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ROS1 Gene Translocation

MedGen UID:
1387352
•Concept ID:
C4331215
•
Cell or Molecular Dysfunction
Synonyms: c-ros-1 Gene Translocation; MCF3 Gene Translocation; ROS Gene Translocation; ROS Proto-Oncogene 1, Receptor Tyrosine Kinase Gene Translocation; ROS1 Translocation

Definition

A cytogenetic abnormality that refers to any translocation involving the ROS1 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVROS1 Gene Translocation

Professional guidelines

PubMed

Deepening the Knowledge of ROS1 Rearrangements in Non-Small Cell Lung Cancer: Diagnosis, Treatment, Resistance and Concomitant Alterations.
Guaitoli G, Bertolini F, Bettelli S, Manfredini S, Maur M, Trudu L, Aramini B, Masciale V, Grisendi G, Dominici M, Barbieri F
Int J Mol Sci 2021 Nov 28;22(23) doi: 10.3390/ijms222312867. PMID: 34884672Free PMC Article
The role of anaplastic lymphoma kinase inhibitors in the treatment of advanced nonsmall cell lung cancer.
D'Arcangelo M, Wynes MW, Hirsch FR
Curr Opin Oncol 2013 Mar;25(2):121-9. doi: 10.1097/CCO.0b013e32835d8175. PMID: 23385859
Crizotinib in the treatment of non-small-cell lung cancer.
Forde PM, Rudin CM
Expert Opin Pharmacother 2012 Jun;13(8):1195-201. doi: 10.1517/14656566.2012.688029. PMID: 22594847

Recent clinical studies

Etiology

Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
A Single-Institute Experience with C-ros Oncogene 1 Translocation in Non-Small Cell Lung Cancers in Taiwan.
Wang HS, Liu CY, Hsu SC, Huang SC, Hung TH, Ng KF, Chen TC
Int J Mol Sci 2022 May 21;23(10) doi: 10.3390/ijms23105789. PMID: 35628598Free PMC Article
Clinicopathological features and immunohistochemical utility of NTRK-, ALK-, and ROS1-rearranged papillary thyroid carcinomas and anaplastic thyroid carcinomas.
Nozaki Y, Yamamoto H, Iwasaki T, Sato M, Jiromaru R, Hongo T, Yasumatsu R, Oda Y
Hum Pathol 2020 Dec;106:82-92. Epub 2020 Sep 25 doi: 10.1016/j.humpath.2020.09.004. PMID: 32980422
High-throughput diagnostic profiling of clinically actionable gene fusions in lung cancer.
Pfarr N, Stenzinger A, Penzel R, Warth A, Dienemann H, Schirmacher P, Weichert W, Endris V
Genes Chromosomes Cancer 2016 Jan;55(1):30-44. Epub 2015 Sep 23 doi: 10.1002/gcc.22297. PMID: 26394895
ALK and ROS1 overexpression is very rare in colorectal adenocarcinoma.
Houang M, Toon CW, Clarkson A, Sioson L, de Silva K, Watson N, Singh NR, Chou A, Gill AJ
Appl Immunohistochem Mol Morphol 2015 Feb;23(2):134-8. doi: 10.1097/PAI.0000000000000025. PMID: 24992173

Diagnosis

Analysis of rare fusions in NSCLC: Genomic architecture and clinical implications.
Seker-Cin H, Tay TKY, Kazdal D, Kluck K, Ball M, Neumann O, Winter H, Herth F, Heußel CP, Savai R, Schirmacher P, Thomas M, Budczies J, Allgäuer M, Christopoulos P, Stenzinger A, Volckmar AL
Lung Cancer 2023 Oct;184:107317. Epub 2023 Jul 27 doi: 10.1016/j.lungcan.2023.107317. PMID: 37586177
Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
Molecular testing and targeted therapy for non-small cell lung cancer: Current status and perspectives.
Imyanitov EN, Iyevleva AG, Levchenko EV
Crit Rev Oncol Hematol 2021 Jan;157:103194. Epub 2020 Dec 11 doi: 10.1016/j.critrevonc.2020.103194. PMID: 33316418
Use of Fluorescence In Situ Hybridization (FISH) in Diagnosis and Tailored Therapies in Solid Tumors.
Chrzanowska NM, Kowalewski J, Lewandowska MA
Molecules 2020 Apr 17;25(8) doi: 10.3390/molecules25081864. PMID: 32316657Free PMC Article
Liquid biopsy in lung cancer.
Mlika M, Hofman P, Dziri C, Mezni F
Tunis Med 2017 Novembre;95(11):965-971. PMID: 29877554

