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Thickened aortic valve cusp

MedGen UID:
1613159
Concept ID:
C4531033
Anatomical Abnormality
HPO: HP:0031568

Definition

An abnormally increased thickness of a leaflet of the aortic valve. [from HPO]

Term Hierarchy

Conditions with this feature

Mucopolysaccharidosis, type 10
MedGen UID:
1794274
Concept ID:
C5562064
Disease or Syndrome
Mucopolysaccharidosis type X (MPS10) is an autosomal recessive childhood-onset disorder associated with disproportionate short-trunk short stature and skeletal, cardiac, and ophthalmologic abnormalities (Verheyen et al., 2022).

Professional guidelines

PubMed

Tan T, Cabrita IZ, Hensman D, Grogono J, Dhillo WS, Baynes KC, Eliahoo J, Meeran K, Robinson S, Nihoyannopoulos P, Martin NM
Clin Endocrinol (Oxf) 2010 Sep;73(3):369-74. Epub 2010 Jun 9 doi: 10.1111/j.1365-2265.2010.03827.x. PMID: 20550538

Recent clinical studies

Etiology

Rosinski BF, Hodges K, Vargo PR, Roselli EE, Koprivanac M, Tong M, Rajeswaran J, Blackstone EH, Svensson LG
J Thorac Cardiovasc Surg 2024 Jan;167(1):101-111.e4. Epub 2023 Jul 31 doi: 10.1016/j.jtcvs.2023.07.038. PMID: 37532029
Chen IY, Vedula V, Malik SB, Liang T, Chang AY, Chung KS, Sayed N, Tsao PS, Giacomini JC, Marsden AL, Wu JC
Circ Cardiovasc Imaging 2021 Dec;14(12):1122-1132. Epub 2021 Dec 17 doi: 10.1161/CIRCIMAGING.121.012884. PMID: 34915729Free PMC Article
Themudo R, Kastengren M, Bacsovics Brolin E, Cederlund K, Svensson A, Dalén M
Heart Vessels 2020 Jun;35(6):868-875. Epub 2020 Jan 16 doi: 10.1007/s00380-020-01553-9. PMID: 31950251Free PMC Article
Kari FA, Kroll J, Kiss J, Hess C, Stiller B, Siepe M, Beyersdorf F
Pediatr Cardiol 2016 Jan;37(1):84-9. Epub 2015 Aug 13 doi: 10.1007/s00246-015-1243-0. PMID: 26266328
Hawkins JA, Minich LL, Shaddy RE, Tani LY, Orsmond GS, Sturtevant JE, McGough EC
Ann Thorac Surg 1996 May;61(5):1355-8. doi: 10.1016/0003-4975(96)00018-5. PMID: 8633940

Diagnosis

Kari FA, Kroll J, Kiss J, Hess C, Stiller B, Siepe M, Beyersdorf F
Pediatr Cardiol 2016 Jan;37(1):84-9. Epub 2015 Aug 13 doi: 10.1007/s00246-015-1243-0. PMID: 26266328
Tan CO, Weinberg L, Pillai P, Fernandes J
BMJ Case Rep 2013 Nov 22;2013:200675. doi: 10.1136/bcr-2013-200675. PMID: 24273009Free PMC Article
Rodger JC, Morley P
Br Heart J 1982 Apr;47(4):337-43. doi: 10.1136/hrt.47.4.337. PMID: 7066118Free PMC Article
Chang S, Clements S, Chang J
Am J Cardiol 1977 Apr;39(4):499-504. doi: 10.1016/s0002-9149(77)80157-4. PMID: 848433
Davies MJ, Pomerance A, Teare RD
J Clin Pathol 1974 Jul;27(7):529-35. doi: 10.1136/jcp.27.7.529. PMID: 4472994Free PMC Article

