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Aggressive Papillary Tumor

MedGen UID:
1390433
•Concept ID:
C4518570
•
Neoplastic Process
Synonym: Aggressive papillary tumor
SNOMED CT: Aggressive papillary tumor (733074001)

Definition

A locally invasive, papillary epithelial neoplasm arising in any area of the middle ear, including the mastoid process and air cells, and may fill the tympanic cavity. It is characterized by the presence of a papillary glandular pattern, with complex interdigitating papillae lying loosely or infiltrating fibrous connective tissue. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAggressive Papillary Tumor

Professional guidelines

PubMed

Indications and Strategy for Active Surveillance of Adult Low-Risk Papillary Thyroid Microcarcinoma: Consensus Statements from the Japan Association of Endocrine Surgery Task Force on Management for Papillary Thyroid Microcarcinoma.
Sugitani I, Ito Y, Takeuchi D, Nakayama H, Masaki C, Shindo H, Teshima M, Horiguchi K, Yoshida Y, Kanai T, Hirokawa M, Hames KY, Tabei I, Miyauchi A
Thyroid 2021 Feb;31(2):183-192. Epub 2020 Nov 2 doi: 10.1089/thy.2020.0330. PMID: 33023426Free PMC Article
Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657Free PMC Article
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Recent clinical studies

Etiology

Adenomatous tumors of the middle ear and temporal bone: clinical, morphological and tumor biological characteristics of challenging neoplastic lesions.
Duderstadt M, Förster C, Welkoborsky HJ, Ostertag H
Eur Arch Otorhinolaryngol 2012 Mar;269(3):823-31. Epub 2011 Aug 24 doi: 10.1007/s00405-011-1729-1. PMID: 21863251
Adenomatous lesions of the temporal bone immunohistochemical analysis and theories of histogenesis.
Bold EL, Wanamaker JR, Hughes GB, Rhee CK, Sebek BA, Kinney SE
Am J Otol 1995 Mar;16(2):146-52. PMID: 8572112

Diagnosis

Adenomatous tumors of the middle ear and temporal bone: clinical, morphological and tumor biological characteristics of challenging neoplastic lesions.
Duderstadt M, Förster C, Welkoborsky HJ, Ostertag H
Eur Arch Otorhinolaryngol 2012 Mar;269(3):823-31. Epub 2011 Aug 24 doi: 10.1007/s00405-011-1729-1. PMID: 21863251
Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): sine qua non radiology-pathology and the University of Texas MD Anderson Cancer Center experience.
Bell D, Gidley P, Levine N, Fuller GN
Ann Diagn Pathol 2011 Apr;15(2):117-23. Epub 2010 Dec 16 doi: 10.1016/j.anndiagpath.2010.08.009. PMID: 21167761
Aggressive papillary tumor of the middle ear: a true entity or an endolymphatic sac neoplasm?
Tysome JR, Harcourt J, Patel MC, Sandison A, Michaels L
Ear Nose Throat J 2008 Jul;87(7):378-93. PMID: 18633929
Endolymphatic sac tumor (low-grade papillary adenocarcinoma) of the temporal bone.
Devaney KO, Ferlito A, Rinaldo A
Acta Otolaryngol 2003 Dec;123(9):1022-6. doi: 10.1080/00016480310000494. PMID: 14710902
Aggressive papillary tumor of middle ear/temporal bone and adnexal papillary cystadenoma. Manifestations of von Hippel-Lindau disease.
Gaffey MJ, Mills SE, Boyd JC
Am J Surg Pathol 1994 Dec;18(12):1254-60. doi: 10.1097/00000478-199412000-00009. PMID: 7977949

Prognosis

Adenomatous tumors of the middle ear and temporal bone: clinical, morphological and tumor biological characteristics of challenging neoplastic lesions.
Duderstadt M, Förster C, Welkoborsky HJ, Ostertag H
Eur Arch Otorhinolaryngol 2012 Mar;269(3):823-31. Epub 2011 Aug 24 doi: 10.1007/s00405-011-1729-1. PMID: 21863251
Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): sine qua non radiology-pathology and the University of Texas MD Anderson Cancer Center experience.
Bell D, Gidley P, Levine N, Fuller GN
Ann Diagn Pathol 2011 Apr;15(2):117-23. Epub 2010 Dec 16 doi: 10.1016/j.anndiagpath.2010.08.009. PMID: 21167761
Endolymphatic sac tumor (low-grade papillary adenocarcinoma) of the temporal bone.
Devaney KO, Ferlito A, Rinaldo A
Acta Otolaryngol 2003 Dec;123(9):1022-6. doi: 10.1080/00016480310000494. PMID: 14710902

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