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Borderline personality disorder

MedGen UID:
14197
Concept ID:
C0006012
Mental or Behavioral Dysfunction
Synonym: Borderline personality disorder (disease)
SNOMED CT: Borderline personality disorder (20010003); BPD - borderline personality disorder (20010003)
 
HPO: HP:0012076
Monarch Initiative: MONDO:0001156

Definition

A personality disorder characterized by impulsive behavior and unpredictable, capricious mood. Affected individuals show a tendency to have outbursts of emotion and an inability to control these behavioral explosions. They generally experience an intense fear of abandonment or instability and also struggle with feelings of emptiness. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline personality disorder

Conditions with this feature

Professional guidelines

PubMed

Chanen AM, Nicol K, Betts JK, Thompson KN
Curr Psychiatry Rep 2020 Apr 25;22(5):25. doi: 10.1007/s11920-020-01144-5. PMID: 32335771
Bayes A, Parker G, Paris J
Curr Psychiatry Rep 2019 Nov 20;21(12):125. doi: 10.1007/s11920-019-1120-2. PMID: 31749106
Paris J
Psychiatr Clin North Am 2018 Dec;41(4):575-582. Epub 2018 Oct 16 doi: 10.1016/j.psc.2018.07.001. PMID: 30447725

Recent clinical studies

Etiology

Mendez-Miller M, Naccarato J, Radico JA
Am Fam Physician 2022 Feb 1;105(2):156-161. PMID: 35166488
Reichl C, Kaess M
Curr Opin Psychol 2021 Feb;37:139-144. Epub 2021 Jan 6 doi: 10.1016/j.copsyc.2020.12.007. PMID: 33548678
Stone MH
Psychodyn Psychiatry 2019 Spring;47(1):5-26. doi: 10.1521/pdps.2019.47.1.5. PMID: 30840560
Gunderson JG, Herpertz SC, Skodol AE, Torgersen S, Zanarini MC
Nat Rev Dis Primers 2018 May 24;4:18029. doi: 10.1038/nrdp.2018.29. PMID: 29795363
Leichsenring F, Leibing E, Kruse J, New AS, Leweke F
Lancet 2011 Jan 1;377(9759):74-84. doi: 10.1016/S0140-6736(10)61422-5. PMID: 21195251

Diagnosis

Leichsenring F, Heim N, Leweke F, Spitzer C, Steinert C, Kernberg OF
JAMA 2023 Feb 28;329(8):670-679. doi: 10.1001/jama.2023.0589. PMID: 36853245
Mendez-Miller M, Naccarato J, Radico JA
Am Fam Physician 2022 Feb 1;105(2):156-161. PMID: 35166488
Chanen AM, Nicol K, Betts JK, Thompson KN
Curr Psychiatry Rep 2020 Apr 25;22(5):25. doi: 10.1007/s11920-020-01144-5. PMID: 32335771
Paris J
Psychiatr Clin North Am 2018 Dec;41(4):575-582. Epub 2018 Oct 16 doi: 10.1016/j.psc.2018.07.001. PMID: 30447725
Leichsenring F, Leibing E, Kruse J, New AS, Leweke F
Lancet 2011 Jan 1;377(9759):74-84. doi: 10.1016/S0140-6736(10)61422-5. PMID: 21195251

Therapy

Stoffers-Winterling JM, Storebø OJ, Kongerslev MT, Faltinsen E, Todorovac A, Sedoc Jørgensen M, Sales CP, Edemann Callesen H, Pereira Ribeiro J, Völlm BA, Lieb K, Simonsen E
Br J Psychiatry 2022 Sep;221(3):538-552. doi: 10.1192/bjp.2021.204. PMID: 35088687
Gartlehner G, Crotty K, Kennedy S, Edlund MJ, Ali R, Siddiqui M, Fortman R, Wines R, Persad E, Viswanathan M
CNS Drugs 2021 Oct;35(10):1053-1067. Epub 2021 Sep 8 doi: 10.1007/s40263-021-00855-4. PMID: 34495494Free PMC Article
Del Casale A, Bonanni L, Bargagna P, Novelli F, Fiaschè F, Paolini M, Forcina F, Anibaldi G, Cortese FN, Iannuccelli A, Adriani B, Brugnoli R, Girardi P, Paris J, Pompili M
Curr Neuropharmacol 2021;19(10):1760-1779. doi: 10.2174/1570159X19666210610092958. PMID: 34151763Free PMC Article
Storebø OJ, Stoffers-Winterling JM, Völlm BA, Kongerslev MT, Mattivi JT, Jørgensen MS, Faltinsen E, Todorovac A, Sales CP, Callesen HE, Lieb K, Simonsen E
Cochrane Database Syst Rev 2020 May 4;5(5):CD012955. doi: 10.1002/14651858.CD012955.pub2. PMID: 32368793Free PMC Article
Stoffers JM, Völlm BA, Rücker G, Timmer A, Huband N, Lieb K
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD005652. doi: 10.1002/14651858.CD005652.pub2. PMID: 22895952Free PMC Article

