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Alcohol withdrawal delirium

MedGen UID:
1398
Concept ID:
C0001957
Disease or Syndrome
Synonyms: Alcohol Withdrawal Delirium; Alcohol Withdrawal Induced Delirium Tremens; Alcohol Withdrawal-Induced Delirium Tremens; Delirium Tremens; Delirium Tremens, Alcohol Withdrawal Induced; Delirium, Alcohol Withdrawal
SNOMED CT: Alcohol withdrawal delirium (8635005); Delirium tremens (8635005); DTs - delirium tremens (8635005)
 
Monarch Initiative: MONDO:0006642

Definition

An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include confusion; delusions; vivid hallucinations; tremor; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlcohol withdrawal delirium

Professional guidelines

PubMed

Nishimura Y, Choi H, Colgan B, Kistler H, Mercado F
Eur J Intern Med 2023 Jun;112:52-61. Epub 2023 Mar 21 doi: 10.1016/j.ejim.2023.03.006. PMID: 36935249
Nisavic M, Nejad SH, Isenberg BM, Bajwa EK, Currier P, Wallace PM, Velmahos G, Wilens T
Psychosomatics 2019 Sep-Oct;60(5):458-467. Epub 2019 Feb 14 doi: 10.1016/j.psym.2019.02.002. PMID: 30876654
Mainerova B, Prasko J, Latalova K, Axmann K, Cerna M, Horacek R, Bradacova R
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2015 Mar;159(1):44-52. Epub 2013 Dec 11 doi: 10.5507/bp.2013.089. PMID: 24399242

Recent clinical studies

Etiology

Nisavic M, Nejad SH, Isenberg BM, Bajwa EK, Currier P, Wallace PM, Velmahos G, Wilens T
Psychosomatics 2019 Sep-Oct;60(5):458-467. Epub 2019 Feb 14 doi: 10.1016/j.psym.2019.02.002. PMID: 30876654
Tidwell WP, Thomas TL, Pouliot JD, Canonico AE, Webber AJ
Am J Crit Care 2018 Nov;27(6):454-460. doi: 10.4037/ajcc2018745. PMID: 30385536
Attilia F, Perciballi R, Rotondo C, Capriglione I, Iannuzzi S, Attilia ML, Coriale G, Vitali M, Cereatti F, Fiore M, Ceccanti M; Interdisciplinary Study Group CRARL - SITAC - SIPaD - SITD - SIPDip
Riv Psichiatr 2018 May-Jun;53(3):118-122. doi: 10.1708/2925.29413. PMID: 29912213
Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH
Am J Gastroenterol 2018 Feb;113(2):175-194. Epub 2018 Jan 16 doi: 10.1038/ajg.2017.469. PMID: 29336434Free PMC Article
Schuckit MA
Lancet 2009 Feb 7;373(9662):492-501. Epub 2009 Jan 23 doi: 10.1016/S0140-6736(09)60009-X. PMID: 19168210

Diagnosis

Attilia F, Perciballi R, Rotondo C, Capriglione I, Iannuzzi S, Attilia ML, Coriale G, Vitali M, Cereatti F, Fiore M, Ceccanti M; Interdisciplinary Study Group CRARL - SITAC - SIPaD - SITD - SIPDip
Riv Psichiatr 2018 May-Jun;53(3):118-122. doi: 10.1708/2925.29413. PMID: 29912213
Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH
Am J Gastroenterol 2018 Feb;113(2):175-194. Epub 2018 Jan 16 doi: 10.1038/ajg.2017.469. PMID: 29336434Free PMC Article
Jesse S, Bråthen G, Ferrara M, Keindl M, Ben-Menachem E, Tanasescu R, Brodtkorb E, Hillbom M, Leone MA, Ludolph AC
Acta Neurol Scand 2017 Jan;135(1):4-16. Epub 2016 Sep 1 doi: 10.1111/ane.12671. PMID: 27586815Free PMC Article
Schuckit MA
N Engl J Med 2014 Nov 27;371(22):2109-13. doi: 10.1056/NEJMra1407298. PMID: 25427113
Schuckit MA
Lancet 2009 Feb 7;373(9662):492-501. Epub 2009 Jan 23 doi: 10.1016/S0140-6736(09)60009-X. PMID: 19168210

