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Hendra virus infection

MedGen UID:
1388276
•Concept ID:
C4505487
•
Disease or Syndrome
Synonyms: Hendra Virus Infection; Hendra Virus Infections; Infection, Hendra Virus; Virus Infection, Hendra; Virus Infections, Hendra
SNOMED CT: Infection caused by Hendra virus (773582002); Hendra virus infection (773582002)
 
Monarch Initiative: MONDO:0017942
Orphanet: ORPHA324632

Definition

A rare viral infection disorder caused by the Hendra virus with characteristics of the onset of flu-like symptoms (fever, myalgia, headaches, lethargy) approximately one week after having been in close contact with bodily fluids of infected horses. Neurological manifestations (for example vertigo, confusion, ataxia) and progressive respiratory failure, leading to death, have also been reported. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHendra virus infection

Professional guidelines

PubMed

A Brighton Collaboration standardized template with key considerations for a benefit/risk assessment for a soluble glycoprotein vaccine to prevent disease caused by Nipah or Hendra viruses.
Eldridge JH, Egan MA, Matassov D, Hamm S, Hermida L, Chen T, Tremblay M, Sciotto-Brown S, Xu R, Dimitrov A, Smith ER, Gurwith M, Chen RT; Benefit-Risk Assessment of VAccines by TechnolOgy Working Group BRAVATO, ex-V3SWG)
Vaccine 2021 Sep 7;39(38):5436-5441. Epub 2021 Aug 7 doi: 10.1016/j.vaccine.2021.07.030. PMID: 34373117
A novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment.
Rockx B, Bossart KN, Feldmann F, Geisbert JB, Hickey AC, Brining D, Callison J, Safronetz D, Marzi A, Kercher L, Long D, Broder CC, Feldmann H, Geisbert TW
J Virol 2010 Oct;84(19):9831-9. Epub 2010 Jul 21 doi: 10.1128/JVI.01163-10. PMID: 20660198Free PMC Article
Combined chloroquine and ribavirin treatment does not prevent death in a hamster model of Nipah and Hendra virus infection.
Freiberg AN, Worthy MN, Lee B, Holbrook MR
J Gen Virol 2010 Mar;91(Pt 3):765-72. Epub 2009 Nov 4 doi: 10.1099/vir.0.017269-0. PMID: 19889926Free PMC Article

Recent clinical studies

Etiology

A Brighton Collaboration standardized template with key considerations for a benefit/risk assessment for a soluble glycoprotein vaccine to prevent disease caused by Nipah or Hendra viruses.
Eldridge JH, Egan MA, Matassov D, Hamm S, Hermida L, Chen T, Tremblay M, Sciotto-Brown S, Xu R, Dimitrov A, Smith ER, Gurwith M, Chen RT; Benefit-Risk Assessment of VAccines by TechnolOgy Working Group BRAVATO, ex-V3SWG)
Vaccine 2021 Sep 7;39(38):5436-5441. Epub 2021 Aug 7 doi: 10.1016/j.vaccine.2021.07.030. PMID: 34373117
Time of year, age class and body condition predict Hendra virus infection in Australian black flying foxes (Pteropus alecto).
Edson D, Peel AJ, Huth L, Mayer DG, Vidgen ME, McMichael L, Broos A, Melville D, Kristoffersen J, de Jong C, McLaughlin A, Field HE
Epidemiol Infect 2019 Jan;147:e240. doi: 10.1017/S0950268819001237. PMID: 31364577Free PMC Article
"Why won't they just vaccinate?" Horse owner risk perception and uptake of the Hendra virus vaccine.
Manyweathers J, Field H, Longnecker N, Agho K, Smith C, Taylor M
BMC Vet Res 2017 Apr 13;13(1):103. doi: 10.1186/s12917-017-1006-7. PMID: 28407738Free PMC Article
Hendra virus.
Middleton D
Vet Clin North Am Equine Pract 2014 Dec;30(3):579-89. Epub 2014 Sep 30 doi: 10.1016/j.cveq.2014.08.004. PMID: 25281398Free PMC Article
Evidence of endemic Hendra virus infection in flying-foxes (Pteropus conspicillatus)--implications for disease risk management.
Breed AC, Breed MF, Meers J, Field HE
PLoS One 2011;6(12):e28816. Epub 2011 Dec 14 doi: 10.1371/journal.pone.0028816. PMID: 22194920Free PMC Article

Diagnosis

Aptamer and aptasensor technology for diagnosis of infectious diseases: A mini review.
Madalgi RK, Arakera SB, Kulkarni RD
Indian J Med Microbiol 2024 Sep-Oct;51:100694. Epub 2024 Aug 17 doi: 10.1016/j.ijmmb.2024.100694. PMID: 39074769
No evidence of prolonged Hendra virus shedding by 2 patients, Australia.
Taylor C, Playford EG, McBride WJ, McMahon J, Warrilow D
Emerg Infect Dis 2012 Dec;18(12):2025-7. doi: 10.3201/eid1812.120722. PMID: 23171522Free PMC Article
Hendra virus: what do we know?
Hess IM, Massey PD, Walker B, Middleton DJ, Wright TM
N S W Public Health Bull 2011 Jul;22(5-6):118-22. doi: 10.1071/NB10077. PMID: 21781619
Nipah/Hendra virus outbreak in Siliguri, West Bengal, India in 2001.
Harit AK, Ichhpujani RL, Gupta S, Gill KS, Lal S, Ganguly NK, Agarwal SP
Indian J Med Res 2006 Apr;123(4):553-60. PMID: 16783047

