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Ocular onchocerciasis

MedGen UID:
45196
•Concept ID:
C0029002
•
Disease or Syndrome
Synonyms: Blindness, River; Ocular Onchocerciases; Ocular Onchocerciasis; Onchocerciases, Ocular; Onchocerciasis, Ocular; River Blindness
SNOMED CT: Ocular onchocerciasis (240842000); River blindness (240842000)
 
Monarch Initiative: MONDO:0005878

Definition

Onchocerciasis affecting the eye. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOcular onchocerciasis

Professional guidelines

PubMed

Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis.
Abegunde AT, Ahuja RM, Okafor NJ
Cochrane Database Syst Rev 2016 Jan 15;2016(1):CD011146. doi: 10.1002/14651858.CD011146.pub2. PMID: 26771164Free PMC Article
Ocular involvement in patients with onchocerciasis after repeated treatment with ivermectin.
Rothova A, Van der Lelij A, Stilma JS, Klaassen-Broekema N, Wilson WR, Barbe RF
Am J Ophthalmol 1990 Jul 15;110(1):6-16. doi: 10.1016/s0002-9394(14)76930-2. PMID: 2368822
Acute ocular onchocerciasis and its treatment.
RODGER FC
Br J Ophthalmol 1957 Sep;41(9):544-57. doi: 10.1136/bjo.41.9.544. PMID: 13460222Free PMC Article

Recent clinical studies

Etiology

Reaching the last mile: main challenges relating to and recommendations to accelerate onchocerciasis elimination in Africa.
Gebrezgabiher G, Mekonnen Z, Yewhalaw D, Hailu A
Infect Dis Poverty 2019 Jul 4;8(1):60. doi: 10.1186/s40249-019-0567-z. PMID: 31269966Free PMC Article
Loiasis: African eye worm.
Padgett JJ, Jacobsen KH
Trans R Soc Trop Med Hyg 2008 Oct;102(10):983-9. Epub 2008 May 7 doi: 10.1016/j.trstmh.2008.03.022. PMID: 18466939
Blindness in Africa: present situation and future needs.
Lewallen S, Courtright P
Br J Ophthalmol 2001 Aug;85(8):897-903. doi: 10.1136/bjo.85.8.897. PMID: 11466240Free PMC Article
Distribution and severity of onchocerciasis in southern Benin, Ghana and Togo.
De Sole G, Accorsi S, Cresveaux H, Remme J, Walsh F, Hendrickx J
Acta Trop 1992 Dec;52(2-3):87-97. doi: 10.1016/0001-706x(92)90024-r. PMID: 1363185
Ocular onchocerciasis.
Thylefors B
Bull World Health Organ 1978;56(1):63-73. PMID: 307448Free PMC Article

Diagnosis

Pocket laboratories.
Perkel JM
Nature 2017 May 3;545(7652):119-121. doi: 10.1038/545119a. PMID: 28470200
Loiasis: African eye worm.
Padgett JJ, Jacobsen KH
Trans R Soc Trop Med Hyg 2008 Oct;102(10):983-9. Epub 2008 May 7 doi: 10.1016/j.trstmh.2008.03.022. PMID: 18466939
Onchocerciasis--river blindness.
Enk CD
Clin Dermatol 2006 May-Jun;24(3):176-80. doi: 10.1016/j.clindermatol.2005.11.008. PMID: 16714198
Molecular approaches to the diagnosis of onchocerciasis.
Bradley JE, Unnasch TR
Adv Parasitol 1996;37:57-106. doi: 10.1016/s0065-308x(08)60219-5. PMID: 8881598
Onchocerciasis.
Taylor HR
Int Ophthalmol 1990 May;14(3):189-94. doi: 10.1007/BF00158317. PMID: 2188920

Therapy

River Blindness: Mathematical Models for Control and Elimination.
Basáñez MG, Walker M, Turner HC, Coffeng LE, de Vlas SJ, Stolk WA
Adv Parasitol 2016;94:247-341. Epub 2016 Oct 7 doi: 10.1016/bs.apar.2016.08.003. PMID: 27756456
Loiasis: African eye worm.
Padgett JJ, Jacobsen KH
Trans R Soc Trop Med Hyg 2008 Oct;102(10):983-9. Epub 2008 May 7 doi: 10.1016/j.trstmh.2008.03.022. PMID: 18466939
Onchocerciasis.
Malatt AE, Taylor HR
Infect Dis Clin North Am 1992 Dec;6(4):963-77. PMID: 1460274
Onchocerciasis.
Taylor HR
Int Ophthalmol 1990 May;14(3):189-94. doi: 10.1007/BF00158317. PMID: 2188920
Ocular onchocerciasis.
Thylefors B
Bull World Health Organ 1978;56(1):63-73. PMID: 307448Free PMC Article

