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Benign neoplasm of endometrium

MedGen UID:
146349
•Concept ID:
C0686239
•
Neoplastic Process
Synonyms: Benign Endometrial Neoplasm; benign endometrial neoplasm; Benign Endometrial Tumor; benign endometrial tumor; benign endometrial tumour; Benign Endometrium Neoplasm; benign endometrium neoplasm; Benign Endometrium Tumor; benign endometrium tumor; benign endometrium tumour; Benign Neoplasm of Endometrium; benign neoplasm of endometrium; Benign Neoplasm of the Endometrium; benign neoplasm of the endometrium; Benign Tumor of Endometrium; benign tumor of endometrium; Benign Tumor of the Endometrium; benign tumor of the endometrium; benign tumour of endometrium; benign tumour of the endometrium; endometrium benign neoplasm
SNOMED CT: Benign neoplasm of endometrium (92086004)
 
Monarch Initiative: MONDO:0021471

Definition

A neoplastic endometrial proliferation that is confined to the endometrium and does not have metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of endometrium

Professional guidelines

PubMed

Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
Evaluation and management of abnormal uterine bleeding.
Achanna KS, Nanda J
Med J Malaysia 2022 May;77(3):374-383. PMID: 35638495
Diagnosis and Management of Endometrial Cancer.
Braun MM, Overbeek-Wager EA, Grumbo RJ
Am Fam Physician 2016 Mar 15;93(6):468-74. PMID: 26977831

Recent clinical studies

Etiology

Autophagy in the physiological endometrium and cancer.
Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Navàs D
Autophagy 2021 May;17(5):1077-1095. Epub 2020 May 13 doi: 10.1080/15548627.2020.1752548. PMID: 32401642Free PMC Article
Endometrial Carcinoma and its Precursors.
Javadian P, Nezhat F
Adv Exp Med Biol 2020;1242:59-72. doi: 10.1007/978-3-030-38474-6_4. PMID: 32406028
Scaffold-Free Endometrial Organoids Respond to Excess Androgens Associated With Polycystic Ovarian Syndrome.
Wiwatpanit T, Murphy AR, Lu Z, Urbanek M, Burdette JE, Woodruff TK, Kim JJ
J Clin Endocrinol Metab 2020 Mar 1;105(3):769-80. doi: 10.1210/clinem/dgz100. PMID: 31614364Free PMC Article
Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia.
Ip PP, Irving JA, McCluggage WG, Clement PB, Young RH
Am J Surg Pathol 2013 Feb;37(2):167-77. doi: 10.1097/PAS.0b013e318272d428. PMID: 23211295
Terms, definitions and measurements to describe the sonographic features of the endometrium and intrauterine lesions: a consensus opinion from the International Endometrial Tumor Analysis (IETA) group.
Leone FP, Timmerman D, Bourne T, Valentin L, Epstein E, Goldstein SR, Marret H, Parsons AK, Gull B, Istre O, Sepulveda W, Ferrazzi E, Van den Bosch T
Ultrasound Obstet Gynecol 2010 Jan;35(1):103-12. doi: 10.1002/uog.7487. PMID: 20014360

Diagnosis

Minimally invasive approaches for the early detection of endometrial cancer.
Shen Y, Yang W, Liu J, Zhang Y
Mol Cancer 2023 Mar 17;22(1):53. doi: 10.1186/s12943-023-01757-3. PMID: 36932368Free PMC Article
Ultrasound features of endometrial pathology in women without abnormal uterine bleeding: results from the International Endometrial Tumor Analysis study (IETA3).
Heremans R, Van Den Bosch T, Valentin L, Wynants L, Pascual MA, Fruscio R, Testa AC, Buonomo F, Guerriero S, Epstein E, Bourne T, Timmerman D, Leone FPG; IETA Consortium
Ultrasound Obstet Gynecol 2022 Aug;60(2):243-255. doi: 10.1002/uog.24910. PMID: 35385178
Endometrial Carcinoma and its Precursors.
Javadian P, Nezhat F
Adv Exp Med Biol 2020;1242:59-72. doi: 10.1007/978-3-030-38474-6_4. PMID: 32406028
Uterine Carcinosarcomas.
Sagebiel TL, Bhosale PR, Patnana M, Faria SC, Devine CE
Semin Ultrasound CT MR 2019 Aug;40(4):295-301. Epub 2019 Mar 9 doi: 10.1053/j.sult.2019.03.004. PMID: 31375170
Endometriosis.
Zondervan KT, Becker CM, Koga K, Missmer SA, Taylor RN, Viganò P
Nat Rev Dis Primers 2018 Jul 19;4(1):9. doi: 10.1038/s41572-018-0008-5. PMID: 30026507

Therapy

HER2 Testing in Endometrial Serous Carcinoma: Time for Standardized Pathology Practice to Meet the Clinical Demand.
Buza N
Arch Pathol Lab Med 2021 Jun 1;145(6):687-691. doi: 10.5858/arpa.2020-0207-RA. PMID: 32649220
Risk Factors Associated with Endometrial Pathology in Premenopausal Breast Cancer Patients Treated with Tamoxifen.
Lee M, Piao J, Jeon MJ
Yonsei Med J 2020 Apr;61(4):317-322. doi: 10.3349/ymj.2020.61.4.317. PMID: 32233174Free PMC Article
Scaffold-Free Endometrial Organoids Respond to Excess Androgens Associated With Polycystic Ovarian Syndrome.
Wiwatpanit T, Murphy AR, Lu Z, Urbanek M, Burdette JE, Woodruff TK, Kim JJ
J Clin Endocrinol Metab 2020 Mar 1;105(3):769-80. doi: 10.1210/clinem/dgz100. PMID: 31614364Free PMC Article
The impact of micronized progesterone on breast cancer risk: a systematic review.
Stute P, Wildt L, Neulen J
Climacteric 2018 Apr;21(2):111-122. Epub 2018 Jan 31 doi: 10.1080/13697137.2017.1421925. PMID: 29384406
Raloxifene.
Kellen JA
Curr Drug Targets 2001 Dec;2(4):423-5. doi: 10.2174/1389450013348263. PMID: 11732640

