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Heavy-chain paraproteinemia

MedGen UID:
1393831
Concept ID:
C4476930
Finding
HPO: HP:0031049

Definition

An abnormal immunoglobulin heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeavy-chain paraproteinemia

Professional guidelines

PubMed

Gertz MA
Am J Hematol 2024 Feb;99(2):309-324. Epub 2023 Dec 14 doi: 10.1002/ajh.27177. PMID: 38095141
Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
Ryšavá R
Nephrol Dial Transplant 2019 Sep 1;34(9):1460-1466. doi: 10.1093/ndt/gfy291. PMID: 30299492

Recent clinical studies

Etiology

Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
Mann BK, Bhandohal JS, Cobos E, Chitturi C, Eppanapally S
J Investig Med 2022 Feb;70(2):348-353. Epub 2021 Nov 30 doi: 10.1136/jim-2021-002149. PMID: 34848562
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Ryšavá R
Nephrol Dial Transplant 2019 Sep 1;34(9):1460-1466. doi: 10.1093/ndt/gfy291. PMID: 30299492
Witzig TE, Wahner-Roedler DL
Curr Treat Options Oncol 2002 Jun;3(3):247-54. doi: 10.1007/s11864-002-0014-3. PMID: 12057070

Diagnosis

Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
Mann BK, Bhandohal JS, Cobos E, Chitturi C, Eppanapally S
J Investig Med 2022 Feb;70(2):348-353. Epub 2021 Nov 30 doi: 10.1136/jim-2021-002149. PMID: 34848562
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Ryšavá R
Nephrol Dial Transplant 2019 Sep 1;34(9):1460-1466. doi: 10.1093/ndt/gfy291. PMID: 30299492
Sethi S, Rajkumar SV, D'Agati VD
J Am Soc Nephrol 2018 Jul;29(7):1810-1823. Epub 2018 Apr 27 doi: 10.1681/ASN.2017121319. PMID: 29703839Free PMC Article

Therapy

Hambach J, Mann AM, Bannas P, Koch-Nolte F
Front Immunol 2022;13:1005800. Epub 2022 Nov 2 doi: 10.3389/fimmu.2022.1005800. PMID: 36405759Free PMC Article
Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
Bianchi G, Sohani AR
Curr Gastroenterol Rep 2018 Jan 25;20(1):3. doi: 10.1007/s11894-018-0608-y. PMID: 29372346
Walker BA, Boyle EM, Wardell CP, Murison A, Begum DB, Dahir NM, Proszek PZ, Johnson DC, Kaiser MF, Melchor L, Aronson LI, Scales M, Pawlyn C, Mirabella F, Jones JR, Brioli A, Mikulasova A, Cairns DA, Gregory WM, Quartilho A, Drayson MT, Russell N, Cook G, Jackson GH, Leleu X, Davies FE, Morgan GJ
J Clin Oncol 2015 Nov 20;33(33):3911-20. Epub 2015 Aug 17 doi: 10.1200/JCO.2014.59.1503. PMID: 26282654Free PMC Article
Johnson SA, Oscier DG, Leblond V
Blood Rev 2002 Sep;16(3):175-84. doi: 10.1016/s0268-960x(02)00016-4. PMID: 12163003

Prognosis

Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Ryšavá R
Nephrol Dial Transplant 2019 Sep 1;34(9):1460-1466. doi: 10.1093/ndt/gfy291. PMID: 30299492
Sethi S, Rajkumar SV, D'Agati VD
J Am Soc Nephrol 2018 Jul;29(7):1810-1823. Epub 2018 Apr 27 doi: 10.1681/ASN.2017121319. PMID: 29703839Free PMC Article
Wahner-Roedler DL, Kyle RA
Best Pract Res Clin Haematol 2005;18(4):729-46. doi: 10.1016/j.beha.2005.01.029. PMID: 16026747

Clinical prediction guides

Wang J, Yan Y, Xiong W, Song G, Wang Y, Zhao J, Jia Y, Li C, Yu Z, Yu Y, Chen J, Jiao Y, Wang T, Lyu R, Li Q, Ma Y, Liu W, Zou D, An G, Sun Q, Wang H, Xiao Z, Wang J, Qiu L, Yi S
Blood Adv 2022 Jul 12;6(13):4049-4059. doi: 10.1182/bloodadvances.2022007279. PMID: 35537114Free PMC Article
Tewari R, Chatterjee T, Mendonca S, Dogra M, Pramanik SK, Yanamandra U
Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):298-306. doi: 10.4103/1319-2442.335440. PMID: 35017322
Walker BA, Boyle EM, Wardell CP, Murison A, Begum DB, Dahir NM, Proszek PZ, Johnson DC, Kaiser MF, Melchor L, Aronson LI, Scales M, Pawlyn C, Mirabella F, Jones JR, Brioli A, Mikulasova A, Cairns DA, Gregory WM, Quartilho A, Drayson MT, Russell N, Cook G, Jackson GH, Leleu X, Davies FE, Morgan GJ
J Clin Oncol 2015 Nov 20;33(33):3911-20. Epub 2015 Aug 17 doi: 10.1200/JCO.2014.59.1503. PMID: 26282654Free PMC Article
van de Donk NW, Palumbo A, Johnsen HE, Engelhardt M, Gay F, Gregersen H, Hajek R, Kleber M, Ludwig H, Morgan G, Musto P, Plesner T, Sezer O, Terpos E, Waage A, Zweegman S, Einsele H, Sonneveld P, Lokhorst HM; European Myeloma Network
Haematologica 2014 Jun;99(6):984-96. Epub 2014 Mar 21 doi: 10.3324/haematol.2013.100552. PMID: 24658815Free PMC Article
Kraj M
Adv Clin Exp Med 2014 Jan-Feb;23(1):127-33. doi: 10.17219/acem/37036. PMID: 24596015

Recent systematic reviews

Cárdenas MC, García-Sanz R, Puig N, Pérez-Surribas D, Flores-Montero J, Ortiz-Espejo M, de la Rubia J, Cruz-Iglesias E
Clin Chem Lab Med 2023 Nov 27;61(12):2115-2130. Epub 2023 Jul 24 doi: 10.1515/cclm-2023-0326. PMID: 37477188

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