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Recurrent B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

MedGen UID:
1626864
•Concept ID:
C4525406
•
Neoplastic Process
Synonyms: Recurrent B Acute Lymphoblastic Leukemia with BCR-ABL1-Like Features; Recurrent B Acute Lymphoblastic Leukemia with BCR::ABL1-Like Features; Recurrent B Acute Lymphoblastic Leukemia, BCR::ABL1-Like; Recurrent B-Acute Lymphoblastic Leukemia, BCR-ABL1-Like; Recurrent B-Acute Lymphoblastic Leukemia, BCR::ABL1-Like; Recurrent Ph-Like Acute Lymphoblastic Leukemia

Definition

The reemergence of B-acute lymphoblastic leukemia, BCR-ABL1-like after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent B Acute Lymphoblastic Leukemia, BCR-ABL1-Like

Recent clinical studies

Etiology

Mucin 4 protein is expressed in B-acute lymphoblastic leukemia and is restricted to BCR::ABL1-positive and BCR::ABL-like subtypes.
Gestrich CK, De Lancy SJ, Kresak A, Sinno MG, Yalley A, Pateva I, Meyerson H, Shetty S, Oduro KA Jr
Hum Pathol 2023 Jun;136:75-83. Epub 2023 Apr 5 doi: 10.1016/j.humpath.2023.03.018. PMID: 37023866
Clinico-hematological and Outcome Profile of Pediatric B-other-ALL and BCR::ABL1-like pre-B-ALL: An Integrated Genomic Study From North India.
Peyam S, Bhatia P, Singh M, Sharma P, Sreedharanunni S, Sachdeva MS, Naseem S, Bansal D, Varma N, Thakur R, Trehan A
Clin Lymphoma Myeloma Leuk 2022 Aug;22(8):e667-e679. Epub 2022 Mar 19 doi: 10.1016/j.clml.2022.03.007. PMID: 35484080
Clinical application of whole transcriptome sequencing for the classification of patients with acute lymphoblastic leukemia.
Walter W, Shahswar R, Stengel A, Meggendorfer M, Kern W, Haferlach T, Haferlach C
BMC Cancer 2021 Aug 2;21(1):886. doi: 10.1186/s12885-021-08635-5. PMID: 34340673Free PMC Article
Have any strategies in Ph-like ALL been shown to be effective?
Aldoss I, Advani AS
Best Pract Res Clin Haematol 2021 Mar;34(1):101242. Epub 2021 Jan 11 doi: 10.1016/j.beha.2021.101242. PMID: 33762097
Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort.
Zaliova M, Stuchly J, Winkowska L, Musilova A, Fiser K, Slamova M, Starkova J, Vaskova M, Hrusak O, Sramkova L, Stary J, Zuna J, Trka J
Haematologica 2019 Jul;104(7):1396-1406. Epub 2019 Jan 10 doi: 10.3324/haematol.2018.204974. PMID: 30630978Free PMC Article

Diagnosis

IGJ and SPATS2L immunohistochemistry sensitively and specifically identify BCR::ABL1+ and BCR::ABL1-like B-acute lymphoblastic leukaemia.
Gestrich CK, De Lancy SJ, Kresak A, Meyerson H, Pateva I, Yalley AK, Ryder C, Shetty S, Bledsoe J, Moore EM, Oduro KA Jr
Br J Haematol 2024 Jan;204(1):229-239. Epub 2023 Oct 23 doi: 10.1111/bjh.19142. PMID: 37871900
'Evaluation of adverse prognostic gene alterations & MRD positivity in BCR::ABL1-like B-lineage acute lymphoblastic leukaemia patients, in a resource-constrained setting.
Gupta DG, Varma N, Sreedharanunni S, Abdulkadir SA, Naseem S, Sachdeva MUS, Binota J, Bose P, Malhotra P, Khadwal A, Varma S
Br J Cancer 2023 Jul;129(1):143-152. Epub 2023 May 8 doi: 10.1038/s41416-023-02294-y. PMID: 37156894Free PMC Article
Genetics and Diagnostic Approach to Lymphoblastic Leukemia/Lymphoma.
Afkhami M, Ally F, Pullarkat V, Pillai RK
Cancer Treat Res 2021;181:17-43. doi: 10.1007/978-3-030-78311-2_2. PMID: 34626353
Have any strategies in Ph-like ALL been shown to be effective?
Aldoss I, Advani AS
Best Pract Res Clin Haematol 2021 Mar;34(1):101242. Epub 2021 Jan 11 doi: 10.1016/j.beha.2021.101242. PMID: 33762097
Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort.
Zaliova M, Stuchly J, Winkowska L, Musilova A, Fiser K, Slamova M, Starkova J, Vaskova M, Hrusak O, Sramkova L, Stary J, Zuna J, Trka J
Haematologica 2019 Jul;104(7):1396-1406. Epub 2019 Jan 10 doi: 10.3324/haematol.2018.204974. PMID: 30630978Free PMC Article

