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In Situ Follicular Neoplasia

MedGen UID:
1613668
•Concept ID:
C4524188
•
Neoplastic Process
Synonyms: Follicular Lymphoma In Situ; In Situ Follicular Lymphoma; In situ follicular neoplasia; ISFN - in situ follicular neoplasia
SNOMED CT: ISFN - in situ follicular neoplasia (786856002); In situ follicular neoplasia (786856002)

Definition

A follicular neoplasia confined to the germinal centers of the lymph nodes, without evidence of disseminated disease. It is characterized by the replacement of a germinal center by neoplastic centrocytes with uniformly intense positivity for BCL2. The surrounding mantle cuff and lymphoid architecture are intact. It has a low rate of progression to follicular lymphoma, but is often associated with prior or synchronous overt lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIn Situ Follicular Neoplasia

Professional guidelines

PubMed

Incidence, clinicopathological features and genetics of in-situ follicular neoplasia: a comprehensive screening study in a Japanese cohort.
Oishi N, Segawa T, Miyake K, Mochizuki K, Kondo T
Histopathology 2022 Apr;80(5):820-826. Epub 2022 Feb 22 doi: 10.1111/his.14617. PMID: 35038193

Recent clinical studies

Etiology

Incidence, clinicopathological features and genetics of in-situ follicular neoplasia: a comprehensive screening study in a Japanese cohort.
Oishi N, Segawa T, Miyake K, Mochizuki K, Kondo T
Histopathology 2022 Apr;80(5):820-826. Epub 2022 Feb 22 doi: 10.1111/his.14617. PMID: 35038193
In-situ follicular neoplasia: a clinicopathological spectrum.
Tamber GS, Chévarie-Davis M, Warner M, Séguin C, Caron C, Michel RP
Histopathology 2021 Dec;79(6):1072-1086. Epub 2021 Sep 22 doi: 10.1111/his.14535. PMID: 34333806
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
Genetic evolution of in situ follicular neoplasia to aggressive B-cell lymphoma of germinal center subtype.
Vogelsberg A, Steinhilber J, Mankel B, Federmann B, Schmidt J, Montes-Mojarro IA, Hüttl K, Rodriguez-Pinilla M, Baskaran P, Nahnsen S, Piris MA, Ott G, Quintanilla-Martinez L, Bonzheim I, Fend F
Haematologica 2021 Oct 1;106(10):2673-2681. doi: 10.3324/haematol.2020.254854. PMID: 32855278Free PMC Article
Lymphadenectomy Specimens in a Large Retrospective Cohort of Pediatric Patients Reveal No in situ Lymphomas but a Broad Spectrum of Reactive Changes.
Banz Y, Tzankov A, Dirnhofer S, Perren A, Hoeller S
Pathobiology 2017;84(3):139-143. Epub 2016 Nov 3 doi: 10.1159/000449253. PMID: 27806371

Diagnosis

In-situ follicular neoplasia: a clinicopathological spectrum.
Tamber GS, Chévarie-Davis M, Warner M, Séguin C, Caron C, Michel RP
Histopathology 2021 Dec;79(6):1072-1086. Epub 2021 Sep 22 doi: 10.1111/his.14535. PMID: 34333806
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
Early Events in Lymphoid Neoplasms and Indolent Follicular Lymphomas.
Perincheri S
Surg Pathol Clin 2019 Sep;12(3):719-731. Epub 2019 May 15 doi: 10.1016/j.path.2019.03.004. PMID: 31352984
Premalignant Clonal Hematopoietic Proliferations.
Nardi V, Kuo FC, Hasserjian RP
Am J Clin Pathol 2019 Aug 1;152(3):347-358. doi: 10.1093/ajcp/aqz079. PMID: 31305863
In situ neoplasia in lymph node pathology.
Oishi N, Montes-Moreno S, Feldman AL
Semin Diagn Pathol 2018 Jan;35(1):76-83. Epub 2017 Nov 10 doi: 10.1053/j.semdp.2017.11.001. PMID: 29129357

Prognosis

Incidence, clinicopathological features and genetics of in-situ follicular neoplasia: a comprehensive screening study in a Japanese cohort.
Oishi N, Segawa T, Miyake K, Mochizuki K, Kondo T
Histopathology 2022 Apr;80(5):820-826. Epub 2022 Feb 22 doi: 10.1111/his.14617. PMID: 35038193
Early Events in Lymphoid Neoplasms and Indolent Follicular Lymphomas.
Perincheri S
Surg Pathol Clin 2019 Sep;12(3):719-731. Epub 2019 May 15 doi: 10.1016/j.path.2019.03.004. PMID: 31352984
Composite Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia and Follicular Lymphoma: A Clinicopathological Study of Six Cases.
Jelloul FZ, Chen QH, Yang T, Haghi N, Brody J, Zhang X, Sheikh-Fayyaz S
Int J Surg Pathol 2018 Apr;26(2):135-144. Epub 2017 Oct 26 doi: 10.1177/1066896917737161. PMID: 29069998
IgG4-related Orbital Disease and Its Mimics in a Western Population.
Ferry JA, Klepeis V, Sohani AR, Harris NL, Preffer FI, Stone JH, Grove A, Deshpande V
Am J Surg Pathol 2015 Dec;39(12):1688-700. doi: 10.1097/PAS.0000000000000497. PMID: 26379149
In situ follicular neoplasia/lymphoma: three illustrative cases exemplifying unique disease presentations.
Sakhadeo U, Mane A, Shet T
Indian J Pathol Microbiol 2012 Apr-Jun;55(2):218-21. doi: 10.4103/0377-4929.97878. PMID: 22771648

Clinical prediction guides

Widespread in situ follicular neoplasia in patients who subsequently developed follicular lymphoma.
Dobson R, Wotherspoon A, Liu SA, Cucco F, Chen Z, Tang Y, Du MQ
J Pathol 2022 Apr;256(4):369-377. Epub 2022 Mar 3 doi: 10.1002/path.5861. PMID: 34957565Free PMC Article
In-situ follicular neoplasia: a clinicopathological spectrum.
Tamber GS, Chévarie-Davis M, Warner M, Séguin C, Caron C, Michel RP
Histopathology 2021 Dec;79(6):1072-1086. Epub 2021 Sep 22 doi: 10.1111/his.14535. PMID: 34333806
The t(14;18) translocation is absent from endothelial and follicular dendritic cells of follicular lymphoma (FL) and shows heterogeneous presence in preserved FL mantle zones.
Kosmidis P, Mankel B, Fend F, Adam P
Diagn Pathol 2018 May 2;13(1):25. doi: 10.1186/s13000-018-0703-2. PMID: 29720207Free PMC Article
Lymphadenectomy Specimens in a Large Retrospective Cohort of Pediatric Patients Reveal No in situ Lymphomas but a Broad Spectrum of Reactive Changes.
Banz Y, Tzankov A, Dirnhofer S, Perren A, Hoeller S
Pathobiology 2017;84(3):139-143. Epub 2016 Nov 3 doi: 10.1159/000449253. PMID: 27806371
IgG4-related Orbital Disease and Its Mimics in a Western Population.
Ferry JA, Klepeis V, Sohani AR, Harris NL, Preffer FI, Stone JH, Grove A, Deshpande V
Am J Surg Pathol 2015 Dec;39(12):1688-700. doi: 10.1097/PAS.0000000000000497. PMID: 26379149

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