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Recurrent High Risk Myelodysplastic Syndrome

MedGen UID:
1616932
•Concept ID:
C4528177
•
Neoplastic Process

Definition

The reemergence of high risk myelodysplastic syndrome after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent High Risk Myelodysplastic Syndrome

Professional guidelines

PubMed

Hematopoietic Cell Transplantation in the Management of Myelodysplastic Syndrome: An Evidence-Based Review from the American Society for Transplantation and Cellular Therapy Committee on Practice Guidelines.
DeFilipp Z, Ciurea SO, Cutler C, Robin M, Warlick ED, Nakamura R, Brunner AM, Dholaria B, Walker AR, Kröger N, Bejanyan N, Atallah E, Tamari R, Solh MM, Percival ME, de Lima M, Scott B, Oran B, Garcia-Manero G, Hamadani M, Carpenter P, DeZern AE
Transplant Cell Ther 2023 Feb;29(2):71-81. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.014. PMID: 36436780
Recent developments and persisting challenges in the prevention and treatment of venous thromboembolism in patients with hematological malignancies.
Sorigue M, Cañamero E, Siguenza P, Nomdedeu M, López-Núñez JJ
Leuk Lymphoma 2020 Jun;61(6):1277-1291. Epub 2020 Jan 21 doi: 10.1080/10428194.2020.1713321. PMID: 31960713
Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment.
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article

Recent clinical studies

Etiology

How I reduce and treat posttransplant relapse of MDS.
Mina A, Greenberg PL, Deeg HJ
Blood 2024 Apr 4;143(14):1344-1354. doi: 10.1182/blood.2023023005. PMID: 38306658Free PMC Article
Hematopoietic Cell Transplantation in the Management of Myelodysplastic Syndrome: An Evidence-Based Review from the American Society for Transplantation and Cellular Therapy Committee on Practice Guidelines.
DeFilipp Z, Ciurea SO, Cutler C, Robin M, Warlick ED, Nakamura R, Brunner AM, Dholaria B, Walker AR, Kröger N, Bejanyan N, Atallah E, Tamari R, Solh MM, Percival ME, de Lima M, Scott B, Oran B, Garcia-Manero G, Hamadani M, Carpenter P, DeZern AE
Transplant Cell Ther 2023 Feb;29(2):71-81. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.014. PMID: 36436780
Low-dose decitabine plus venetoclax is safe and effective as post-transplant maintenance therapy for high-risk acute myeloid leukemia and myelodysplastic syndrome.
Wei Y, Xiong X, Li X, Lu W, He X, Jin X, Sun R, Lyu H, Yuan T, Sun T, Zhao M
Cancer Sci 2021 Sep;112(9):3636-3644. Epub 2021 Jul 21 doi: 10.1111/cas.15048. PMID: 34185931Free PMC Article
Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment.
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article
Acute myeloid leukaemia.
Khwaja A, Bjorkholm M, Gale RE, Levine RL, Jordan CT, Ehninger G, Bloomfield CD, Estey E, Burnett A, Cornelissen JJ, Scheinberg DA, Bouscary D, Linch DC
Nat Rev Dis Primers 2016 Mar 10;2:16010. doi: 10.1038/nrdp.2016.10. PMID: 27159408