Therapy

Case Report: Specific ABL-Inhibitor Imatinib Is an Effective Targeted Agent as the First Line Therapy to Treat B-Cell Acute Lymphoblastic Leukemia With a Cryptic NUP214::ABL1 Gene Fusion.
Stukaite-Ruibiene E, Norvilas R, Dirse V, Stankeviciene S, Vaitkeviciene GE
Pathol Oncol Res 2022;28:1610570. Epub 2022 Sep 12 doi: 10.3389/pore.2022.1610570. PMID: 36172171Free PMC Article
Chemotherapy Resistance in B-ALL with Cryptic NUP214-ABL1 Is Amenable to Kinase Inhibition and Immunotherapy.
Nardi V, McAfee SL, Dal Cin P, Tsai HK, Amrein PC, Hobbs GS, Brunner AM, Narayan R, Foster J, Fathi AT, Hock H
Oncologist 2022 Mar 4;27(2):82-86. doi: 10.1093/oncolo/oyab052. PMID: 35641210Free PMC Article
Beneficial tyrosine kinase inhibitor therapy in a patient with relapsed BCR-ABL1-like acute lymphoblastic leukemia with CCDC88C-PDGFRB fusion.
Oya S, Morishige S, Ozawa H, Sasaki K, Semba Y, Yamasaki Y, Nakamura T, Aoyama K, Seki R, Mouri F, Osaki K, Miyamoto T, Maeda T, Nagafuji K
Int J Hematol 2021 Feb;113(2):285-289. Epub 2020 Sep 19 doi: 10.1007/s12185-020-03006-5. PMID: 32951102
Successful Use of Nilotinib in the Therapy of a Patient with a Chemoresistant Relapse of BCR-ABL1-Like Phenotype Acute Lymphoblastic Leukemia.
Piekarska A, Sadowska-Klasa A, Libura M, Karabin K, Hellmann A
Oncol Res Treat 2018;41(9):550-553. Epub 2018 Aug 20 doi: 10.1159/000490121. PMID: 30121665
Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features.
Schwab CJ, Chilton L, Morrison H, Jones L, Al-Shehhi H, Erhorn A, Russell LJ, Moorman AV, Harrison CJ
Haematologica 2013 Jul;98(7):1081-8. Epub 2013 Mar 18 doi: 10.3324/haematol.2013.085175. PMID: 23508010Free PMC Article

