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Abnormal mitral valve physiology

MedGen UID:
1624687
•Concept ID:
C4531094
•
Anatomical Abnormality
HPO: HP:0031481

Definition

Any functional anomaly of the mitral valve. [from HPO]

Professional guidelines

PubMed

The MAP3K7 gene: Further delineation of clinical characteristics and genotype/phenotype correlations.
van Woerden GM, Senden R, de Konink C, Trezza RA, Baban A, Bassetti JA, van Bever Y, Bird LM, van Bon BW, Brooks AS, Guan Q, Klee EW, Marcelis C, Rosado JM, Schimmenti LA, Shikany AR, Terhal PA, Nicole Weaver K, Wessels MW, van Wieringen H, Hurst AC, Gooch CF, Steindl K, Joset P, Rauch A, Tartaglia M, Niceta M, Elgersma Y, Demirdas S
Hum Mutat 2022 Oct;43(10):1377-1395. Epub 2022 Jul 29 doi: 10.1002/humu.24425. PMID: 35730652Free PMC Article
Floppy mitral valve/mitral valve prolapse: A complex entity with multiple genotypes and phenotypes.
Boudoulas KD, Pitsis AA, Mazzaferri EL, Gumina RJ, Triposkiadis F, Boudoulas H
Prog Cardiovasc Dis 2020 May-Jun;63(3):308-326. Epub 2020 Mar 19 doi: 10.1016/j.pcad.2020.03.004. PMID: 32201287
Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Whitlock RP, Sun JC, Fremes SE, Rubens FD, Teoh KH
Chest 2012 Feb;141(2 Suppl):e576S-e600S. doi: 10.1378/chest.11-2305. PMID: 22315272Free PMC Article

Recent clinical studies

Etiology

Accessory mitral valve tissue: anatomical and clinical perspectives.
Yetkin E, Cuglan B, Turhan H, Yalta K
Cardiovasc Pathol 2021 Jan-Feb;50:107277. Epub 2020 Aug 31 doi: 10.1016/j.carpath.2020.107277. PMID: 32882373
Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights.
Parwani P, Avierinos JF, Levine RA, Delling FN
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):361-369. Epub 2017 Nov 6 doi: 10.1016/j.pcad.2017.10.007. PMID: 29122631Free PMC Article
Mitral Annulus Calcification.
Abramowitz Y, Jilaihawi H, Chakravarty T, Mack MJ, Makkar RR
J Am Coll Cardiol 2015 Oct 27;66(17):1934-41. doi: 10.1016/j.jacc.2015.08.872. PMID: 26493666
Mitral regurgitation.
Ahmed MI, McGiffin DC, O'Rourke RA, Dell'Italia LJ
Curr Probl Cardiol 2009 Mar;34(3):93-136. doi: 10.1016/j.cpcardiol.2008.11.002. PMID: 19232244

Diagnosis

Accessory mitral valve tissue: anatomical and clinical perspectives.
Yetkin E, Cuglan B, Turhan H, Yalta K
Cardiovasc Pathol 2021 Jan-Feb;50:107277. Epub 2020 Aug 31 doi: 10.1016/j.carpath.2020.107277. PMID: 32882373
Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights.
Parwani P, Avierinos JF, Levine RA, Delling FN
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):361-369. Epub 2017 Nov 6 doi: 10.1016/j.pcad.2017.10.007. PMID: 29122631Free PMC Article
Mitral Annulus Calcification.
Abramowitz Y, Jilaihawi H, Chakravarty T, Mack MJ, Makkar RR
J Am Coll Cardiol 2015 Oct 27;66(17):1934-41. doi: 10.1016/j.jacc.2015.08.872. PMID: 26493666
Mitral regurgitation.
Ahmed MI, McGiffin DC, O'Rourke RA, Dell'Italia LJ
Curr Probl Cardiol 2009 Mar;34(3):93-136. doi: 10.1016/j.cpcardiol.2008.11.002. PMID: 19232244

