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Light-chain paraproteinemia

MedGen UID:
1390883
•Concept ID:
C4476929
•
Finding
HPO: HP:0031048

Definition

An abnormal immunoglobulin light chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLight-chain paraproteinemia

Professional guidelines

PubMed

Diagnosis and Treatment of AL Amyloidosis.
Palladini G, Milani P
Drugs 2023 Feb;83(3):203-216. Epub 2023 Jan 18 doi: 10.1007/s40265-022-01830-z. PMID: 36652193
Multiple myeloma: 2022 update on diagnosis, risk stratification, and management.
Rajkumar SV
Am J Hematol 2022 Aug;97(8):1086-1107. Epub 2022 May 23 doi: 10.1002/ajh.26590. PMID: 35560063Free PMC Article
Diagnosis and Management of Multiple Myeloma: A Review.
Cowan AJ, Green DJ, Kwok M, Lee S, Coffey DG, Holmberg LA, Tuazon S, Gopal AK, Libby EN
JAMA 2022 Feb 1;327(5):464-477. doi: 10.1001/jama.2022.0003. PMID: 35103762

Recent clinical studies

Diagnosis

Papular mucinosis with myopathy, arthritis, and eosinophilia. A histopathologic study.
McAdam LP, Pearson CM, Pitts WH, Sadoff L, Verity MA
Arthritis Rheum 1977 May;20(4):989-96. doi: 10.1002/art.1780200412. PMID: 405019

Therapy

Papular mucinosis with myopathy, arthritis, and eosinophilia. A histopathologic study.
McAdam LP, Pearson CM, Pitts WH, Sadoff L, Verity MA
Arthritis Rheum 1977 May;20(4):989-96. doi: 10.1002/art.1780200412. PMID: 405019

Prognosis

Extended survival of patients with primary systemic amyloidosis.
Wallis MS, Stough DB 4th
Cutis 1992 Mar;49(3):193-5. PMID: 1572224

Clinical prediction guides

Scleromyxedema myopathy. Histochemical and electron microscopic observations.
Verity MA, Toop J, McAdam LP, Pearson CM
Am J Clin Pathol 1978 Apr;69(4):446-51. doi: 10.1093/ajcp/69.4.446. PMID: 645644
Kappa-type light chain crystal storage histiocytosis.
Terashima K, Takahashi K, Kojima M, Imai Y, Tsuchida S, Migita S, Ebina S, Itoh C
Acta Pathol Jpn 1978 Jan;28(1):111-38. doi: 10.1111/j.1440-1827.1978.tb01254.x. PMID: 416650
Papular mucinosis with myopathy, arthritis, and eosinophilia. A histopathologic study.
McAdam LP, Pearson CM, Pitts WH, Sadoff L, Verity MA
Arthritis Rheum 1977 May;20(4):989-96. doi: 10.1002/art.1780200412. PMID: 405019

Supplemental Content

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