Diagnosis

Real-World Validation of Molecular International Prognostic Scoring System for Myelodysplastic Syndromes.
Sauta E, Robin M, Bersanelli M, Travaglino E, Meggendorfer M, Zhao LP, Caballero Berrocal JC, Sala C, Maggioni G, Bernardi M, Di Grazia C, Vago L, Rivoli G, Borin L, D'Amico S, Tentori CA, Ubezio M, Campagna A, Russo A, Mannina D, Lanino L, Chiusolo P, Giaccone L, Voso MT, Riva M, Oliva EN, Zampini M, Riva E, Nibourel O, Bicchieri M, Bolli N, Rambaldi A, Passamonti F, Savevski V, Santoro A, Germing U, Kordasti S, Santini V, Diez-Campelo M, Sanz G, Sole F, Kern W, Platzbecker U, Ades L, Fenaux P, Haferlach T, Castellani G, Della Porta MG
J Clin Oncol 2023 May 20;41(15):2827-2842. Epub 2023 Mar 17 doi: 10.1200/JCO.22.01784. PMID: 36930857Free PMC Article
Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment.
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article
Clinical significance of somatic mutation in unexplained blood cytopenia.
Malcovati L, Gallì A, Travaglino E, Ambaglio I, Rizzo E, Molteni E, Elena C, Ferretti VV, Catricalà S, Bono E, Todisco G, Bianchessi A, Rumi E, Zibellini S, Pietra D, Boveri E, Camaschella C, Toniolo D, Papaemmanuil E, Ogawa S, Cazzola M
Blood 2017 Jun 22;129(25):3371-3378. Epub 2017 Apr 19 doi: 10.1182/blood-2017-01-763425. PMID: 28424163Free PMC Article
Therapy-related myeloid neoplasms.
Ganser A, Heuser M
Curr Opin Hematol 2017 Mar;24(2):152-158. doi: 10.1097/MOH.0000000000000316. PMID: 27930389
Acute myeloid leukaemia.
Khwaja A, Bjorkholm M, Gale RE, Levine RL, Jordan CT, Ehninger G, Bloomfield CD, Estey E, Burnett A, Cornelissen JJ, Scheinberg DA, Bouscary D, Linch DC
Nat Rev Dis Primers 2016 Mar 10;2:16010. doi: 10.1038/nrdp.2016.10. PMID: 27159408

Therapy

Niraparib first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer: final overall survival results from the PRIMA/ENGOT-OV26/GOG-3012 trial.
Monk BJ, Barretina-Ginesta MP, Pothuri B, Vergote I, Graybill W, Mirza MR, McCormick CC, Lorusso D, Moore RG, Freyer G, O'Cearbhaill RE, Heitz F, O'Malley DM, Redondo A, Shahin MS, Vulsteke C, Bradley WH, Haslund CA, Chase DM, Pisano C, Holman LL, Pérez MJR, DiSilvestro P, Gaba L, Herzog TJ, Bruchim I, Compton N, Shtessel L, Malinowska IA, González-Martín A
Ann Oncol 2024 Nov;35(11):981-992. Epub 2024 Sep 14 doi: 10.1016/j.annonc.2024.08.2241. PMID: 39284381
How I reduce and treat posttransplant relapse of MDS.
Mina A, Greenberg PL, Deeg HJ
Blood 2024 Apr 4;143(14):1344-1354. doi: 10.1182/blood.2023023005. PMID: 38306658Free PMC Article
Low-dose decitabine plus venetoclax is safe and effective as post-transplant maintenance therapy for high-risk acute myeloid leukemia and myelodysplastic syndrome.
Wei Y, Xiong X, Li X, Lu W, He X, Jin X, Sun R, Lyu H, Yuan T, Sun T, Zhao M
Cancer Sci 2021 Sep;112(9):3636-3644. Epub 2021 Jul 21 doi: 10.1111/cas.15048. PMID: 34185931Free PMC Article
10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial.
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Immunological effects of hypomethylating agents.
Lindblad KE, Goswami M, Hourigan CS, Oetjen KA
Expert Rev Hematol 2017 Aug;10(8):745-752. Epub 2017 Jul 3 doi: 10.1080/17474086.2017.1346470. PMID: 28644756Free PMC Article

