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Benign neoplasm of corpus uteri

MedGen UID:
57808
•Concept ID:
C0153998
•
Neoplastic Process
Synonyms: Benign Corpus Uteri Neoplasm; benign corpus uteri neoplasm; Benign Corpus Uteri Tumor; benign corpus uteri tumor; benign corpus uteri tumour; Benign neoplasm of body of uterus; Benign Neoplasm of Body of Uterus; benign neoplasm of body of uterus; Benign Neoplasm of Corpus Uteri; benign neoplasm of corpus uteri; Benign Neoplasm of the Body of Uterus; benign neoplasm of the body of uterus; Benign Neoplasm of the Corpus Uteri; benign neoplasm of the corpus uteri; Benign Neoplasm of the Uterine Body; benign neoplasm of the uterine body; Benign Neoplasm of the Uterine Corpus; benign neoplasm of the uterine corpus; Benign Neoplasm of Uterine Body; benign neoplasm of uterine body; Benign Neoplasm of Uterine Corpus; benign neoplasm of uterine corpus; Benign Tumor of Body of Uterus; benign tumor of body of uterus; Benign Tumor of Corpus Uteri; benign tumor of corpus uteri; Benign Tumor of the Body of Uterus; benign tumor of the body of uterus; Benign Tumor of the Corpus Uteri; benign tumor of the corpus uteri; Benign Tumor of the Uterine Body; benign tumor of the uterine body; Benign Tumor of the Uterine Corpus; benign tumor of the uterine corpus; Benign Tumor of Uterine Body; benign tumor of uterine body; Benign Tumor of Uterine Corpus; benign tumor of uterine corpus; benign tumour of body of uterus; benign tumour of corpus uteri; benign tumour of the body of uterus; benign tumour of the corpus uteri; benign tumour of the uterine body; benign tumour of the uterine corpus; benign tumour of uterine body; benign tumour of uterine corpus; Benign Uterine Body Neoplasm; benign uterine body neoplasm; Benign Uterine Body Tumor; benign uterine body tumor; benign uterine body tumour; Benign Uterine Corpus Neoplasm; benign uterine corpus neoplasm; Benign Uterine Corpus Tumor; benign uterine corpus tumor; benign uterine corpus tumour; body of uterus benign neoplasm
SNOMED CT: Benign neoplasm of body of uterus (92021007); Benign neoplasm of corpus uteri (92021007)
 
Monarch Initiative: MONDO:0021525

Definition

A neoplasm that arises from the uterine corpus and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include leiomyoma, adenomyoma, endometrial stromal nodule, and endometrial polyp. [from NCI]

Professional guidelines

PubMed

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Abnormal Uterine Bleeding in Reproductive Age Women: Role of Imaging in the Diagnosis and Management.
Hill S, Shetty MK
Semin Ultrasound CT MR 2023 Dec;44(6):511-518. Epub 2023 Oct 11 doi: 10.1053/j.sult.2023.10.002. PMID: 37832698
FIGO staging for carcinoma of the vulva, cervix, and corpus uteri.
FIGO Committee on Gynecologic Oncology
Int J Gynaecol Obstet 2014 May;125(2):97-8. Epub 2014 Feb 22 doi: 10.1016/j.ijgo.2014.02.003. PMID: 24630859

Recent clinical studies

Etiology

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Cancer of the corpus uteri: 2021 update.
Koskas M, Amant F, Mirza MR, Creutzberg CL
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):45-60. doi: 10.1002/ijgo.13866. PMID: 34669196Free PMC Article
Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration
JAMA 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. PMID: 26746459Free PMC Article

Diagnosis

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration
JAMA 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. PMID: 26746459Free PMC Article
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Imaging of uterine malignancies.
Sohaib SA, Verma H, Attygalle AD, Ind TE
Semin Ultrasound CT MR 2010 Oct;31(5):377-87. doi: 10.1053/j.sult.2010.07.005. PMID: 20974357

