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Borderline personality disorder

MedGen UID:
14197
Concept ID:
C0006012
Mental or Behavioral Dysfunction
Synonym: Borderline personality disorder (disease)
SNOMED CT: Borderline personality disorder (20010003); BPD - borderline personality disorder (20010003)
 
HPO: HP:0012076
Monarch Initiative: MONDO:0001156

Definition

A personality disorder characterized by impulsive behavior and unpredictable, capricious mood. Affected individuals show a tendency to have outbursts of emotion and an inability to control these behavioral explosions. They generally experience an intense fear of abandonment or instability and also struggle with feelings of emptiness. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline personality disorder

Conditions with this feature

Intellectual developmental disorder with or without epilepsy or cerebellar ataxia
MedGen UID:
1648354
Concept ID:
C4748041
Disease or Syndrome

Professional guidelines

PubMed

Cichoń L, Janas-Kozik M, Siwiec A, Rybakowski JK
Psychiatr Pol 2020 Mar 29;54(1):35-50. doi: 10.12740/PP/OnlineFirst/92740. PMID: 32447355
Bayes A, Parker G, Paris J
Curr Psychiatry Rep 2019 Nov 20;21(12):125. doi: 10.1007/s11920-019-1120-2. PMID: 31749106
Paris J
Psychiatr Clin North Am 2018 Dec;41(4):575-582. Epub 2018 Oct 16 doi: 10.1016/j.psc.2018.07.001. PMID: 30447725

Recent clinical studies

Etiology

Mendez-Miller M, Naccarato J, Radico JA
Am Fam Physician 2022 Feb 1;105(2):156-161. PMID: 35166488
Stone MH
Psychodyn Psychiatry 2019 Spring;47(1):5-26. doi: 10.1521/pdps.2019.47.1.5. PMID: 30840560
Shah R, Zanarini MC
Psychiatr Clin North Am 2018 Dec;41(4):583-593. Epub 2018 Oct 16 doi: 10.1016/j.psc.2018.07.009. PMID: 30447726
Gunderson JG, Herpertz SC, Skodol AE, Torgersen S, Zanarini MC
Nat Rev Dis Primers 2018 May 24;4:18029. doi: 10.1038/nrdp.2018.29. PMID: 29795363
Leichsenring F, Leibing E, Kruse J, New AS, Leweke F
Lancet 2011 Jan 1;377(9759):74-84. doi: 10.1016/S0140-6736(10)61422-5. PMID: 21195251

Diagnosis

Leichsenring F, Heim N, Leweke F, Spitzer C, Steinert C, Kernberg OF
JAMA 2023 Feb 28;329(8):670-679. doi: 10.1001/jama.2023.0589. PMID: 36853245
Mendez-Miller M, Naccarato J, Radico JA
Am Fam Physician 2022 Feb 1;105(2):156-161. PMID: 35166488
Rao S, Broadbear J
Australas Psychiatry 2019 Dec;27(6):573-577. Epub 2019 Oct 1 doi: 10.1177/1039856219878643. PMID: 31573324
Paris J
Psychiatr Clin North Am 2018 Dec;41(4):575-582. Epub 2018 Oct 16 doi: 10.1016/j.psc.2018.07.001. PMID: 30447725
Leichsenring F, Leibing E, Kruse J, New AS, Leweke F
Lancet 2011 Jan 1;377(9759):74-84. doi: 10.1016/S0140-6736(10)61422-5. PMID: 21195251

Therapy

Stoffers-Winterling JM, Storebø OJ, Kongerslev MT, Faltinsen E, Todorovac A, Sedoc Jørgensen M, Sales CP, Edemann Callesen H, Pereira Ribeiro J, Völlm BA, Lieb K, Simonsen E
Br J Psychiatry 2022 Sep;221(3):538-552. doi: 10.1192/bjp.2021.204. PMID: 35088687
Gartlehner G, Crotty K, Kennedy S, Edlund MJ, Ali R, Siddiqui M, Fortman R, Wines R, Persad E, Viswanathan M
CNS Drugs 2021 Oct;35(10):1053-1067. Epub 2021 Sep 8 doi: 10.1007/s40263-021-00855-4. PMID: 34495494Free PMC Article
Del Casale A, Bonanni L, Bargagna P, Novelli F, Fiaschè F, Paolini M, Forcina F, Anibaldi G, Cortese FN, Iannuccelli A, Adriani B, Brugnoli R, Girardi P, Paris J, Pompili M
Curr Neuropharmacol 2021;19(10):1760-1779. doi: 10.2174/1570159X19666210610092958. PMID: 34151763Free PMC Article
Cristea IA, Gentili C, Cotet CD, Palomba D, Barbui C, Cuijpers P
JAMA Psychiatry 2017 Apr 1;74(4):319-328. doi: 10.1001/jamapsychiatry.2016.4287. PMID: 28249086
Stoffers JM, Völlm BA, Rücker G, Timmer A, Huband N, Lieb K
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD005652. doi: 10.1002/14651858.CD005652.pub2. PMID: 22895952Free PMC Article

