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Borderline personality disorder

MedGen UID:
14197
Concept ID:
C0006012
Mental or Behavioral Dysfunction
Synonym: Borderline personality disorder (disease)
SNOMED CT: Borderline personality disorder (20010003); BPD - borderline personality disorder (20010003)
 
HPO: HP:0012076
Monarch Initiative: MONDO:0001156

Definition

A personality disorder characterized by impulsive behavior and unpredictable, capricious mood. Affected individuals show a tendency to have outbursts of emotion and an inability to control these behavioral explosions. They generally experience an intense fear of abandonment or instability and also struggle with feelings of emptiness. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline personality disorder

Conditions with this feature

Intellectual developmental disorder with or without epilepsy or cerebellar ataxia
MedGen UID:
1648354
Concept ID:
C4748041
Disease or Syndrome

Professional guidelines

PubMed

Pascual JC, Arias L, Soler J
CNS Drugs 2023 Jun;37(6):489-497. Epub 2023 May 31 doi: 10.1007/s40263-023-01015-6. PMID: 37256484Free PMC Article
Bayes A, Parker G, Paris J
Curr Psychiatry Rep 2019 Nov 20;21(12):125. doi: 10.1007/s11920-019-1120-2. PMID: 31749106
Parker JD, Naeem A
Am Fam Physician 2019 Mar 1;99(5):Online. PMID: 30811158

Recent clinical studies

Etiology

Mendez-Miller M, Naccarato J, Radico JA
Am Fam Physician 2022 Feb 1;105(2):156-161. PMID: 35166488
Reichl C, Kaess M
Curr Opin Psychol 2021 Feb;37:139-144. Epub 2021 Jan 6 doi: 10.1016/j.copsyc.2020.12.007. PMID: 33548678
Stone MH
Psychodyn Psychiatry 2019 Spring;47(1):5-26. doi: 10.1521/pdps.2019.47.1.5. PMID: 30840560
Gunderson JG, Herpertz SC, Skodol AE, Torgersen S, Zanarini MC
Nat Rev Dis Primers 2018 May 24;4:18029. doi: 10.1038/nrdp.2018.29. PMID: 29795363
Leichsenring F, Leibing E, Kruse J, New AS, Leweke F
Lancet 2011 Jan 1;377(9759):74-84. doi: 10.1016/S0140-6736(10)61422-5. PMID: 21195251

Diagnosis

Leichsenring F, Heim N, Leweke F, Spitzer C, Steinert C, Kernberg OF
JAMA 2023 Feb 28;329(8):670-679. doi: 10.1001/jama.2023.0589. PMID: 36853245
Mendez-Miller M, Naccarato J, Radico JA
Am Fam Physician 2022 Feb 1;105(2):156-161. PMID: 35166488
Reichl C, Kaess M
Curr Opin Psychol 2021 Feb;37:139-144. Epub 2021 Jan 6 doi: 10.1016/j.copsyc.2020.12.007. PMID: 33548678
Nat Rev Dis Primers 2018 May 24;4:18030. doi: 10.1038/nrdp.2018.30. PMID: 29795174
Leichsenring F, Leibing E, Kruse J, New AS, Leweke F
Lancet 2011 Jan 1;377(9759):74-84. doi: 10.1016/S0140-6736(10)61422-5. PMID: 21195251

Therapy

Stoffers-Winterling JM, Storebø OJ, Kongerslev MT, Faltinsen E, Todorovac A, Sedoc Jørgensen M, Sales CP, Edemann Callesen H, Pereira Ribeiro J, Völlm BA, Lieb K, Simonsen E
Br J Psychiatry 2022 Sep;221(3):538-552. doi: 10.1192/bjp.2021.204. PMID: 35088687
Gartlehner G, Crotty K, Kennedy S, Edlund MJ, Ali R, Siddiqui M, Fortman R, Wines R, Persad E, Viswanathan M
CNS Drugs 2021 Oct;35(10):1053-1067. Epub 2021 Sep 8 doi: 10.1007/s40263-021-00855-4. PMID: 34495494Free PMC Article
Del Casale A, Bonanni L, Bargagna P, Novelli F, Fiaschè F, Paolini M, Forcina F, Anibaldi G, Cortese FN, Iannuccelli A, Adriani B, Brugnoli R, Girardi P, Paris J, Pompili M
Curr Neuropharmacol 2021;19(10):1760-1779. doi: 10.2174/1570159X19666210610092958. PMID: 34151763Free PMC Article
Storebø OJ, Stoffers-Winterling JM, Völlm BA, Kongerslev MT, Mattivi JT, Jørgensen MS, Faltinsen E, Todorovac A, Sales CP, Callesen HE, Lieb K, Simonsen E
Cochrane Database Syst Rev 2020 May 4;5(5):CD012955. doi: 10.1002/14651858.CD012955.pub2. PMID: 32368793Free PMC Article
Stoffers JM, Völlm BA, Rücker G, Timmer A, Huband N, Lieb K
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD005652. doi: 10.1002/14651858.CD005652.pub2. PMID: 22895952Free PMC Article

