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High Risk Myelodysplastic Syndrome

MedGen UID:
1623190
Concept ID:
C4528176
Neoplastic Process

Definition

Myelodysplastic syndrome with more than 4.5 to 6 points, according to the revised International Prognostic Scoring System (IPSS-R). [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Mei C, Ye L, Ren Y, Zhou X, Ma L, Xu G, Xu W, Lu C, Yang H, Luo Y, Jiang L, Lang W, Zhu H, Jin J, Tong H
Hematol Oncol 2023 Aug;41(3):546-554. Epub 2023 Jan 18 doi: 10.1002/hon.3112. PMID: 36516239
Gemici A, Ozkalemkas F, Dogu MH, Tekinalp A, Alacacioglu I, Guney T, Ince I, Geduk A, Cagliyan GA, Maral S, Serin I, Gunduz E, Karakus V, Bekoz HS, Eren R, Pinar IE, Gunes AK, Sargın FD, Sevindik OG
Clin Lymphoma Myeloma Leuk 2021 Aug;21(8):e686-e692. Epub 2021 Apr 20 doi: 10.1016/j.clml.2021.04.004. PMID: 34059487
Prébet T, Gore SD, Esterni B, Gardin C, Itzykson R, Thepot S, Dreyfus F, Rauzy OB, Recher C, Adès L, Quesnel B, Beach CL, Fenaux P, Vey N
J Clin Oncol 2011 Aug 20;29(24):3322-7. Epub 2011 Jul 25 doi: 10.1200/JCO.2011.35.8135. PMID: 21788559Free PMC Article

Recent clinical studies

Etiology

Watts JM, Baer MR, Yang J, Prebet T, Lee S, Schiller GJ, Dinner SN, Pigneux A, Montesinos P, Wang ES, Seiter KP, Wei AH, De Botton S, Arnan M, Donnellan W, Schwarer AP, Récher C, Jonas BA, Ferrell PB Jr, Marzac C, Kelly P, Sweeney J, Forsyth S, Guichard SM, Brevard J, Henrick P, Mohamed H, Cortes JE
Lancet Haematol 2023 Jan;10(1):e46-e58. Epub 2022 Nov 10 doi: 10.1016/S2352-3026(22)00292-7. PMID: 36370742
Lachowiez CA, Reville PK, Kantarjian H, Jabbour E, Borthakur G, Daver N, Loghavi S, Furudate K, Xiao L, Pierce S, Short NJ, Maiti A, Yilmaz M, Sasaki K, Takahashi K, Konopleva M, Pemmaraju N, Popat U, Shpall E, Garcia-Manero G, Ravandi F, DiNardo CD, Kadia TM
Lancet Haematol 2022 May;9(5):e350-e360. doi: 10.1016/S2352-3026(22)00076-X. PMID: 35483396Free PMC Article
Grob T, Al Hinai ASA, Sanders MA, Kavelaars FG, Rijken M, Gradowska PL, Biemond BJ, Breems DA, Maertens J, van Marwijk Kooy M, Pabst T, de Weerdt O, Ossenkoppele GJ, van de Loosdrecht AA, Huls GA, Cornelissen JJ, Beverloo HB, Löwenberg B, Jongen-Lavrencic M, Valk PJM
Blood 2022 Apr 14;139(15):2347-2354. doi: 10.1182/blood.2021014472. PMID: 35108372Free PMC Article
Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM
Lancet Haematol 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. PMID: 34329576Free PMC Article
Silverman LR, Demakos EP, Peterson BL, Kornblith AB, Holland JC, Odchimar-Reissig R, Stone RM, Nelson D, Powell BL, DeCastro CM, Ellerton J, Larson RA, Schiffer CA, Holland JF
J Clin Oncol 2002 May 15;20(10):2429-40. doi: 10.1200/JCO.2002.04.117. PMID: 12011120

Diagnosis

Holmes A, Wechsler B, Lynch D
S D Med 2023 Mar;76(3):112-115. PMID: 36898196
Lachowiez CA, Reville PK, Kantarjian H, Jabbour E, Borthakur G, Daver N, Loghavi S, Furudate K, Xiao L, Pierce S, Short NJ, Maiti A, Yilmaz M, Sasaki K, Takahashi K, Konopleva M, Pemmaraju N, Popat U, Shpall E, Garcia-Manero G, Ravandi F, DiNardo CD, Kadia TM
Lancet Haematol 2022 May;9(5):e350-e360. doi: 10.1016/S2352-3026(22)00076-X. PMID: 35483396Free PMC Article
Grob T, Al Hinai ASA, Sanders MA, Kavelaars FG, Rijken M, Gradowska PL, Biemond BJ, Breems DA, Maertens J, van Marwijk Kooy M, Pabst T, de Weerdt O, Ossenkoppele GJ, van de Loosdrecht AA, Huls GA, Cornelissen JJ, Beverloo HB, Löwenberg B, Jongen-Lavrencic M, Valk PJM
Blood 2022 Apr 14;139(15):2347-2354. doi: 10.1182/blood.2021014472. PMID: 35108372Free PMC Article
Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM
Lancet Haematol 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. PMID: 34329576Free PMC Article
Bose P, McCue D, Wurster S, Wiederhold NP, Konopleva M, Kadia TM, Borthakur G, Ravandi F, Masarova L, Takahashi K, Estrov Z, Yilmaz M, Daver N, Pemmaraju N, Naqvi K, Rausch CR, Marx KR, Qiao W, Huang X, Bivins CA, Pierce SA, Kantarjian HM, Kontoyiannis DP
Clin Infect Dis 2021 May 18;72(10):1755-1763. doi: 10.1093/cid/ciaa358. PMID: 32236406Free PMC Article

