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Ovarian carcinosarcoma

MedGen UID:
140705
Concept ID:
C0392998
Neoplastic Process
Synonyms: Carcinosarcoma of ovary; Carcinosarcoma of Ovary; carcinosarcoma of ovary; Carcinosarcoma of the Ovary; carcinosarcoma of the ovary; Malignant Mixed Mesodermal Mullerian Neoplasm of Ovary; malignant mixed mesodermal Mullerian neoplasm of ovary; Malignant Mixed Mesodermal Mullerian Neoplasm of the Ovary; malignant mixed mesodermal Mullerian neoplasm of the ovary; Malignant Mixed Mesodermal Mullerian Tumor of Ovary; malignant mixed mesodermal Mullerian tumor of ovary; Malignant Mixed Mesodermal Mullerian Tumor of the Ovary; malignant mixed mesodermal Mullerian tumor of the ovary; malignant mixed mesodermal Mullerian tumour of ovary; malignant mixed mesodermal Mullerian tumour of the ovary; Malignant Mixed Mesodermal Müllerian Neoplasm of Ovary; malignant mixed mesodermal Müllerian neoplasm of ovary; Malignant Mixed Mesodermal Müllerian Neoplasm of the Ovary; malignant mixed mesodermal Müllerian neoplasm of the ovary; Malignant Mixed Mesodermal Müllerian Tumor of Ovary; malignant mixed mesodermal Müllerian tumor of ovary; Malignant Mixed Mesodermal Müllerian Tumor of the Ovary; malignant mixed mesodermal Müllerian tumor of the ovary; malignant mixed mesodermal Müllerian tumour of ovary; malignant mixed mesodermal Müllerian tumour of the ovary; malignant mixed Müllerian tumor of the ovary; Malignant mixed Müllerian tumor of the ovary; malignant mixed Müllerian tumour of the ovary; MMMT of the ovary; Ovarian Carcinosarcoma; ovarian carcinosarcoma; ovarian carcinosarcoma/malignant mixed mesodermal tumor; ovarian carcinosarcoma/malignant mixed mesodermal tumour; Ovarian Malignant Mesodermal (Mullerian) Mixed Tumor; ovarian malignant mesodermal (Mullerian) mixed tumor; ovarian malignant mesodermal (mullerian) mixed tumor; ovarian malignant mesodermal (mullerian) mixed tumour; ovarian malignant mesodermal (Mullerian) mixed tumour; Ovarian Malignant Mesodermal (Müllerian) Mixed Tumor; ovarian malignant mesodermal (Müllerian) mixed tumor; ovarian malignant mesodermal (Müllerian) mixed tumour; Ovarian malignant mixed epithelial mesenchymal tumor; ovarian malignant mixed epithelial mesenchymal tumor; ovarian malignant mixed epithelial mesenchymal tumour; Ovarian Malignant Mixed Mesodermal (Mullerian) Tumor; ovarian malignant mixed mesodermal (Mullerian) tumor; ovarian malignant mixed mesodermal (Mullerian) tumour; Ovarian Malignant Mixed Mesodermal (Müllerian) Tumor; ovarian malignant mixed mesodermal (Müllerian) tumor; ovarian malignant mixed mesodermal (Müllerian) tumour; Ovarian Malignant Mixed Mesodermal Mullerian Neoplasm; ovarian malignant mixed mesodermal Mullerian neoplasm; Ovarian Malignant Mixed Mesodermal Mullerian Tumor; ovarian malignant mixed mesodermal Mullerian tumor; ovarian malignant mixed mesodermal Mullerian tumour; Ovarian Malignant Mixed Mesodermal Müllerian Neoplasm; ovarian malignant mixed mesodermal Müllerian neoplasm; Ovarian Malignant Mixed Mesodermal Müllerian Tumor; ovarian malignant mixed mesodermal Müllerian tumor; ovarian malignant mixed mesodermal Müllerian tumour; Ovarian Malignant Mixed Mullerian Neoplasm; ovarian malignant mixed Mullerian neoplasm; Ovarian Malignant Mixed Mullerian Tumor; ovarian malignant mixed Mullerian tumor; ovarian malignant mixed Mullerian tumour; Ovarian Malignant Mixed Müllerian Neoplasm; ovarian malignant mixed Müllerian neoplasm; Ovarian Malignant Mixed Müllerian Tumor; Ovarian malignant mixed Müllerian tumor; ovarian malignant mixed Müllerian tumor; ovarian malignant mixed Müllerian tumour; ovarian MMMT; ovary carcinosarcoma
SNOMED CT: Carcinosarcoma of ovary (702368000)
 