Therapy

Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers.
Cheong TC, Jang A, Wang Q, Leonardi GC, Ricciuti B, Alessi JV, Di Federico A, Awad MM, Lehtinen MK, Harris MH, Chiarle R
Nat Commun 2024 Jun 14;15(1):5110. doi: 10.1038/s41467-024-49499-0. PMID: 38877018Free PMC Article
Cancer Therapy Guided by Mutation Tests: Current Status and Perspectives.
Aleksakhina SN, Imyanitov EN
Int J Mol Sci 2021 Oct 10;22(20) doi: 10.3390/ijms222010931. PMID: 34681592Free PMC Article
Emerging Biomarkers in Personalized Therapy of Lung Cancer.
Cagle PT, Raparia K, Portier BP
Adv Exp Med Biol 2016;890:25-36. doi: 10.1007/978-3-319-24932-2_2. PMID: 26703797
Crizotinib therapy for advanced lung adenocarcinoma and a ROS1 rearrangement: results from the EUROS1 cohort.
Mazières J, Zalcman G, Crinò L, Biondani P, Barlesi F, Filleron T, Dingemans AM, Léna H, Monnet I, Rothschild SI, Cappuzzo F, Besse B, Thiberville L, Rouvière D, Dziadziuszko R, Smit EF, Wolf J, Spirig C, Pecuchet N, Leenders F, Heuckmann JM, Diebold J, Milia JD, Thomas RK, Gautschi O
J Clin Oncol 2015 Mar 20;33(9):992-9. Epub 2015 Feb 9 doi: 10.1200/JCO.2014.58.3302. PMID: 25667280
ALK and ROS1 overexpression is very rare in colorectal adenocarcinoma.
Houang M, Toon CW, Clarkson A, Sioson L, de Silva K, Watson N, Singh NR, Chou A, Gill AJ
Appl Immunohistochem Mol Morphol 2015 Feb;23(2):134-8. doi: 10.1097/PAI.0000000000000025. PMID: 24992173

Prognosis

Abdominal inflammatory myofibroblastic tumour: Clinicopathological and molecular analysis of 20 cases, highlighting potential therapeutic targets.
Vernemmen AIP, Samarska IV, Speel EM, Riedl RG, Goudkade D, de Bruïne AP, Wouda S, van Marion AM, Verlinden IV, van Lijnschoten I, Friederich P, Winnepenninckx VJL, Zur Hausen A, Sciot RME, van den Hout MFCM
Histopathology 2024 Apr;84(5):794-809. Epub 2023 Dec 28 doi: 10.1111/his.15122. PMID: 38155480
Cancer Therapy Guided by Mutation Tests: Current Status and Perspectives.
Aleksakhina SN, Imyanitov EN
Int J Mol Sci 2021 Oct 10;22(20) doi: 10.3390/ijms222010931. PMID: 34681592Free PMC Article
Molecular testing and targeted therapy for non-small cell lung cancer: Current status and perspectives.
Imyanitov EN, Iyevleva AG, Levchenko EV
Crit Rev Oncol Hematol 2021 Jan;157:103194. Epub 2020 Dec 11 doi: 10.1016/j.critrevonc.2020.103194. PMID: 33316418
Gene rearrangement detection by next-generation sequencing in patients with non-small cell lung carcinoma.
Brisudova A, Skarda J
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020 Jun;164(2):127-132. Epub 2020 Apr 6 doi: 10.5507/bp.2020.015. PMID: 32284620
Emerging Biomarkers in Personalized Therapy of Lung Cancer.
Cagle PT, Raparia K, Portier BP
Adv Exp Med Biol 2016;890:25-36. doi: 10.1007/978-3-319-24932-2_2. PMID: 26703797

Clinical prediction guides

Cost-Efficient Detection of NTRK1/2/3 Gene Fusions: Single-Center Analysis of 8075 Tumor Samples.
Romanko AA, Mulkidjan RS, Tiurin VI, Saitova ES, Preobrazhenskaya EV, Krivosheyeva EA, Mitiushkina NV, Shestakova AD, Belogubova EV, Ivantsov AO, Iyevleva AG, Imyanitov EN
Int J Mol Sci 2023 Sep 17;24(18) doi: 10.3390/ijms241814203. PMID: 37762506Free PMC Article
ALK, ROS1, RET and NTRK1-3 Gene Fusions in Colorectal and Non-Colorectal Microsatellite-Unstable Cancers.
Mulkidjan RS, Saitova ES, Preobrazhenskaya EV, Asadulaeva KA, Bubnov MG, Otradnova EA, Terina DM, Shulga SS, Martynenko DE, Semina MV, Belogubova EV, Tiurin VI, Amankwah PS, Martianov AS, Imyanitov EN
Int J Mol Sci 2023 Sep 2;24(17) doi: 10.3390/ijms241713610. PMID: 37686416Free PMC Article
Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
Molecular testing and targeted therapy for non-small cell lung cancer: Current status and perspectives.
Imyanitov EN, Iyevleva AG, Levchenko EV
Crit Rev Oncol Hematol 2021 Jan;157:103194. Epub 2020 Dec 11 doi: 10.1016/j.critrevonc.2020.103194. PMID: 33316418
Liquid biopsy in lung cancer.
Mlika M, Hofman P, Dziri C, Mezni F
Tunis Med 2017 Novembre;95(11):965-971. PMID: 29877554

Recent systematic reviews

Comparison of liquid-based to tissue-based biopsy analysis by targeted next generation sequencing in advanced non-small cell lung cancer: a comprehensive systematic review.
Esagian SM, Grigoriadou GΙ, Nikas IP, Boikou V, Sadow PM, Won JK, Economopoulos KP
J Cancer Res Clin Oncol 2020 Aug;146(8):2051-2066. Epub 2020 May 27 doi: 10.1007/s00432-020-03267-x. PMID: 32462295Free PMC Article

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