Therapy

Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
How to follow patients with mitral and aortic valve disease.
Carabello B
Med Clin North Am 2015 Jul;99(4):739-57. Epub 2015 Apr 18 doi: 10.1016/j.mcna.2015.02.005. PMID: 26042880
Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Whitlock RP, Sun JC, Fremes SE, Rubens FD, Teoh KH
Chest 2012 Feb;141(2 Suppl):e576S-e600S. doi: 10.1378/chest.11-2305. PMID: 22315272Free PMC Article
Mitral regurgitation.
Ahmed MI, McGiffin DC, O'Rourke RA, Dell'Italia LJ
Curr Probl Cardiol 2009 Mar;34(3):93-136. doi: 10.1016/j.cpcardiol.2008.11.002. PMID: 19232244
Idiopathic ventricular tachycardia.
Altemose GT, Buxton AE
Annu Rev Med 1999;50:159-77. doi: 10.1146/annurev.med.50.1.159. PMID: 10073270

Prognosis

Accessory mitral valve tissue: anatomical and clinical perspectives.
Yetkin E, Cuglan B, Turhan H, Yalta K
Cardiovasc Pathol 2021 Jan-Feb;50:107277. Epub 2020 Aug 31 doi: 10.1016/j.carpath.2020.107277. PMID: 32882373
Atrial functional mitral regurgitation.
Hoit BD
Curr Opin Cardiol 2020 Sep;35(5):474-481. doi: 10.1097/HCO.0000000000000761. PMID: 32649349
Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights.
Parwani P, Avierinos JF, Levine RA, Delling FN
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):361-369. Epub 2017 Nov 6 doi: 10.1016/j.pcad.2017.10.007. PMID: 29122631Free PMC Article
STRUCTURAL HEART ANOMALIES (REVIEW).
Osovska N, Kuzminova N, Ovcharuk M, Serhiychuk O
Georgian Med News 2016 Jun;(255):66-77. PMID: 27441539

Clinical prediction guides

Accessory mitral valve tissue: anatomical and clinical perspectives.
Yetkin E, Cuglan B, Turhan H, Yalta K
Cardiovasc Pathol 2021 Jan-Feb;50:107277. Epub 2020 Aug 31 doi: 10.1016/j.carpath.2020.107277. PMID: 32882373
Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Assessment of the severity of native mitral valve regurgitation.
El-Tallawi KC, Messika-Zeitoun D, Zoghbi WA
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):322-333. Epub 2017 Nov 22 doi: 10.1016/j.pcad.2017.11.005. PMID: 29174559
Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights.
Parwani P, Avierinos JF, Levine RA, Delling FN
Prog Cardiovasc Dis 2017 Nov-Dec;60(3):361-369. Epub 2017 Nov 6 doi: 10.1016/j.pcad.2017.10.007. PMID: 29122631Free PMC Article
Mechanical dyssynchrony and functional mitral regurgitation: pathophysiology and clinical implications.
Agricola E, Galderisi M, Mele D, Ansalone G, Dini FL, Di Salvo G, Gallina S, Montisci R, Sciomer S, Di Bello V, Mondillo S, Marino PN; Echocardiographic Study Group of the Italian Society of Cardiology
J Cardiovasc Med (Hagerstown) 2008 May;9(5):461-9. doi: 10.2459/JCM.0b013e3282ef39c5. PMID: 18403997

Recent systematic reviews

Clinical features and complications of Loeys-Dietz syndrome: A systematic review.
Gouda P, Kay R, Habib M, Aziz A, Aziza E, Welsh R
Int J Cardiol 2022 Sep 1;362:158-167. Epub 2022 Jun 1 doi: 10.1016/j.ijcard.2022.05.065. PMID: 35662564
Mitral valve prolapse and sudden cardiac death: a systematic review and meta-analysis.
Nalliah CJ, Mahajan R, Elliott AD, Haqqani H, Lau DH, Vohra JK, Morton JB, Semsarian C, Marwick T, Kalman JM, Sanders P
Heart 2019 Jan;105(2):144-151. Epub 2018 Sep 21 doi: 10.1136/heartjnl-2017-312932. PMID: 30242141
Genomic analysis in patients with myxomatous mitral valve prolapse: current state of knowledge.
Gasser S, Reichenspurner H, Girdauskas E
BMC Cardiovasc Disord 2018 Feb 27;18(1):41. doi: 10.1186/s12872-018-0755-y. PMID: 29486707Free PMC Article
Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis.
Familiari A, Morlando M, Khalil A, Sonesson SE, Scala C, Rizzo G, Del Sordo G, Vassallo C, Elena Flacco M, Manzoli L, Lanzone A, Scambia G, Acharya G, D'Antonio F
Circulation 2017 Feb 21;135(8):772-785. Epub 2016 Dec 29 doi: 10.1161/CIRCULATIONAHA.116.024068. PMID: 28034902

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