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Cardiomyocyte degeneration

MedGen UID:
1619769
•Concept ID:
C4531191
•
Finding
HPO: HP:0031332

Definition

Deterioration of cardiomyocyte characterized by abnormal features such as loss of myofilaments, occurrence of cellular sequestration, decreased mitochondrial sizes and cellular debris. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardiomyocyte degeneration

Professional guidelines

PubMed

Effect of a long-term treatment with a low-dose granulocyte colony-stimulating factor on post-infarction process in the heart.
Okada H, Takemura G, Li Y, Ohno T, Li L, Maruyama R, Esaki M, Miyata S, Kanamori H, Ogino A, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H
J Cell Mol Med 2008 Aug;12(4):1272-83. Epub 2008 Feb 24 doi: 10.1111/j.1582-4934.2008.00294.x. PMID: 18298650Free PMC Article

Recent clinical studies

Etiology

SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B.
Ye Y, Yang K, Liu H, Yu Y, Song M, Huang D, Lei J, Zhang Y, Liu Z, Chu Q, Fan Y, Zhang S, Jing Y, Esteban CR, Wang S, Belmonte JCI, Qu J, Zhang W, Liu GH
Nat Aging 2023 Oct;3(10):1269-1287. Epub 2023 Oct 2 doi: 10.1038/s43587-023-00486-y. PMID: 37783815
Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model.
Li C, Chen Y, Zhao Y, Lung DC, Ye Z, Song W, Liu FF, Cai JP, Wong WM, Yip CC, Chan JF, To KK, Sridhar S, Hung IF, Chu H, Kok KH, Jin DY, Zhang AJ, Yuen KY
Clin Infect Dis 2022 Jun 10;74(11):1933-1950. doi: 10.1093/cid/ciab707. PMID: 34406358Free PMC Article
Effect of Verapamil, an L-Type Calcium Channel Inhibitor, on Caveolin-3 Expression in Septic Mouse Hearts.
Rattis BAC, Freitas AC, Oliveira JF, Calandrini-Lima JLA, Figueiredo MJ, Soave DF, Ramos SG, Celes MRN
Oxid Med Cell Longev 2021;2021:6667074. Epub 2021 Apr 8 doi: 10.1155/2021/6667074. PMID: 33927797Free PMC Article
Structural remodelling during chronic atrial fibrillation: act of programmed cell survival.
Thijssen VL, Ausma J, Borgers M
Cardiovasc Res 2001 Oct;52(1):14-24. doi: 10.1016/s0008-6363(01)00367-4. PMID: 11557230
Myocyte degeneration and cell death in hibernating human myocardium.
Schwarz ER, Schaper J, vom Dahl J, Altehoefer C, Grohmann B, Schoendube F, Sheehan FH, Uebis R, Buell U, Messmer BJ, Schaper W, Hanrath P
J Am Coll Cardiol 1996 Jun;27(7):1577-85. doi: 10.1016/0735-1097(96)00059-9. PMID: 8636539

Diagnosis

Clinical significance of endomyocardial biopsy in conjunction with cardiac magnetic resonance imaging to predict left ventricular reverse remodeling in idiopathic dilated cardiomyopathy.
Ishii S, Inomata T, Fujita T, Iida Y, Ikeda Y, Nabeta T, Yanagisawa T, Naruke T, Mizutani T, Koitabashi T, Takeuchi I, Ako J
Heart Vessels 2016 Dec;31(12):1960-1968. Epub 2016 Feb 26 doi: 10.1007/s00380-016-0815-0. PMID: 26920939