Therapy

The role of serum interleukins in Cancer: A Multi-center Mendelian Randomization study.
Zhang Z, Wang J, Teng M, Yan X, Liu Q
Int Immunopharmacol 2024 Aug 20;137:112520. Epub 2024 Jun 19 doi: 10.1016/j.intimp.2024.112520. PMID: 38901247
Mitochondrial DNA copy number and cancer risks: A comprehensive Mendelian randomization analysis.
Cai X, Liang C, Zhang M, Dong Z, Weng Y, Yu W
Int J Cancer 2024 Apr 15;154(8):1504-1513. Epub 2023 Dec 27 doi: 10.1002/ijc.34833. PMID: 38151753
Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
Alcohol and gynecological cancers: an overview.
Hjartåker A, Meo MS, Weiderpass E
Eur J Cancer Prev 2010 Jan;19(1):1-10. doi: 10.1097/CEJ.0b013e328333fb3a. PMID: 19926999
Luteal phase insufficiency.
Jones GS
Clin Obstet Gynecol 1973 Sep;16(3):255-73. doi: 10.1097/00003081-197309000-00016. PMID: 4590322

Prognosis

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Cancer of the corpus uteri: 2021 update.
Koskas M, Amant F, Mirza MR, Creutzberg CL
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):45-60. doi: 10.1002/ijgo.13866. PMID: 34669196Free PMC Article
Cancer of the corpus uteri.
Amant F, Mirza MR, Koskas M, Creutzberg CL
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:37-50. doi: 10.1002/ijgo.12612. PMID: 30306580
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration
JAMA 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. PMID: 26746459Free PMC Article

Clinical prediction guides

Mitochondrial DNA copy number and cancer risks: A comprehensive Mendelian randomization analysis.
Cai X, Liang C, Zhang M, Dong Z, Weng Y, Yu W
Int J Cancer 2024 Apr 15;154(8):1504-1513. Epub 2023 Dec 27 doi: 10.1002/ijc.34833. PMID: 38151753
Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
The five major autoimmune diseases increase the risk of cancer: epidemiological data from a large-scale cohort study in China.
Zhou Z, Liu H, Yang Y, Zhou J, Zhao L, Chen H, Fei Y, Zhang W, Li M, Zhao Y, Zeng X, Zhang F, Yang H, Zhang X
Cancer Commun (Lond) 2022 May;42(5):435-446. Epub 2022 Mar 31 doi: 10.1002/cac2.12283. PMID: 35357093Free PMC Article
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration
JAMA 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. PMID: 26746459Free PMC Article

Recent systematic reviews

Risks of second non-breast primaries following breast cancer in women: a systematic review and meta-analysis.
Allen I, Hassan H, Sofianopoulou E, Eccles D, Turnbull C, Tischkowitz M, Pharoah P, Antoniou AC
Breast Cancer Res 2023 Feb 10;25(1):18. doi: 10.1186/s13058-023-01610-x. PMID: 36765408Free PMC Article
Mistletoe in oncological treatment: a systematic review : Part 1: survival and safety.
Freuding M, Keinki C, Micke O, Buentzel J, Huebner J
J Cancer Res Clin Oncol 2019 Mar;145(3):695-707. Epub 2019 Jan 23 doi: 10.1007/s00432-018-02837-4. PMID: 30673873
Is periodontitis a risk indicator for cancer? A meta-analysis.
Corbella S, Veronesi P, Galimberti V, Weinstein R, Del Fabbro M, Francetti L
PLoS One 2018;13(4):e0195683. Epub 2018 Apr 17 doi: 10.1371/journal.pone.0195683. PMID: 29664916Free PMC Article
Association between reproductive cancer and fetal outcomes: a systematic review.
Mogos MF, Rahman S, Salihu HM, Salinas-Miranda AA, Sultan DH
Int J Gynecol Cancer 2013 Sep;23(7):1171-7. doi: 10.1097/IGC.0b013e31829e9fe2. PMID: 23970154
Role of MRI in detecting involvement of the uterine internal os in uterine cervical cancer: systematic review of diagnostic test accuracy.
de Boer P, Adam JA, Buist MR, van de Vijver MJ, Rasch CR, Stoker J, Bipat S, Stalpers LJ
Eur J Radiol 2013 Sep;82(9):e422-8. Epub 2013 May 25 doi: 10.1016/j.ejrad.2013.04.027. PMID: 23711423

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