Therapy

A Cross-Reactive Humanized Monoclonal Antibody Targeting Fusion Glycoprotein Function Protects Ferrets Against Lethal Nipah Virus and Hendra Virus Infection.
Mire CE, Chan YP, Borisevich V, Cross RW, Yan L, Agans KN, Dang HV, Veesler D, Fenton KA, Geisbert TW, Broder CC
J Infect Dis 2020 May 11;221(Suppl 4):S471-S479. doi: 10.1093/infdis/jiz515. PMID: 31686101Free PMC Article
"Why won't they just vaccinate?" Horse owner risk perception and uptake of the Hendra virus vaccine.
Manyweathers J, Field H, Longnecker N, Agho K, Smith C, Taylor M
BMC Vet Res 2017 Apr 13;13(1):103. doi: 10.1186/s12917-017-1006-7. PMID: 28407738Free PMC Article
Combined chloroquine and ribavirin treatment does not prevent death in a hamster model of Nipah and Hendra virus infection.
Freiberg AN, Worthy MN, Lee B, Holbrook MR
J Gen Virol 2010 Mar;91(Pt 3):765-72. Epub 2009 Nov 4 doi: 10.1099/vir.0.017269-0. PMID: 19889926Free PMC Article
Developments towards effective treatments for Nipah and Hendra virus infection.
Bossart KN, Broder CC
Expert Rev Anti Infect Ther 2006 Feb;4(1):43-55. doi: 10.1586/14787210.4.1.43. PMID: 16441208
Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein.
Bossart KN, Mungall BA, Crameri G, Wang LF, Eaton BT, Broder CC
Virol J 2005 Jul 18;2:57. doi: 10.1186/1743-422X-2-57. PMID: 16026621Free PMC Article

Prognosis

Time of year, age class and body condition predict Hendra virus infection in Australian black flying foxes (Pteropus alecto).
Edson D, Peel AJ, Huth L, Mayer DG, Vidgen ME, McMichael L, Broos A, Melville D, Kristoffersen J, de Jong C, McLaughlin A, Field HE
Epidemiol Infect 2019 Jan;147:e240. doi: 10.1017/S0950268819001237. PMID: 31364577Free PMC Article
No evidence of prolonged Hendra virus shedding by 2 patients, Australia.
Taylor C, Playford EG, McBride WJ, McMahon J, Warrilow D
Emerg Infect Dis 2012 Dec;18(12):2025-7. doi: 10.3201/eid1812.120722. PMID: 23171522Free PMC Article
Evidence of endemic Hendra virus infection in flying-foxes (Pteropus conspicillatus)--implications for disease risk management.
Breed AC, Breed MF, Meers J, Field HE
PLoS One 2011;6(12):e28816. Epub 2011 Dec 14 doi: 10.1371/journal.pone.0028816. PMID: 22194920Free PMC Article
Hendra virus outbreak with novel clinical features, Australia.
Field H, Schaaf K, Kung N, Simon C, Waltisbuhl D, Hobert H, Moore F, Middleton D, Crook A, Smith G, Daniels P, Glanville R, Lovell D
Emerg Infect Dis 2010 Feb;16(2):338-40. doi: 10.3201/eid1602.090780. PMID: 20113576Free PMC Article
Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein.
Bossart KN, Mungall BA, Crameri G, Wang LF, Eaton BT, Broder CC
Virol J 2005 Jul 18;2:57. doi: 10.1186/1743-422X-2-57. PMID: 16026621Free PMC Article

Clinical prediction guides

Time of year, age class and body condition predict Hendra virus infection in Australian black flying foxes (Pteropus alecto).
Edson D, Peel AJ, Huth L, Mayer DG, Vidgen ME, McMichael L, Broos A, Melville D, Kristoffersen J, de Jong C, McLaughlin A, Field HE
Epidemiol Infect 2019 Jan;147:e240. doi: 10.1017/S0950268819001237. PMID: 31364577Free PMC Article
Detailed morphological characterisation of Hendra virus infection of different cell types using super-resolution and conventional imaging.
Monaghan P, Green D, Pallister J, Klein R, White J, Williams C, McMillan P, Tilley L, Lampe M, Hawes P, Wang LF
Virol J 2014 Nov 27;11:200. doi: 10.1186/s12985-014-0200-5. PMID: 25428656Free PMC Article
Evidence of endemic Hendra virus infection in flying-foxes (Pteropus conspicillatus)--implications for disease risk management.
Breed AC, Breed MF, Meers J, Field HE
PLoS One 2011;6(12):e28816. Epub 2011 Dec 14 doi: 10.1371/journal.pone.0028816. PMID: 22194920Free PMC Article
Combined chloroquine and ribavirin treatment does not prevent death in a hamster model of Nipah and Hendra virus infection.
Freiberg AN, Worthy MN, Lee B, Holbrook MR
J Gen Virol 2010 Mar;91(Pt 3):765-72. Epub 2009 Nov 4 doi: 10.1099/vir.0.017269-0. PMID: 19889926Free PMC Article
Human Hendra virus infection causes acute and relapsing encephalitis.
Wong KT, Robertson T, Ong BB, Chong JW, Yaiw KC, Wang LF, Ansford AJ, Tannenberg A
Neuropathol Appl Neurobiol 2009 Jun;35(3):296-305. Epub 2008 Oct 2 doi: 10.1111/j.1365-2990.2008.00991.x. PMID: 19473296

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