Prognosis

Tate AE, Sahlin H, Liu S, Lu Y, Lundström S, Larsson H, Lichtenstein P, Kuja-Halkola R
Mol Psychiatry 2022 May;27(5):2514-2521. Epub 2022 Mar 18 doi: 10.1038/s41380-022-01503-z. PMID: 35304564Free PMC Article
West ML, Guest RM, Carmel A
Personal Ment Health 2021 Aug;15(3):208-222. Epub 2021 May 5 doi: 10.1002/pmh.1509. PMID: 33955194
Temes CM, Zanarini MC
Psychiatr Clin North Am 2018 Dec;41(4):685-694. Epub 2018 Oct 16 doi: 10.1016/j.psc.2018.07.002. PMID: 30447732
Biskin RS, Paris J
CMAJ 2012 Nov 6;184(16):1789-94. Epub 2012 Sep 17 doi: 10.1503/cmaj.090618. PMID: 22988153Free PMC Article
Linehan MM, Comtois KA, Murray AM, Brown MZ, Gallop RJ, Heard HL, Korslund KE, Tutek DA, Reynolds SK, Lindenboim N
Arch Gen Psychiatry 2006 Jul;63(7):757-66. doi: 10.1001/archpsyc.63.7.757. PMID: 16818865

Clinical prediction guides

Richman Czégel MJ, Unoka Z, Dudas RB, Demetrovics Z
J Pers Disord 2022 Aug;36(4):399-412. doi: 10.1521/pedi.2022.36.4.399. PMID: 35913769
Lekgabe E, Pogos D, Sawyer SM, Court A, Hughes EK
Brain Behav 2021 Dec;11(12):e2443. Epub 2021 Nov 22 doi: 10.1002/brb3.2443. PMID: 34807527Free PMC Article
Peter M, Arntz A, Klimstra T, Vingerhoets AJJM
Psychiatry Res 2019 Mar;273:100-107. Epub 2019 Jan 8 doi: 10.1016/j.psychres.2019.01.024. PMID: 30640050
Lyssenko L, Schmahl C, Bockhacker L, Vonderlin R, Bohus M, Kleindienst N
Am J Psychiatry 2018 Jan 1;175(1):37-46. Epub 2017 Sep 26 doi: 10.1176/appi.ajp.2017.17010025. PMID: 28946763
Zanarini MC, Vujanovic AA, Parachini EA, Boulanger JL, Frankenburg FR, Hennen J
J Pers Disord 2003 Jun;17(3):233-42. doi: 10.1521/pedi.17.3.233.22147. PMID: 12839102

Recent systematic reviews

Stoffers-Winterling JM, Storebø OJ, Kongerslev MT, Faltinsen E, Todorovac A, Sedoc Jørgensen M, Sales CP, Edemann Callesen H, Pereira Ribeiro J, Völlm BA, Lieb K, Simonsen E
Br J Psychiatry 2022 Sep;221(3):538-552. doi: 10.1192/bjp.2021.204. PMID: 35088687
Gartlehner G, Crotty K, Kennedy S, Edlund MJ, Ali R, Siddiqui M, Fortman R, Wines R, Persad E, Viswanathan M
CNS Drugs 2021 Oct;35(10):1053-1067. Epub 2021 Sep 8 doi: 10.1007/s40263-021-00855-4. PMID: 34495494Free PMC Article
Cristea IA, Gentili C, Cotet CD, Palomba D, Barbui C, Cuijpers P
JAMA Psychiatry 2017 Apr 1;74(4):319-328. doi: 10.1001/jamapsychiatry.2016.4287. PMID: 28249086
Amad A, Ramoz N, Thomas P, Jardri R, Gorwood P
Neurosci Biobehav Rev 2014 Mar;40:6-19. Epub 2014 Jan 20 doi: 10.1016/j.neubiorev.2014.01.003. PMID: 24456942
Stoffers JM, Völlm BA, Rücker G, Timmer A, Huband N, Lieb K
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD005652. doi: 10.1002/14651858.CD005652.pub2. PMID: 22895952Free PMC Article

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