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End stage liver disease

MedGen UID:
148174
Concept ID:
C0745744
Disease or Syndrome
Synonym: End Stage Liver Disease
SNOMED CT: End stage liver disease (708248004)

Definition

A disorder characterized by irreversible damage to the liver tissue, leading to complete liver failure. Causes include cirrhosis, viral hepatitis, metastases to the liver, genetic disorders, toxins, and drugs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEnd stage liver disease

Professional guidelines

PubMed

Levy C, Manns M, Hirschfield G
Clin Gastroenterol Hepatol 2023 Jul;21(8):2076-2087. Epub 2023 Feb 19 doi: 10.1016/j.cgh.2023.02.005. PMID: 36809835
Paternostro R, Trauner M
J Intern Med 2022 Aug;292(2):190-204. Epub 2022 Jul 7 doi: 10.1111/joim.13531. PMID: 35796150Free PMC Article
Singal AK, Mathurin P
JAMA 2021 Jul 13;326(2):165-176. doi: 10.1001/jama.2021.7683. PMID: 34255003

Recent clinical studies

Etiology

Ruf A, Dirchwolf M, Freeman RB
Ann Hepatol 2022 Jan-Feb;27(1):100535. Epub 2021 Sep 22 doi: 10.1016/j.aohep.2021.100535. PMID: 34560316
Kim WR, Mannalithara A, Heimbach JK, Kamath PS, Asrani SK, Biggins SW, Wood NL, Gentry SE, Kwong AJ
Gastroenterology 2021 Dec;161(6):1887-1895.e4. Epub 2021 Sep 3 doi: 10.1053/j.gastro.2021.08.050. PMID: 34481845Free PMC Article
Perumpail BJ, Khan MA, Yoo ER, Cholankeril G, Kim D, Ahmed A
World J Gastroenterol 2017 Dec 21;23(47):8263-8276. doi: 10.3748/wjg.v23.i47.8263. PMID: 29307986Free PMC Article
Jiménez JV, Carrillo-Pérez DL, Rosado-Canto R, García-Juárez I, Torre A, Kershenobich D, Carrillo-Maravilla E
Dig Dis Sci 2017 Aug;62(8):1855-1871. Epub 2017 May 13 doi: 10.1007/s10620-017-4597-8. PMID: 28501971
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu
J Hepatol 2016 Feb;64(2):433-485. Epub 2015 Nov 17 doi: 10.1016/j.jhep.2015.10.006. PMID: 26597456

Diagnosis

Ruf A, Dirchwolf M, Freeman RB
Ann Hepatol 2022 Jan-Feb;27(1):100535. Epub 2021 Sep 22 doi: 10.1016/j.aohep.2021.100535. PMID: 34560316
Kim WR, Mannalithara A, Heimbach JK, Kamath PS, Asrani SK, Biggins SW, Wood NL, Gentry SE, Kwong AJ
Gastroenterology 2021 Dec;161(6):1887-1895.e4. Epub 2021 Sep 3 doi: 10.1053/j.gastro.2021.08.050. PMID: 34481845Free PMC Article
Bodzin AS, Baker TB
Liver Transpl 2018 Oct;24(10):1470-1475. doi: 10.1002/lt.25320. PMID: 30080954
Charlton M, Levitsky J, Aqel B, OʼGrady J, Hemibach J, Rinella M, Fung J, Ghabril M, Thomason R, Burra P, Little EC, Berenguer M, Shaked A, Trotter J, Roberts J, Rodriguez-Davalos M, Rela M, Pomfret E, Heyrend C, Gallegos-Orozco J, Saliba F
Transplantation 2018 May;102(5):727-743. doi: 10.1097/TP.0000000000002147. PMID: 29485508
Jiménez JV, Carrillo-Pérez DL, Rosado-Canto R, García-Juárez I, Torre A, Kershenobich D, Carrillo-Maravilla E
Dig Dis Sci 2017 Aug;62(8):1855-1871. Epub 2017 May 13 doi: 10.1007/s10620-017-4597-8. PMID: 28501971

