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Decreased retinol-binding protein level

MedGen UID:
1388725
Concept ID:
C4476920
Finding
HPO: HP:0031032

Definition

A reduced blood concentration of retinol-binding protein. This finding predicts vitamin A deficiency with high sensitivity and specificity. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased retinol-binding protein level

Conditions with this feature

Progressive retinal dystrophy due to retinol transport defect
MedGen UID:
767507
Concept ID:
C3554593
Disease or Syndrome
Progressive retinal dystrophy due to retinol transport defect is a rare, genetic, metabolite absorption and transport disorder characterized by progressive rod-cone dystrophy, usually presenting with impaired night vision in childhood, progressive loss of visual acuity and severe retinol deficiency without keratomalacia. Association with ocular colobomas, severe acne and hypercholesterolemia has been reported.

Professional guidelines

PubMed

Zhang Y, Jia R, Zhang Y, Sun X, Mei Y, Zou R, Niu L, Dong S
BMC Oral Health 2023 Oct 5;23(1):717. doi: 10.1186/s12903-023-03383-3. PMID: 37798684Free PMC Article
Zhang Y, Wang YY, Fu R, Yan X
J Biol Regul Homeost Agents 2019 Mar-Apr;33(2):427-432. PMID: 30974931
Różańska D, Regulska-Ilow B
Adv Clin Exp Med 2018 Jan;27(1):135-142. doi: 10.17219/acem/64983. PMID: 29521054

Recent clinical studies

Etiology

Vollenberg R, Tepasse PR, Fobker M, Hüsing-Kabar A
Nutrients 2022 May 10;14(10) doi: 10.3390/nu14102007. PMID: 35631143Free PMC Article
Ma Y, Belyaeva OV, Brown PM, Fujita K, Valles K, Karki S, de Boer YS, Koh C, Chen Y, Du X, Handelman SK, Chen V, Speliotes EK, Nestlerode C, Thomas E, Kleiner DE, Zmuda JM, Sanyal AJ; (for the Nonalcoholic Steatohepatitis Clinical Research Network), Kedishvili NY, Liang TJ, Rotman Y
Hepatology 2019 Apr;69(4):1504-1519. Epub 2019 Mar 5 doi: 10.1002/hep.30350. PMID: 30415504Free PMC Article
Vergès B
Diabetologia 2015 May;58(5):886-99. Epub 2015 Mar 1 doi: 10.1007/s00125-015-3525-8. PMID: 25725623Free PMC Article
Lira LQ, Dimenstein R
Rev Assoc Med Bras (1992) 2010 May-Jun;56(3):355-9. doi: 10.1590/s0104-42302010000300023. PMID: 20676546
Dawson MI
Curr Pharm Des 2000 Feb;6(3):311-25. doi: 10.2174/1381612003401190. PMID: 10637381

Diagnosis

Flores-Cortez YA, Barragán-Bonilla MI, Mendoza-Bello JM, González-Calixto C, Flores-Alfaro E, Espinoza-Rojo M
Mol Med Rep 2022 Jul;26(1) Epub 2022 Jun 3 doi: 10.3892/mmr.2022.12760. PMID: 35656886Free PMC Article
Yao Q, Li Y
J Psychiatr Res 2020 Oct;129:24-30. Epub 2020 Jun 5 doi: 10.1016/j.jpsychires.2020.05.030. PMID: 32559505
Elmaadawy E, Elgarhy LH, Shareef M
J Cosmet Dermatol 2019 Apr;18(2):659-664. Epub 2018 Dec 16 doi: 10.1111/jocd.12833. PMID: 30556317
Polyzos SA, Kountouras J, Mantzoros CS
Metabolism 2016 Aug;65(8):1062-79. Epub 2015 Nov 24 doi: 10.1016/j.metabol.2015.11.006. PMID: 26725002
Wolf G
Nutr Rev 2007 May;65(5):251-6. doi: 10.1111/j.1753-4887.2007.tb00302.x. PMID: 17566551