Prognosis

Jørgensen MS, Møller L, Bo S, Kongerslev M, Hastrup LH, Chanen A, Storebø OJ, Poulsen S, Beck E, Simonsen E
Compr Psychiatry 2024 Jul;132:152478. Epub 2024 Mar 21 doi: 10.1016/j.comppsych.2024.152478. PMID: 38522259
Temes CM, Zanarini MC
Psychiatr Clin North Am 2018 Dec;41(4):685-694. Epub 2018 Oct 16 doi: 10.1016/j.psc.2018.07.002. PMID: 30447732
Biskin RS, Paris J
CMAJ 2012 Nov 6;184(16):1789-94. Epub 2012 Sep 17 doi: 10.1503/cmaj.090618. PMID: 22988153Free PMC Article
Linehan MM, Comtois KA, Murray AM, Brown MZ, Gallop RJ, Heard HL, Korslund KE, Tutek DA, Reynolds SK, Lindenboim N
Arch Gen Psychiatry 2006 Jul;63(7):757-66. doi: 10.1001/archpsyc.63.7.757. PMID: 16818865
Paris J
CMAJ 2005 Jun 7;172(12):1579-83. doi: 10.1503/cmaj.045281. PMID: 15939918Free PMC Article

Clinical prediction guides

Bettinger S, Höpfner S, Deest-Gaubatz S, Simon L, Matin-Mann F, Weber C, Schülke R, Bleich S, Frieling H, Neyazi A, Maier HB
Prog Neuropsychopharmacol Biol Psychiatry 2024 Dec 20;135:111118. Epub 2024 Aug 22 doi: 10.1016/j.pnpbp.2024.111118. PMID: 39173992
Shafiei G, Keller AS, Bertolero M, Shanmugan S, Bassett DS, Chen AA, Covitz S, Houghton A, Luo A, Mehta K, Salo T, Shinohara RT, Fair D, Hallquist MN, Satterthwaite TD
Biol Psychiatry 2024 Sep 15;96(6):486-494. Epub 2024 Mar 7 doi: 10.1016/j.biopsych.2024.02.1016. PMID: 38460580Free PMC Article
Richman Czégel MJ, Unoka Z, Dudas RB, Demetrovics Z
J Pers Disord 2022 Aug;36(4):399-412. doi: 10.1521/pedi.2022.36.4.399. PMID: 35913769
Lyssenko L, Schmahl C, Bockhacker L, Vonderlin R, Bohus M, Kleindienst N
Am J Psychiatry 2018 Jan 1;175(1):37-46. Epub 2017 Sep 26 doi: 10.1176/appi.ajp.2017.17010025. PMID: 28946763
Zanarini MC, Vujanovic AA, Parachini EA, Boulanger JL, Frankenburg FR, Hennen J
J Pers Disord 2003 Jun;17(3):233-42. doi: 10.1521/pedi.17.3.233.22147. PMID: 12839102

Recent systematic reviews

Stoffers-Winterling JM, Storebø OJ, Pereira Ribeiro J, Kongerslev MT, Völlm BA, Mattivi JT, Faltinsen E, Todorovac A, Jørgensen MS, Callesen HE, Sales CP, Schaug JP, Simonsen E, Lieb K
Cochrane Database Syst Rev 2022 Nov 14;11(11):CD012956. doi: 10.1002/14651858.CD012956.pub2. PMID: 36375174Free PMC Article
Stoffers-Winterling JM, Storebø OJ, Kongerslev MT, Faltinsen E, Todorovac A, Sedoc Jørgensen M, Sales CP, Edemann Callesen H, Pereira Ribeiro J, Völlm BA, Lieb K, Simonsen E
Br J Psychiatry 2022 Sep;221(3):538-552. doi: 10.1192/bjp.2021.204. PMID: 35088687
Gartlehner G, Crotty K, Kennedy S, Edlund MJ, Ali R, Siddiqui M, Fortman R, Wines R, Persad E, Viswanathan M
CNS Drugs 2021 Oct;35(10):1053-1067. Epub 2021 Sep 8 doi: 10.1007/s40263-021-00855-4. PMID: 34495494Free PMC Article
Storebø OJ, Stoffers-Winterling JM, Völlm BA, Kongerslev MT, Mattivi JT, Jørgensen MS, Faltinsen E, Todorovac A, Sales CP, Callesen HE, Lieb K, Simonsen E
Cochrane Database Syst Rev 2020 May 4;5(5):CD012955. doi: 10.1002/14651858.CD012955.pub2. PMID: 32368793Free PMC Article
Stoffers JM, Völlm BA, Rücker G, Timmer A, Huband N, Lieb K
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD005652. doi: 10.1002/14651858.CD005652.pub2. PMID: 22895952Free PMC Article

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