Therapy

Rosinski BF, Hodges K, Vargo PR, Roselli EE, Koprivanac M, Tong M, Rajeswaran J, Blackstone EH, Svensson LG
J Thorac Cardiovasc Surg 2024 Jan;167(1):101-111.e4. Epub 2023 Jul 31 doi: 10.1016/j.jtcvs.2023.07.038. PMID: 37532029
Themudo R, Kastengren M, Bacsovics Brolin E, Cederlund K, Svensson A, Dalén M
Heart Vessels 2020 Jun;35(6):868-875. Epub 2020 Jan 16 doi: 10.1007/s00380-020-01553-9. PMID: 31950251Free PMC Article
Pinkes ME, White C, Wong CS
BMC Infect Dis 2019 Oct 24;19(1):891. doi: 10.1186/s12879-019-4532-z. PMID: 31651255Free PMC Article
Kari FA, Kroll J, Kiss J, Hess C, Stiller B, Siepe M, Beyersdorf F
Pediatr Cardiol 2016 Jan;37(1):84-9. Epub 2015 Aug 13 doi: 10.1007/s00246-015-1243-0. PMID: 26266328
Borowiec JW, Dubiel TW, Hansson HE, Landelius J, Nyström SO
Angiology 1998 Jan;49(1):1-11. doi: 10.1177/000331979804900101. PMID: 9456159

Prognosis

Rosinski BF, Hodges K, Vargo PR, Roselli EE, Koprivanac M, Tong M, Rajeswaran J, Blackstone EH, Svensson LG
J Thorac Cardiovasc Surg 2024 Jan;167(1):101-111.e4. Epub 2023 Jul 31 doi: 10.1016/j.jtcvs.2023.07.038. PMID: 37532029
Chen IY, Vedula V, Malik SB, Liang T, Chang AY, Chung KS, Sayed N, Tsao PS, Giacomini JC, Marsden AL, Wu JC
Circ Cardiovasc Imaging 2021 Dec;14(12):1122-1132. Epub 2021 Dec 17 doi: 10.1161/CIRCIMAGING.121.012884. PMID: 34915729Free PMC Article
Pinkes ME, White C, Wong CS
BMC Infect Dis 2019 Oct 24;19(1):891. doi: 10.1186/s12879-019-4532-z. PMID: 31651255Free PMC Article
Matsuyama K, Ueda Y, Ogino H, Sugita T, Matsubayashi K, Nomoto T, Yoshimura S, Yoshioka T
Jpn Circ J 1999 Sep;63(9):725-6. doi: 10.1253/jcj.63.725. PMID: 10496490
Borowiec JW, Dubiel TW, Hansson HE, Landelius J, Nyström SO
Angiology 1998 Jan;49(1):1-11. doi: 10.1177/000331979804900101. PMID: 9456159

Clinical prediction guides

Rosinski BF, Hodges K, Vargo PR, Roselli EE, Koprivanac M, Tong M, Rajeswaran J, Blackstone EH, Svensson LG
J Thorac Cardiovasc Surg 2024 Jan;167(1):101-111.e4. Epub 2023 Jul 31 doi: 10.1016/j.jtcvs.2023.07.038. PMID: 37532029
Chen IY, Vedula V, Malik SB, Liang T, Chang AY, Chung KS, Sayed N, Tsao PS, Giacomini JC, Marsden AL, Wu JC
Circ Cardiovasc Imaging 2021 Dec;14(12):1122-1132. Epub 2021 Dec 17 doi: 10.1161/CIRCIMAGING.121.012884. PMID: 34915729Free PMC Article
Themudo R, Kastengren M, Bacsovics Brolin E, Cederlund K, Svensson A, Dalén M
Heart Vessels 2020 Jun;35(6):868-875. Epub 2020 Jan 16 doi: 10.1007/s00380-020-01553-9. PMID: 31950251Free PMC Article
Lin SL, Liu CP, Chen CY, Ger LP, Chiang HT
Zhonghua Yi Xue Za Zhi (Taipei) 1997 Aug;60(2):92-7. PMID: 9360334
Rodger JC, Morley P
Br Heart J 1982 Apr;47(4):337-43. doi: 10.1136/hrt.47.4.337. PMID: 7066118Free PMC Article

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