U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chronic Leukemia in Remission

MedGen UID:
151944
•Concept ID:
C0686589
•
Neoplastic Process
Synonyms: Chronic Leukemia (in Remission); Chronic leukemia in remission
SNOMED CT: Chronic leukemia in remission (92811003)

Definition

A finding of chronic leukemia that is not growing and responds to treatment. [from NCI]

Professional guidelines

PubMed

Management of chronic myeloid leukemia in 2023 - common ground and common sense.
Senapati J, Sasaki K, Issa GC, Lipton JH, Radich JP, Jabbour E, Kantarjian HM
Blood Cancer J 2023 Apr 24;13(1):58. doi: 10.1038/s41408-023-00823-9. PMID: 37088793Free PMC Article
Chronic myelomonocytic leukemia: 2022 update on diagnosis, risk stratification, and management.
Patnaik MM, Tefferi A
Am J Hematol 2022 Mar 1;97(3):352-372. Epub 2022 Jan 27 doi: 10.1002/ajh.26455. PMID: 34985762
Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811

Recent clinical studies

Etiology

Prognosis in Chronic Myeloid Leukemia: Baseline Factors, Dynamic Risk Assessment and Novel Insights.
Iezza M, Cortesi S, Ottaviani E, Mancini M, Venturi C, Monaldi C, De Santis S, Testoni N, Soverini S, Rosti G, Cavo M, Castagnetti F
Cells 2023 Jun 23;12(13) doi: 10.3390/cells12131703. PMID: 37443737Free PMC Article
Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease.
Zuna J, Hovorkova L, Krotka J, Koehrmann A, Bardini M, Winkowska L, Fronkova E, Alten J, Koehler R, Eckert C, Brizzolara L, Trkova M, Stuchly J, Zimmermann M, De Lorenzo P, Valsecchi MG, Conter V, Stary J, Schrappe M, Biondi A, Trka J, Zaliova M, Cazzaniga G, Cario G
Leukemia 2022 Dec;36(12):2793-2801. Epub 2022 Aug 6 doi: 10.1038/s41375-022-01668-0. PMID: 35933523
How I diagnose and treat chronic myelomonocytic leukemia.
Patnaik MM
Haematologica 2022 Jul 1;107(7):1503-1517. doi: 10.3324/haematol.2021.279500. PMID: 35236051Free PMC Article
Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions.
Osman AEG, Deininger MW
Blood Rev 2021 Sep;49:100825. Epub 2021 Mar 16 doi: 10.1016/j.blre.2021.100825. PMID: 33773846Free PMC Article
Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811

Diagnosis

Myeloid sarcoma: more and less than a distinct entity.
Loscocco GG, Vannucchi AM
Ann Hematol 2023 Aug;102(8):1973-1984. Epub 2023 Jun 7 doi: 10.1007/s00277-023-05288-1. PMID: 37286874Free PMC Article
Guidelines for the treatment of chronic myeloid leukemia from the NCCN and ELN: differences and similarities.
Narlı Özdemir Z, Kılıçaslan NA, Yılmaz M, Eşkazan AE
Int J Hematol 2023 Jan;117(1):3-15. Epub 2022 Sep 5 doi: 10.1007/s12185-022-03446-1. PMID: 36064839
How I diagnose and treat chronic myelomonocytic leukemia.
Patnaik MM
Haematologica 2022 Jul 1;107(7):1503-1517. doi: 10.3324/haematol.2021.279500. PMID: 35236051Free PMC Article
Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions.
Osman AEG, Deininger MW
Blood Rev 2021 Sep;49:100825. Epub 2021 Mar 16 doi: 10.1016/j.blre.2021.100825. PMID: 33773846Free PMC Article
Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811

Therapy

Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions.
Osman AEG, Deininger MW
Blood Rev 2021 Sep;49:100825. Epub 2021 Mar 16 doi: 10.1016/j.blre.2021.100825. PMID: 33773846Free PMC Article
The argument for using imatinib in CML.
Claudiani S, Apperley JF
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):161-167. doi: 10.1182/asheducation-2018.1.161. PMID: 30504305Free PMC Article
Dasatinib.
Lindauer M, Hochhaus A
Recent Results Cancer Res 2018;212:29-68. doi: 10.1007/978-3-319-91439-8_2. PMID: 30069624
Dasatinib.
Lindauer M, Hochhaus A
Recent Results Cancer Res 2014;201:27-65. doi: 10.1007/978-3-642-54490-3_2. PMID: 24756784
The leukemias.
Preisler HD
Dis Mon 1994 Oct;40(10):525-79. PMID: 7924833