Monarch Initiative: MONDO:0003792
Orphanet: ORPHA213512

Definition

Malignant mixed Müllerian tumor of the ovary is a rare and very aggressive neoplasm presenting most commonly in postmenopausal women and is composed of adenocarcinomatous and sarcomatous elements and, depending on the types of these elements, can be classified as homologous or heterologous. It often has a poor prognosis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian carcinosarcoma

Professional guidelines

PubMed

Wu JWY, Dand S, Doig L, Papenfuss AT, Scott CL, Ho G, Ooi JD
Front Immunol 2021;12:672502. Epub 2021 Apr 13 doi: 10.3389/fimmu.2021.672502. PMID: 33927729Free PMC Article
Rauh-Hain JA, Birrer M, Del Carmen MG
Gynecol Oncol 2016 Aug;142(2):248-54. Epub 2016 Jun 16 doi: 10.1016/j.ygyno.2016.06.003. PMID: 27321238
Mano MS, Rosa DD, Azambuja E, Ismael G, Braga S, D'Hondt V, Piccart M, Awada A
Int J Gynecol Cancer 2007 Mar-Apr;17(2):316-24. doi: 10.1111/j.1525-1438.2006.00760.x. PMID: 17362309

Recent clinical studies

Etiology

Ismail A, Choi S, Boussios S
Curr Treat Options Oncol 2023 Dec;24(12):1667-1682. Epub 2023 Nov 8 doi: 10.1007/s11864-023-01138-4. PMID: 37938504Free PMC Article
Sia TY, Gordhandas SB, Birsoy O, Kemel Y, Maio A, Salo-Mullen E, Sheehan M, Hensley ML, Rubinstein M, Makker V, Grisham RN, O'Cearbhaill RE, Roche KL, Mueller JJ, Leitao MM Jr, Sonoda Y, Chi DS, Abu-Rustum NR, Berger MF, Ellenson LH, Latham A, Stadler Z, Offit K, Aghajanian C, Weigelt B, Mandelker D, Liu YL
Gynecol Oncol 2023 Jul;174:34-41. Epub 2023 May 5 doi: 10.1016/j.ygyno.2023.04.024. PMID: 37149903Free PMC Article
Aust S, Eberst L, Tredan O, Rousset-Jablonski C, Treilleux I, Méeus P, Chopin N, Beurrier F, Charreton A, Véronique D, Hallouz A, Coulon A, Ricoeur A, Mastier C, Bouhamama A, Racadot S, Devouassoux-Shisheboran M, Haddad V, Ray-Coquard I
Bull Cancer 2020 Mar;107(3):385-390. Epub 2020 Feb 27 doi: 10.1016/j.bulcan.2020.01.011. PMID: 32115180
Rauh-Hain JA, Birrer M, Del Carmen MG
Gynecol Oncol 2016 Aug;142(2):248-54. Epub 2016 Jun 16 doi: 10.1016/j.ygyno.2016.06.003. PMID: 27321238
Shylasree TS, Bryant A, Athavale R
Cochrane Database Syst Rev 2013 Feb 28;2013(2):CD006246. doi: 10.1002/14651858.CD006246.pub2. PMID: 23450567Free PMC Article