Prognosis

Gillespie C, Murphy M, Joyce M
J Pers Disord 2022 Aug;36(4):431-454. doi: 10.1521/pedi.2022.36.4.431. PMID: 35913768
Bateman A, Constantinou MP, Fonagy P, Holzer S
Personal Disord 2021 Jul;12(4):291-299. Epub 2020 Jun 25 doi: 10.1037/per0000422. PMID: 32584091
Biskin RS, Paris J
CMAJ 2012 Nov 6;184(16):1789-94. Epub 2012 Sep 17 doi: 10.1503/cmaj.090618. PMID: 22988153Free PMC Article
Fenton WS
J Clin Psychiatry 2000;61 Suppl 4:10-4. PMID: 10739325
Suicide Life Threat Behav 1990 Spring;20(1):85-92. PMID: 2336682

Clinical prediction guides

Alberdi-Paramo I, Saiz-Gonzalez MD, Diaz-Marsa M, Carrasco-Perera JL
Psychiatry Res 2020 Mar;285:112730. Epub 2019 Dec 4 doi: 10.1016/j.psychres.2019.112730. PMID: 31831199
Puri P, Kumar D, Muralidharan K, Kishore MT
Psychiatry Res 2018 Sep;267:414-419. Epub 2018 Jun 19 doi: 10.1016/j.psychres.2018.06.040. PMID: 29960939
Lyssenko L, Schmahl C, Bockhacker L, Vonderlin R, Bohus M, Kleindienst N
Am J Psychiatry 2018 Jan 1;175(1):37-46. Epub 2017 Sep 26 doi: 10.1176/appi.ajp.2017.17010025. PMID: 28946763
Barnow S, Aldinger M, Arens EA, Ulrich I, Spitzer C, Grabe HJ, Stopsack M
J Pers Disord 2013 Dec;27(6):806-19. Epub 2012 Aug 28 doi: 10.1521/pedi_2012_26_058. PMID: 22928848
Zanarini MC, Vujanovic AA, Parachini EA, Boulanger JL, Frankenburg FR, Hennen J
J Pers Disord 2003 Jun;17(3):233-42. doi: 10.1521/pedi.17.3.233.22147. PMID: 12839102

Recent systematic reviews

Stoffers-Winterling JM, Storebø OJ, Pereira Ribeiro J, Kongerslev MT, Völlm BA, Mattivi JT, Faltinsen E, Todorovac A, Jørgensen MS, Callesen HE, Sales CP, Schaug JP, Simonsen E, Lieb K
Cochrane Database Syst Rev 2022 Nov 14;11(11):CD012956. doi: 10.1002/14651858.CD012956.pub2. PMID: 36375174Free PMC Article
Stoffers-Winterling JM, Storebø OJ, Kongerslev MT, Faltinsen E, Todorovac A, Sedoc Jørgensen M, Sales CP, Edemann Callesen H, Pereira Ribeiro J, Völlm BA, Lieb K, Simonsen E
Br J Psychiatry 2022 Sep;221(3):538-552. doi: 10.1192/bjp.2021.204. PMID: 35088687
Gartlehner G, Crotty K, Kennedy S, Edlund MJ, Ali R, Siddiqui M, Fortman R, Wines R, Persad E, Viswanathan M
CNS Drugs 2021 Oct;35(10):1053-1067. Epub 2021 Sep 8 doi: 10.1007/s40263-021-00855-4. PMID: 34495494Free PMC Article
Storebø OJ, Stoffers-Winterling JM, Völlm BA, Kongerslev MT, Mattivi JT, Jørgensen MS, Faltinsen E, Todorovac A, Sales CP, Callesen HE, Lieb K, Simonsen E
Cochrane Database Syst Rev 2020 May 4;5(5):CD012955. doi: 10.1002/14651858.CD012955.pub2. PMID: 32368793Free PMC Article
Stoffers JM, Völlm BA, Rücker G, Timmer A, Huband N, Lieb K
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD005652. doi: 10.1002/14651858.CD005652.pub2. PMID: 22895952Free PMC Article

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