U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cutaneous sclerotic plaque

MedGen UID:
1612942
•Concept ID:
C4531175
•
Finding
HPO: HP:0031359

Definition

A solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter that is characterized by hardening (sclerosis) of the affected skin area (related to collagen thickening). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous sclerotic plaque

Professional guidelines

PubMed

Long-term treatment of cutaneous manifestations of tuberous sclerosis complex with topical 1% sirolimus cream: A prospective study of 25 patients.
Malissen N, Vergely L, Simon M, Roubertie A, Malinge MC, Bessis D
J Am Acad Dermatol 2017 Sep;77(3):464-472.e3. Epub 2017 May 11 doi: 10.1016/j.jaad.2017.04.005. PMID: 28502378
The efficacy of pulsed dye laser treatment for inflammatory skin diseases: a systematic review.
Erceg A, de Jong EM, van de Kerkhof PC, Seyger MM
J Am Acad Dermatol 2013 Oct;69(4):609-615.e8. Epub 2013 May 24 doi: 10.1016/j.jaad.2013.03.029. PMID: 23711766

Recent clinical studies

Etiology

Cutaneous mucinosis of infancy: report of a rare case and review of the literature.
Chan C, Mann JA, Mihm MC Jr, Yan S, Momtahen S
Dermatol Online J 2018 Oct 15;24(10) PMID: 30677812
The efficacy of pulsed dye laser treatment for inflammatory skin diseases: a systematic review.
Erceg A, de Jong EM, van de Kerkhof PC, Seyger MM
J Am Acad Dermatol 2013 Oct;69(4):609-615.e8. Epub 2013 May 24 doi: 10.1016/j.jaad.2013.03.029. PMID: 23711766
Post-stripping sclerodermiform dermatitis.
French LE, Braun R, Masouyé I, Ramelet AA, Humbert PG, Saurat JH
Arch Dermatol 1999 Nov;135(11):1387-91. doi: 10.1001/archderm.135.11.1387. PMID: 10566839
Classification of morphea (localized scleroderma).
Peterson LS, Nelson AM, Su WP
Mayo Clin Proc 1995 Nov;70(11):1068-76. doi: 10.4065/70.11.1068. PMID: 7475336
Tuberous sclerosis.
Kwiatkowski DJ, Short MP
Arch Dermatol 1994 Mar;130(3):348-54. PMID: 8129414

Diagnosis

Tuberous Sclerosis.
Amorim BDB, Azulay D, Ramos-E-Silva M
Skinmed 2021;19(3):179-185. Epub 2021 Jun 1 PMID: 34303387
Nephrogenic systemic fibrosis/nephrogenic fibrosing dermopathy: clinical aspects.
Piera-Velázquez S, Sandorfi N, Jiménez SA
Skinmed 2007 Jan-Feb;6(1):24-7. doi: 10.1111/j.1540-9740.2007.05829.x. PMID: 17215616
Localized and systemic scleroderma.
Hawk A, English JC 3rd
Semin Cutan Med Surg 2001 Mar;20(1):27-37. doi: 10.1053/sder.2001.23093. PMID: 11308134
Post-stripping sclerodermiform dermatitis.
French LE, Braun R, Masouyé I, Ramelet AA, Humbert PG, Saurat JH
Arch Dermatol 1999 Nov;135(11):1387-91. doi: 10.1001/archderm.135.11.1387. PMID: 10566839
Tuberous sclerosis.
Kwiatkowski DJ, Short MP
Arch Dermatol 1994 Mar;130(3):348-54. PMID: 8129414

Therapy

Subacute cutaneous lupus erythematosus as a rare complication of disease-modifying therapy administration in multiple sclerosis: case report.
Xu K, Zhang M, Yang S, Yu G, Zheng P, Qin X, Feng J
BMC Neurol 2023 Apr 26;23(1):168. doi: 10.1186/s12883-023-03146-1. PMID: 37101279Free PMC Article
Nivolumab-induced plaque morphea in a malign melanoma patient.
Acar A, Oraloglu G, Yaman B, Karaarslan I
J Cosmet Dermatol 2021 Aug;20(8):2645-2647. Epub 2020 Dec 28 doi: 10.1111/jocd.13914. PMID: 33355973
The efficacy of pulsed dye laser treatment for inflammatory skin diseases: a systematic review.
Erceg A, de Jong EM, van de Kerkhof PC, Seyger MM
J Am Acad Dermatol 2013 Oct;69(4):609-615.e8. Epub 2013 May 24 doi: 10.1016/j.jaad.2013.03.029. PMID: 23711766
Localized and systemic scleroderma.
Hawk A, English JC 3rd
Semin Cutan Med Surg 2001 Mar;20(1):27-37. doi: 10.1053/sder.2001.23093. PMID: 11308134
Post-stripping sclerodermiform dermatitis.
French LE, Braun R, Masouyé I, Ramelet AA, Humbert PG, Saurat JH
Arch Dermatol 1999 Nov;135(11):1387-91. doi: 10.1001/archderm.135.11.1387. PMID: 10566839