Diagnosis

Ismail A, Choi S, Boussios S
Curr Treat Options Oncol 2023 Dec;24(12):1667-1682. Epub 2023 Nov 8 doi: 10.1007/s11864-023-01138-4. PMID: 37938504Free PMC Article
Sia TY, Gordhandas SB, Birsoy O, Kemel Y, Maio A, Salo-Mullen E, Sheehan M, Hensley ML, Rubinstein M, Makker V, Grisham RN, O'Cearbhaill RE, Roche KL, Mueller JJ, Leitao MM Jr, Sonoda Y, Chi DS, Abu-Rustum NR, Berger MF, Ellenson LH, Latham A, Stadler Z, Offit K, Aghajanian C, Weigelt B, Mandelker D, Liu YL
Gynecol Oncol 2023 Jul;174:34-41. Epub 2023 May 5 doi: 10.1016/j.ygyno.2023.04.024. PMID: 37149903Free PMC Article
Ho GY, Kyran EL, Bedo J, Wakefield MJ, Ennis DP, Mirza HB, Vandenberg CJ, Lieschke E, Farrell A, Hadla A, Lim R, Dall G, Vince JE, Chua NK, Kondrashova O, Upstill-Goddard R, Bailey UM, Dowson S, Roxburgh P, Glasspool RM, Bryson G, Biankin AV; Scottish Genomes Partnership, Cooke SL, Ratnayake G, McNally O, Traficante N; Australian Ovarian Cancer Study12,13, DeFazio A, Weroha SJ, Bowtell DD, McNeish IA, Papenfuss AT, Scott CL, Barker HE
Cancer Res 2022 Dec 2;82(23):4457-4473. doi: 10.1158/0008-5472.CAN-21-4012. PMID: 36206301Free PMC Article
Boussios S, Karathanasi A, Zakynthinakis-Kyriakou N, Tsiouris AK, Chatziantoniou AA, Kanellos FS, Tatsi K
Crit Rev Oncol Hematol 2019 Feb;134:46-55. Epub 2018 Dec 24 doi: 10.1016/j.critrevonc.2018.12.006. PMID: 30771873
Rauh-Hain JA, Birrer M, Del Carmen MG
Gynecol Oncol 2016 Aug;142(2):248-54. Epub 2016 Jun 16 doi: 10.1016/j.ygyno.2016.06.003. PMID: 27321238

Therapy

Ramphal K, Hadfield MJ, Bandera CM, Hart J, Dizon DS
Am J Clin Oncol 2023 Dec 1;46(12):572-576. Epub 2023 Oct 17 doi: 10.1097/COC.0000000000001056. PMID: 37986208
Mauricio D, Bellone S, Mutlu L, McNamara B, Manavella DD, Demirkiran C, Verzosa MSZ, Buza N, Hui P, Hartwich TMP, Harold J, Yang-Hartwich Y, Zipponi M, Altwerger G, Ratner E, Huang GS, Clark M, Andikyan V, Azodi M, Schwartz PE, Santin AD
Gynecol Oncol 2023 Mar;170:38-45. Epub 2023 Jan 5 doi: 10.1016/j.ygyno.2022.12.018. PMID: 36610380Free PMC Article
Powell MA, Filiaci VL, Hensley ML, Huang HQ, Moore KN, Tewari KS, Copeland LJ, Secord AA, Mutch DG, Santin A, Warshal DP, Spirtos NM, DiSilvestro PA, Ioffe OB, Miller DS
J Clin Oncol 2022 Mar 20;40(9):968-977. Epub 2022 Jan 10 doi: 10.1200/JCO.21.02050. PMID: 35007153Free PMC Article
Wu JWY, Dand S, Doig L, Papenfuss AT, Scott CL, Ho G, Ooi JD
Front Immunol 2021;12:672502. Epub 2021 Apr 13 doi: 10.3389/fimmu.2021.672502. PMID: 33927729Free PMC Article
Shylasree TS, Bryant A, Athavale R
Cochrane Database Syst Rev 2013 Feb 28;2013(2):CD006246. doi: 10.1002/14651858.CD006246.pub2. PMID: 23450567Free PMC Article

