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Ocular onchocerciasis

MedGen UID:
45196
•Concept ID:
C0029002
•
Disease or Syndrome
Synonyms: Blindness, River; Ocular Onchocerciases; Ocular Onchocerciasis; Onchocerciases, Ocular; Onchocerciasis, Ocular; River Blindness
SNOMED CT: Ocular onchocerciasis (240842000); River blindness (240842000)
 
Monarch Initiative: MONDO:0005878

Definition

Onchocerciasis affecting the eye. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOcular onchocerciasis

Professional guidelines

PubMed

Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis.
Abegunde AT, Ahuja RM, Okafor NJ
Cochrane Database Syst Rev 2016 Jan 15;2016(1):CD011146. doi: 10.1002/14651858.CD011146.pub2. PMID: 26771164Free PMC Article
Ocular involvement in patients with onchocerciasis after repeated treatment with ivermectin.
Rothova A, Van der Lelij A, Stilma JS, Klaassen-Broekema N, Wilson WR, Barbe RF
Am J Ophthalmol 1990 Jul 15;110(1):6-16. doi: 10.1016/s0002-9394(14)76930-2. PMID: 2368822
Changes in ocular onchocerciasis four and twelve months after community-based treatment with ivermectin in a holoendemic onchocerciasis focus.
Dadzie KY, Remme J, Alley ES, de Sole G
Trans R Soc Trop Med Hyg 1990 Jan-Feb;84(1):103-8. doi: 10.1016/0035-9203(90)90395-u. PMID: 2345906

Recent clinical studies

Etiology

Reaching the last mile: main challenges relating to and recommendations to accelerate onchocerciasis elimination in Africa.
Gebrezgabiher G, Mekonnen Z, Yewhalaw D, Hailu A
Infect Dis Poverty 2019 Jul 4;8(1):60. doi: 10.1186/s40249-019-0567-z. PMID: 31269966Free PMC Article
Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis.
Abegunde AT, Ahuja RM, Okafor NJ
Cochrane Database Syst Rev 2016 Jan 15;2016(1):CD011146. doi: 10.1002/14651858.CD011146.pub2. PMID: 26771164Free PMC Article
Loiasis: African eye worm.
Padgett JJ, Jacobsen KH
Trans R Soc Trop Med Hyg 2008 Oct;102(10):983-9. Epub 2008 May 7 doi: 10.1016/j.trstmh.2008.03.022. PMID: 18466939
Onchocerciasis and other eye problems in developing countries: a challenge for optometrists.
Berger IB, Nnadozie J
J Am Optom Assoc 1993 Oct;64(10):699-702. PMID: 8245390
Ocular onchocerciasis.
Thylefors B
Bull World Health Organ 1978;56(1):63-73. PMID: 307448Free PMC Article

Diagnosis

Onchocerciasis (river blindness) - more than a century of research and control.
Brattig NW, Cheke RA, Garms R
Acta Trop 2021 Jun;218:105677. Epub 2020 Aug 26 doi: 10.1016/j.actatropica.2020.105677. PMID: 32857984
Pocket laboratories.
Perkel JM
Nature 2017 May 3;545(7652):119-121. doi: 10.1038/545119a. PMID: 28470200
Loiasis: African eye worm.
Padgett JJ, Jacobsen KH
Trans R Soc Trop Med Hyg 2008 Oct;102(10):983-9. Epub 2008 May 7 doi: 10.1016/j.trstmh.2008.03.022. PMID: 18466939
Onchocerciasis--river blindness.
Enk CD
Clin Dermatol 2006 May-Jun;24(3):176-80. doi: 10.1016/j.clindermatol.2005.11.008. PMID: 16714198
Onchocerciasis.
Taylor HR
Int Ophthalmol 1990 May;14(3):189-94. doi: 10.1007/BF00158317. PMID: 2188920

Therapy

River Blindness: Mathematical Models for Control and Elimination.
Basáñez MG, Walker M, Turner HC, Coffeng LE, de Vlas SJ, Stolk WA
Adv Parasitol 2016;94:247-341. Epub 2016 Oct 7 doi: 10.1016/bs.apar.2016.08.003. PMID: 27756456
Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis.
Abegunde AT, Ahuja RM, Okafor NJ
Cochrane Database Syst Rev 2016 Jan 15;2016(1):CD011146. doi: 10.1002/14651858.CD011146.pub2. PMID: 26771164Free PMC Article
Loiasis: African eye worm.
Padgett JJ, Jacobsen KH
Trans R Soc Trop Med Hyg 2008 Oct;102(10):983-9. Epub 2008 May 7 doi: 10.1016/j.trstmh.2008.03.022. PMID: 18466939
Onchocerciasis.
Taylor HR
Int Ophthalmol 1990 May;14(3):189-94. doi: 10.1007/BF00158317. PMID: 2188920
Ocular onchocerciasis.
Thylefors B
Bull World Health Organ 1978;56(1):63-73. PMID: 307448Free PMC Article

