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Abnormal response to insulin tolerance test

MedGen UID:
1391626
Concept ID:
C4476954
Finding
HPO: HP:0031075

Definition

An anomalous response to the insulin tolerance test (ITT), in which insulin is administered intravenously and blood glucose and potentially other compounds are measured at intervals. Insulin administration is intended to induce extreme hypoglycemia (bloodgluoce below 40 mg/dl), which in turn induces release of adrenocorticotropic hormone (ACTH) and growth hormone (GH). ACTH induces the adrenal gland to release cortisol, which together with GH opposes the action of insulin on the blood glucose level. [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Ng N, Mijares Zamuner M, Siddique N, Kim J, Burke M, Byrne MM
Acta Diabetol 2022 Jan;59(1):83-93. Epub 2021 Sep 6 doi: 10.1007/s00592-021-01794-8. PMID: 34487217
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society
Endocr Pract 2015 Dec;21(12):1415-26. doi: 10.4158/EP15748.DSCPT2. PMID: 26642102
Triplitt C, Cersosimo E, DeFronzo RA
Vasc Health Risk Manag 2010 Sep 7;6:671-90. doi: 10.2147/vhrm.s4852. PMID: 20859539Free PMC Article

Recent clinical studies

Etiology

Libman I, Bingley PJ, Becker D, Buckner JH, DiMeglio LA, Gitelman SE, Greenbaum C, Haller MJ, Ismail HM, Krischer J, Moore WV, Moran A, Muir AB, Raman V, Steck AK, Toledo FGS, Wentworth J, Wherrett D, White P, You L, Herold KC; Type 1 Diabetes TrialNet Study Group
Diabetes Care 2023 Nov 1;46(11):2035-2043. doi: 10.2337/dc23-1096. PMID: 37708415Free PMC Article
Russell WE, Bundy BN, Anderson MS, Cooney LA, Gitelman SE, Goland RS, Gottlieb PA, Greenbaum CJ, Haller MJ, Krischer JP, Libman IM, Linsley PS, Long SA, Lord SM, Moore DJ, Moore WV, Moran AM, Muir AB, Raskin P, Skyler JS, Wentworth JM, Wherrett DK, Wilson DM, Ziegler AG, Herold KC; Type 1 Diabetes TrialNet Study Group
Diabetes Care 2023 May 1;46(5):1005-1013. doi: 10.2337/dc22-2200. PMID: 36920087Free PMC Article
Lages M, Barros R, Moreira P, Guarino MP
Nutrients 2022 May 12;14(10) doi: 10.3390/nu14102032. PMID: 35631171Free PMC Article
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society
Endocr Pract 2015 Dec;21(12):1415-26. doi: 10.4158/EP15748.DSCPT2. PMID: 26642102
Reimondo G, Bovio S, Allasino B, Terzolo M, Angeli A
Pituitary 2008;11(2):147-54. doi: 10.1007/s11102-008-0108-4. PMID: 18418713

Diagnosis

Russell WE, Bundy BN, Anderson MS, Cooney LA, Gitelman SE, Goland RS, Gottlieb PA, Greenbaum CJ, Haller MJ, Krischer JP, Libman IM, Linsley PS, Long SA, Lord SM, Moore DJ, Moore WV, Moran AM, Muir AB, Raskin P, Skyler JS, Wentworth JM, Wherrett DK, Wilson DM, Ziegler AG, Herold KC; Type 1 Diabetes TrialNet Study Group
Diabetes Care 2023 May 1;46(5):1005-1013. doi: 10.2337/dc22-2200. PMID: 36920087Free PMC Article
Lages M, Barros R, Moreira P, Guarino MP
Nutrients 2022 May 12;14(10) doi: 10.3390/nu14102032. PMID: 35631171Free PMC Article
Orsi E, Grancini V, Menini S, Aghemo A, Pugliese G
Liver Int 2017 Jul;37(7):950-962. Epub 2016 Dec 31 doi: 10.1111/liv.13337. PMID: 27943508
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society
Endocr Pract 2015 Dec;21(12):1415-26. doi: 10.4158/EP15748.DSCPT2. PMID: 26642102
Reimondo G, Bovio S, Allasino B, Terzolo M, Angeli A
Pituitary 2008;11(2):147-54. doi: 10.1007/s11102-008-0108-4. PMID: 18418713

