U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Thickened aortic valve cusp

MedGen UID:
1613159
•Concept ID:
C4531033
•
Anatomical Abnormality
HPO: HP:0031568

Definition

An abnormally increased thickness of a leaflet of the aortic valve. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThickened aortic valve cusp

Conditions with this feature

Mucopolysaccharidosis, type 10
MedGen UID:
1794274
•Concept ID:
C5562064
•
Disease or Syndrome
Mucopolysaccharidosis type X (MPS10) is an autosomal recessive childhood-onset disorder associated with disproportionate short-trunk short stature and skeletal, cardiac, and ophthalmologic abnormalities (Verheyen et al., 2022).
See: Condition Record
Mucopolysaccharidosis, type 10

Professional guidelines

PubMed

Assessment of cardiac valve dysfunction in patients receiving cabergoline treatment for hyperprolactinaemia.
Tan T, Cabrita IZ, Hensman D, Grogono J, Dhillo WS, Baynes KC, Eliahoo J, Meeran K, Robinson S, Nihoyannopoulos P, Martin NM
Clin Endocrinol (Oxf) 2010 Sep;73(3):369-74. Epub 2010 Jun 9 doi: 10.1111/j.1365-2265.2010.03827.x. PMID: 20550538

Recent clinical studies

Etiology

Outcomes of aortic root replacement with tricuspid aortic valve reimplantation in patients with residual aortic regurgitation.
Rosinski BF, Hodges K, Vargo PR, Roselli EE, Koprivanac M, Tong M, Rajeswaran J, Blackstone EH, Svensson LG
J Thorac Cardiovasc Surg 2024 Jan;167(1):101-111.e4. Epub 2023 Jul 31 doi: 10.1016/j.jtcvs.2023.07.038. PMID: 37532029
Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis.
Chen IY, Vedula V, Malik SB, Liang T, Chang AY, Chung KS, Sayed N, Tsao PS, Giacomini JC, Marsden AL, Wu JC
Circ Cardiovasc Imaging 2021 Dec;14(12):1122-1132. Epub 2021 Dec 17 doi: 10.1161/CIRCIMAGING.121.012884. PMID: 34915729Free PMC Article
Leaflet thickening and stent geometry in sutureless bioprosthetic aortic valves.
Themudo R, Kastengren M, Bacsovics Brolin E, Cederlund K, Svensson A, Dalén M
Heart Vessels 2020 Jun;35(6):868-875. Epub 2020 Jan 16 doi: 10.1007/s00380-020-01553-9. PMID: 31950251Free PMC Article
Progression of Aortic Regurgitation After Different Repair Techniques for Congenital Aortic Valve Stenosis.
Kari FA, Kroll J, Kiss J, Hess C, Stiller B, Siepe M, Beyersdorf F
Pediatr Cardiol 2016 Jan;37(1):84-9. Epub 2015 Aug 13 doi: 10.1007/s00246-015-1243-0. PMID: 26266328
Aortic valve repair and replacement after balloon aortic valvuloplasty in children.
Hawkins JA, Minich LL, Shaddy RE, Tani LY, Orsmond GS, Sturtevant JE, McGough EC
Ann Thorac Surg 1996 May;61(5):1355-8. doi: 10.1016/0003-4975(96)00018-5. PMID: 8633940

Diagnosis

Progression of Aortic Regurgitation After Different Repair Techniques for Congenital Aortic Valve Stenosis.
Kari FA, Kroll J, Kiss J, Hess C, Stiller B, Siepe M, Beyersdorf F
Pediatr Cardiol 2016 Jan;37(1):84-9. Epub 2015 Aug 13 doi: 10.1007/s00246-015-1243-0. PMID: 26266328
Intraoperative transoesophageal echocardiographic diagnosis and successful management of mycotic aortitis and pseudoaneurysm.
Tan CO, Weinberg L, Pillai P, Fernandes J
BMJ Case Rep 2013 Nov 22;2013:200675. doi: 10.1136/bcr-2013-200675. PMID: 24273009Free PMC Article
Abnormal aortic valve echoes in mitral prolapse. Echocardiographic features of floppy aortic valve.
Rodger JC, Morley P
Br Heart J 1982 Apr;47(4):337-43. doi: 10.1136/hrt.47.4.337. PMID: 7066118Free PMC Article
Aortic stenosis: echocardiographic cusp separation and surgical description of aortic valve in 22 patients.
Chang S, Clements S, Chang J
Am J Cardiol 1977 Apr;39(4):499-504. doi: 10.1016/s0002-9149(77)80157-4. PMID: 848433
Pathological features of hypertrophic obstructive cardiomyopathy.
Davies MJ, Pomerance A, Teare RD
J Clin Pathol 1974 Jul;27(7):529-35. doi: 10.1136/jcp.27.7.529. PMID: 4472994Free PMC Article