Prognosis

Niraparib first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer: final overall survival results from the PRIMA/ENGOT-OV26/GOG-3012 trial.
Monk BJ, Barretina-Ginesta MP, Pothuri B, Vergote I, Graybill W, Mirza MR, McCormick CC, Lorusso D, Moore RG, Freyer G, O'Cearbhaill RE, Heitz F, O'Malley DM, Redondo A, Shahin MS, Vulsteke C, Bradley WH, Haslund CA, Chase DM, Pisano C, Holman LL, Pérez MJR, DiSilvestro P, Gaba L, Herzog TJ, Bruchim I, Compton N, Shtessel L, Malinowska IA, González-Martín A
Ann Oncol 2024 Nov;35(11):981-992. Epub 2024 Sep 14 doi: 10.1016/j.annonc.2024.08.2241. PMID: 39284381
Real-World Validation of Molecular International Prognostic Scoring System for Myelodysplastic Syndromes.
Sauta E, Robin M, Bersanelli M, Travaglino E, Meggendorfer M, Zhao LP, Caballero Berrocal JC, Sala C, Maggioni G, Bernardi M, Di Grazia C, Vago L, Rivoli G, Borin L, D'Amico S, Tentori CA, Ubezio M, Campagna A, Russo A, Mannina D, Lanino L, Chiusolo P, Giaccone L, Voso MT, Riva M, Oliva EN, Zampini M, Riva E, Nibourel O, Bicchieri M, Bolli N, Rambaldi A, Passamonti F, Savevski V, Santoro A, Germing U, Kordasti S, Santini V, Diez-Campelo M, Sanz G, Sole F, Kern W, Platzbecker U, Ades L, Fenaux P, Haferlach T, Castellani G, Della Porta MG
J Clin Oncol 2023 May 20;41(15):2827-2842. Epub 2023 Mar 17 doi: 10.1200/JCO.22.01784. PMID: 36930857Free PMC Article
Low-dose decitabine plus venetoclax is safe and effective as post-transplant maintenance therapy for high-risk acute myeloid leukemia and myelodysplastic syndrome.
Wei Y, Xiong X, Li X, Lu W, He X, Jin X, Sun R, Lyu H, Yuan T, Sun T, Zhao M
Cancer Sci 2021 Sep;112(9):3636-3644. Epub 2021 Jul 21 doi: 10.1111/cas.15048. PMID: 34185931Free PMC Article
Clinical significance of somatic mutation in unexplained blood cytopenia.
Malcovati L, Gallì A, Travaglino E, Ambaglio I, Rizzo E, Molteni E, Elena C, Ferretti VV, Catricalà S, Bono E, Todisco G, Bianchessi A, Rumi E, Zibellini S, Pietra D, Boveri E, Camaschella C, Toniolo D, Papaemmanuil E, Ogawa S, Cazzola M
Blood 2017 Jun 22;129(25):3371-3378. Epub 2017 Apr 19 doi: 10.1182/blood-2017-01-763425. PMID: 28424163Free PMC Article
Therapy-related myeloid neoplasms.
Ganser A, Heuser M
Curr Opin Hematol 2017 Mar;24(2):152-158. doi: 10.1097/MOH.0000000000000316. PMID: 27930389

