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Factor VII Inactivation

MedGen UID:
1391171
•Concept ID:
C4329968
•
Disease or Syndrome

Definition

Presence of inactivating antibodies to factor VII in the blood. [from NCI]

Professional guidelines

PubMed

Treatment of rare factor deficiencies in 2016.
Peyvandi F, Menegatti M
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):663-669. doi: 10.1182/asheducation-2016.1.663. PMID: 27913544Free PMC Article
Race against the clock: overcoming challenges in the management of anticoagulant-associated intracerebral hemorrhage.
Le Roux P, Pollack CV Jr, Milan M, Schaefer A
J Neurosurg 2014 Aug;121 Suppl:1-20. doi: 10.3171/2014.8.paradigm. PMID: 25081496
Clinical review: Clinical management of new oral anticoagulants: a structured review with emphasis on the reversal of bleeding complications.
Lazo-Langner A, Lang ES, Douketis J
Crit Care 2013 Jun 17;17(3):230. doi: 10.1186/cc12592. PMID: 23806169Free PMC Article

Recent clinical studies

Therapy

A review of oral anticoagulants, old and new, in major bleeding and the need for urgent surgery.
Milling TJ Jr, Ziebell CM
Trends Cardiovasc Med 2020 Feb;30(2):86-90. Epub 2019 Mar 26 doi: 10.1016/j.tcm.2019.03.004. PMID: 30952383Free PMC Article
Treatment of rare factor deficiencies in 2016.
Peyvandi F, Menegatti M
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):663-669. doi: 10.1182/asheducation-2016.1.663. PMID: 27913544Free PMC Article
Race against the clock: overcoming challenges in the management of anticoagulant-associated intracerebral hemorrhage.
Le Roux P, Pollack CV Jr, Milan M, Schaefer A
J Neurosurg 2014 Aug;121 Suppl:1-20. doi: 10.3171/2014.8.paradigm. PMID: 25081496
Challenges for new haemophilia products from a manufacturer's perspective.
Schulte S
Thromb Res 2014 Nov;134 Suppl 1:S72-6. Epub 2013 Dec 21 doi: 10.1016/j.thromres.2013.10.021. PMID: 24360931
Anticoagulation: a surgical perspective.
Perry MO
Am J Surg 1988 Feb;155(2):268-76. doi: 10.1016/s0002-9610(88)80712-8. PMID: 3277474

Prognosis

Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk.
Olson NC, Raffield LM, Lange LA, Lange EM, Longstreth WT Jr, Chauhan G, Debette S, Seshadri S, Reiner AP, Tracy RP
J Thromb Haemost 2018 Jan;16(1):19-30. Epub 2017 Dec 8 doi: 10.1111/jth.13899. PMID: 29112333Free PMC Article
Quantitative PET Imaging of Tissue Factor Expression Using 18F-Labeled Active Site-Inhibited Factor VII.
Nielsen CH, Erlandsson M, Jeppesen TE, Jensen MM, Kristensen LK, Madsen J, Petersen LC, Kjaer A
J Nucl Med 2016 Jan;57(1):89-95. Epub 2015 Sep 17 doi: 10.2967/jnumed.115.154849. PMID: 26383146
Effects of anti-factor VIII inhibitor antibodies on factor VIIa/tissue factor-catalysed activation and inactivation of factor VIII.
Yada K, Nogami K, Ogiwara K, Shibata M, Shima M
Thromb Haemost 2011 Jun;105(6):989-98. Epub 2011 Mar 24 doi: 10.1160/TH10-12-0781. PMID: 21437361
Anticoagulation proteins C and S.
Esmon CT, Vigano-D'Angelo S, D'Angelo A, Comp PC
Adv Exp Med Biol 1987;214:47-54. doi: 10.1007/978-1-4757-5985-3_4. PMID: 2959034
The activation and inactivation of human factor VIII by thrombin: effect of inhibitors of thrombin.
Hultin MB, Jesty J
Blood 1981 Mar;57(3):476-82. PMID: 6779877

Clinical prediction guides

Literature review and clinical observation of acquired idiopathic hemophilia with a new missense mutation in the factor VIII gene (His2026Arg).
Ershov VI, Gadaev IY, Perina FG, Surin VL, Salomashkina VV, Pshenichnikova OS, Zozulya NI
Ter Arkh 2018 Aug 17;90(7):118-122. doi: 10.26442/terarkh2018907118-122. PMID: 30701933
Tissue factor pathway inhibitor is an inhibitor of factor VII-activating protease.
Stephan F, Dienava-Verdoold I, Bulder I, Wouters D, Mast AE, Te Velthuis H, Aarden LA, Zeerleder S
J Thromb Haemost 2012 Jun;10(6):1165-71. doi: 10.1111/j.1538-7836.2012.04712.x. PMID: 22449009Free PMC Article
Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases.
Wygrecka M, Jablonska E, Guenther A, Preissner KT, Markart P
Thromb Haemost 2008 Mar;99(3):494-501. doi: 10.1160/TH07-11-0666. PMID: 18327397
Sources of tissue factor.
Østerud B, Bjørklid E
Semin Thromb Hemost 2006 Feb;32(1):11-23. doi: 10.1055/s-2006-933336. PMID: 16479458
The activation and inactivation of human factor VIII by thrombin: effect of inhibitors of thrombin.
Hultin MB, Jesty J
Blood 1981 Mar;57(3):476-82. PMID: 6779877

Recent systematic reviews

Clinical review: Clinical management of new oral anticoagulants: a structured review with emphasis on the reversal of bleeding complications.
Lazo-Langner A, Lang ES, Douketis J
Crit Care 2013 Jun 17;17(3):230. doi: 10.1186/cc12592. PMID: 23806169Free PMC Article

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