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Onchocerciasis

MedGen UID:
14477
Concept ID:
C0029001
Disease or Syndrome
Synonyms: River blindness; Robles' disease
SNOMED CT: Infection caused by Onchocerca volvulus (38539003); Infection by Onchocerca volvulus (38539003); Onchocerciasis (38539003); Onchocercosis (38539003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0017137
Orphanet: ORPHA2737

Definition

A form of filariasis, caused by the parasitic worm <i> Onchocerca volvulus</i>, transmitted by the black fly. The infection can either be asymptomatic or manifest as an ocular disease (river blindness) with itchy eyes, erythema, photophobia, onchodermatitis or onchocercal skin disease (classified into acute papular, chronic papular, lichenified, atrophic, and depigmentated) and onchocercomas (over bony prominences). Other classic clinical manifestations are ichthyosis-like lesions (''lizard skin'') and ''hanging groin'', which may be associated with lymphadenopathy. [from ORDO]

Professional guidelines

PubMed

Marques LLM, Beneti SC, Pinzon C, Cardoso FAR
Braz J Biol 2022;84:e258325. Epub 2022 May 20 doi: 10.1590/1519-6984.258325. PMID: 35584459
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Expert Rev Anti Infect Ther 2020 Nov;18(11):1067-1081. Epub 2020 Jul 26 doi: 10.1080/14787210.2020.1792772. PMID: 32715787
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Infect Dis Poverty 2019 Feb 10;8(1):11. doi: 10.1186/s40249-019-0523-y. PMID: 30738437Free PMC Article

Recent clinical studies

Etiology

Hadermann A, Amaral LJ, Van Cutsem G, Siewe Fodjo JN, Colebunders R
Trends Parasitol 2023 Feb;39(2):126-138. Epub 2022 Dec 15 doi: 10.1016/j.pt.2022.11.010. PMID: 36528471
Wan Sulaiman WA, Kamtchum-Tatuene J, Mohamed MH, Ramachandran V, Ching SM, Sazlly Lim SM, Hashim HZ, Inche Mat LN, Hoo FK, Basri H
Indian J Med Res 2019 Jun;149(6):706-714. doi: 10.4103/ijmr.IJMR_454_17. PMID: 31496523Free PMC Article
Showler AJ, Nutman TB
Curr Opin Infect Dis 2018 Oct;31(5):393-398. doi: 10.1097/QCO.0000000000000483. PMID: 30113326Free PMC Article
Makepeace BL, Tanya VN
Trends Parasitol 2016 Dec;32(12):966-978. Epub 2016 Sep 21 doi: 10.1016/j.pt.2016.08.013. PMID: 27665524
Padgett JJ, Jacobsen KH
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Diagnosis

Perkel JM
Nature 2017 May 3;545(7652):119-121. doi: 10.1038/545119a. PMID: 28470200
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Therapy

Hadermann A, Amaral LJ, Van Cutsem G, Siewe Fodjo JN, Colebunders R
Trends Parasitol 2023 Feb;39(2):126-138. Epub 2022 Dec 15 doi: 10.1016/j.pt.2022.11.010. PMID: 36528471
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Prognosis

Showler AJ, Nutman TB
Curr Opin Infect Dis 2018 Oct;31(5):393-398. doi: 10.1097/QCO.0000000000000483. PMID: 30113326Free PMC Article
Lupi O, Downing C, Lee M, Pino L, Bravo F, Giglio P, Sethi A, Klaus S, Sangueza OP, Fuller C, Mendoza N, Ladizinski B, Woc-Colburn L, Tyring SK
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Dowell SF, Sejvar JJ, Riek L, Vandemaele KA, Lamunu M, Kuesel AC, Schmutzhard E, Matuja W, Bunga S, Foltz J, Nutman TB, Winkler AS, Mbonye AK
Emerg Infect Dis 2013;19(9):1374-84. doi: 10.3201/eid1909.130401. PMID: 23965548Free PMC Article
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Clinical prediction guides

Atmakuri S, Nene S, Khatri D, Singh SB, Sinha VR, Srivastava S
Curr Drug Deliv 2023;20(8):1049-1066. doi: 10.2174/1567201819666220516163242. PMID: 35578879
Ehrens A, Hoerauf A, Hübner MP
Front Immunol 2022;13:983812. Epub 2022 Oct 31 doi: 10.3389/fimmu.2022.983812. PMID: 36389745Free PMC Article
Colebunders R, Nelson Siewe FJ, Hotterbeekx A
Trends Parasitol 2018 Mar;34(3):208-216. Epub 2017 Dec 26 doi: 10.1016/j.pt.2017.11.009. PMID: 29288080
Cheke RA
Expert Rev Anti Infect Ther 2017 Apr;15(4):377-386. Epub 2017 Feb 3 doi: 10.1080/14787210.2017.1286980. PMID: 28117596
Enk CD
Clin Dermatol 2006 May-Jun;24(3):176-80. doi: 10.1016/j.clindermatol.2005.11.008. PMID: 16714198

Recent systematic reviews

Waje T, Iliyasu C, Yaki LM, Auta IK
Pan Afr Med J 2024;47:142. Epub 2024 Mar 27 doi: 10.11604/pamj.2024.47.142.39746. PMID: 38933431Free PMC Article
Luna J, Metanmo S, Boumediene F, Mbelesso P, Auditeau E, Ajzenberg D, Preux PM
J Neurol Sci 2021 Feb 15;421:117314. Epub 2021 Jan 9 doi: 10.1016/j.jns.2021.117314. PMID: 33493958
Keating J, Yukich JO, Mollenkopf S, Tediosi F
Acta Trop 2014 Jul;135:86-95. Epub 2014 Apr 1 doi: 10.1016/j.actatropica.2014.03.017. PMID: 24699086
Kaiser C, Pion SD, Boussinesq M
PLoS Negl Trop Dis 2013;7(3):e2147. Epub 2013 Mar 28 doi: 10.1371/journal.pntd.0002147. PMID: 23556028Free PMC Article
Pion SD, Kaiser C, Boutros-Toni F, Cournil A, Taylor MM, Meredith SE, Stufe A, Bertocchi I, Kipp W, Preux PM, Boussinesq M
PLoS Negl Trop Dis 2009 Jun 16;3(6):e461. doi: 10.1371/journal.pntd.0000461. PMID: 19529767Free PMC Article

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