Prognosis

Eczematous graft-vs-host disease: A report of three cases and review of the literature.
Chan SL, Wood BA, Mesbah Ardakani N
J Cutan Pathol 2020 Nov;47(11):1085-1095. Epub 2020 Aug 28 doi: 10.1111/cup.13836. PMID: 32767402
Challenges in the diagnosis and treatment of disabling pansclerotic morphea of childhood: case-based review.
Soh HJ, Samuel C, Heaton V, Renton WD, Cox A, Munro J
Rheumatol Int 2019 May;39(5):933-941. Epub 2019 Mar 5 doi: 10.1007/s00296-019-04269-w. PMID: 30838436
The efficacy of pulsed dye laser treatment for inflammatory skin diseases: a systematic review.
Erceg A, de Jong EM, van de Kerkhof PC, Seyger MM
J Am Acad Dermatol 2013 Oct;69(4):609-615.e8. Epub 2013 May 24 doi: 10.1016/j.jaad.2013.03.029. PMID: 23711766
Localized and systemic scleroderma.
Hawk A, English JC 3rd
Semin Cutan Med Surg 2001 Mar;20(1):27-37. doi: 10.1053/sder.2001.23093. PMID: 11308134
Diagnosis of Lyme disease based on dermatologic manifestations.
Malane MS, Grant-Kels JM, Feder HM Jr, Luger SW
Ann Intern Med 1991 Mar 15;114(6):490-8. doi: 10.7326/0003-4819-114-6-490. PMID: 1994797

Clinical prediction guides

Periodontal disease and its association to endothelial dysfunction and clinical changes in limited systemic sclerosis: A case-control study.
Jud P, Wimmer G, Meinitzer A, Strohmaier H, Schwantzer G, Moazedi-Fürst F, Schweiger L, Brodmann M, Hafner F, Arefnia B
J Periodontal Res 2023 Jun;58(3):621-633. Epub 2023 Mar 15 doi: 10.1111/jre.13111. PMID: 36919705
Clinical characteristics of sarcoidosis patients with systemic sclerosis-specific autoantibody: Possible involvement of thymus and activation-regulated chemokine and a review of the published works.
Ueda-Hayakawa I, Nguyen CTH, Kishimoto I, Ly NTM, Okamoto H
J Dermatol 2019 Jul;46(7):577-583. Epub 2019 May 27 doi: 10.1111/1346-8138.14932. PMID: 31131913
Fibrous cephalic plaques in tuberous sclerosis complex.
Oyerinde O, Buccine D, Treichel A, Hong C, Lee CR, Moss J, Darling TN
J Am Acad Dermatol 2018 Apr;78(4):717-724. Epub 2017 Dec 16 doi: 10.1016/j.jaad.2017.12.027. PMID: 29258863Free PMC Article
Post-stripping sclerodermiform dermatitis.
French LE, Braun R, Masouyé I, Ramelet AA, Humbert PG, Saurat JH
Arch Dermatol 1999 Nov;135(11):1387-91. doi: 10.1001/archderm.135.11.1387. PMID: 10566839
Tuberous sclerosis.
Kwiatkowski DJ, Short MP
Arch Dermatol 1994 Mar;130(3):348-54. PMID: 8129414

Recent systematic reviews

The efficacy of pulsed dye laser treatment for inflammatory skin diseases: a systematic review.
Erceg A, de Jong EM, van de Kerkhof PC, Seyger MM
J Am Acad Dermatol 2013 Oct;69(4):609-615.e8. Epub 2013 May 24 doi: 10.1016/j.jaad.2013.03.029. PMID: 23711766

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...