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Audiogenic seizures

MedGen UID:
155927
•Concept ID:
C0751791
•
Disease or Syndrome
Synonyms: Audiogenic Epilepsies; Audiogenic Epilepsy; Audiogenic Reflex Epilepsies; Audiogenic Reflex Epilepsy; Epilepsies, Audiogenic Reflex; Epilepsy, Audiogenic; Epilepsy, Audiogenic Reflex; Reflex Epilepsies, Audiogenic; Reflex Epilepsy, Audiogenic
SNOMED CT: Audiogenic epilepsy (765216006); Audiogenic seizures (765216006)
 
Monarch Initiative: MONDO:0015644
Orphanet: ORPHA166415

Definition

A rare neurologic disease with characteristics of seizures that are triggered by acoustic stimulation, which can be simple (as in startle epilepsy) or complex (for example musicogenic seizures, seizures triggered by the voice). [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAudiogenic seizures
Follow this link to review classifications for Audiogenic seizures in Orphanet.

Professional guidelines

PubMed

Levetiracetam in the management of feline audiogenic reflex seizures: a randomised, controlled, open-label study.
Lowrie M, Thomson S, Bessant C, Sparkes A, Harvey RJ, Garosi L
J Feline Med Surg 2017 Feb;19(2):200-206. Epub 2016 Jul 9 doi: 10.1177/1098612X15622806. PMID: 26690830Free PMC Article
Genetic factors in neurotoxicology and neuropharmacology: a critical evaluation of the use of genetics as a research tool.
Festing MF
Experientia 1991 Oct 15;47(10):990-8. doi: 10.1007/BF01923334. PMID: 1936208

Recent clinical studies

Etiology

ADGRV1 is implicated in myoclonic epilepsy.
Myers KA, Nasioulas S, Boys A, McMahon JM, Slater H, Lockhart P, Sart DD, Scheffer IE
Epilepsia 2018 Feb;59(2):381-388. Epub 2017 Dec 20 doi: 10.1111/epi.13980. PMID: 29266188
Levetiracetam in the management of feline audiogenic reflex seizures: a randomised, controlled, open-label study.
Lowrie M, Thomson S, Bessant C, Sparkes A, Harvey RJ, Garosi L
J Feline Med Surg 2017 Feb;19(2):200-206. Epub 2016 Jul 9 doi: 10.1177/1098612X15622806. PMID: 26690830Free PMC Article
The efficacy and tolerability of Levetiracetam as an add-on therapy in patients with startle epilepsy.
Gürses C, Alpay K, Ciftçi FD, Bebek N, Baykan B, Gökyiğit A
Seizure 2008 Oct;17(7):625-30. doi: 10.1016/j.seizure.2008.04.003. PMID: 18486495
Role of the substantia nigra in audiogenic seizures: a neuroethological analysis in the rat.
Garcia-Cairasco N, Sabbatini RM
Braz J Med Biol Res 1983 Jul;16(2):171-83. PMID: 6686072
Simple method for producing an alcohol withdrawal syndrome in rats.
Mucha RF, Pinel JP, Oot PH
Pharmacol Biochem Behav 1975 Sep-Oct;3(5):765-9. doi: 10.1016/0091-3057(75)90104-5. PMID: 1239771

Diagnosis

Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat.
Manis AD, Palygin O, Isaeva E, Levchenko V, LaViolette PS, Pavlov TS, Hodges MR, Staruschenko A
JCI Insight 2021 Jan 11;6(1) doi: 10.1172/jci.insight.143251. PMID: 33232300Free PMC Article
Reflex epileptic mechanisms in humans: Lessons about natural ictogenesis.
Wolf P
Epilepsy Behav 2017 Jun;71(Pt B):118-123. Epub 2015 May 6 doi: 10.1016/j.yebeh.2015.01.009. PMID: 25958226
The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression [corrected].
Sarkisova K, van Luijtelaar G
Prog Neuropsychopharmacol Biol Psychiatry 2011 Jun 1;35(4):854-76. Epub 2010 Nov 17 doi: 10.1016/j.pnpbp.2010.11.010. PMID: 21093520
Studies on the very large G protein-coupled receptor: from initial discovery to determining its role in sensorineural deafness in higher animals.
McMillan DR, White PC
Adv Exp Med Biol 2010;706:76-86. doi: 10.1007/978-1-4419-7913-1_6. PMID: 21618827
Physiologically based pharmacokinetic/pharmacodynamic animal-to-man prediction of therapeutic dose in a model of epilepsy.
Brochot A, Zamacona M, Stockis A
Basic Clin Pharmacol Toxicol 2010 Mar;106(3):256-62. Epub 2010 Jan 25 doi: 10.1111/j.1742-7843.2009.00536.x. PMID: 20102365

