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Increased factor VIII activity

MedGen UID:
1393349
•Concept ID:
C4476890
•
Finding
Synonym: Elevated factor VIII level
 
HPO: HP:0030977

Definition

Increased activity of the coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased factor VIII activity

Conditions with this feature

Thrombophilia, X-linked, due to factor 8 defect
MedGen UID:
1805414
•Concept ID:
C5676879
•
Disease or Syndrome
X-linked thrombophilia due to factor VIII defect (THPH13) is associated with markedly elevated F8 levels and severe thrombophilia (summary by Simioni et al., 2021).
See: Condition Record
Thrombophilia, X-linked, due to factor 8 defect

Professional guidelines

PubMed

COVID-19 Associated Hypercoagulability: Manifestations, Mechanisms, and Management.
Mazzeffi MA, Chow JH, Tanaka K
Shock 2021 Apr 1;55(4):465-471. doi: 10.1097/SHK.0000000000001660. PMID: 32890309Free PMC Article
Diagnostic algorithm for thrombophilia screening.
Margetic S
Clin Chem Lab Med 2010 Dec;48 Suppl 1:S27-39. Epub 2010 Nov 5 doi: 10.1515/CCLM.2010.362. PMID: 21054193
Diagnosis of von Willebrand's disease. A comparative study of diagnostic tests on nine families with von Willebrand's disease and its differential diagnosis from hemophilia and thrombocytopathy.
Lian EC, Deykin D
Am J Med 1976 Mar;60(3):344-56. doi: 10.1016/0002-9343(76)90750-6. PMID: 1083143

Recent clinical studies

Etiology

Interdependence of coagulation with immunotherapy and BRAF/MEK inhibitor therapy: results from a prospective study.
Beckmann M, Schlüter J, Erdmann M, Kramer R, Cunningham S, Hackstein H, Zimmermann R, Heinzerling L
Cancer Immunol Immunother 2024 Nov 2;74(1):5. doi: 10.1007/s00262-024-03850-y. PMID: 39487855Free PMC Article
Endovascular Thrombectomy and Lysis for Acute Renal Vein Thrombosis: Indications, Technical Aspects, Outcome, and Disease Etiology.
Low R, Crane J, Sackey F, Malina M
J Endovasc Ther 2024 Feb;31(1):136-139. Epub 2022 Jun 29 doi: 10.1177/15266028221107878. PMID: 35766441Free PMC Article
Increased Factor VIII Activity Is Predictive of the Occurrence of Portal Vein Thrombosis in Cirrhosis.
Jiang S, Ai Y, Fan X, Huang X, Wu L, Ni L, Li F, Chen S
Thromb Haemost 2023 Jul;123(7):714-722. Epub 2023 Mar 13 doi: 10.1055/a-2052-9381. PMID: 36913976
Diagnostic algorithm for thrombophilia screening.
Margetic S
Clin Chem Lab Med 2010 Dec;48 Suppl 1:S27-39. Epub 2010 Nov 5 doi: 10.1515/CCLM.2010.362. PMID: 21054193
Fibrinogen concentration and factor VIII activity in women with preeclampsia.
Williams VK, Griffiths AB, Carbone S, Hague WM
Hypertens Pregnancy 2007;26(4):415-21. doi: 10.1080/10641950701548240. PMID: 18066960

Diagnosis

COVID-19 Associated Hypercoagulability: Manifestations, Mechanisms, and Management.
Mazzeffi MA, Chow JH, Tanaka K
Shock 2021 Apr 1;55(4):465-471. doi: 10.1097/SHK.0000000000001660. PMID: 32890309Free PMC Article
A Case of Cerebral Venous Thrombosis and Deep Venous Thrombosis Due to Hyperthyroidism with Increased Factor VIII Activity.
Yokoyama M, Yamashita R, Furuya M, Yamazaki M, Koyama K, Tanaka F
J Stroke Cerebrovasc Dis 2019 Nov;28(11):104364. Epub 2019 Sep 11 doi: 10.1016/j.jstrokecerebrovasdis.2019.104364. PMID: 31521516
Diagnostic algorithm for thrombophilia screening.
Margetic S
Clin Chem Lab Med 2010 Dec;48 Suppl 1:S27-39. Epub 2010 Nov 5 doi: 10.1515/CCLM.2010.362. PMID: 21054193
Risk factors and long-term follow-up of patients with the immune type of heparin-induced thrombocytopenia.
Lindhoff-Last E, Wenning B, Stein M, Gerdsen F, Bauersachs R, Wagner R
Clin Appl Thromb Hemost 2002 Oct;8(4):347-52. doi: 10.1177/107602960200800406. PMID: 12516684
Diagnosis of von Willebrand's disease. A comparative study of diagnostic tests on nine families with von Willebrand's disease and its differential diagnosis from hemophilia and thrombocytopathy.
Lian EC, Deykin D
Am J Med 1976 Mar;60(3):344-56. doi: 10.1016/0002-9343(76)90750-6. PMID: 1083143