Therapy

Libman I, Bingley PJ, Becker D, Buckner JH, DiMeglio LA, Gitelman SE, Greenbaum C, Haller MJ, Ismail HM, Krischer J, Moore WV, Moran A, Muir AB, Raman V, Steck AK, Toledo FGS, Wentworth J, Wherrett D, White P, You L, Herold KC; Type 1 Diabetes TrialNet Study Group
Diabetes Care 2023 Nov 1;46(11):2035-2043. doi: 10.2337/dc23-1096. PMID: 37708415Free PMC Article
Russell WE, Bundy BN, Anderson MS, Cooney LA, Gitelman SE, Goland RS, Gottlieb PA, Greenbaum CJ, Haller MJ, Krischer JP, Libman IM, Linsley PS, Long SA, Lord SM, Moore DJ, Moore WV, Moran AM, Muir AB, Raskin P, Skyler JS, Wentworth JM, Wherrett DK, Wilson DM, Ziegler AG, Herold KC; Type 1 Diabetes TrialNet Study Group
Diabetes Care 2023 May 1;46(5):1005-1013. doi: 10.2337/dc22-2200. PMID: 36920087Free PMC Article
Sanna S, van Zuydam NR, Mahajan A, Kurilshikov A, Vich Vila A, Võsa U, Mujagic Z, Masclee AAM, Jonkers DMAE, Oosting M, Joosten LAB, Netea MG, Franke L, Zhernakova A, Fu J, Wijmenga C, McCarthy MI
Nat Genet 2019 Apr;51(4):600-605. Epub 2019 Feb 18 doi: 10.1038/s41588-019-0350-x. PMID: 30778224Free PMC Article
Orsi E, Grancini V, Menini S, Aghemo A, Pugliese G
Liver Int 2017 Jul;37(7):950-962. Epub 2016 Dec 31 doi: 10.1111/liv.13337. PMID: 27943508
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society
Endocr Pract 2015 Dec;21(12):1415-26. doi: 10.4158/EP15748.DSCPT2. PMID: 26642102

Prognosis

Kamenický P, Blanchard A, Lamaziere A, Piedvache C, Donadille B, Duranteau L, Bry H, Gautier JF, Salenave S, Raffin-Sanson ML, Genc S, Pietri L, Christin-Maitre S, Thomas J, Lorthioir A, Azizi M, Chanson P, Le Bouc Y, Brailly-Tabard S, Young J
J Clin Endocrinol Metab 2020 Jan 1;105(1) doi: 10.1210/clinem/dgz005. PMID: 31529070
Wang Q, Jokelainen J, Auvinen J, Puukka K, Keinänen-Kiukaanniemi S, Järvelin MR, Kettunen J, Mäkinen VP, Ala-Korpela M
BMC Med 2019 Nov 29;17(1):217. doi: 10.1186/s12916-019-1440-4. PMID: 31779625Free PMC Article
Orsi E, Grancini V, Menini S, Aghemo A, Pugliese G
Liver Int 2017 Jul;37(7):950-962. Epub 2016 Dec 31 doi: 10.1111/liv.13337. PMID: 27943508
Veijola R, Koskinen M, Helminen O, Hekkala A
Pediatr Diabetes 2016 Jul;17 Suppl 22:25-30. doi: 10.1111/pedi.12392. PMID: 27411433
Lee CC, Watkins SM, Lorenzo C, Wagenknecht LE, Il'yasova D, Chen YD, Haffner SM, Hanley AJ
Diabetes Care 2016 Apr;39(4):582-8. Epub 2016 Feb 19 doi: 10.2337/dc15-2284. PMID: 26895884Free PMC Article

Clinical prediction guides

Karacan Küçükali G, Keskin M, Aycan Z, Savaş-Erdeve Ş, Çetinkaya S
Eur J Med Genet 2023 Oct;66(10):104828. Epub 2023 Sep 4 doi: 10.1016/j.ejmg.2023.104828. PMID: 37673300
Kosuda M, Watanabe K, Koike M, Morikawa A, Saito H, Kohno G, Ishihara H
J Nippon Med Sch 2022 Mar 11;89(1):102-107. Epub 2021 Sep 14 doi: 10.1272/jnms.JNMS.2022_89-205. PMID: 34526455
Orsi E, Grancini V, Menini S, Aghemo A, Pugliese G
Liver Int 2017 Jul;37(7):950-962. Epub 2016 Dec 31 doi: 10.1111/liv.13337. PMID: 27943508
Veijola R, Koskinen M, Helminen O, Hekkala A
Pediatr Diabetes 2016 Jul;17 Suppl 22:25-30. doi: 10.1111/pedi.12392. PMID: 27411433
Marini MA, Frontoni S, Succurro E, Arturi F, Sciacqua A, Hribal ML, Perticone F, Sesti G
Nutr Metab Cardiovasc Dis 2014 Jan;24(1):27-33. Epub 2013 Apr 16 doi: 10.1016/j.numecd.2013.01.011. PMID: 23601331

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