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Borderline personality disorder

MedGen UID:
14197
•Concept ID:
C0006012
•
Mental or Behavioral Dysfunction
Synonym: Borderline personality disorder (disease)
SNOMED CT: Borderline personality disorder (20010003); BPD - borderline personality disorder (20010003)
 
HPO: HP:0012076
Monarch Initiative: MONDO:0001156

Definition

A personality disorder characterized by impulsive behavior and unpredictable, capricious mood. Affected individuals show a tendency to have outbursts of emotion and an inability to control these behavioral explosions. They generally experience an intense fear of abandonment or instability and also struggle with feelings of emptiness. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline personality disorder

Conditions with this feature

Professional guidelines

PubMed

Diagnosis and Treatment of Borderline Personality Disorder in Young People.
Chanen AM, Nicol K, Betts JK, Thompson KN
Curr Psychiatry Rep 2020 Apr 25;22(5):25. doi: 10.1007/s11920-020-01144-5. PMID: 32335771
Differential Diagnosis of Bipolar II Disorder and Borderline Personality Disorder.
Bayes A, Parker G, Paris J
Curr Psychiatry Rep 2019 Nov 20;21(12):125. doi: 10.1007/s11920-019-1120-2. PMID: 31749106
Differential Diagnosis of Borderline Personality Disorder.
Paris J
Psychiatr Clin North Am 2018 Dec;41(4):575-582. Epub 2018 Oct 16 doi: 10.1016/j.psc.2018.07.001. PMID: 30447725

Recent clinical studies

Etiology

Borderline Personality Disorder.
Mendez-Miller M, Naccarato J, Radico JA
Am Fam Physician 2022 Feb 1;105(2):156-161. PMID: 35166488
Self-harm in the context of borderline personality disorder.
Reichl C, Kaess M
Curr Opin Psychol 2021 Feb;37:139-144. Epub 2021 Jan 6 doi: 10.1016/j.copsyc.2020.12.007. PMID: 33548678
Borderline Personality Disorder: Clinical Guidelines for Treatment.
Stone MH
Psychodyn Psychiatry 2019 Spring;47(1):5-26. doi: 10.1521/pdps.2019.47.1.5. PMID: 30840560
Borderline personality disorder.
Gunderson JG, Herpertz SC, Skodol AE, Torgersen S, Zanarini MC
Nat Rev Dis Primers 2018 May 24;4:18029. doi: 10.1038/nrdp.2018.29. PMID: 29795363
Borderline personality disorder.
Leichsenring F, Leibing E, Kruse J, New AS, Leweke F
Lancet 2011 Jan 1;377(9759):74-84. doi: 10.1016/S0140-6736(10)61422-5. PMID: 21195251

Diagnosis

Borderline Personality Disorder: A Review.
Leichsenring F, Heim N, Leweke F, Spitzer C, Steinert C, Kernberg OF
JAMA 2023 Feb 28;329(8):670-679. doi: 10.1001/jama.2023.0589. PMID: 36853245
Borderline Personality Disorder.
Mendez-Miller M, Naccarato J, Radico JA
Am Fam Physician 2022 Feb 1;105(2):156-161. PMID: 35166488
Diagnosis and Treatment of Borderline Personality Disorder in Young People.
Chanen AM, Nicol K, Betts JK, Thompson KN
Curr Psychiatry Rep 2020 Apr 25;22(5):25. doi: 10.1007/s11920-020-01144-5. PMID: 32335771
Differential Diagnosis of Borderline Personality Disorder.
Paris J
Psychiatr Clin North Am 2018 Dec;41(4):575-582. Epub 2018 Oct 16 doi: 10.1016/j.psc.2018.07.001. PMID: 30447725
Borderline personality disorder.
Leichsenring F, Leibing E, Kruse J, New AS, Leweke F
Lancet 2011 Jan 1;377(9759):74-84. doi: 10.1016/S0140-6736(10)61422-5. PMID: 21195251