Therapy

Outcomes of aortic root replacement with tricuspid aortic valve reimplantation in patients with residual aortic regurgitation.
Rosinski BF, Hodges K, Vargo PR, Roselli EE, Koprivanac M, Tong M, Rajeswaran J, Blackstone EH, Svensson LG
J Thorac Cardiovasc Surg 2024 Jan;167(1):101-111.e4. Epub 2023 Jul 31 doi: 10.1016/j.jtcvs.2023.07.038. PMID: 37532029
Leaflet thickening and stent geometry in sutureless bioprosthetic aortic valves.
Themudo R, Kastengren M, Bacsovics Brolin E, Cederlund K, Svensson A, Dalén M
Heart Vessels 2020 Jun;35(6):868-875. Epub 2020 Jan 16 doi: 10.1007/s00380-020-01553-9. PMID: 31950251Free PMC Article
Native-valve Enterococcus hirae endocarditis: a case report and review of the literature.
Pinkes ME, White C, Wong CS
BMC Infect Dis 2019 Oct 24;19(1):891. doi: 10.1186/s12879-019-4532-z. PMID: 31651255Free PMC Article
Progression of Aortic Regurgitation After Different Repair Techniques for Congenital Aortic Valve Stenosis.
Kari FA, Kroll J, Kiss J, Hess C, Stiller B, Siepe M, Beyersdorf F
Pediatr Cardiol 2016 Jan;37(1):84-9. Epub 2015 Aug 13 doi: 10.1007/s00246-015-1243-0. PMID: 26266328
Pericarbon pericardial valve prosthesis: midterm results of the aortic valve replacement.
Borowiec JW, Dubiel TW, Hansson HE, Landelius J, Nyström SO
Angiology 1998 Jan;49(1):1-11. doi: 10.1177/000331979804900101. PMID: 9456159

Prognosis

Outcomes of aortic root replacement with tricuspid aortic valve reimplantation in patients with residual aortic regurgitation.
Rosinski BF, Hodges K, Vargo PR, Roselli EE, Koprivanac M, Tong M, Rajeswaran J, Blackstone EH, Svensson LG
J Thorac Cardiovasc Surg 2024 Jan;167(1):101-111.e4. Epub 2023 Jul 31 doi: 10.1016/j.jtcvs.2023.07.038. PMID: 37532029
Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis.
Chen IY, Vedula V, Malik SB, Liang T, Chang AY, Chung KS, Sayed N, Tsao PS, Giacomini JC, Marsden AL, Wu JC
Circ Cardiovasc Imaging 2021 Dec;14(12):1122-1132. Epub 2021 Dec 17 doi: 10.1161/CIRCIMAGING.121.012884. PMID: 34915729Free PMC Article
Native-valve Enterococcus hirae endocarditis: a case report and review of the literature.
Pinkes ME, White C, Wong CS
BMC Infect Dis 2019 Oct 24;19(1):891. doi: 10.1186/s12879-019-4532-z. PMID: 31651255Free PMC Article
Aortic valve replacement for aortic regurgitation in a patient with primary antiphospholipid syndrome.
Matsuyama K, Ueda Y, Ogino H, Sugita T, Matsubayashi K, Nomoto T, Yoshimura S, Yoshioka T
Jpn Circ J 1999 Sep;63(9):725-6. doi: 10.1253/jcj.63.725. PMID: 10496490
Pericarbon pericardial valve prosthesis: midterm results of the aortic valve replacement.
Borowiec JW, Dubiel TW, Hansson HE, Landelius J, Nyström SO
Angiology 1998 Jan;49(1):1-11. doi: 10.1177/000331979804900101. PMID: 9456159

Clinical prediction guides

Outcomes of aortic root replacement with tricuspid aortic valve reimplantation in patients with residual aortic regurgitation.
Rosinski BF, Hodges K, Vargo PR, Roselli EE, Koprivanac M, Tong M, Rajeswaran J, Blackstone EH, Svensson LG
J Thorac Cardiovasc Surg 2024 Jan;167(1):101-111.e4. Epub 2023 Jul 31 doi: 10.1016/j.jtcvs.2023.07.038. PMID: 37532029
Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis.
Chen IY, Vedula V, Malik SB, Liang T, Chang AY, Chung KS, Sayed N, Tsao PS, Giacomini JC, Marsden AL, Wu JC
Circ Cardiovasc Imaging 2021 Dec;14(12):1122-1132. Epub 2021 Dec 17 doi: 10.1161/CIRCIMAGING.121.012884. PMID: 34915729Free PMC Article
Leaflet thickening and stent geometry in sutureless bioprosthetic aortic valves.
Themudo R, Kastengren M, Bacsovics Brolin E, Cederlund K, Svensson A, Dalén M
Heart Vessels 2020 Jun;35(6):868-875. Epub 2020 Jan 16 doi: 10.1007/s00380-020-01553-9. PMID: 31950251Free PMC Article
The relation between thickened aortic valve and coronary artery disease.
Lin SL, Liu CP, Chen CY, Ger LP, Chiang HT
Zhonghua Yi Xue Za Zhi (Taipei) 1997 Aug;60(2):92-7. PMID: 9360334
The aortic valve after heart transplantation.
Valente M, Faggian G, Billingham ME, Talenti E, Calabrese F, Casula R, Shumway NE, Thiene G
Ann Thorac Surg 1995 Aug;60(2 Suppl):S135-40. doi: 10.1016/0003-4975(95)00251-f. PMID: 7646145

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...