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Chronic renal insufficiency

MedGen UID:
140787
Concept ID:
C0403447
Disease or Syndrome
Synonyms: Chronic Kidney Insufficiencies; Chronic Kidney Insufficiency; Chronic Renal Insufficiencies; Chronic Renal Insufficiency; Kidney Insufficiencies, Chronic; Kidney Insufficiency, Chronic; Renal Insufficiencies, Chronic; Renal Insufficiency, Chronic
SNOMED CT: Chronic renal impairment (709044004); Chronic renal insufficiency (723190009)

Definition

Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic renal insufficiency

Professional guidelines

PubMed

Kostopoulou M, Pitsigavdaki S, Bertsias G
Drugs 2022 May;82(7):735-748. Epub 2022 Apr 29 doi: 10.1007/s40265-022-01715-1. PMID: 35486369
Gossard TR, Trotti LM, Videnovic A, St Louis EK
Neurotherapeutics 2021 Jan;18(1):140-155. Epub 2021 Apr 20 doi: 10.1007/s13311-021-01019-4. PMID: 33880737Free PMC Article
Dubin RF, Rhee EP
Clin J Am Soc Nephrol 2020 Mar 6;15(3):404-411. Epub 2019 Oct 21 doi: 10.2215/CJN.07420619. PMID: 31636087Free PMC Article

Recent clinical studies

Etiology

Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group
Kidney Int 2022 Nov;102(5S):S1-S127. doi: 10.1016/j.kint.2022.06.008. PMID: 36272764
Charles C, Ferris AH
Prim Care 2020 Dec;47(4):585-595. Epub 2020 Sep 25 doi: 10.1016/j.pop.2020.08.001. PMID: 33121630
Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group
Kidney Int 2020 Oct;98(4S):S1-S115. doi: 10.1016/j.kint.2020.06.019. PMID: 32998798
Ammirati AL
Rev Assoc Med Bras (1992) 2020 Jan 13;66Suppl 1(Suppl 1):s03-s09. doi: 10.1590/1806-9282.66.S1.3. PMID: 31939529
Drawz P, Rahman M
Ann Intern Med 2015 Jun 2;162(11):ITC1-16. doi: 10.7326/AITC201506020. PMID: 26030647

Diagnosis

Levey AS
Nephron 2022;146(3):302-305. Epub 2021 Jun 24 doi: 10.1159/000516647. PMID: 34167119
Charles C, Ferris AH
Prim Care 2020 Dec;47(4):585-595. Epub 2020 Sep 25 doi: 10.1016/j.pop.2020.08.001. PMID: 33121630
Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group
Kidney Int 2020 Oct;98(4S):S1-S115. doi: 10.1016/j.kint.2020.06.019. PMID: 32998798
Akchurin OM
Pediatr Clin North Am 2019 Feb;66(1):247-267. doi: 10.1016/j.pcl.2018.09.007. PMID: 30454747Free PMC Article
Drawz P, Rahman M
Ann Intern Med 2015 Jun 2;162(11):ITC1-16. doi: 10.7326/AITC201506020. PMID: 26030647

Therapy

Tsai WC, Hsu SP, Chiu YL, Yang JY, Pai MF, Ko MJ, Tu YK, Hung KY, Chien KL, Peng YS, Wu HY
BMJ Open 2022 Oct 14;12(10):e060655. doi: 10.1136/bmjopen-2021-060655. PMID: 36241355Free PMC Article
Zheng J, Zhang Y, Rasheed H, Walker V, Sugawara Y, Li J, Leng Y, Elsworth B, Wootton RE, Fang S, Yang Q, Burgess S, Haycock PC, Borges MC, Cho Y, Carnegie R, Howell A, Robinson J, Thomas LF, Brumpton BM, Hveem K, Hallan S, Franceschini N, Morris AP, Köttgen A, Pattaro C, Wuttke M, Yamamoto M, Kashihara N, Akiyama M, Kanai M, Matsuda K, Kamatani Y, Okada Y, Walters R, Millwood IY, Chen Z, Davey Smith G, Barbour S, Yu C, Åsvold BO, Zhang H, Gaunt TR
Int J Epidemiol 2022 Jan 6;50(6):1995-2010. Epub 2021 Oct 20 doi: 10.1093/ije/dyab203. PMID: 34999880Free PMC Article
Villanego F, Naranjo J, Vigara LA, Cazorla JM, Montero ME, García T, Torrado J, Mazuecos A
Nefrologia (Engl Ed) 2020 May-Jun;40(3):237-252. Epub 2020 Apr 15 doi: 10.1016/j.nefro.2020.01.002. PMID: 32305232
Mallamaci F, Pisano A, Tripepi G
Nephrol Dial Transplant 2020 Mar 1;35(Suppl 2):ii18-ii22. doi: 10.1093/ndt/gfaa012. PMID: 32162664Free PMC Article
Zha Y, Qian Q
Nutrients 2017 Feb 27;9(3) doi: 10.3390/nu9030208. PMID: 28264439Free PMC Article