Therapy

Psychotherapies for borderline personality disorder: a focused systematic review and meta-analysis.
Stoffers-Winterling JM, Storebø OJ, Kongerslev MT, Faltinsen E, Todorovac A, Sedoc Jørgensen M, Sales CP, Edemann Callesen H, Pereira Ribeiro J, Völlm BA, Lieb K, Simonsen E
Br J Psychiatry 2022 Sep;221(3):538-552. doi: 10.1192/bjp.2021.204. PMID: 35088687
Pharmacological Treatments for Borderline Personality Disorder: A Systematic Review and Meta-Analysis.
Gartlehner G, Crotty K, Kennedy S, Edlund MJ, Ali R, Siddiqui M, Fortman R, Wines R, Persad E, Viswanathan M
CNS Drugs 2021 Oct;35(10):1053-1067. Epub 2021 Sep 8 doi: 10.1007/s40263-021-00855-4. PMID: 34495494Free PMC Article
Current Clinical Psychopharmacology in Borderline Personality Disorder.
Del Casale A, Bonanni L, Bargagna P, Novelli F, Fiaschè F, Paolini M, Forcina F, Anibaldi G, Cortese FN, Iannuccelli A, Adriani B, Brugnoli R, Girardi P, Paris J, Pompili M
Curr Neuropharmacol 2021;19(10):1760-1779. doi: 10.2174/1570159X19666210610092958. PMID: 34151763Free PMC Article
Psychological therapies for people with borderline personality disorder.
Storebø OJ, Stoffers-Winterling JM, Völlm BA, Kongerslev MT, Mattivi JT, Jørgensen MS, Faltinsen E, Todorovac A, Sales CP, Callesen HE, Lieb K, Simonsen E
Cochrane Database Syst Rev 2020 May 4;5(5):CD012955. doi: 10.1002/14651858.CD012955.pub2. PMID: 32368793Free PMC Article
Psychological therapies for people with borderline personality disorder.
Stoffers JM, Völlm BA, Rücker G, Timmer A, Huband N, Lieb K
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD005652. doi: 10.1002/14651858.CD005652.pub2. PMID: 22895952Free PMC Article

Prognosis

The course of borderline personality disorder from adolescence to early adulthood: A 5-year follow-up study.
Jørgensen MS, Møller L, Bo S, Kongerslev M, Hastrup LH, Chanen A, Storebø OJ, Poulsen S, Beck E, Simonsen E
Compr Psychiatry 2024 Jul;132:152478. Epub 2024 Mar 21 doi: 10.1016/j.comppsych.2024.152478. PMID: 38522259
The Longitudinal Course of Borderline Personality Disorder.
Temes CM, Zanarini MC
Psychiatr Clin North Am 2018 Dec;41(4):685-694. Epub 2018 Oct 16 doi: 10.1016/j.psc.2018.07.002. PMID: 30447732
Diagnosing borderline personality disorder.
Biskin RS, Paris J
CMAJ 2012 Nov 6;184(16):1789-94. Epub 2012 Sep 17 doi: 10.1503/cmaj.090618. PMID: 22988153Free PMC Article
Two-year randomized controlled trial and follow-up of dialectical behavior therapy vs therapy by experts for suicidal behaviors and borderline personality disorder.
Linehan MM, Comtois KA, Murray AM, Brown MZ, Gallop RJ, Heard HL, Korslund KE, Tutek DA, Reynolds SK, Lindenboim N
Arch Gen Psychiatry 2006 Jul;63(7):757-66. doi: 10.1001/archpsyc.63.7.757. PMID: 16818865
Borderline personality disorder.
Paris J
CMAJ 2005 Jun 7;172(12):1579-83. doi: 10.1503/cmaj.045281. PMID: 15939918Free PMC Article