Prognosis

Onchocerciasis (river blindness) - more than a century of research and control.
Brattig NW, Cheke RA, Garms R
Acta Trop 2021 Jun;218:105677. Epub 2020 Aug 26 doi: 10.1016/j.actatropica.2020.105677. PMID: 32857984
Blackflies and whitewater: onchocerciasis and the eye.
Rowe SG, Durand M
Int Ophthalmol Clin 1998 Winter;38(1):231-40. doi: 10.1097/00004397-199803810-00018. PMID: 9532484
Blindness in the tropics.
Narita AS, Taylor HR
Med J Aust 1993 Sep 20;159(6):416-20. doi: 10.5694/j.1326-5377.1993.tb137921.x. PMID: 8377695
Onchocerciasis in Zaïre.
Maertens K
Int Ophthalmol 1990 May;14(3):181-8. doi: 10.1007/BF00158316. PMID: 2188919
Ocular onchocerciasis and intensity of infection in the community. I. West African savanna.
Remme J, Dadzie KY, Rolland A, Thylefors B
Trop Med Parasitol 1989 Sep;40(3):340-7. PMID: 2617045

Clinical prediction guides

Feline ocular onchocercosis by Onchocerca lupi: Phylogenetic insights and implication for veterinary health.
Tudor P, Ionașcu I, Mateescu CI, Bezerra-Santos MA, Gurău MR, Mateescu RE, Gagniuc E, Tudor N, Otranto D
Acta Trop 2023 Jan;237:106723. Epub 2022 Oct 22 doi: 10.1016/j.actatropica.2022.106723. PMID: 36283498
Prevalence of onchocerciasis and associated clinical manifestations in selected hypoendemic communities in Ghana following long-term administration of ivermectin.
Otabil KB, Gyasi SF, Awuah E, Obeng-Ofori D, Atta-Nyarko RJ, Andoh D, Conduah B, Agbenyikey L, Aseidu P, Ankrah CB, Nuhu AR, Schallig HDFH
BMC Infect Dis 2019 May 17;19(1):431. doi: 10.1186/s12879-019-4076-2. PMID: 31101085Free PMC Article
Onchocerciasis--river blindness.
Enk CD
Clin Dermatol 2006 May-Jun;24(3):176-80. doi: 10.1016/j.clindermatol.2005.11.008. PMID: 16714198
Population biology of human onchocerciasis.
Basáñez MG, Boussinesq M
Philos Trans R Soc Lond B Biol Sci 1999 Apr 29;354(1384):809-26. doi: 10.1098/rstb.1999.0433. PMID: 10365406Free PMC Article
Major retinal cell components recognized by onchocerciasis sera are associated with the cell surface and nucleoli.
Zhou Y, Dziak E, Unnasch TR, Opas M
Invest Ophthalmol Vis Sci 1994 Mar;35(3):1089-99. PMID: 7510272

Recent systematic reviews

Elimination of transmission of onchocerciasis (river blindness) with long-term ivermectin mass drug administration with or without vector control in sub-Saharan Africa: a systematic review and meta-analysis.
Mutono N, Basáñez MG, James A, Stolk WA, Makori A, Kimani TN, Hollingsworth TD, Vasconcelos A, Dixon MA, de Vlas SJ, Thumbi SM
Lancet Glob Health 2024 May;12(5):e771-e782. Epub 2024 Mar 11 doi: 10.1016/S2214-109X(24)00043-3. PMID: 38484745Free PMC Article
Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis.
Abegunde AT, Ahuja RM, Okafor NJ
Cochrane Database Syst Rev 2016 Jan 15;2016(1):CD011146. doi: 10.1002/14651858.CD011146.pub2. PMID: 26771164Free PMC Article
Ivermectin for onchocercal eye disease (river blindness).
Ejere HO, Schwartz E, Wormald R, Evans JR
Cochrane Database Syst Rev 2012 Aug 15;2012(8):CD002219. doi: 10.1002/14651858.CD002219.pub2. PMID: 22895928Free PMC Article
Oral drug therapy for multiple neglected tropical diseases: a systematic review.
Reddy M, Gill SS, Kalkar SR, Wu W, Anderson PJ, Rochon PA
JAMA 2007 Oct 24;298(16):1911-24. doi: 10.1001/jama.298.16.1911. PMID: 17954542
Ivermectin for onchocercal eye disease (river blindness).
Ejere H, Schwartz E, Wormald R
Cochrane Database Syst Rev 2001;(1):CD002219. doi: 10.1002/14651858.CD002219. PMID: 11279760

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