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Integumentary System Signs and Symptoms

MedGen UID:
232646
•Concept ID:
C1334192
•
Sign or Symptom

Definition

Patient complaints (symptoms), physical and/or laboratory findings related to the skin or integument. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntegumentary System Signs and Symptoms

Professional guidelines

PubMed

Itch: Pathogenesis and treatment.
Sutaria N, Adawi W, Goldberg R, Roh YS, Choi J, Kwatra SG
J Am Acad Dermatol 2022 Jan;86(1):17-34. Epub 2021 Oct 12 doi: 10.1016/j.jaad.2021.07.078. PMID: 34648873
European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative.
Ozen S, Marks SD, Brogan P, Groot N, de Graeff N, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Pilkington C, Ravelli A, van Royen A, Uziel Y, Vastert B, Wulffraat N, Kamphuis S, Beresford MW
Rheumatology (Oxford) 2019 Sep 1;58(9):1607-1616. doi: 10.1093/rheumatology/kez041. PMID: 30879080
Herpes Zoster and Postherpetic Neuralgia: Prevention and Management.
Saguil A, Kane S, Mercado M, Lauters R
Am Fam Physician 2017 Nov 15;96(10):656-663. PMID: 29431387

Recent clinical studies

Etiology

The 2020 International Alliance for the Control of Scabies Consensus Criteria for the Diagnosis of Scabies.
Engelman D, Yoshizumi J, Hay RJ, Osti M, Micali G, Norton S, Walton S, Boralevi F, Bernigaud C, Bowen AC, Chang AY, Chosidow O, Estrada-Chavez G, Feldmeier H, Ishii N, Lacarrubba F, Mahé A, Maurer T, Mahdi MMA, Murdoch ME, Pariser D, Nair PA, Rehmus W, Romani L, Tilakaratne D, Tuicakau M, Walker SL, Wanat KA, Whitfeld MJ, Yotsu RR, Steer AC, Fuller LC
Br J Dermatol 2020 Nov;183(5):808-820. Epub 2020 Mar 29 doi: 10.1111/bjd.18943. PMID: 32034956Free PMC Article
Mechanisms and Management of Itch in Dry Skin.
Moniaga CS, Tominaga M, Takamori K
Acta Derm Venereol 2020 Jan 15;100(2):adv00024. doi: 10.2340/00015555-3344. PMID: 31940044Free PMC Article
Skin changes in the obese patient.
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Herpes Zoster and Postherpetic Neuralgia: Prevention and Management.
Saguil A, Kane S, Mercado M, Lauters R
Am Fam Physician 2017 Nov 15;96(10):656-663. PMID: 29431387
Role of topical peptides in preventing or treating aged skin.
Gorouhi F, Maibach HI
Int J Cosmet Sci 2009 Oct;31(5):327-45. Epub 2009 Jun 30 doi: 10.1111/j.1468-2494.2009.00490.x. PMID: 19570099

Diagnosis

Small fiber neuropathy.
Finsterer J, Scorza FA
Acta Neurol Scand 2022 May;145(5):493-503. Epub 2022 Feb 7 doi: 10.1111/ane.13591. PMID: 35130356
Itch: Pathogenesis and treatment.
Sutaria N, Adawi W, Goldberg R, Roh YS, Choi J, Kwatra SG
J Am Acad Dermatol 2022 Jan;86(1):17-34. Epub 2021 Oct 12 doi: 10.1016/j.jaad.2021.07.078. PMID: 34648873
Red scrotum syndrome: An update on clinicopathologic features, pathogenesis, diagnosis, and management.
Khalil S, Kurban M, Abbas O
J Am Acad Dermatol 2022 Sep;87(3):614-622. Epub 2020 Jun 1 doi: 10.1016/j.jaad.2020.05.113. PMID: 32497688
2020 guidelines for the diagnosis and treatment of prurigo.
Satoh T, Yokozeki H, Murota H, Tokura Y, Kabashima K, Takamori K, Shiohara T, Morita E, Aiba S, Aoyama Y, Hashimoto T, Katayama I
J Dermatol 2021 Sep;48(9):e414-e431. Epub 2021 Jul 27 doi: 10.1111/1346-8138.16067. PMID: 34314056
Mechanisms and Management of Itch in Dry Skin.
Moniaga CS, Tominaga M, Takamori K
Acta Derm Venereol 2020 Jan 15;100(2):adv00024. doi: 10.2340/00015555-3344. PMID: 31940044Free PMC Article

