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Chronic Myelomonocytic Leukemia in Remission

MedGen UID:
163129
•Concept ID:
C0854199
•
Neoplastic Process
Synonym: Chronic Myelomonocytic Leukaemia (in Remission)

Definition

A finding of chronic myelomonocytic leukemia that is not growing and responds to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic Myelomonocytic Leukemia in Remission

Professional guidelines

PubMed

Chronic myelomonocytic leukemia: 2022 update on diagnosis, risk stratification, and management.
Patnaik MM, Tefferi A
Am J Hematol 2022 Mar 1;97(3):352-372. Epub 2022 Jan 27 doi: 10.1002/ajh.26455. PMID: 34985762
Management and Outcomes of Blast Transformed Chronic Myelomonocytic Leukemia.
Hammond D, Montalban-Bravo G
Curr Hematol Malig Rep 2021 Oct;16(5):405-417. Epub 2021 Sep 9 doi: 10.1007/s11899-021-00643-3. PMID: 34499330
Chronic myelomonocytic leukemia: 2018 update on diagnosis, risk stratification and management.
Patnaik MM, Tefferi A
Am J Hematol 2018 Jun;93(6):824-840. doi: 10.1002/ajh.25104. PMID: 29878489Free PMC Article

Recent clinical studies

Therapy

Proposals for Clinical Trials in Chronic Myelomonocytic Leukemia.
Rezazadeh A, Deininger M, Atallah E
Curr Treat Options Oncol 2023 Aug;24(8):1036-1051. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01105-z. PMID: 37300657
Management and Outcomes of Blast Transformed Chronic Myelomonocytic Leukemia.
Hammond D, Montalban-Bravo G
Curr Hematol Malig Rep 2021 Oct;16(5):405-417. Epub 2021 Sep 9 doi: 10.1007/s11899-021-00643-3. PMID: 34499330
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Current Management and Recent Advances in the Treatment of Chronic Myelomonocytic Leukemia.
Hunter AM, Zhang L, Padron E
Curr Treat Options Oncol 2018 Oct 27;19(12):67. doi: 10.1007/s11864-018-0581-6. PMID: 30367269
Chronic myelomonocytic leukemia: 2018 update on diagnosis, risk stratification and management.
Patnaik MM, Tefferi A
Am J Hematol 2018 Jun;93(6):824-840. doi: 10.1002/ajh.25104. PMID: 29878489Free PMC Article

Prognosis

Proposals for Clinical Trials in Chronic Myelomonocytic Leukemia.
Rezazadeh A, Deininger M, Atallah E
Curr Treat Options Oncol 2023 Aug;24(8):1036-1051. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01105-z. PMID: 37300657
How I diagnose and treat chronic myelomonocytic leukemia.
Patnaik MM
Haematologica 2022 Jul 1;107(7):1503-1517. doi: 10.3324/haematol.2021.279500. PMID: 35236051Free PMC Article
Chronic myelomonocytic leukemia: 2022 update on diagnosis, risk stratification, and management.
Patnaik MM, Tefferi A
Am J Hematol 2022 Mar 1;97(3):352-372. Epub 2022 Jan 27 doi: 10.1002/ajh.26455. PMID: 34985762
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Chronic myelomonocytic leukemia: 2018 update on diagnosis, risk stratification and management.
Patnaik MM, Tefferi A
Am J Hematol 2018 Jun;93(6):824-840. doi: 10.1002/ajh.25104. PMID: 29878489Free PMC Article

Clinical prediction guides

Preclinical characterization and clinical trial of CFI-400945, a polo-like kinase 4 inhibitor, in patients with relapsed/refractory acute myeloid leukemia and higher-risk myelodysplastic neoplasms.
Murphy T, Mason JM, Leber B, Bray MR, Chan SM, Gupta V, Khalaf D, Maze D, McNamara CJ, Schimmer AD, Schuh AC, Sibai H, Trus M, Valiquette D, Martin K, Nguyen L, Li X, Mak TW, Minden MD, Yee KWL
Leukemia 2024 Mar;38(3):502-512. Epub 2023 Dec 19 doi: 10.1038/s41375-023-02110-9. PMID: 38114624
Population Pharmacokinetics of Oral Azacitidine, and Exposure-Response Analysis in Acute Myeloid Leukemia.
Gaudy A, Laille E, Bailey R, Zhou S, Skikne B, Beach CL
Clin Pharmacol Ther 2023 Oct;114(4):845-852. Epub 2023 Jul 24 doi: 10.1002/cpt.2982. PMID: 37422689
Outcomes following venetoclax-based treatment in therapy-related myeloid neoplasms.
Shah MV, Chhetri R, Dholakia R, Kok CH, Gangat N, Alkhateeb HB, Al-Kali A, Patnaik MM, Baranwal A, Greipp PT, He R, Begna KH, Tiong IS, Wei AH, Hiwase D
Am J Hematol 2022 Aug;97(8):1013-1022. Epub 2022 May 27 doi: 10.1002/ajh.26589. PMID: 35560061Free PMC Article
How I diagnose and treat chronic myelomonocytic leukemia.
Patnaik MM
Haematologica 2022 Jul 1;107(7):1503-1517. doi: 10.3324/haematol.2021.279500. PMID: 35236051Free PMC Article
Current Management and Recent Advances in the Treatment of Chronic Myelomonocytic Leukemia.
Hunter AM, Zhang L, Padron E
Curr Treat Options Oncol 2018 Oct 27;19(12):67. doi: 10.1007/s11864-018-0581-6. PMID: 30367269

Recent systematic reviews

A systematic review and meta-analysis of the efficacy and adverse events of azacitidine-plus-lenalidomide treatment for patients with acute myeloid leukemia, myelodysplastic syndromes and chronic myelomonocytic leukemia (1).
Kunacheewa C, Thongthang P, Ungprasert P, Utchariyaprasit E, Owattanapanich W
Hematology 2019 Dec;24(1):498-506. doi: 10.1080/16078454.2019.1631425. PMID: 31221030
Systematic Literature Review of Treatment Options and Clinical Outcomes for Patients With Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia.
Bell JA, Galaznik A, Huelin R, Stokes M, Guo Y, Fram RJ, Faller DV
Clin Lymphoma Myeloma Leuk 2018 Apr;18(4):e157-e166. Epub 2018 Feb 8 doi: 10.1016/j.clml.2018.02.001. PMID: 29475821

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