Clinical prediction guides

Neurological soft signs and olfactory dysfunction in patients with borderline personality disorder.
Bettinger S, Höpfner S, Deest-Gaubatz S, Simon L, Matin-Mann F, Weber C, Schülke R, Bleich S, Frieling H, Neyazi A, Maier HB
Prog Neuropsychopharmacol Biol Psychiatry 2024 Dec 20;135:111118. Epub 2024 Aug 22 doi: 10.1016/j.pnpbp.2024.111118. PMID: 39173992
Generalizable Links Between Borderline Personality Traits and Functional Connectivity.
Shafiei G, Keller AS, Bertolero M, Shanmugan S, Bassett DS, Chen AA, Covitz S, Houghton A, Luo A, Mehta K, Salo T, Shinohara RT, Fair D, Hallquist MN, Satterthwaite TD
Biol Psychiatry 2024 Sep 15;96(6):486-494. Epub 2024 Mar 7 doi: 10.1016/j.biopsych.2024.02.1016. PMID: 38460580Free PMC Article
Rumination in Borderline Personality Disorder: A Meta-analytic Review.
Richman Czégel MJ, Unoka Z, Dudas RB, Demetrovics Z
J Pers Disord 2022 Aug;36(4):399-412. doi: 10.1521/pedi.2022.36.4.399. PMID: 35913769
Dissociation in Psychiatric Disorders: A Meta-Analysis of Studies Using the Dissociative Experiences Scale.
Lyssenko L, Schmahl C, Bockhacker L, Vonderlin R, Bohus M, Kleindienst N
Am J Psychiatry 2018 Jan 1;175(1):37-46. Epub 2017 Sep 26 doi: 10.1176/appi.ajp.2017.17010025. PMID: 28946763
Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD): a continuous measure of DSM-IV borderline psychopathology.
Zanarini MC, Vujanovic AA, Parachini EA, Boulanger JL, Frankenburg FR, Hennen J
J Pers Disord 2003 Jun;17(3):233-42. doi: 10.1521/pedi.17.3.233.22147. PMID: 12839102

Recent systematic reviews

Pharmacological interventions for people with borderline personality disorder.
Stoffers-Winterling JM, Storebø OJ, Pereira Ribeiro J, Kongerslev MT, Völlm BA, Mattivi JT, Faltinsen E, Todorovac A, Jørgensen MS, Callesen HE, Sales CP, Schaug JP, Simonsen E, Lieb K
Cochrane Database Syst Rev 2022 Nov 14;11(11):CD012956. doi: 10.1002/14651858.CD012956.pub2. PMID: 36375174Free PMC Article
Psychotherapies for borderline personality disorder: a focused systematic review and meta-analysis.
Stoffers-Winterling JM, Storebø OJ, Kongerslev MT, Faltinsen E, Todorovac A, Sedoc Jørgensen M, Sales CP, Edemann Callesen H, Pereira Ribeiro J, Völlm BA, Lieb K, Simonsen E
Br J Psychiatry 2022 Sep;221(3):538-552. doi: 10.1192/bjp.2021.204. PMID: 35088687
Pharmacological Treatments for Borderline Personality Disorder: A Systematic Review and Meta-Analysis.
Gartlehner G, Crotty K, Kennedy S, Edlund MJ, Ali R, Siddiqui M, Fortman R, Wines R, Persad E, Viswanathan M
CNS Drugs 2021 Oct;35(10):1053-1067. Epub 2021 Sep 8 doi: 10.1007/s40263-021-00855-4. PMID: 34495494Free PMC Article
Psychological therapies for people with borderline personality disorder.
Storebø OJ, Stoffers-Winterling JM, Völlm BA, Kongerslev MT, Mattivi JT, Jørgensen MS, Faltinsen E, Todorovac A, Sales CP, Callesen HE, Lieb K, Simonsen E
Cochrane Database Syst Rev 2020 May 4;5(5):CD012955. doi: 10.1002/14651858.CD012955.pub2. PMID: 32368793Free PMC Article
Psychological therapies for people with borderline personality disorder.
Stoffers JM, Völlm BA, Rücker G, Timmer A, Huband N, Lieb K
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD005652. doi: 10.1002/14651858.CD005652.pub2. PMID: 22895952Free PMC Article

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