U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

In Situ Follicular Neoplasia

MedGen UID:
1613668
•Concept ID:
C4524188
•
Neoplastic Process
Synonyms: Follicular Lymphoma In Situ; In Situ Follicular B-Cell Neoplasm; In Situ Follicular Lymphoma; In situ follicular neoplasia; ISFN - in situ follicular neoplasia
SNOMED CT: ISFN - in situ follicular neoplasia (786856002); In situ follicular neoplasia (786856002)

Definition

A follicular neoplasia confined to the germinal centers of the lymph nodes, without evidence of disseminated disease. It is characterized by the replacement of a germinal center by neoplastic centrocytes with uniformly intense positivity for BCL2. The surrounding mantle cuff and lymphoid architecture are intact. It has a low rate of progression to follicular lymphoma, but is often associated with prior or synchronous overt lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIn Situ Follicular Neoplasia

Professional guidelines

PubMed

Incidence, clinicopathological features and genetics of in-situ follicular neoplasia: a comprehensive screening study in a Japanese cohort.
Oishi N, Segawa T, Miyake K, Mochizuki K, Kondo T
Histopathology 2022 Apr;80(5):820-826. Epub 2022 Feb 22 doi: 10.1111/his.14617. PMID: 35038193

Recent clinical studies

Etiology

Incidence, clinicopathological features and genetics of in-situ follicular neoplasia: a comprehensive screening study in a Japanese cohort.
Oishi N, Segawa T, Miyake K, Mochizuki K, Kondo T
Histopathology 2022 Apr;80(5):820-826. Epub 2022 Feb 22 doi: 10.1111/his.14617. PMID: 35038193
In-situ follicular neoplasia: a clinicopathological spectrum.
Tamber GS, Chévarie-Davis M, Warner M, Séguin C, Caron C, Michel RP
Histopathology 2021 Dec;79(6):1072-1086. Epub 2021 Sep 22 doi: 10.1111/his.14535. PMID: 34333806
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
Genetic evolution of in situ follicular neoplasia to aggressive B-cell lymphoma of germinal center subtype.
Vogelsberg A, Steinhilber J, Mankel B, Federmann B, Schmidt J, Montes-Mojarro IA, Hüttl K, Rodriguez-Pinilla M, Baskaran P, Nahnsen S, Piris MA, Ott G, Quintanilla-Martinez L, Bonzheim I, Fend F
Haematologica 2021 Oct 1;106(10):2673-2681. doi: 10.3324/haematol.2020.254854. PMID: 32855278Free PMC Article
Next generation sequencing of the clonal IGH rearrangement detects ongoing mutations and interfollicular trafficking in in situ follicular neoplasia.
Kosmidis P, Bonzheim I, Dufke C, Colak S, Hentrich T, Schroeder C, Bauer P, Adam P, Fend F
PLoS One 2017;12(6):e0178503. Epub 2017 Jun 22 doi: 10.1371/journal.pone.0178503. PMID: 28640838Free PMC Article

Diagnosis

In-situ follicular neoplasia: a clinicopathological spectrum.
Tamber GS, Chévarie-Davis M, Warner M, Séguin C, Caron C, Michel RP
Histopathology 2021 Dec;79(6):1072-1086. Epub 2021 Sep 22 doi: 10.1111/his.14535. PMID: 34333806
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
Early Events in Lymphoid Neoplasms and Indolent Follicular Lymphomas.
Perincheri S
Surg Pathol Clin 2019 Sep;12(3):719-731. Epub 2019 May 15 doi: 10.1016/j.path.2019.03.004. PMID: 31352984
Premalignant Clonal Hematopoietic Proliferations.
Nardi V, Kuo FC, Hasserjian RP
Am J Clin Pathol 2019 Aug 1;152(3):347-358. doi: 10.1093/ajcp/aqz079. PMID: 31305863
In situ neoplasia in lymph node pathology.
Oishi N, Montes-Moreno S, Feldman AL
Semin Diagn Pathol 2018 Jan;35(1):76-83. Epub 2017 Nov 10 doi: 10.1053/j.semdp.2017.11.001. PMID: 29129357

Prognosis

Incidence, clinicopathological features and genetics of in-situ follicular neoplasia: a comprehensive screening study in a Japanese cohort.
Oishi N, Segawa T, Miyake K, Mochizuki K, Kondo T
Histopathology 2022 Apr;80(5):820-826. Epub 2022 Feb 22 doi: 10.1111/his.14617. PMID: 35038193
Early Events in Lymphoid Neoplasms and Indolent Follicular Lymphomas.
Perincheri S
Surg Pathol Clin 2019 Sep;12(3):719-731. Epub 2019 May 15 doi: 10.1016/j.path.2019.03.004. PMID: 31352984
Composite Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia and Follicular Lymphoma: A Clinicopathological Study of Six Cases.
Jelloul FZ, Chen QH, Yang T, Haghi N, Brody J, Zhang X, Sheikh-Fayyaz S
Int J Surg Pathol 2018 Apr;26(2):135-144. Epub 2017 Oct 26 doi: 10.1177/1066896917737161. PMID: 29069998
IgG4-related Orbital Disease and Its Mimics in a Western Population.
Ferry JA, Klepeis V, Sohani AR, Harris NL, Preffer FI, Stone JH, Grove A, Deshpande V
Am J Surg Pathol 2015 Dec;39(12):1688-700. doi: 10.1097/PAS.0000000000000497. PMID: 26379149
In situ follicular neoplasia/lymphoma: three illustrative cases exemplifying unique disease presentations.
Sakhadeo U, Mane A, Shet T
Indian J Pathol Microbiol 2012 Apr-Jun;55(2):218-21. doi: 10.4103/0377-4929.97878. PMID: 22771648

Clinical prediction guides

Widespread in situ follicular neoplasia in patients who subsequently developed follicular lymphoma.
Dobson R, Wotherspoon A, Liu SA, Cucco F, Chen Z, Tang Y, Du MQ
J Pathol 2022 Apr;256(4):369-377. Epub 2022 Mar 3 doi: 10.1002/path.5861. PMID: 34957565Free PMC Article
In-situ follicular neoplasia: a clinicopathological spectrum.
Tamber GS, Chévarie-Davis M, Warner M, Séguin C, Caron C, Michel RP
Histopathology 2021 Dec;79(6):1072-1086. Epub 2021 Sep 22 doi: 10.1111/his.14535. PMID: 34333806
The t(14;18) translocation is absent from endothelial and follicular dendritic cells of follicular lymphoma (FL) and shows heterogeneous presence in preserved FL mantle zones.
Kosmidis P, Mankel B, Fend F, Adam P
Diagn Pathol 2018 May 2;13(1):25. doi: 10.1186/s13000-018-0703-2. PMID: 29720207Free PMC Article
Lymphadenectomy Specimens in a Large Retrospective Cohort of Pediatric Patients Reveal No in situ Lymphomas but a Broad Spectrum of Reactive Changes.
Banz Y, Tzankov A, Dirnhofer S, Perren A, Hoeller S
Pathobiology 2017;84(3):139-143. Epub 2016 Nov 3 doi: 10.1159/000449253. PMID: 27806371
IgG4-related Orbital Disease and Its Mimics in a Western Population.
Ferry JA, Klepeis V, Sohani AR, Harris NL, Preffer FI, Stone JH, Grove A, Deshpande V
Am J Surg Pathol 2015 Dec;39(12):1688-700. doi: 10.1097/PAS.0000000000000497. PMID: 26379149

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...