Therapy

Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Zwirner S, Abu Rmilah AA, Klotz S, Pfaffenroth B, Kloevekorn P, Moschopoulou AA, Schuette S, Haag M, Selig R, Li K, Zhou W, Nelson E, Poso A, Chen H, Amiot B, Jia Y, Minshew A, Michalak G, Cui W, Rist E, Longerich T, Jung B, Felgendreff P, Trompak O, Premsrirut PK, Gries K, Muerdter TE, Heinkele G, Wuestefeld T, Shapiro D, Weissbach M, Koenigsrainer A, Sipos B, Ab E, Zacarias MO, Theisgen S, Gruenheit N, Biskup S, Schwab M, Albrecht W, Laufer S, Nyberg S, Zender L
Cell 2024 Mar 28;187(7):1666-1684.e26. Epub 2024 Mar 14 doi: 10.1016/j.cell.2024.02.023. PMID: 38490194Free PMC Article
Tingle SJ, Dobbins JJ, Thompson ER, Figueiredo RS, Mahendran B, Pandanaboyana S, Wilson C
Cochrane Database Syst Rev 2023 Sep 12;9(9):CD014685. doi: 10.1002/14651858.CD014685.pub2. PMID: 37698189Free PMC Article
Guo Z, Zhao Q, Jia Z, Huang C, Wang D, Ju W, Zhang J, Yang L, Huang S, Chen M, Zhu X, Hu A, Ma Y, Wu L, Chen Y, Han M, Tang Y, Wang G, Wang L, Li L, Xiong W, Zhang Z, Shen Y, Tang Z, Zhu C, Chen X, Hu X, Guo Y, Chen H, Ma Y, Zhang T, Huang S, Zeng P, Lai S, Wang T, Chen Z, Gong J, Yu J, Sun C, Li C, Tan H, Liu Y, Dong Y, Sun C, Liao B, Ren J, Zhou Z, Andrea S, Björn N, Cai C, Gong F, Rong J, Huang W, Guan X, Clavien PA, Stefan TG, Huang J, He X
J Hepatol 2023 Aug;79(2):394-402. Epub 2023 Apr 20 doi: 10.1016/j.jhep.2023.04.010. PMID: 37086919
Grottke O, Mallaiah S, Karkouti K, Saner F, Haas T
Semin Thromb Hemost 2020 Feb;46(1):38-49. Epub 2019 Oct 1 doi: 10.1055/s-0039-1696946. PMID: 31574543

Prognosis

Mroskowiak A, Suleja A, Stec M, Kuczmik W, Migacz M, Holecki M
Medicina (Kaunas) 2022 Jul 4;58(7) doi: 10.3390/medicina58070896. PMID: 35888614Free PMC Article
Morales-Arráez D, Ventura-Cots M, Altamirano J, Abraldes JG, Cruz-Lemini M, Thursz MR, Atkinson SR, Sarin SK, Kim W, Chavez-Araujo R, Higuera-de la Tijera MF, Singal AK, Shah VH, Kamath PS, Duarte-Rojo A, Charles EA, Vargas V, Jager M, Rautou PE, Rincon D, Zamarripa F, Restrepo-Gutiérrez JC, Torre A, Lucey MR, Arab JP, Mathurin P, Louvet A, García-Tsao G, González JA, Verna EC, Brown RS Jr, Argemi J, Fernández-Carrillo C, Clemente A, Alvarado-Tapias E, Forrest E, Allison M, Bataller R
Am J Gastroenterol 2022 Feb 1;117(2):301-310. doi: 10.14309/ajg.0000000000001596. PMID: 34962498Free PMC Article
Velez JCQ, Therapondos G, Juncos LA
Nat Rev Nephrol 2020 Mar;16(3):137-155. Epub 2019 Nov 13 doi: 10.1038/s41581-019-0218-4. PMID: 31723234
Shen T, Liu Y, Shang J, Xie Q, Li J, Yan M, Xu J, Niu J, Liu J, Watkins PB, Aithal GP, Andrade RJ, Dou X, Yao L, Lv F, Wang Q, Li Y, Zhou X, Zhang Y, Zong P, Wan B, Zou Z, Yang D, Nie Y, Li D, Wang Y, Han X, Zhuang H, Mao Y, Chen C
Gastroenterology 2019 Jun;156(8):2230-2241.e11. Epub 2019 Feb 8 doi: 10.1053/j.gastro.2019.02.002. PMID: 30742832
Lai JC, Covinsky KE, Dodge JL, Boscardin WJ, Segev DL, Roberts JP, Feng S
Hepatology 2017 Aug;66(2):564-574. Epub 2017 Jun 28 doi: 10.1002/hep.29219. PMID: 28422306Free PMC Article

