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Ocular onchocerciasis

MedGen UID:
45196
•Concept ID:
C0029002
•
Disease or Syndrome
Synonyms: Blindness, River; Ocular Onchocerciases; Ocular Onchocerciasis; Onchocerciases, Ocular; Onchocerciasis, Ocular; River Blindness
SNOMED CT: Ocular onchocerciasis (240842000); River blindness (240842000)
 
Monarch Initiative: MONDO:0005878

Definition

Onchocerciasis affecting the eye. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOcular onchocerciasis

Professional guidelines

PubMed

Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis.
Abegunde AT, Ahuja RM, Okafor NJ
Cochrane Database Syst Rev 2016 Jan 15;2016(1):CD011146. doi: 10.1002/14651858.CD011146.pub2. PMID: 26771164Free PMC Article
Ocular involvement in patients with onchocerciasis after repeated treatment with ivermectin.
Rothova A, Van der Lelij A, Stilma JS, Klaassen-Broekema N, Wilson WR, Barbe RF
Am J Ophthalmol 1990 Jul 15;110(1):6-16. doi: 10.1016/s0002-9394(14)76930-2. PMID: 2368822
Acute ocular onchocerciasis and its treatment.
RODGER FC
Br J Ophthalmol 1957 Sep;41(9):544-57. doi: 10.1136/bjo.41.9.544. PMID: 13460222Free PMC Article

Recent clinical studies

Etiology

Reaching the last mile: main challenges relating to and recommendations to accelerate onchocerciasis elimination in Africa.
Gebrezgabiher G, Mekonnen Z, Yewhalaw D, Hailu A
Infect Dis Poverty 2019 Jul 4;8(1):60. doi: 10.1186/s40249-019-0567-z. PMID: 31269966Free PMC Article
Loiasis: African eye worm.
Padgett JJ, Jacobsen KH
Trans R Soc Trop Med Hyg 2008 Oct;102(10):983-9. Epub 2008 May 7 doi: 10.1016/j.trstmh.2008.03.022. PMID: 18466939
Blindness in Africa: present situation and future needs.
Lewallen S, Courtright P
Br J Ophthalmol 2001 Aug;85(8):897-903. doi: 10.1136/bjo.85.8.897. PMID: 11466240Free PMC Article
Distribution and severity of onchocerciasis in southern Benin, Ghana and Togo.
De Sole G, Accorsi S, Cresveaux H, Remme J, Walsh F, Hendrickx J
Acta Trop 1992 Dec;52(2-3):87-97. doi: 10.1016/0001-706x(92)90024-r. PMID: 1363185
Ocular onchocerciasis.
Thylefors B
Bull World Health Organ 1978;56(1):63-73. PMID: 307448Free PMC Article

Diagnosis

Onchocerciasis (river blindness) - more than a century of research and control.
Brattig NW, Cheke RA, Garms R
Acta Trop 2021 Jun;218:105677. Epub 2020 Aug 26 doi: 10.1016/j.actatropica.2020.105677. PMID: 32857984
Pocket laboratories.
Perkel JM
Nature 2017 May 3;545(7652):119-121. doi: 10.1038/545119a. PMID: 28470200
Loiasis: African eye worm.
Padgett JJ, Jacobsen KH
Trans R Soc Trop Med Hyg 2008 Oct;102(10):983-9. Epub 2008 May 7 doi: 10.1016/j.trstmh.2008.03.022. PMID: 18466939
Onchocerciasis--river blindness.
Enk CD
Clin Dermatol 2006 May-Jun;24(3):176-80. doi: 10.1016/j.clindermatol.2005.11.008. PMID: 16714198
Onchocerciasis.
Taylor HR
Int Ophthalmol 1990 May;14(3):189-94. doi: 10.1007/BF00158317. PMID: 2188920

Therapy

River Blindness: Mathematical Models for Control and Elimination.
Basáñez MG, Walker M, Turner HC, Coffeng LE, de Vlas SJ, Stolk WA
Adv Parasitol 2016;94:247-341. Epub 2016 Oct 7 doi: 10.1016/bs.apar.2016.08.003. PMID: 27756456
Loiasis: African eye worm.
Padgett JJ, Jacobsen KH
Trans R Soc Trop Med Hyg 2008 Oct;102(10):983-9. Epub 2008 May 7 doi: 10.1016/j.trstmh.2008.03.022. PMID: 18466939
Onchocerciasis.
Malatt AE, Taylor HR
Infect Dis Clin North Am 1992 Dec;6(4):963-77. PMID: 1460274
Onchocerciasis.
Taylor HR
Int Ophthalmol 1990 May;14(3):189-94. doi: 10.1007/BF00158317. PMID: 2188920
Ocular onchocerciasis.
Thylefors B
Bull World Health Organ 1978;56(1):63-73. PMID: 307448Free PMC Article

