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Injection Site Thrombophlebitis

MedGen UID:
154229
•Concept ID:
C0542237
•
Finding

Definition

Thrombophlebitis in the veins surrounding an injection site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInjection Site Thrombophlebitis

Professional guidelines

PubMed

Safety and Tolerability of 23.4% Hypertonic Saline Administered Over 2 to 5 Minutes for the Treatment of Cerebral Herniation and Intracranial Pressure Elevation.
O'Brien SK, Koehl JL, Demers LB, Hayes BD, Barra ME
Neurocrit Care 2023 Apr;38(2):312-319. Epub 2022 Sep 28 doi: 10.1007/s12028-022-01604-1. PMID: 36171519

Recent clinical studies

Etiology

Evaluation and Management of Buprenorphine Extended-Release Injection Thrombophlebitis: A Case Report.
Barrett J, Schapiro R, Casey E, Chertok J
J Addict Med 2024 Mar-Apr 01;18(2):209-211. Epub 2024 Jan 15 doi: 10.1097/ADM.0000000000001261. PMID: 38227854
Ultrasound- and fluoroscopy-guided foam sclerotherapy for lower extremity venous ulcers.
Zhu Y, Wu D, Sun D, Song K, Li J, Lin J
J Vasc Surg Venous Lymphat Disord 2020 Sep;8(5):783-788. Epub 2020 Jan 6 doi: 10.1016/j.jvsv.2019.11.006. PMID: 31917182
Clinical Experience with Rituximab and Intravenous Immunoglobulin for Pretibial Myxedema: A Case Series.
Kotwal A, Turcu AF, Sonawane V, Bahn RS, Pittelkow MR, Bridges A, Stan MN
Thyroid 2019 May;29(5):692-699. Epub 2019 Apr 8 doi: 10.1089/thy.2018.0706. PMID: 30854936
Systematic review of foam sclerotherapy for varicose veins.
Jia X, Mowatt G, Burr JM, Cassar K, Cook J, Fraser C
Br J Surg 2007 Aug;94(8):925-36. doi: 10.1002/bjs.5891. PMID: 17636511
Tinzaparin. A review of its pharmacology and clinical potential in the prevention and treatment of thromboembolic disorders.
Friedel HA, Balfour JA
Drugs 1994 Oct;48(4):638-60. doi: 10.2165/00003495-199448040-00010. PMID: 7528134

Diagnosis

Right-sided neck pain in an intravenous drug user.
Brown C, Jhun P
Emerg Med J 2021 Aug;38(8):593-623. doi: 10.1136/emermed-2020-209762. PMID: 34449430
A fixed-dose combination of low molecular weight heparin with dihydroergotamine versus adjusted-dose unfractionated heparin in the prevention of deep-vein thrombosis after total hip replacement.
Horbach T, Wolf H, Michaelis HC, Wagner W, Hoffmann A, Schmidt A, Beck H
Thromb Haemost 1996 Feb;75(2):246-50. PMID: 8815569
Thromboprophylactic effect of low molecular weight heparin started in the evening before elective general abdominal surgery: a comparison with low-dose heparin.
Bergqvist D, Burmark US, Frisell J, Guilbaud O, Hallböök T, Horn A, Lindhagen A, Ljungner H, Ljungström KG, Mätzsch T
Semin Thromb Hemost 1990 Oct;16 Suppl:19-24. PMID: 1962900
Diazepam-associated thrombophlebitis: a review and discussion of possible prevention.
Mitchell PF
J Am Dent Assoc 1980 Sep;101(3):492-5. doi: 10.14219/jada.archive.1980.0299. PMID: 6932436
A COMPARISON OF THE ORAL AND INTRAVENOUS GLUCOSE TOLERANCE TESTS IN NON-DIABETIC, POSSIBLE DIABETIC AND DIABETIC SUBJECTS.
NADON GW, LITTLE JA, HALL WE, O'SULLIVAN MO
Can Med Assoc J 1964 Dec 26;91(26):1350-3. PMID: 14228226Free PMC Article