Clinical prediction guides

Deutsch-Link S, Fortuna D, Weinberg EM
Semin Liver Dis 2018 Aug;38(3):284-297. Epub 2018 Jul 24 doi: 10.1055/s-0038-1666853. PMID: 30041280
Laube R, Wang H, Park L, Heyman JK, Vidot H, Majumdar A, Strasser SI, McCaughan GW, Liu K
Liver Int 2018 Dec;38(12):2117-2128. Epub 2018 Jul 15 doi: 10.1111/liv.13917. PMID: 29935102
Lai JC, Covinsky KE, Dodge JL, Boscardin WJ, Segev DL, Roberts JP, Feng S
Hepatology 2017 Aug;66(2):564-574. Epub 2017 Jun 28 doi: 10.1002/hep.29219. PMID: 28422306Free PMC Article
Parajuli S, Foley D, Djamali A, Mandelbrot D
Transplantation 2015 Sep;99(9):1756-64. doi: 10.1097/TP.0000000000000820. PMID: 26308413
Tumgor G
World J Gastroenterol 2014 Mar 14;20(10):2586-94. doi: 10.3748/wjg.v20.i10.2586. PMID: 24627594Free PMC Article

Recent systematic reviews

Juanola A, Ma AT, de Wit K, Gananandan K, Roux O, Zaccherini G, Jiménez C, Tonon M, Solé C, Villaseca C, Uschner FE, Graupera I, Pose E, Moreta MJ, Campion D, Beuers U, Mookerjee RP, Francoz C, Durand F, Vargas V, Piano S, Alonso S, Trebicka J, Laleman W, Asrani SK, Soriano G, Alessandria C, Serra-Burriel M, Morales-Ruiz M, Torres F, Allegretti AS, Krag A, Caraceni P, Watson H, Abraldes JG, Solà E, Kamath PS, Hernaez R, Ginès P; LiverHope Investigators
Gut 2023 Dec 7;73(1):156-165. doi: 10.1136/gutjnl-2023-329923. PMID: 37884354
Tingle SJ, Dobbins JJ, Thompson ER, Figueiredo RS, Mahendran B, Pandanaboyana S, Wilson C
Cochrane Database Syst Rev 2023 Sep 12;9(9):CD014685. doi: 10.1002/14651858.CD014685.pub2. PMID: 37698189Free PMC Article
Vogli S, Naska A, Marinos G, Kasdagli MI, Orfanos P
Nutrients 2023 Aug 25;15(17) doi: 10.3390/nu15173733. PMID: 37686767Free PMC Article
Pan J, Wang L, Gao F, An Y, Yin Y, Guo X, Nery FG, Yoshida EM, Qi X
Eur J Intern Med 2022 Oct;104:21-32. Epub 2022 Jun 7 doi: 10.1016/j.ejim.2022.05.032. PMID: 35688747
Peng JK, Hepgul N, Higginson IJ, Gao W
Palliat Med 2019 Jan;33(1):24-36. Epub 2018 Oct 22 doi: 10.1177/0269216318807051. PMID: 30345878Free PMC Article

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