Therapy

Carboxytherapy in dermatology.
Kroumpouzos G, Arora G, Kassir M, Galadari H, Wollina U, Lotti T, Grabbe S, Goldust M
Clin Dermatol 2022 May-Jun;40(3):305-309. Epub 2021 Aug 20 doi: 10.1016/j.clindermatol.2021.08.020. PMID: 35667826
Small fiber neuropathy.
Finsterer J, Scorza FA
Acta Neurol Scand 2022 May;145(5):493-503. Epub 2022 Feb 7 doi: 10.1111/ane.13591. PMID: 35130356
Insights Into the Pathophysiology of Cellulite: A Review.
Bass LS, Kaminer MS
Dermatol Surg 2020 Oct;46 Suppl 1(1):S77-S85. doi: 10.1097/DSS.0000000000002388. PMID: 32976174Free PMC Article
Mechanisms and Management of Itch in Dry Skin.
Moniaga CS, Tominaga M, Takamori K
Acta Derm Venereol 2020 Jan 15;100(2):adv00024. doi: 10.2340/00015555-3344. PMID: 31940044Free PMC Article
Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis.
Guttman-Yassky E, Bissonnette R, Ungar B, Suárez-Fariñas M, Ardeleanu M, Esaki H, Suprun M, Estrada Y, Xu H, Peng X, Silverberg JI, Menter A, Krueger JG, Zhang R, Chaudhry U, Swanson B, Graham NMH, Pirozzi G, Yancopoulos GD, D Hamilton JD
J Allergy Clin Immunol 2019 Jan;143(1):155-172. Epub 2018 Sep 5 doi: 10.1016/j.jaci.2018.08.022. PMID: 30194992

Prognosis

An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic Dermatitis.
Moniaga CS, Tominaga M, Takamori K
Cells 2022 Dec 5;11(23) doi: 10.3390/cells11233930. PMID: 36497188Free PMC Article
Pediatric Penile Bee Sting.
Huseynov M, Cebisli A, Ozturk A, Sahin M, Akin Ozdemir M, Polat M
Pediatr Emerg Care 2022 Aug 1;38(8):e1469-e1471. Epub 2022 Jun 23 doi: 10.1097/PEC.0000000000002791. PMID: 35904958
Multisystemic manifestations of IgA vasculitis.
Du L, Wang P, Liu C, Li S, Yue S, Yang Y
Clin Rheumatol 2021 Jan;40(1):43-52. Epub 2020 Jun 16 doi: 10.1007/s10067-020-05166-5. PMID: 32557258
Scleromyxedema.
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
The rash with maculopapules and fever in adults.
Muzumdar S, Rothe MJ, Grant-Kels JM
Clin Dermatol 2019 Mar-Apr;37(2):109-118. Epub 2018 Dec 5 doi: 10.1016/j.clindermatol.2018.12.004. PMID: 30981291

Clinical prediction guides

Nail psoriasis and nail lichen planus: Updates on diagnosis and management.
Hwang JK, Grover C, Iorizzo M, Lebwohl MG, Piraccini BM, Rigopoulos DG, Lipner SR
J Am Acad Dermatol 2024 Mar;90(3):585-596. Epub 2023 Nov 24 doi: 10.1016/j.jaad.2023.11.024. PMID: 38007038
Is Atopic Dermatitis Only a Skin Disease?
Mesjasz A, Zawadzka M, Chałubiński M, Trzeciak M
Int J Mol Sci 2023 Jan 3;24(1) doi: 10.3390/ijms24010837. PMID: 36614274Free PMC Article
Phototherapy for Prurigo Nodularis: Our Experience and a Review of the Literature.
Arrieta A, Jaka A, Del Alcázar E, Blanco M, Carrascosa JM
Actas Dermosifiliogr (Engl Ed) 2021 Apr;112(4):339-344. Epub 2020 Nov 19 doi: 10.1016/j.ad.2020.11.007. PMID: 33221272
Rosacea and Demodicosis: Little-known Diagnostic Signs and Symptoms.
Forton FMN, De Maertelaer V
Acta Derm Venereol 2019 Jan 1;99(1):47-52. doi: 10.2340/00015555-3041. PMID: 30226528
Ultraviolet Radiation on the Skin: A Painful Experience?
Lopes DM, McMahon SB
CNS Neurosci Ther 2016 Feb;22(2):118-26. Epub 2015 Aug 30 doi: 10.1111/cns.12444. PMID: 26331607Free PMC Article

Recent systematic reviews

Non-Atopic Chronic Nodular Prurigo (Prurigo Nodularis Hyde): A Systematic Review of Best-Evidenced Treatment Options.
Frølunde AS, Wiis MAK, Ben Abdallah H, Elsgaard S, Danielsen AK, Deleuran M, Vestergaard C
Dermatology 2022;238(5):950-960. Epub 2022 Apr 13 doi: 10.1159/000523700. PMID: 35417906
A Systematic Review of Drug-Induced Pemphigoid.
Verheyden MJ, Bilgic A, Murrell DF
Acta Derm Venereol 2020 Aug 17;100(15):adv00224. doi: 10.2340/00015555-3457. PMID: 32176310Free PMC Article
Treatment of urticarial vasculitis: A systematic review.
Kolkhir P, Grakhova M, Bonnekoh H, Krause K, Maurer M
J Allergy Clin Immunol 2019 Feb;143(2):458-466. Epub 2018 Sep 27 doi: 10.1016/j.jaci.2018.09.007. PMID: 30268388
Effectiveness of topical skin products in the treatment and prevention of incontinence-associated dermatitis: a systematic review.
Pather P, Hines S, Kynoch K, Coyer F
JBI Database System Rev Implement Rep 2017 May;15(5):1473-1496. doi: 10.11124/JBISRIR-2016-003015. PMID: 28498177
Trachoma.
Solomon A, Mabey D
BMJ Clin Evid 2007 Nov 7;2007 PMID: 19450349Free PMC Article

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