Clinical prediction guides

Niraparib first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer: final overall survival results from the PRIMA/ENGOT-OV26/GOG-3012 trial.
Monk BJ, Barretina-Ginesta MP, Pothuri B, Vergote I, Graybill W, Mirza MR, McCormick CC, Lorusso D, Moore RG, Freyer G, O'Cearbhaill RE, Heitz F, O'Malley DM, Redondo A, Shahin MS, Vulsteke C, Bradley WH, Haslund CA, Chase DM, Pisano C, Holman LL, Pérez MJR, DiSilvestro P, Gaba L, Herzog TJ, Bruchim I, Compton N, Shtessel L, Malinowska IA, González-Martín A
Ann Oncol 2024 Nov;35(11):981-992. Epub 2024 Sep 14 doi: 10.1016/j.annonc.2024.08.2241. PMID: 39284381
Real-World Validation of Molecular International Prognostic Scoring System for Myelodysplastic Syndromes.
Sauta E, Robin M, Bersanelli M, Travaglino E, Meggendorfer M, Zhao LP, Caballero Berrocal JC, Sala C, Maggioni G, Bernardi M, Di Grazia C, Vago L, Rivoli G, Borin L, D'Amico S, Tentori CA, Ubezio M, Campagna A, Russo A, Mannina D, Lanino L, Chiusolo P, Giaccone L, Voso MT, Riva M, Oliva EN, Zampini M, Riva E, Nibourel O, Bicchieri M, Bolli N, Rambaldi A, Passamonti F, Savevski V, Santoro A, Germing U, Kordasti S, Santini V, Diez-Campelo M, Sanz G, Sole F, Kern W, Platzbecker U, Ades L, Fenaux P, Haferlach T, Castellani G, Della Porta MG
J Clin Oncol 2023 May 20;41(15):2827-2842. Epub 2023 Mar 17 doi: 10.1200/JCO.22.01784. PMID: 36930857Free PMC Article
Low-dose decitabine plus venetoclax is safe and effective as post-transplant maintenance therapy for high-risk acute myeloid leukemia and myelodysplastic syndrome.
Wei Y, Xiong X, Li X, Lu W, He X, Jin X, Sun R, Lyu H, Yuan T, Sun T, Zhao M
Cancer Sci 2021 Sep;112(9):3636-3644. Epub 2021 Jul 21 doi: 10.1111/cas.15048. PMID: 34185931Free PMC Article
Immunological effects of hypomethylating agents.
Lindblad KE, Goswami M, Hourigan CS, Oetjen KA
Expert Rev Hematol 2017 Aug;10(8):745-752. Epub 2017 Jul 3 doi: 10.1080/17474086.2017.1346470. PMID: 28644756Free PMC Article
Clinical significance of somatic mutation in unexplained blood cytopenia.
Malcovati L, Gallì A, Travaglino E, Ambaglio I, Rizzo E, Molteni E, Elena C, Ferretti VV, Catricalà S, Bono E, Todisco G, Bianchessi A, Rumi E, Zibellini S, Pietra D, Boveri E, Camaschella C, Toniolo D, Papaemmanuil E, Ogawa S, Cazzola M
Blood 2017 Jun 22;129(25):3371-3378. Epub 2017 Apr 19 doi: 10.1182/blood-2017-01-763425. PMID: 28424163Free PMC Article

Recent systematic reviews

Long-term effects of hematopoietic growth factors in aplastic anemia patients treated with immunosuppression: Meta-analysis of randomized controlled trials.
Wang A, Su D, Luo J, Fu Y, Li Q, Chen S
Medicine (Baltimore) 2022 Oct 21;101(42):e31103. doi: 10.1097/MD.0000000000031103. PMID: 36281138Free PMC Article
Effects of all-trans retinoic acid (ATRA) in addition to chemotherapy for adults with acute myeloid leukaemia (AML) (non-acute promyelocytic leukaemia (non-APL)).
Küley-Bagheri Y, Kreuzer KA, Monsef I, Lübbert M, Skoetz N
Cochrane Database Syst Rev 2018 Aug 6;8(8):CD011960. doi: 10.1002/14651858.CD011960.pub2. PMID: 30080246Free PMC Article
Eculizumab for treating patients with paroxysmal nocturnal hemoglobinuria.
Martí-Carvajal AJ, Anand V, Cardona AF, Solà I
Cochrane Database Syst Rev 2014 Oct 30;(10):CD010340. doi: 10.1002/14651858.CD010340.pub2. PMID: 25356860
High-dose therapy with autologous stem cell transplantation versus chemotherapy or immuno-chemotherapy for follicular lymphoma in adults.
Schaaf M, Reiser M, Borchmann P, Engert A, Skoetz N
Cochrane Database Syst Rev 2012 Jan 18;1:CD007678. doi: 10.1002/14651858.CD007678.pub2. PMID: 22258971

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