Prognosis

Onchocerciasis (river blindness) - more than a century of research and control.
Brattig NW, Cheke RA, Garms R
Acta Trop 2021 Jun;218:105677. Epub 2020 Aug 26 doi: 10.1016/j.actatropica.2020.105677. PMID: 32857984
Blackflies and whitewater: onchocerciasis and the eye.
Rowe SG, Durand M
Int Ophthalmol Clin 1998 Winter;38(1):231-40. doi: 10.1097/00004397-199803810-00018. PMID: 9532484
Blindness in the tropics.
Narita AS, Taylor HR
Med J Aust 1993 Sep 20;159(6):416-20. doi: 10.5694/j.1326-5377.1993.tb137921.x. PMID: 8377695
Onchocerciasis in Zaïre.
Maertens K
Int Ophthalmol 1990 May;14(3):181-8. doi: 10.1007/BF00158316. PMID: 2188919
Ocular onchocerciasis and intensity of infection in the community. I. West African savanna.
Remme J, Dadzie KY, Rolland A, Thylefors B
Trop Med Parasitol 1989 Sep;40(3):340-7. PMID: 2617045

Clinical prediction guides

Feline ocular onchocercosis by Onchocerca lupi: Phylogenetic insights and implication for veterinary health.
Tudor P, Ionașcu I, Mateescu CI, Bezerra-Santos MA, Gurău MR, Mateescu RE, Gagniuc E, Tudor N, Otranto D
Acta Trop 2023 Jan;237:106723. Epub 2022 Oct 22 doi: 10.1016/j.actatropica.2022.106723. PMID: 36283498
Prevalence of onchocerciasis and associated clinical manifestations in selected hypoendemic communities in Ghana following long-term administration of ivermectin.
Otabil KB, Gyasi SF, Awuah E, Obeng-Ofori D, Atta-Nyarko RJ, Andoh D, Conduah B, Agbenyikey L, Aseidu P, Ankrah CB, Nuhu AR, Schallig HDFH
BMC Infect Dis 2019 May 17;19(1):431. doi: 10.1186/s12879-019-4076-2. PMID: 31101085Free PMC Article
Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness.
Walker M, Specht S, Churcher TS, Hoerauf A, Taylor MJ, Basáñez MG
Clin Infect Dis 2015 Apr 15;60(8):1199-207. Epub 2014 Dec 23 doi: 10.1093/cid/ciu1152. PMID: 25537873Free PMC Article
Onchocerciasis--river blindness.
Enk CD
Clin Dermatol 2006 May-Jun;24(3):176-80. doi: 10.1016/j.clindermatol.2005.11.008. PMID: 16714198
Population biology of human onchocerciasis.
Basáñez MG, Boussinesq M
Philos Trans R Soc Lond B Biol Sci 1999 Apr 29;354(1384):809-26. doi: 10.1098/rstb.1999.0433. PMID: 10365406Free PMC Article

Recent systematic reviews

Elimination of transmission of onchocerciasis (river blindness) with long-term ivermectin mass drug administration with or without vector control in sub-Saharan Africa: a systematic review and meta-analysis.
Mutono N, Basáñez MG, James A, Stolk WA, Makori A, Kimani TN, Hollingsworth TD, Vasconcelos A, Dixon MA, de Vlas SJ, Thumbi SM
Lancet Glob Health 2024 May;12(5):e771-e782. Epub 2024 Mar 11 doi: 10.1016/S2214-109X(24)00043-3. PMID: 38484745Free PMC Article
Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis.
Abegunde AT, Ahuja RM, Okafor NJ
Cochrane Database Syst Rev 2016 Jan 15;2016(1):CD011146. doi: 10.1002/14651858.CD011146.pub2. PMID: 26771164Free PMC Article
Ivermectin for onchocercal eye disease (river blindness).
Ejere HO, Schwartz E, Wormald R, Evans JR
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD002219. doi: 10.1002/14651858.CD002219.pub2. PMID: 22895928Free PMC Article
Oral drug therapy for multiple neglected tropical diseases: a systematic review.
Reddy M, Gill SS, Kalkar SR, Wu W, Anderson PJ, Rochon PA
JAMA 2007 Oct 24;298(16):1911-24. doi: 10.1001/jama.298.16.1911. PMID: 17954542
Ivermectin for onchocercal eye disease (river blindness).
Ejere H, Schwartz E, Wormald R
Cochrane Database Syst Rev 2001;(1):CD002219. doi: 10.1002/14651858.CD002219. PMID: 11279760

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