Therapy

Watts JM, Baer MR, Yang J, Prebet T, Lee S, Schiller GJ, Dinner SN, Pigneux A, Montesinos P, Wang ES, Seiter KP, Wei AH, De Botton S, Arnan M, Donnellan W, Schwarer AP, Récher C, Jonas BA, Ferrell PB Jr, Marzac C, Kelly P, Sweeney J, Forsyth S, Guichard SM, Brevard J, Henrick P, Mohamed H, Cortes JE
Lancet Haematol 2023 Jan;10(1):e46-e58. Epub 2022 Nov 10 doi: 10.1016/S2352-3026(22)00292-7. PMID: 36370742
Lachowiez CA, Reville PK, Kantarjian H, Jabbour E, Borthakur G, Daver N, Loghavi S, Furudate K, Xiao L, Pierce S, Short NJ, Maiti A, Yilmaz M, Sasaki K, Takahashi K, Konopleva M, Pemmaraju N, Popat U, Shpall E, Garcia-Manero G, Ravandi F, DiNardo CD, Kadia TM
Lancet Haematol 2022 May;9(5):e350-e360. doi: 10.1016/S2352-3026(22)00076-X. PMID: 35483396Free PMC Article
Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM
Lancet Haematol 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. PMID: 34329576Free PMC Article
Germing U, Schroeder T, Kaivers J, Kündgen A, Kobbe G, Gattermann N
Expert Rev Hematol 2019 Oct;12(10):893-908. Epub 2019 Jul 31 doi: 10.1080/17474086.2019.1647778. PMID: 31353975
Silverman LR, Demakos EP, Peterson BL, Kornblith AB, Holland JC, Odchimar-Reissig R, Stone RM, Nelson D, Powell BL, DeCastro CM, Ellerton J, Larson RA, Schiffer CA, Holland JF
J Clin Oncol 2002 May 15;20(10):2429-40. doi: 10.1200/JCO.2002.04.117. PMID: 12011120

Prognosis

Zavras PD, Sinanidis I, Tsakiroglou P, Karantanos T
Int J Mol Sci 2023 Mar 6;24(5) doi: 10.3390/ijms24055018. PMID: 36902450Free PMC Article
Grob T, Al Hinai ASA, Sanders MA, Kavelaars FG, Rijken M, Gradowska PL, Biemond BJ, Breems DA, Maertens J, van Marwijk Kooy M, Pabst T, de Weerdt O, Ossenkoppele GJ, van de Loosdrecht AA, Huls GA, Cornelissen JJ, Beverloo HB, Löwenberg B, Jongen-Lavrencic M, Valk PJM
Blood 2022 Apr 14;139(15):2347-2354. doi: 10.1182/blood.2021014472. PMID: 35108372Free PMC Article
Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM
Lancet Haematol 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. PMID: 34329576Free PMC Article
Bouchla A, Thomopoulos TP, Papageorgiou SG, Apostolopoulou C, Loucari C, Mpazani E, Pappa V
Epigenomics 2021 Jul;13(14):1129-1143. Epub 2021 Jul 22 doi: 10.2217/epi-2021-0124. PMID: 34291653
Germing U, Schroeder T, Kaivers J, Kündgen A, Kobbe G, Gattermann N
Expert Rev Hematol 2019 Oct;12(10):893-908. Epub 2019 Jul 31 doi: 10.1080/17474086.2019.1647778. PMID: 31353975

Clinical prediction guides

Zavras PD, Sinanidis I, Tsakiroglou P, Karantanos T
Int J Mol Sci 2023 Mar 6;24(5) doi: 10.3390/ijms24055018. PMID: 36902450Free PMC Article
Lachowiez CA, Reville PK, Kantarjian H, Jabbour E, Borthakur G, Daver N, Loghavi S, Furudate K, Xiao L, Pierce S, Short NJ, Maiti A, Yilmaz M, Sasaki K, Takahashi K, Konopleva M, Pemmaraju N, Popat U, Shpall E, Garcia-Manero G, Ravandi F, DiNardo CD, Kadia TM
Lancet Haematol 2022 May;9(5):e350-e360. doi: 10.1016/S2352-3026(22)00076-X. PMID: 35483396Free PMC Article
Grob T, Al Hinai ASA, Sanders MA, Kavelaars FG, Rijken M, Gradowska PL, Biemond BJ, Breems DA, Maertens J, van Marwijk Kooy M, Pabst T, de Weerdt O, Ossenkoppele GJ, van de Loosdrecht AA, Huls GA, Cornelissen JJ, Beverloo HB, Löwenberg B, Jongen-Lavrencic M, Valk PJM
Blood 2022 Apr 14;139(15):2347-2354. doi: 10.1182/blood.2021014472. PMID: 35108372Free PMC Article
Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM
Lancet Haematol 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. PMID: 34329576Free PMC Article
Germing U, Schroeder T, Kaivers J, Kündgen A, Kobbe G, Gattermann N
Expert Rev Hematol 2019 Oct;12(10):893-908. Epub 2019 Jul 31 doi: 10.1080/17474086.2019.1647778. PMID: 31353975

Recent systematic reviews

Kunacheewa C, Thongthang P, Ungprasert P, Utchariyaprasit E, Owattanapanich W
Hematology 2019 Dec;24(1):498-506. doi: 10.1080/16078454.2019.1631425. PMID: 31221030
Gurion R, Vidal L, Gafter-Gvili A, Belnik Y, Yeshurun M, Raanani P, Shpilberg O
Haematologica 2010 Feb;95(2):303-10. Epub 2009 Sep 22 doi: 10.3324/haematol.2009.010611. PMID: 19773261Free PMC Article

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