Therapy

Day E, Daly C
Addiction 2022 Mar;117(3):804-814. Epub 2021 Aug 22 doi: 10.1111/add.15647. PMID: 34288186
Attilia F, Perciballi R, Rotondo C, Capriglione I, Iannuzzi S, Attilia ML, Coriale G, Vitali M, Cereatti F, Fiore M, Ceccanti M; Interdisciplinary Study Group CRARL - SITAC - SIPaD - SITD - SIPDip
Riv Psichiatr 2018 May-Jun;53(3):118-122. doi: 10.1708/2925.29413. PMID: 29912213
Maldonado JR
Crit Care Clin 2017 Jul;33(3):559-599. doi: 10.1016/j.ccc.2017.03.012. PMID: 28601135
Schuckit MA
N Engl J Med 2014 Nov 27;371(22):2109-13. doi: 10.1056/NEJMra1407298. PMID: 25427113
Schuckit MA
Lancet 2009 Feb 7;373(9662):492-501. Epub 2009 Jan 23 doi: 10.1016/S0140-6736(09)60009-X. PMID: 19168210

Prognosis

Silczuk A, Habrat B
Alcohol 2020 Aug;86:9-16. Epub 2020 Apr 21 doi: 10.1016/j.alcohol.2020.02.166. PMID: 32330589
Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH
Am J Gastroenterol 2018 Feb;113(2):175-194. Epub 2018 Jan 16 doi: 10.1038/ajg.2017.469. PMID: 29336434Free PMC Article
Mainerova B, Prasko J, Latalova K, Axmann K, Cerna M, Horacek R, Bradacova R
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2015 Mar;159(1):44-52. Epub 2013 Dec 11 doi: 10.5507/bp.2013.089. PMID: 24399242
Maldonado JR, Sher Y, Ashouri JF, Hills-Evans K, Swendsen H, Lolak S, Miller AC
Alcohol 2014 Jun;48(4):375-90. Epub 2014 Feb 19 doi: 10.1016/j.alcohol.2014.01.004. PMID: 24657098
Carlson RW, Kumar NN, Wong-Mckinstry E, Ayyagari S, Puri N, Jackson FK, Shashikumar S
Crit Care Clin 2012 Oct;28(4):549-85. doi: 10.1016/j.ccc.2012.07.004. PMID: 22998991

Clinical prediction guides

Bahji A, Bach P, Danilewitz M, Crockford D, El-Guebaly N, Devoe DJ, Saitz R
Addiction 2022 Oct;117(10):2591-2601. Epub 2022 Mar 15 doi: 10.1111/add.15853. PMID: 35194860Free PMC Article
Silczuk A, Habrat B
Alcohol 2020 Aug;86:9-16. Epub 2020 Apr 21 doi: 10.1016/j.alcohol.2020.02.166. PMID: 32330589
Maldonado JR, Sher Y, Ashouri JF, Hills-Evans K, Swendsen H, Lolak S, Miller AC
Alcohol 2014 Jun;48(4):375-90. Epub 2014 Feb 19 doi: 10.1016/j.alcohol.2014.01.004. PMID: 24657098
Manasco A, Chang S, Larriviere J, Hamm LL, Glass M
South Med J 2012 Nov;105(11):607-12. doi: 10.1097/SMJ.0b013e31826efb2d. PMID: 23128805
Lugaresi E, Provini F, Cortelli P
Sleep Med 2011 Dec;12 Suppl 2:S3-10. doi: 10.1016/j.sleep.2011.10.004. PMID: 22136896

Recent systematic reviews

Nishimura Y, Choi H, Colgan B, Kistler H, Mercado F
Eur J Intern Med 2023 Jun;112:52-61. Epub 2023 Mar 21 doi: 10.1016/j.ejim.2023.03.006. PMID: 36935249
Bahji A, Bach P, Danilewitz M, Crockford D, El-Guebaly N, Devoe DJ, Saitz R
Addiction 2022 Oct;117(10):2591-2601. Epub 2022 Mar 15 doi: 10.1111/add.15853. PMID: 35194860Free PMC Article
Goodson CM, Clark BJ, Douglas IS
Alcohol Clin Exp Res 2014 Oct;38(10):2664-77. doi: 10.1111/acer.12529. PMID: 25346507
Maldonado JR, Sher Y, Ashouri JF, Hills-Evans K, Swendsen H, Lolak S, Miller AC
Alcohol 2014 Jun;48(4):375-90. Epub 2014 Feb 19 doi: 10.1016/j.alcohol.2014.01.004. PMID: 24657098
Awissi DK, Lebrun G, Coursin DB, Riker RR, Skrobik Y
Intensive Care Med 2013 Jan;39(1):16-30. Epub 2012 Nov 27 doi: 10.1007/s00134-012-2758-y. PMID: 23184039

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