27(1):135-142. doi: 10.17219/acem/64983. PMID: 29521054
Fenretinide: A Potential Treatment for Endometriosis.
Pavone ME, Malpani SS, Dyson M, Kim JJ, Bulun SE
Reprod Sci 2016 Sep;23(9):1139-47. Epub 2016 Feb 25 doi: 10.1177/1933719116632920. PMID: 26919975Free PMC Article

Recent clinical studies

Therapy

Effect of periodontal therapy on adipokine biomarkers in overweight.
Matern J, Koch R, Petersmann A, Kocher T, Eickholz P, Lorenz K, Kim TS, Meyle J, Kaner D, Schlagenhauf U, Gravemeier M, Harks I, Ehmke B
J Clin Periodontol 2020 Jul;47(7):842-850. Epub 2020 May 11 doi: 10.1111/jcpe.13288. PMID: 32248552
Pharmacotherapy of retinal disease with visual cycle modulators.
Hussain RM, Gregori NZ, Ciulla TA, Lam BL
Expert Opin Pharmacother 2018 Apr;19(5):471-481. Epub 2018 Mar 15 doi: 10.1080/14656566.2018.1448060. PMID: 29542350
Fenretinide: A Potential Treatment for Endometriosis.
Pavone ME, Malpani SS, Dyson M, Kim JJ, Bulun SE
Reprod Sci 2016 Sep;23(9):1139-47. Epub 2016 Feb 25 doi: 10.1177/1933719116632920. PMID: 26919975Free PMC Article
Retinol Binding Protein-4 and Adiponectin Levels in Thyroid Overt and Subclinical Dysfunction.
Kokkinos S, Papazoglou D, Zisimopoulos A, Papanas N, Tiaka E, Antonoglou C, Maltezos E
Exp Clin Endocrinol Diabetes 2016 Feb;124(2):87-92. Epub 2015 Nov 17 doi: 10.1055/s-0035-1564199. PMID: 26575118
Obesity in chronic kidney disease: good or bad?
Axelsson J
Blood Purif 2008;26(1):23-9. Epub 2008 Jan 10 doi: 10.1159/000110559. PMID: 18182791

Prognosis

Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review).
Flores-Cortez YA, Barragán-Bonilla MI, Mendoza-Bello JM, González-Calixto C, Flores-Alfaro E, Espinoza-Rojo M
Mol Med Rep 2022 Jul;26(1) Epub 2022 Jun 3 doi: 10.3892/mmr.2022.12760. PMID: 35656886Free PMC Article
Retinol-binding protein 4 in combination with lipids to predict the regression phenomenon of autism spectrum disorders.
Chen J, Chen J, Xu Y, Cheng P, Yu S, Fu Y, Du Y
Lipids Health Dis 2021 Aug 26;20(1):93. doi: 10.1186/s12944-021-01522-9. PMID: 34446012Free PMC Article
Study of decreased serum levels of retinol binding protein 4 in major depressive disorder.
Yao Q, Li Y
J Psychiatr Res 2020 Oct;129:24-30. Epub 2020 Jun 5 doi: 10.1016/j.jpsychires.2020.05.030. PMID: 32559505
Urinary Kininogen-1 and Retinol binding protein-4 respond to Acute Kidney Injury: predictors of patient prognosis?
Gonzalez-Calero L, Martin-Lorenzo M, Ramos-Barron A, Ruiz-Criado J, Maroto AS, Ortiz A, Gomez-Alamillo C, Arias M, Vivanco F, Alvarez-Llamas G
Sci Rep 2016 Jan 21;6:19667. doi: 10.1038/srep19667. PMID: 26792617Free PMC Article
Retinol-binding protein 4 as a risk factor for cholesterol gallstone formation.
Han T, Zhang D, Fu Z, Sun Y, Yang W, Yuan C
Mol Cell Biochem 2013 May;377(1-2):219-27. Epub 2013 Feb 19 doi: 10.1007/s11010-013-1587-9. PMID: 23420326

Clinical prediction guides

Significantly Reduced Retinol Binding Protein 4 (RBP4) Levels in Critically Ill COVID-19 Patients.
Vollenberg R, Tepasse PR, Fobker M, Hüsing-Kabar A
Nutrients 2022 May 10;14(10) doi: 10.3390/nu14102007. PMID: 35631143Free PMC Article
The significance of anthocyanins in the prevention and treatment of type 2 diabetes.
Różańska D, Regulska-Ilow B
Adv Clin Exp Med 2018 Jan;27(1):135-142. doi: 10.17219/acem/64983. PMID: 29521054
Retinol Binding Protein-4 and Adiponectin Levels in Thyroid Overt and Subclinical Dysfunction.
Kokkinos S, Papazoglou D, Zisimopoulos A, Papanas N, Tiaka E, Antonoglou C, Maltezos E
Exp Clin Endocrinol Diabetes 2016 Feb;124(2):87-92. Epub 2015 Nov 17 doi: 10.1055/s-0035-1564199. PMID: 26575118
Pathophysiology of diabetic dyslipidaemia: where are we?
Vergès B
Diabetologia 2015 May;58(5):886-99. Epub 2015 Mar 1 doi: 10.1007/s00125-015-3525-8. PMID: 25725623Free PMC Article
The importance of vitamin A in nutrition.
Dawson MI
Curr Pharm Des 2000 Feb;6(3):311-25. doi: 10.2174/1381612003401190. PMID: 10637381

Recent systematic reviews

Effect of non-surgical periodontal treatment on cytokines/adipocytokines levels among periodontitis patients with or without obesity: a systematic review and meta-analysis.
Zhang Y, Jia R, Zhang Y, Sun X, Mei Y, Zou R, Niu L, Dong S
BMC Oral Health 2023 Oct 5;23(1):717. doi: 10.1186/s12903-023-03383-3. PMID: 37798684Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...