Therapy

Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model.
Li C, Chen Y, Zhao Y, Lung DC, Ye Z, Song W, Liu FF, Cai JP, Wong WM, Yip CC, Chan JF, To KK, Sridhar S, Hung IF, Chu H, Kok KH, Jin DY, Zhang AJ, Yuen KY
Clin Infect Dis 2022 Jun 10;74(11):1933-1950. doi: 10.1093/cid/ciab707. PMID: 34406358Free PMC Article
Effect of Verapamil, an L-Type Calcium Channel Inhibitor, on Caveolin-3 Expression in Septic Mouse Hearts.
Rattis BAC, Freitas AC, Oliveira JF, Calandrini-Lima JLA, Figueiredo MJ, Soave DF, Ramos SG, Celes MRN
Oxid Med Cell Longev 2021;2021:6667074. Epub 2021 Apr 8 doi: 10.1155/2021/6667074. PMID: 33927797Free PMC Article
Selenium- and zinc-deficient cardiomyopathy in human intestinal malabsorption: preliminary results of selenium/zinc infusion.
Frustaci A, Sabbioni E, Fortaner S, Farina M, del Torchio R, Tafani M, Morgante E, Ciriolo MR, Russo MA, Chimenti C
Eur J Heart Fail 2012 Feb;14(2):202-10. Epub 2011 Dec 20 doi: 10.1093/eurjhf/hfr167. PMID: 22186680
Effect of a long-term treatment with a low-dose granulocyte colony-stimulating factor on post-infarction process in the heart.
Okada H, Takemura G, Li Y, Ohno T, Li L, Maruyama R, Esaki M, Miyata S, Kanamori H, Ogino A, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H
J Cell Mol Med 2008 Aug;12(4):1272-83. Epub 2008 Feb 24 doi: 10.1111/j.1582-4934.2008.00294.x. PMID: 18298650Free PMC Article
Carvedilol improves myocardial contractility compared with metoprolol in patients with chronic hibernating myocardium after revascularization.
Schwarz ER, Gupta R, Diep TP, Nowak B, Kostin S, Grohmann B, Uretsky BF, Schaper J
J Cardiovasc Pharmacol Ther 2005 Sep;10(3):181-90. doi: 10.1177/107424840501000306. PMID: 16211207

Prognosis

Clinical significance of endomyocardial biopsy in conjunction with cardiac magnetic resonance imaging to predict left ventricular reverse remodeling in idiopathic dilated cardiomyopathy.
Ishii S, Inomata T, Fujita T, Iida Y, Ikeda Y, Nabeta T, Yanagisawa T, Naruke T, Mizutani T, Koitabashi T, Takeuchi I, Ako J
Heart Vessels 2016 Dec;31(12):1960-1968. Epub 2016 Feb 26 doi: 10.1007/s00380-016-0815-0. PMID: 26920939
Myocardial inflammatory cell infiltrates in cases of dilated cardiomyopathy as a determinant of outcome following partial left ventriculectomy.
Kanzaki Y, Terasaki F, Okabe M, Hayashi T, Toko H, Shimomura H, Fujioka S, Kitaura Y, Kawamura K, Horii Y, Isomura T, Suma H
Jpn Circ J 2001 Sep;65(9):797-802. doi: 10.1253/jcj.65.797. PMID: 11548879

Clinical prediction guides

Clinical significance of endomyocardial biopsy in conjunction with cardiac magnetic resonance imaging to predict left ventricular reverse remodeling in idiopathic dilated cardiomyopathy.
Ishii S, Inomata T, Fujita T, Iida Y, Ikeda Y, Nabeta T, Yanagisawa T, Naruke T, Mizutani T, Koitabashi T, Takeuchi I, Ako J
Heart Vessels 2016 Dec;31(12):1960-1968. Epub 2016 Feb 26 doi: 10.1007/s00380-016-0815-0. PMID: 26920939
Carvedilol improves myocardial contractility compared with metoprolol in patients with chronic hibernating myocardium after revascularization.
Schwarz ER, Gupta R, Diep TP, Nowak B, Kostin S, Grohmann B, Uretsky BF, Schaper J
J Cardiovasc Pharmacol Ther 2005 Sep;10(3):181-90. doi: 10.1177/107424840501000306. PMID: 16211207
Autophagic degeneration as a possible mechanism of myocardial cell death in dilated cardiomyopathy.
Shimomura H, Terasaki F, Hayashi T, Kitaura Y, Isomura T, Suma H
Jpn Circ J 2001 Nov;65(11):965-8. doi: 10.1253/jcj.65.965. PMID: 11716248
Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice.
Honda H, Harada K, Komuro I, Terasaki F, Ueno H, Tanaka Y, Kawamura K, Yazaki Y, Hirai H
Oncogene 1999 Jul 1;18(26):3821-30. doi: 10.1038/sj.onc.1202736. PMID: 10445845

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