Prognosis

Sustained remissions in CLL after frontline FCR treatment with very-long-term follow-up.
Thompson PA, Bazinet A, Wierda WG, Tam CS, O'Brien SM, Saha S, Peterson CB, Plunkett W, Keating MJ
Blood 2023 Nov 23;142(21):1784-1788. doi: 10.1182/blood.2023020158. PMID: 37595283Free PMC Article
Novel developments in chronic myeloid leukaemia.
Harrington P, de Lavallade H
Curr Opin Hematol 2021 Mar 1;28(2):122-127. doi: 10.1097/MOH.0000000000000630. PMID: 33464004
Long-term outcomes with frontline nilotinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase: ENESTnd 10-year analysis.
Kantarjian HM, Hughes TP, Larson RA, Kim DW, Issaragrisil S, le Coutre P, Etienne G, Boquimpani C, Pasquini R, Clark RE, Dubruille V, Flinn IW, Kyrcz-Krzemien S, Medras E, Zanichelli M, Bendit I, Cacciatore S, Titorenko K, Aimone P, Saglio G, Hochhaus A
Leukemia 2021 Feb;35(2):440-453. Epub 2021 Jan 7 doi: 10.1038/s41375-020-01111-2. PMID: 33414482Free PMC Article
Chronic lymphocytic leukaemia.
Dighiero G, Hamblin TJ
Lancet 2008 Mar 22;371(9617):1017-29. doi: 10.1016/S0140-6736(08)60456-0. PMID: 18358929
The leukemias.
Preisler HD
Dis Mon 1994 Oct;40(10):525-79. PMID: 7924833

Clinical prediction guides

Clinical features and prognosis of chronic natural killer cell lymphoproliferative disorders.
Liu DL, Wang YJ, Qian SY, Ma SS, Ding MJ, Dong M, Zhang JM, Zhang MZ, Chen QJ, Zhang XD
Hematology 2024 Dec;29(1):2307817. Epub 2024 Feb 6 doi: 10.1080/16078454.2024.2307817. PMID: 38319083
Prognosis in Chronic Myeloid Leukemia: Baseline Factors, Dynamic Risk Assessment and Novel Insights.
Iezza M, Cortesi S, Ottaviani E, Mancini M, Venturi C, Monaldi C, De Santis S, Testoni N, Soverini S, Rosti G, Cavo M, Castagnetti F
Cells 2023 Jun 23;12(13) doi: 10.3390/cells12131703. PMID: 37443737Free PMC Article
Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease.
Zuna J, Hovorkova L, Krotka J, Koehrmann A, Bardini M, Winkowska L, Fronkova E, Alten J, Koehler R, Eckert C, Brizzolara L, Trkova M, Stuchly J, Zimmermann M, De Lorenzo P, Valsecchi MG, Conter V, Stary J, Schrappe M, Biondi A, Trka J, Zaliova M, Cazzaniga G, Cario G
Leukemia 2022 Dec;36(12):2793-2801. Epub 2022 Aug 6 doi: 10.1038/s41375-022-01668-0. PMID: 35933523
How I diagnose and treat chronic myelomonocytic leukemia.
Patnaik MM
Haematologica 2022 Jul 1;107(7):1503-1517. doi: 10.3324/haematol.2021.279500. PMID: 35236051Free PMC Article
Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment.
Hallek M
Am J Hematol 2019 Nov;94(11):1266-1287. Epub 2019 Oct 4 doi: 10.1002/ajh.25595. PMID: 31364186

Recent systematic reviews

Total Body Irradiation Versus Chemotherapy Conditioning in Pediatric Acute Lymphoblastic Leukemia Patients Undergoing Hematopoietic Stem Cell Transplant: A Systematic Review and Meta-Analysis.
Rehman MEU, Chattaraj A, Mahboob A, Ijaz Z, Franco D, Farhan M, Dharma K, Mumtaz H, Saeed S, Basit J, Aslam MM, Iftikhar A, Faraz F, Anwer F
Clin Lymphoma Myeloma Leuk 2023 Apr;23(4):249-258. Epub 2023 Jan 14 doi: 10.1016/j.clml.2023.01.004. PMID: 36725384
A Systematic Review on Second Treatment-Free Remission (TFR) Attempt in Chronic Myeloid Leukemia (CML): Can it be Applied in Clinical Practice?
Çiftçiler R, Akın MG, Erat Z, Eşkazan AE
Clin Lymphoma Myeloma Leuk 2023 Jan;23(1):8-14. Epub 2022 Oct 5 doi: 10.1016/j.clml.2022.09.004. PMID: 36344420
The prognostic importance of BCR-ABL transcripts in Chronic Myeloid Leukemia: A systematic review and meta-analysis.
Ghalesardi OK, Khosravi A, Azizi E, Ahmadi SE, Hajifathali A, Bonakchi H, Shahidi M
Leuk Res 2021 Feb;101:106512. Epub 2021 Jan 19 doi: 10.1016/j.leukres.2021.106512. PMID: 33524640
Remission maintenance treatment options in chronic lymphocytic leukemia.
Egle A, Pleyer L, Melchardt T, Hartmann TN, Greil R
Cancer Treat Rev 2018 Nov;70:56-66. Epub 2018 Aug 10 doi: 10.1016/j.ctrv.2018.08.003. PMID: 30121491
Response to the Therapy in Hairy Cell Leukemia: Systematic Review and Meta-Analysis.
Andrasiak I, Rybka J, Wrobel T
Clin Lymphoma Myeloma Leuk 2018 Jun;18(6):392-399.e3. Epub 2018 Mar 31 doi: 10.1016/j.clml.2018.03.011. PMID: 29685423

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...