Therapy

Interdependence of coagulation with immunotherapy and BRAF/MEK inhibitor therapy: results from a prospective study.
Beckmann M, Schlüter J, Erdmann M, Kramer R, Cunningham S, Hackstein H, Zimmermann R, Heinzerling L
Cancer Immunol Immunother 2024 Nov 2;74(1):5. doi: 10.1007/s00262-024-03850-y. PMID: 39487855Free PMC Article
COVID-19 Associated Hypercoagulability: Manifestations, Mechanisms, and Management.
Mazzeffi MA, Chow JH, Tanaka K
Shock 2021 Apr 1;55(4):465-471. doi: 10.1097/SHK.0000000000001660. PMID: 32890309Free PMC Article
A Case of Cerebral Venous Thrombosis and Deep Venous Thrombosis Due to Hyperthyroidism with Increased Factor VIII Activity.
Yokoyama M, Yamashita R, Furuya M, Yamazaki M, Koyama K, Tanaka F
J Stroke Cerebrovasc Dis 2019 Nov;28(11):104364. Epub 2019 Sep 11 doi: 10.1016/j.jstrokecerebrovasdis.2019.104364. PMID: 31521516
Estrogen treatment improves arterial distensibility, fibrinolysis, and metabolic profile in postmenopausal women with type 2 diabetes mellitus.
Sztejnsznajd C, Silva ME, Nussbacher A, Gebara OE, D'Amico EA, Rocha DM, da Rocha TR, Santos RF, Wajngarten M, Fukui RT, Correia MR, Wajchenberg BL, Ursich MJ
Metabolism 2006 Jul;55(7):953-9. doi: 10.1016/j.metabol.2006.03.003. PMID: 16784970
Risk factors and long-term follow-up of patients with the immune type of heparin-induced thrombocytopenia.
Lindhoff-Last E, Wenning B, Stein M, Gerdsen F, Bauersachs R, Wagner R
Clin Appl Thromb Hemost 2002 Oct;8(4):347-52. doi: 10.1177/107602960200800406. PMID: 12516684

Prognosis

Interdependence of coagulation with immunotherapy and BRAF/MEK inhibitor therapy: results from a prospective study.
Beckmann M, Schlüter J, Erdmann M, Kramer R, Cunningham S, Hackstein H, Zimmermann R, Heinzerling L
Cancer Immunol Immunother 2024 Nov 2;74(1):5. doi: 10.1007/s00262-024-03850-y. PMID: 39487855Free PMC Article
Increased Factor VIII Activity Is Predictive of the Occurrence of Portal Vein Thrombosis in Cirrhosis.
Jiang S, Ai Y, Fan X, Huang X, Wu L, Ni L, Li F, Chen S
Thromb Haemost 2023 Jul;123(7):714-722. Epub 2023 Mar 13 doi: 10.1055/a-2052-9381. PMID: 36913976
Elevated lipoprotein (a) levels are an independent risk factor for retinal vein occlusion.
Kuhli-Hattenbach C, Miesbach W, Lüchtenberg M, Kohnen T, Hattenbach LO
Acta Ophthalmol 2017 Mar;95(2):140-145. Epub 2016 Aug 22 doi: 10.1111/aos.13228. PMID: 27545749
Apparent argatroban resistance in a patient with elevated factor VIII levels.
Kennedy DM, Alaniz C
Ann Pharmacother 2013 Jul-Aug;47(7-8):e29. Epub 2013 Jun 4 doi: 10.1345/aph.1R745. PMID: 23737512
Risk factors and long-term follow-up of patients with the immune type of heparin-induced thrombocytopenia.
Lindhoff-Last E, Wenning B, Stein M, Gerdsen F, Bauersachs R, Wagner R
Clin Appl Thromb Hemost 2002 Oct;8(4):347-52. doi: 10.1177/107602960200800406. PMID: 12516684

Clinical prediction guides

Interdependence of coagulation with immunotherapy and BRAF/MEK inhibitor therapy: results from a prospective study.
Beckmann M, Schlüter J, Erdmann M, Kramer R, Cunningham S, Hackstein H, Zimmermann R, Heinzerling L
Cancer Immunol Immunother 2024 Nov 2;74(1):5. doi: 10.1007/s00262-024-03850-y. PMID: 39487855Free PMC Article
Increased Factor VIII Activity Is Predictive of the Occurrence of Portal Vein Thrombosis in Cirrhosis.
Jiang S, Ai Y, Fan X, Huang X, Wu L, Ni L, Li F, Chen S
Thromb Haemost 2023 Jul;123(7):714-722. Epub 2023 Mar 13 doi: 10.1055/a-2052-9381. PMID: 36913976
Coagulation Profile and its Correlation with Severity of Liver Dysfunction and Gastrointestinal Bleed in Alcoholic Liver Disease Patients.
Bohania N, Agrawal A, Prakash A, Nangia A, Kumar A
J Assoc Physicians India 2021 Jun;69(6):11-12. PMID: 34472786
Prevalence of hyperhomocysteinemia and the MTHFR C677T polymorphism in patients with arterial and venous thrombosis from North Western Russia.
Shmeleva VM, Kapustin SI, Papayan LP, Sobczyńska-Malefora A, Harrington DJ, Savidge GF
Thromb Res 2003;111(6):351-6. doi: 10.1016/j.thromres.2003.10.004. PMID: 14698652
Risk factors and long-term follow-up of patients with the immune type of heparin-induced thrombocytopenia.
Lindhoff-Last E, Wenning B, Stein M, Gerdsen F, Bauersachs R, Wagner R
Clin Appl Thromb Hemost 2002 Oct;8(4):347-52. doi: 10.1177/107602960200800406. PMID: 12516684

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