Therapy

Matern J, Koch R, Petersmann A, Kocher T, Eickholz P, Lorenz K, Kim TS, Meyle J, Kaner D, Schlagenhauf U, Gravemeier M, Harks I, Ehmke B
J Clin Periodontol 2020 Jul;47(7):842-850. Epub 2020 May 11 doi: 10.1111/jcpe.13288. PMID: 32248552
Li W, Zhao M, Qin Z, Chen Q, Fan L, Zhou J, Zhao L
J Food Biochem 2019 May;43(5):e12831. Epub 2019 Mar 12 doi: 10.1111/jfbc.12831. PMID: 31353518
Hussain RM, Gregori NZ, Ciulla TA, Lam BL
Expert Opin Pharmacother 2018 Apr;19(5):471-481. Epub 2018 Mar 15 doi: 10.1080/14656566.2018.1448060. PMID: 29542350
Kokkinos S, Papazoglou D, Zisimopoulos A, Papanas N, Tiaka E, Antonoglou C, Maltezos E
Exp Clin Endocrinol Diabetes 2016 Feb;124(2):87-92. Epub 2015 Nov 17 doi: 10.1055/s-0035-1564199. PMID: 26575118
Han T, Zhang D, Fu Z, Sun Y, Yang W, Yuan C
Mol Cell Biochem 2013 May;377(1-2):219-27. Epub 2013 Feb 19 doi: 10.1007/s11010-013-1587-9. PMID: 23420326

Prognosis

Flores-Cortez YA, Barragán-Bonilla MI, Mendoza-Bello JM, González-Calixto C, Flores-Alfaro E, Espinoza-Rojo M
Mol Med Rep 2022 Jul;26(1) Epub 2022 Jun 3 doi: 10.3892/mmr.2022.12760. PMID: 35656886Free PMC Article
Chen J, Chen J, Xu Y, Cheng P, Yu S, Fu Y, Du Y
Lipids Health Dis 2021 Aug 26;20(1):93. doi: 10.1186/s12944-021-01522-9. PMID: 34446012Free PMC Article
Yang M, Weng H, Pei Q, Jing F, Yi Q
Mediators Inflamm 2021;2021:7029514. Epub 2021 Jan 11 doi: 10.1155/2021/7029514. PMID: 33505217Free PMC Article
Yao Q, Li Y
J Psychiatr Res 2020 Oct;129:24-30. Epub 2020 Jun 5 doi: 10.1016/j.jpsychires.2020.05.030. PMID: 32559505
Han T, Zhang D, Fu Z, Sun Y, Yang W, Yuan C
Mol Cell Biochem 2013 May;377(1-2):219-27. Epub 2013 Feb 19 doi: 10.1007/s11010-013-1587-9. PMID: 23420326

Clinical prediction guides

Vollenberg R, Tepasse PR, Fobker M, Hüsing-Kabar A
Nutrients 2022 May 10;14(10) doi: 10.3390/nu14102007. PMID: 35631143Free PMC Article
Różańska D, Regulska-Ilow B
Adv Clin Exp Med 2018 Jan;27(1):135-142. doi: 10.17219/acem/64983. PMID: 29521054
Kokkinos S, Papazoglou D, Zisimopoulos A, Papanas N, Tiaka E, Antonoglou C, Maltezos E
Exp Clin Endocrinol Diabetes 2016 Feb;124(2):87-92. Epub 2015 Nov 17 doi: 10.1055/s-0035-1564199. PMID: 26575118
Vergès B
Diabetologia 2015 May;58(5):886-99. Epub 2015 Mar 1 doi: 10.1007/s00125-015-3525-8. PMID: 25725623Free PMC Article
Dawson MI
Curr Pharm Des 2000 Feb;6(3):311-25. doi: 10.2174/1381612003401190. PMID: 10637381

Recent systematic reviews

Zhang Y, Jia R, Zhang Y, Sun X, Mei Y, Zou R, Niu L, Dong S
BMC Oral Health 2023 Oct 5;23(1):717. doi: 10.1186/s12903-023-03383-3. PMID: 37798684Free PMC Article

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