Therapy

Audiogenic kindling and secondary subcortico-cortical epileptogenesis: Behavioral correlates and electrographic features.
Vinogradova LV
Epilepsy Behav 2017 Jun;71(Pt B):142-153. Epub 2015 Jul 3 doi: 10.1016/j.yebeh.2015.06.014. PMID: 26148984
Classical neurotransmitters and neuropeptides involved in generalized epilepsy in a multi-neurotransmitter system: How to improve the antiepileptic effect?
Werner FM, Coveñas R
Epilepsy Behav 2017 Jun;71(Pt B):124-129. Epub 2015 Mar 26 doi: 10.1016/j.yebeh.2015.01.038. PMID: 25819950
Atypical antipsychotic drugs and ethanol withdrawal syndrome: a review.
Uzbay TI
Alcohol Alcohol 2012 Jan-Feb;47(1):33-41. Epub 2011 Oct 21 doi: 10.1093/alcalc/agr142. PMID: 22021556
Maltese dilution, chromosome 9, and audiogenic seizures in DBA-2 mice: experimental evaluation.
Collins RL
Brain Res 1974 Apr 26;70(3):541-6. doi: 10.1016/0006-8993(74)90266-2. PMID: 4856582
Audiogenic seizures in rats after gonadectomy and during subsequent replacement therapy.
BEVAN W, STANDARD HC, ALVERSON WE, BEVAN JM
J Genet Psychol 1958 Jun;92(2):183-8. doi: 10.1080/00221325.1958.10532391. PMID: 13563831

Prognosis

The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression [corrected].
Sarkisova K, van Luijtelaar G
Prog Neuropsychopharmacol Biol Psychiatry 2011 Jun 1;35(4):854-76. Epub 2010 Nov 17 doi: 10.1016/j.pnpbp.2010.11.010. PMID: 21093520
Physiologically based pharmacokinetic/pharmacodynamic animal-to-man prediction of therapeutic dose in a model of epilepsy.
Brochot A, Zamacona M, Stockis A
Basic Clin Pharmacol Toxicol 2010 Mar;106(3):256-62. Epub 2010 Jan 25 doi: 10.1111/j.1742-7843.2009.00536.x. PMID: 20102365
The efficacy and tolerability of Levetiracetam as an add-on therapy in patients with startle epilepsy.
Gürses C, Alpay K, Ciftçi FD, Bebek N, Baykan B, Gökyiğit A
Seizure 2008 Oct;17(7):625-30. doi: 10.1016/j.seizure.2008.04.003. PMID: 18486495
Emergent properties of CNS neuronal networks as targets for pharmacology: application to anticonvulsant drug action.
Faingold CL
Prog Neurobiol 2004 Jan;72(1):55-85. doi: 10.1016/j.pneurobio.2003.11.003. PMID: 15019176
Incidence of audiogenic seizures following experimental induction of middle ear disorder.
MARX MH, CHAMBERS RM
J Comp Physiol Psychol 1952 Jun;45(3):239-45. doi: 10.1037/h0056795. PMID: 14946268

Clinical prediction guides

Abnormalities of serotonergic neurotransmission in animal models of SUDEP.
Feng HJ, Faingold CL
Epilepsy Behav 2017 Jun;71(Pt B):174-180. Epub 2015 Aug 10 doi: 10.1016/j.yebeh.2015.06.008. PMID: 26272185Free PMC Article
Atypical antipsychotic drugs and ethanol withdrawal syndrome: a review.
Uzbay TI
Alcohol Alcohol 2012 Jan-Feb;47(1):33-41. Epub 2011 Oct 21 doi: 10.1093/alcalc/agr142. PMID: 22021556
The efficacy and tolerability of Levetiracetam as an add-on therapy in patients with startle epilepsy.
Gürses C, Alpay K, Ciftçi FD, Bebek N, Baykan B, Gökyiğit A
Seizure 2008 Oct;17(7):625-30. doi: 10.1016/j.seizure.2008.04.003. PMID: 18486495
Serotonergic anti-depressants and ethanol withdrawal syndrome: a review.
Uzbay IT
Alcohol Alcohol 2008 Jan-Feb;43(1):15-24. Epub 2007 Oct 12 doi: 10.1093/alcalc/agm145. PMID: 17934195
Simple method for producing an alcohol withdrawal syndrome in rats.
Mucha RF, Pinel JP, Oot PH
Pharmacol Biochem Behav 1975 Sep-Oct;3(5):765-9. doi: 10.1016/0091-3057(75)90104-5. PMID: 1239771

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