Prognosis

IGJ and SPATS2L immunohistochemistry sensitively and specifically identify BCR::ABL1+ and BCR::ABL1-like B-acute lymphoblastic leukaemia.
Gestrich CK, De Lancy SJ, Kresak A, Meyerson H, Pateva I, Yalley AK, Ryder C, Shetty S, Bledsoe J, Moore EM, Oduro KA Jr
Br J Haematol 2024 Jan;204(1):229-239. Epub 2023 Oct 23 doi: 10.1111/bjh.19142. PMID: 37871900
'Evaluation of adverse prognostic gene alterations & MRD positivity in BCR::ABL1-like B-lineage acute lymphoblastic leukaemia patients, in a resource-constrained setting.
Gupta DG, Varma N, Sreedharanunni S, Abdulkadir SA, Naseem S, Sachdeva MUS, Binota J, Bose P, Malhotra P, Khadwal A, Varma S
Br J Cancer 2023 Jul;129(1):143-152. Epub 2023 May 8 doi: 10.1038/s41416-023-02294-y. PMID: 37156894Free PMC Article
Genetics and Diagnostic Approach to Lymphoblastic Leukemia/Lymphoma.
Afkhami M, Ally F, Pullarkat V, Pillai RK
Cancer Treat Res 2021;181:17-43. doi: 10.1007/978-3-030-78311-2_2. PMID: 34626353
Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort.
Zaliova M, Stuchly J, Winkowska L, Musilova A, Fiser K, Slamova M, Starkova J, Vaskova M, Hrusak O, Sramkova L, Stary J, Zuna J, Trka J
Haematologica 2019 Jul;104(7):1396-1406. Epub 2019 Jan 10 doi: 10.3324/haematol.2018.204974. PMID: 30630978Free PMC Article
Rapid identification of BCR/ABL1-like acute lymphoblastic leukaemia patients using a predictive statistical model based on quantitative real time-polymerase chain reaction: clinical, prognostic and therapeutic implications.
Chiaretti S, Messina M, Grammatico S, Piciocchi A, Fedullo AL, Di Giacomo F, Peragine N, Gianfelici V, Lauretti A, Bareja R, Martelli MP, Vignetti M, Apicella V, Vitale A, Li LS, Salek C, Elemento O, Inghirami G, Weinstock DM, Guarini A, Foà R
Br J Haematol 2018 Jun;181(5):642-652. Epub 2018 Apr 19 doi: 10.1111/bjh.15251. PMID: 29675955Free PMC Article

Clinical prediction guides

IGJ and SPATS2L immunohistochemistry sensitively and specifically identify BCR::ABL1+ and BCR::ABL1-like B-acute lymphoblastic leukaemia.
Gestrich CK, De Lancy SJ, Kresak A, Meyerson H, Pateva I, Yalley AK, Ryder C, Shetty S, Bledsoe J, Moore EM, Oduro KA Jr
Br J Haematol 2024 Jan;204(1):229-239. Epub 2023 Oct 23 doi: 10.1111/bjh.19142. PMID: 37871900
Have any strategies in Ph-like ALL been shown to be effective?
Aldoss I, Advani AS
Best Pract Res Clin Haematol 2021 Mar;34(1):101242. Epub 2021 Jan 11 doi: 10.1016/j.beha.2021.101242. PMID: 33762097
Detection of a cryptic NUP214/ABL1 gene fusion by mate-pair sequencing (MPseq) in a newly diagnosed case of pediatric T-lymphoblastic leukemia.
Peterson JF, Pitel BA, Smoley SA, Smadbeck JB, Johnson SH, Vasmatzis G, Koon SJ, Webley MR, McGrath M, Bayerl MG, Baughn LB, Rowsey RA, Ketterling RP, Greipp PT, Hoppman NL
Cold Spring Harb Mol Case Stud 2019 Apr;5(2) Epub 2019 Apr 1 doi: 10.1101/mcs.a003533. PMID: 30936193Free PMC Article
Rapid identification of BCR/ABL1-like acute lymphoblastic leukaemia patients using a predictive statistical model based on quantitative real time-polymerase chain reaction: clinical, prognostic and therapeutic implications.
Chiaretti S, Messina M, Grammatico S, Piciocchi A, Fedullo AL, Di Giacomo F, Peragine N, Gianfelici V, Lauretti A, Bareja R, Martelli MP, Vignetti M, Apicella V, Vitale A, Li LS, Salek C, Elemento O, Inghirami G, Weinstock DM, Guarini A, Foà R
Br J Haematol 2018 Jun;181(5):642-652. Epub 2018 Apr 19 doi: 10.1111/bjh.15251. PMID: 29675955Free PMC Article
Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.
van der Veer A, Waanders E, Pieters R, Willemse ME, Van Reijmersdal SV, Russell LJ, Harrison CJ, Evans WE, van der Velden VH, Hoogerbrugge PM, Van Leeuwen F, Escherich G, Horstmann MA, Mohammadi Khankahdani L, Rizopoulos D, De Groot-Kruseman HA, Sonneveld E, Kuiper RP, Den Boer ML
Blood 2013 Oct 10;122(15):2622-9. Epub 2013 Aug 23 doi: 10.1182/blood-2012-10-462358. PMID: 23974192Free PMC Article

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