Prognosis

Minimally invasive approaches for the early detection of endometrial cancer.
Shen Y, Yang W, Liu J, Zhang Y
Mol Cancer 2023 Mar 17;22(1):53. doi: 10.1186/s12943-023-01757-3. PMID: 36932368Free PMC Article
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
Scaffold-Free Endometrial Organoids Respond to Excess Androgens Associated With Polycystic Ovarian Syndrome.
Wiwatpanit T, Murphy AR, Lu Z, Urbanek M, Burdette JE, Woodruff TK, Kim JJ
J Clin Endocrinol Metab 2020 Mar 1;105(3):769-80. doi: 10.1210/clinem/dgz100. PMID: 31614364Free PMC Article
Uterine Carcinosarcomas.
Sagebiel TL, Bhosale PR, Patnana M, Faria SC, Devine CE
Semin Ultrasound CT MR 2019 Aug;40(4):295-301. Epub 2019 Mar 9 doi: 10.1053/j.sult.2019.03.004. PMID: 31375170
Terms, definitions and measurements to describe the sonographic features of the endometrium and intrauterine lesions: a consensus opinion from the International Endometrial Tumor Analysis (IETA) group.
Leone FP, Timmerman D, Bourne T, Valentin L, Epstein E, Goldstein SR, Marret H, Parsons AK, Gull B, Istre O, Sepulveda W, Ferrazzi E, Van den Bosch T
Ultrasound Obstet Gynecol 2010 Jan;35(1):103-12. doi: 10.1002/uog.7487. PMID: 20014360

Clinical prediction guides

Ultrasound features of endometrial pathology in women without abnormal uterine bleeding: results from the International Endometrial Tumor Analysis study (IETA3).
Heremans R, Van Den Bosch T, Valentin L, Wynants L, Pascual MA, Fruscio R, Testa AC, Buonomo F, Guerriero S, Epstein E, Bourne T, Timmerman D, Leone FPG; IETA Consortium
Ultrasound Obstet Gynecol 2022 Aug;60(2):243-255. doi: 10.1002/uog.24910. PMID: 35385178
Alterations of endometrial epithelial-mesenchymal transition and MAPK signalling components in women with PCOS are partially modulated by metformin in vitro.
Hu M, Zhang Y, Li X, Cui P, Li J, Brännström M, Shao LR, Billig H
Mol Hum Reprod 2020 May 15;26(5):312-326. doi: 10.1093/molehr/gaaa023. PMID: 32202622
Final validation of the ProMisE molecular classifier for endometrial carcinoma in a large population-based case series.
Kommoss S, McConechy MK, Kommoss F, Leung S, Bunz A, Magrill J, Britton H, Kommoss F, Grevenkamp F, Karnezis A, Yang W, Lum A, Krämer B, Taran F, Staebler A, Lax S, Brucker SY, Huntsman DG, Gilks CB, McAlpine JN, Talhouk A
Ann Oncol 2018 May 1;29(5):1180-1188. doi: 10.1093/annonc/mdy058. PMID: 29432521
Terms, definitions and measurements to describe the sonographic features of the endometrium and intrauterine lesions: a consensus opinion from the International Endometrial Tumor Analysis (IETA) group.
Leone FP, Timmerman D, Bourne T, Valentin L, Epstein E, Goldstein SR, Marret H, Parsons AK, Gull B, Istre O, Sepulveda W, Ferrazzi E, Van den Bosch T
Ultrasound Obstet Gynecol 2010 Jan;35(1):103-12. doi: 10.1002/uog.7487. PMID: 20014360
Endometrial cancer.
Sorosky JI
Obstet Gynecol 2008 Feb;111(2 Pt 1):436-47. doi: 10.1097/AOG.0b013e318162f690. PMID: 18238985

Recent systematic reviews

Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose-response meta-analysis of large prospective studies.
Garcia L, Pearce M, Abbas A, Mok A, Strain T, Ali S, Crippa A, Dempsey PC, Golubic R, Kelly P, Laird Y, McNamara E, Moore S, de Sa TH, Smith AD, Wijndaele K, Woodcock J, Brage S
Br J Sports Med 2023 Aug;57(15):979-989. Epub 2023 Feb 28 doi: 10.1136/bjsports-2022-105669. PMID: 36854652Free PMC Article
Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.
Lawler T, Warren Andersen S
Nutrients 2023 Jan 13;15(2) doi: 10.3390/nu15020422. PMID: 36678292Free PMC Article
Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis.
Barry JA, Azizia MM, Hardiman PJ
Hum Reprod Update 2014 Sep-Oct;20(5):748-58. Epub 2014 Mar 30 doi: 10.1093/humupd/dmu012. PMID: 24688118Free PMC Article
Fibroids and infertility: an updated systematic review of the evidence.
Pritts EA, Parker WH, Olive DL
Fertil Steril 2009 Apr;91(4):1215-23. Epub 2008 Mar 12 doi: 10.1016/j.fertnstert.2008.01.051. PMID: 18339376

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