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Neoplasm of mature B-cells

MedGen UID:
235305
•Concept ID:
C1334633
•
Neoplastic Process
Synonyms: Mature B-Cell Lymphocytic Neoplasm; mature B-cell lymphocytic neoplasm; Mature B-Cell Neoplasm; mature B-cell neoplasm; mature B-cell neoplasms; neoplasm of mature B-cells
 
Monarch Initiative: MONDO:0004949

Definition

A neoplasm that arises from mature B-lymphocytes or plasma cells. Representative examples include mature B-cell non-Hodgkin lymphomas, chronic lymphocytic leukemia, hairy cell leukemia, plasma cell neoplasms, and B-cell proliferations of uncertain malignant potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasm of mature B-cells

Professional guidelines

PubMed

Hairy cell leukemia 2024: Update on diagnosis, risk-stratification, and treatment-Annual updates in hematological malignancies.
Troussard X, Maître E, Paillassa J
Am J Hematol 2024 Apr;99(4):679-696. Epub 2024 Mar 5 doi: 10.1002/ajh.27240. PMID: 38440808
Chronic lymphocytic leukaemia: from genetics to treatment.
Bosch F, Dalla-Favera R
Nat Rev Clin Oncol 2019 Nov;16(11):684-701. doi: 10.1038/s41571-019-0239-8. PMID: 31278397
Cutaneous primary B-cell lymphomas: from diagnosis to treatment.
Lima M
An Bras Dermatol 2015 Sep-Oct;90(5):687-706. doi: 10.1590/abd1806-4841.20153638. PMID: 26560215Free PMC Article

Recent clinical studies

Therapy

Bispecific Antibodies in Multiple Myeloma: Present and Future.
Lancman G, Sastow DL, Cho HJ, Jagannath S, Madduri D, Parekh SS, Richard S, Richter J, Sanchez L, Chari A
Blood Cancer Discov 2021 Sep;2(5):423-433. Epub 2021 Aug 17 doi: 10.1158/2643-3230.BCD-21-0028. PMID: 34661161Free PMC Article
BCMA-targeted immunotherapy for multiple myeloma.
Yu B, Jiang T, Liu D
J Hematol Oncol 2020 Sep 17;13(1):125. doi: 10.1186/s13045-020-00962-7. PMID: 32943087Free PMC Article
B-cell maturation antigen (BCMA) in multiple myeloma: rationale for targeting and current therapeutic approaches.
Shah N, Chari A, Scott E, Mezzi K, Usmani SZ
Leukemia 2020 Apr;34(4):985-1005. Epub 2020 Feb 13 doi: 10.1038/s41375-020-0734-z. PMID: 32055000Free PMC Article
Follicular lymphoma.
Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J
Nat Rev Dis Primers 2019 Dec 12;5(1):83. doi: 10.1038/s41572-019-0132-x. PMID: 31831752
Role of Bruton's tyrosine kinase in B cells and malignancies.
Pal Singh S, Dammeijer F, Hendriks RW
Mol Cancer 2018 Feb 19;17(1):57. doi: 10.1186/s12943-018-0779-z. PMID: 29455639Free PMC Article

Prognosis

B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome.
Fridman WH, Meylan M, Petitprez F, Sun CM, Italiano A, Sautès-Fridman C
Nat Rev Clin Oncol 2022 Jul;19(7):441-457. Epub 2022 Apr 1 doi: 10.1038/s41571-022-00619-z. PMID: 35365796
B Cell Lymphoma.
Meng X, Min Q, Wang JY
Adv Exp Med Biol 2020;1254:161-181. doi: 10.1007/978-981-15-3532-1_12. PMID: 32323276
Chronic lymphocytic leukaemia: from genetics to treatment.
Bosch F, Dalla-Favera R
Nat Rev Clin Oncol 2019 Nov;16(11):684-701. doi: 10.1038/s41571-019-0239-8. PMID: 31278397
Human memory B cells.
Seifert M, Küppers R
Leukemia 2016 Dec;30(12):2283-2292. Epub 2016 Aug 8 doi: 10.1038/leu.2016.226. PMID: 27499139
Chronic lymphocytic leukaemia.
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174

Clinical prediction guides

Immunotherapies in MuSK-positive Myasthenia Gravis; an IgG4 antibody-mediated disease.
Vakrakou AG, Karachaliou E, Chroni E, Zouvelou V, Tzanetakos D, Salakou S, Papadopoulou M, Tzartos S, Voumvourakis K, Kilidireas C, Giannopoulos S, Tsivgoulis G, Tzartos J
Front Immunol 2023;14:1212757. Epub 2023 Jul 26 doi: 10.3389/fimmu.2023.1212757. PMID: 37564637Free PMC Article
Neoantigen-specific CD4(+) T cells in human melanoma have diverse differentiation states and correlate with CD8(+) T cell, macrophage, and B cell function.
Veatch JR, Lee SM, Shasha C, Singhi N, Szeto JL, Moshiri AS, Kim TS, Smythe K, Kong P, Fitzgibbon M, Jesernig B, Bhatia S, Tykodi SS, Hall ET, Byrd DR, Thompson JA, Pillarisetty VG, Duhen T, McGarry Houghton A, Newell E, Gottardo R, Riddell SR
Cancer Cell 2022 Apr 11;40(4):393-409.e9. doi: 10.1016/j.ccell.2022.03.006. PMID: 35413271Free PMC Article
B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome.
Fridman WH, Meylan M, Petitprez F, Sun CM, Italiano A, Sautès-Fridman C
Nat Rev Clin Oncol 2022 Jul;19(7):441-457. Epub 2022 Apr 1 doi: 10.1038/s41571-022-00619-z. PMID: 35365796
B Cells and Tertiary Lymphoid Structures: Friends or Foes in Cancer Immunotherapy?
Lauss M, Donia M, Svane IM, Jönsson G
Clin Cancer Res 2022 May 2;28(9):1751-1758. doi: 10.1158/1078-0432.CCR-21-1130. PMID: 34965949Free PMC Article
B-cell maturation antigen (BCMA) in multiple myeloma: rationale for targeting and current therapeutic approaches.
Shah N, Chari A, Scott E, Mezzi K, Usmani SZ
Leukemia 2020 Apr;34(4):985-1005. Epub 2020 Feb 13 doi: 10.1038/s41375-020-0734-z. PMID: 32055000Free PMC Article

Recent systematic reviews

Is acute lymphoblastic leukemia with mature B-cell phenotype and KMT2A rearrangements a new entity? A systematic review and meta-analysis.
Hidalgo-Gómez G, Palacio-Garcia C, Gallur L, Blanco A, Tazón-Vega B, Saumell S, Martínez N, Murillo L, Murciano T, Velasco P, Bosch F, Diaz-Heredia C, Ortega M
Leuk Lymphoma 2021 Sep;62(9):2202-2210. Epub 2021 Apr 7 doi: 10.1080/10428194.2021.1907375. PMID: 33827367
CD43 in the malignant flow cytometry laboratory in 2020.
Sorigue M
Expert Rev Hematol 2021 Jan;14(1):123-136. Epub 2021 Jan 11 doi: 10.1080/17474086.2021.1856653. PMID: 33249940

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