Prognosis

Chung EYM, Palmer SC, Natale P, Krishnan A, Cooper TE, Saglimbene VM, Ruospo M, Au E, Jayanti S, Liang A, Jie Deng DJ, Chui J, Higgins GY, Tong A, Wong G, Teixeira-Pinto A, Hodson EM, Craig JC, Strippoli GFM
Am J Kidney Dis 2021 Dec;78(6):804-815. Epub 2021 Aug 5 doi: 10.1053/j.ajkd.2021.07.003. PMID: 34364906Free PMC Article
Deng Y, Li N, Wu Y, Wang M, Yang S, Zheng Y, Deng X, Xiang D, Zhu Y, Xu P, Zhai Z, Zhang D, Dai Z, Gao J
Front Endocrinol (Lausanne) 2021;12:672350. Epub 2021 Jul 1 doi: 10.3389/fendo.2021.672350. PMID: 34276558Free PMC Article
Weaver RG, James MT, Ravani P, Weaver CGW, Lamb EJ, Tonelli M, Manns BJ, Quinn RR, Jun M, Hemmelgarn BR
J Am Soc Nephrol 2020 Mar;31(3):591-601. Epub 2020 Feb 5 doi: 10.1681/ASN.2019060605. PMID: 32024663Free PMC Article
Fishbane S, Spinowitz B
Am J Kidney Dis 2018 Mar;71(3):423-435. Epub 2018 Jan 11 doi: 10.1053/j.ajkd.2017.09.026. PMID: 29336855
Chen J, Budoff MJ, Reilly MP, Yang W, Rosas SE, Rahman M, Zhang X, Roy JA, Lustigova E, Nessel L, Ford V, Raj D, Porter AC, Soliman EZ, Wright JT Jr, Wolf M, He J; CRIC Investigators
JAMA Cardiol 2017 Jun 1;2(6):635-643. doi: 10.1001/jamacardio.2017.0363. PMID: 28329057Free PMC Article

Clinical prediction guides

Slieker RC, van der Heijden AAWA, Siddiqui MK, Langendoen-Gort M, Nijpels G, Herings R, Feenstra TL, Moons KGM, Bell S, Elders PJ, 't Hart LM, Beulens JWJ
BMJ 2021 Sep 28;374:n2134. doi: 10.1136/bmj.n2134. PMID: 34583929Free PMC Article
Dubin RF, Rhee EP
Clin J Am Soc Nephrol 2020 Mar 6;15(3):404-411. Epub 2019 Oct 21 doi: 10.2215/CJN.07420619. PMID: 31636087Free PMC Article
Mihai S, Codrici E, Popescu ID, Enciu AM, Albulescu L, Necula LG, Mambet C, Anton G, Tanase C
J Immunol Res 2018;2018:2180373. Epub 2018 Sep 6 doi: 10.1155/2018/2180373. PMID: 30271792Free PMC Article
Petrucci I, Clementi A, Sessa C, Torrisi I, Meola M
J Nephrol 2018 Dec;31(6):863-879. Epub 2018 Sep 6 doi: 10.1007/s40620-018-0531-1. PMID: 30191413
Wang S, Chen F, Yang S, Shi J
Int Heart J 2018 Jul 31;59(4):786-790. Epub 2018 Jul 18 doi: 10.1536/ihj.17-154. PMID: 30022770

Recent systematic reviews

Parker K, Hartemink J, Saha A, Mitra R, Lewis P, Power A, Choudhuri S, Mitra S, Thachil J
J Nephrol 2022 Nov;35(8):2015-2033. Epub 2022 Aug 25 doi: 10.1007/s40620-022-01413-x. PMID: 36006608Free PMC Article
Chung EYM, Palmer SC, Natale P, Krishnan A, Cooper TE, Saglimbene VM, Ruospo M, Au E, Jayanti S, Liang A, Jie Deng DJ, Chui J, Higgins GY, Tong A, Wong G, Teixeira-Pinto A, Hodson EM, Craig JC, Strippoli GFM
Am J Kidney Dis 2021 Dec;78(6):804-815. Epub 2021 Aug 5 doi: 10.1053/j.ajkd.2021.07.003. PMID: 34364906Free PMC Article
Villanego F, Naranjo J, Vigara LA, Cazorla JM, Montero ME, García T, Torrado J, Mazuecos A
Nefrologia (Engl Ed) 2020 May-Jun;40(3):237-252. Epub 2020 Apr 15 doi: 10.1016/j.nefro.2020.01.002. PMID: 32305232
Sinha Ray A, Haikal A, Hammoud KA, Yu ASL
Clin J Am Soc Nephrol 2016 Dec 7;11(12):2132-2140. Epub 2016 Nov 28 doi: 10.2215/CJN.05920616. PMID: 27895134Free PMC Article
Hill NR, Fatoba ST, Oke JL, Hirst JA, O'Callaghan CA, Lasserson DS, Hobbs FD
PLoS One 2016;11(7):e0158765. Epub 2016 Jul 6 doi: 10.1371/journal.pone.0158765. PMID: 27383068Free PMC Article

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