Prognosis

Onchocerciasis (river blindness) - more than a century of research and control.
Brattig NW, Cheke RA, Garms R
Acta Trop 2021 Jun;218:105677. Epub 2020 Aug 26 doi: 10.1016/j.actatropica.2020.105677. PMID: 32857984
Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis.
Abegunde AT, Ahuja RM, Okafor NJ
Cochrane Database Syst Rev 2016 Jan 15;2016(1):CD011146. doi: 10.1002/14651858.CD011146.pub2. PMID: 26771164Free PMC Article
Effects of Ivermectin with and without doxycycline on clinical symptoms of onchocerciasis.
Masud H, Qureshi TQ, Dukley M
J Coll Physicians Surg Pak 2009 Jan;19(1):34-8. PMID: 19149978
Onchocerciasis in Zaïre.
Maertens K
Int Ophthalmol 1990 May;14(3):181-8. doi: 10.1007/BF00158316. PMID: 2188919
Ocular onchocerciasis and intensity of infection in the community. I. West African savanna.
Remme J, Dadzie KY, Rolland A, Thylefors B
Trop Med Parasitol 1989 Sep;40(3):340-7. PMID: 2617045

Clinical prediction guides

Feline ocular onchocercosis by Onchocerca lupi: Phylogenetic insights and implication for veterinary health.
Tudor P, Ionașcu I, Mateescu CI, Bezerra-Santos MA, Gurău MR, Mateescu RE, Gagniuc E, Tudor N, Otranto D
Acta Trop 2023 Jan;237:106723. Epub 2022 Oct 22 doi: 10.1016/j.actatropica.2022.106723. PMID: 36283498
Prevalence of onchocerciasis and associated clinical manifestations in selected hypoendemic communities in Ghana following long-term administration of ivermectin.
Otabil KB, Gyasi SF, Awuah E, Obeng-Ofori D, Atta-Nyarko RJ, Andoh D, Conduah B, Agbenyikey L, Aseidu P, Ankrah CB, Nuhu AR, Schallig HDFH
BMC Infect Dis 2019 May 17;19(1):431. doi: 10.1186/s12879-019-4076-2. PMID: 31101085Free PMC Article
Onchocerca volvulus infection and serological prevalence, ocular onchocerciasis and parasite transmission in northern and central Togo after decades of Simulium damnosum s.l. vector control and mass drug administration of ivermectin.
Komlan K, Vossberg PS, Gantin RG, Solim T, Korbmacher F, Banla M, Padjoudoum K, Karabou P, Köhler C, Soboslay PT
PLoS Negl Trop Dis 2018 Mar;12(3):e0006312. Epub 2018 Mar 1 doi: 10.1371/journal.pntd.0006312. PMID: 29494606Free PMC Article
Onchocerciasis--river blindness.
Enk CD
Clin Dermatol 2006 May-Jun;24(3):176-80. doi: 10.1016/j.clindermatol.2005.11.008. PMID: 16714198
Ocular onchocercosis in dogs: a review.
Sréter T, Széll Z, Egyed Z, Varga I
Vet Rec 2002 Aug 10;151(6):176-80. doi: 10.1136/vr.151.6.176. PMID: 12201260

Recent systematic reviews

Elimination of transmission of onchocerciasis (river blindness) with long-term ivermectin mass drug administration with or without vector control in sub-Saharan Africa: a systematic review and meta-analysis.
Mutono N, Basáñez MG, James A, Stolk WA, Makori A, Kimani TN, Hollingsworth TD, Vasconcelos A, Dixon MA, de Vlas SJ, Thumbi SM
Lancet Glob Health 2024 May;12(5):e771-e782. Epub 2024 Mar 11 doi: 10.1016/S2214-109X(24)00043-3. PMID: 38484745Free PMC Article
Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis.
Abegunde AT, Ahuja RM, Okafor NJ
Cochrane Database Syst Rev 2016 Jan 15;2016(1):CD011146. doi: 10.1002/14651858.CD011146.pub2. PMID: 26771164Free PMC Article
Ivermectin for onchocercal eye disease (river blindness).
Ejere HO, Schwartz E, Wormald R, Evans JR
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD002219. doi: 10.1002/14651858.CD002219.pub2. PMID: 22895928Free PMC Article
Oral drug therapy for multiple neglected tropical diseases: a systematic review.
Reddy M, Gill SS, Kalkar SR, Wu W, Anderson PJ, Rochon PA
JAMA 2007 Oct 24;298(16):1911-24. doi: 10.1001/jama.298.16.1911. PMID: 17954542
Ivermectin for onchocercal eye disease (river blindness).
Ejere H, Schwartz E, Wormald R
Cochrane Database Syst Rev 2001;(1):CD002219. doi: 10.1002/14651858.CD002219. PMID: 11279760

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