Therapy

PROMETHAZINE-INDUCED THROMBOPHLEBITIS IN A NIGERIAN MAN: A CASE REPORT.
Dike CM, Okere PCN
West Afr J Med 2023 Dec 4;40(12 Suppl 1):S38. PMID: 38070188
Safety and Tolerability of 23.4% Hypertonic Saline Administered Over 2 to 5 Minutes for the Treatment of Cerebral Herniation and Intracranial Pressure Elevation.
O'Brien SK, Koehl JL, Demers LB, Hayes BD, Barra ME
Neurocrit Care 2023 Apr;38(2):312-319. Epub 2022 Sep 28 doi: 10.1007/s12028-022-01604-1. PMID: 36171519
Polidocanol Sclerotherapy in Pyogenic Granulomas.
Khurana A, Mathachan SR
Dermatol Surg 2022 Jan 1;48(1):72-75. doi: 10.1097/DSS.0000000000003308. PMID: 34816819
Ultrasound- and fluoroscopy-guided foam sclerotherapy for lower extremity venous ulcers.
Zhu Y, Wu D, Sun D, Song K, Li J, Lin J
J Vasc Surg Venous Lymphat Disord 2020 Sep;8(5):783-788. Epub 2020 Jan 6 doi: 10.1016/j.jvsv.2019.11.006. PMID: 31917182
Systematic review of foam sclerotherapy for varicose veins.
Jia X, Mowatt G, Burr JM, Cassar K, Cook J, Fraser C
Br J Surg 2007 Aug;94(8):925-36. doi: 10.1002/bjs.5891. PMID: 17636511

Prognosis

Evaluation and Management of Buprenorphine Extended-Release Injection Thrombophlebitis: A Case Report.
Barrett J, Schapiro R, Casey E, Chertok J
J Addict Med 2024 Mar-Apr 01;18(2):209-211. Epub 2024 Jan 15 doi: 10.1097/ADM.0000000000001261. PMID: 38227854
Practicability and quality of outpatient management of acute deep venous thrombosis.
Blättler W, Kreis N, Blättler IK
J Vasc Surg 2000 Nov;32(5):855-60. doi: 10.1067/mva.2000.110345. PMID: 11054216
Phase I study of the mitomycin C analogue BMS-181174.
Macaulay VM, O'Byrne KJ, Green JA, Philip PA, McKinley L, LaCreta FP, Winograd B, Ganesan TS, Harris AL, Talbot DC
Br J Cancer 1998 Jun;77(11):2020-7. doi: 10.1038/bjc.1998.336. PMID: 9667686Free PMC Article
A fixed-dose combination of low molecular weight heparin with dihydroergotamine versus adjusted-dose unfractionated heparin in the prevention of deep-vein thrombosis after total hip replacement.
Horbach T, Wolf H, Michaelis HC, Wagner W, Hoffmann A, Schmidt A, Beck H
Thromb Haemost 1996 Feb;75(2):246-50. PMID: 8815569
Cytotoxic effects of four antibiotics on endothelial cells.
Lanbeck P, Paulsen O
Pharmacol Toxicol 1995 Dec;77(6):365-70. doi: 10.1111/j.1600-0773.1995.tb01043.x. PMID: 8835360

Clinical prediction guides

Safety and Tolerability of 23.4% Hypertonic Saline Administered Over 2 to 5 Minutes for the Treatment of Cerebral Herniation and Intracranial Pressure Elevation.
O'Brien SK, Koehl JL, Demers LB, Hayes BD, Barra ME
Neurocrit Care 2023 Apr;38(2):312-319. Epub 2022 Sep 28 doi: 10.1007/s12028-022-01604-1. PMID: 36171519
Ultrasound- and fluoroscopy-guided foam sclerotherapy for lower extremity venous ulcers.
Zhu Y, Wu D, Sun D, Song K, Li J, Lin J
J Vasc Surg Venous Lymphat Disord 2020 Sep;8(5):783-788. Epub 2020 Jan 6 doi: 10.1016/j.jvsv.2019.11.006. PMID: 31917182
Subchondral stem cell therapy versus contralateral total knee arthroplasty for osteoarthritis following secondary osteonecrosis of the knee.
Hernigou P, Auregan JC, Dubory A, Flouzat-Lachaniette CH, Chevallier N, Rouard H
Int Orthop 2018 Nov;42(11):2563-2571. Epub 2018 Mar 27 doi: 10.1007/s00264-018-3916-9. PMID: 29589086
Influence of injection site for low-dose heparin on wound complication rates after inguinal hernia repair.
Wright DM, O'Dwyer PJ, Paterson CR
Ann R Coll Surg Engl 1998 Jan;80(1):58-60. PMID: 9579130Free PMC Article
Feasibility of using recombinant factor VIIa in continuous infusion.
Schulman S, Bech Jensen M, Varon D, Keller N, Gitel S, Horoszowski H, Heim M, Martinowitz U
Thromb Haemost 1996 Mar;75(3):432-6. PMID: 8701403

Recent systematic reviews

Systematic review of foam sclerotherapy for varicose veins.
Jia X, Mowatt G, Burr JM, Cassar K, Cook J, Fraser C
Br J Surg 2007 Aug;94(8):925-36. doi: 10.1002/bjs.5891. PMID: 17636511

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