Prognosis

Ramphal K, Hadfield MJ, Bandera CM, Hart J, Dizon DS
Am J Clin Oncol 2023 Dec 1;46(12):572-576. Epub 2023 Oct 17 doi: 10.1097/COC.0000000000001056. PMID: 37986208
Ismail A, Choi S, Boussios S
Curr Treat Options Oncol 2023 Dec;24(12):1667-1682. Epub 2023 Nov 8 doi: 10.1007/s11864-023-01138-4. PMID: 37938504Free PMC Article
Boussios S, Karathanasi A, Zakynthinakis-Kyriakou N, Tsiouris AK, Chatziantoniou AA, Kanellos FS, Tatsi K
Crit Rev Oncol Hematol 2019 Feb;134:46-55. Epub 2018 Dec 24 doi: 10.1016/j.critrevonc.2018.12.006. PMID: 30771873
Rauh-Hain JA, Birrer M, Del Carmen MG
Gynecol Oncol 2016 Aug;142(2):248-54. Epub 2016 Jun 16 doi: 10.1016/j.ygyno.2016.06.003. PMID: 27321238
Shylasree TS, Bryant A, Athavale R
Cochrane Database Syst Rev 2013 Feb 28;2013(2):CD006246. doi: 10.1002/14651858.CD006246.pub2. PMID: 23450567Free PMC Article

Clinical prediction guides

Saito A, Nishikawa T, Yoshida H, Mizoguchi C, Kitadai R, Yamamoto K, Yazaki S, Kojima Y, Ishikawa M, Kato T, Yonemori K
Gynecol Oncol 2023 Sep;176:115-121. Epub 2023 Jul 26 doi: 10.1016/j.ygyno.2023.07.010. PMID: 37506533
Sia TY, Gordhandas SB, Birsoy O, Kemel Y, Maio A, Salo-Mullen E, Sheehan M, Hensley ML, Rubinstein M, Makker V, Grisham RN, O'Cearbhaill RE, Roche KL, Mueller JJ, Leitao MM Jr, Sonoda Y, Chi DS, Abu-Rustum NR, Berger MF, Ellenson LH, Latham A, Stadler Z, Offit K, Aghajanian C, Weigelt B, Mandelker D, Liu YL
Gynecol Oncol 2023 Jul;174:34-41. Epub 2023 May 5 doi: 10.1016/j.ygyno.2023.04.024. PMID: 37149903Free PMC Article
Ciccarone F, Biscione A, Moro F, Fischerova D, Savelli L, Munaretto M, Jokubkiene L, Sladkevicius P, Chiappa V, Fruscio R, Franchi D, Epstein E, Timmerman D, Froyman W, Valentin L, Scambia G, Testa AC
Ultrasound Obstet Gynecol 2022 Feb;59(2):241-247. doi: 10.1002/uog.23733. PMID: 34225386
Saida T, Mori K, Tanaka YO, Sakai M, Amano T, Kikuchi S, Masuoka S, Yoshida M, Masumoto T, Satoh T, Minami M
Jpn J Radiol 2021 Apr;39(4):357-366. Epub 2020 Nov 20 doi: 10.1007/s11604-020-01072-7. PMID: 33216290
Loizzi V, Cormio G, Camporeale A, Falagario M, De Mitri P, Scardigno D, Putignano G, Selvaggi LE
Oncology 2011;80(1-2):102-6. Epub 2011 Jun 14 doi: 10.1159/000328794. PMID: 21677454

Recent systematic reviews

Shylasree TS, Bryant A, Athavale R
Cochrane Database Syst Rev 2013 Feb 28;2013(2):CD006246. doi: 10.1002/14651858.CD006246.pub2. PMID: 23450567Free PMC Article

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