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Aggravated Epilepsy

MedGen UID:
163113
•Concept ID:
C0852977
•
Disease or Syndrome

Definition

An increase in the duration or intensity of epileptic symptoms in the setting of chronic epilepsy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAggravated Epilepsy

Professional guidelines

PubMed

Angelman syndrome caused by deletion: a genotype-phenotype correlation determined by breakpoint.
Valente KD, Varela MC, Koiffmann CP, Andrade JQ, Grossmann R, Kok F, Marques-Dias MJ
Epilepsy Res 2013 Jul;105(1-2):234-9. Epub 2013 Jan 23 doi: 10.1016/j.eplepsyres.2012.12.005. PMID: 23352739

Recent clinical studies

Etiology

Successful treatment of adult Dravet syndrome patients with cenobamate.
Makridis KL, Friedo AL, Kellinghaus C, Losch FP, Schmitz B, Boßelmann C, Kaindl AM
Epilepsia 2022 Dec;63(12):e164-e171. Epub 2022 Oct 14 doi: 10.1111/epi.17427. PMID: 36176237
Update on pharmacotherapy of myoclonic seizures.
Striano P, Belcastro V
Expert Opin Pharmacother 2017 Feb;18(2):187-193. Epub 2017 Jan 23 doi: 10.1080/14656566.2017.1280459. PMID: 28067060
Pharmacotherapy for tonic-clonic seizures.
Rheims S, Ryvlin P
Expert Opin Pharmacother 2014 Jul;15(10):1417-26. Epub 2014 May 6 doi: 10.1517/14656566.2014.915029. PMID: 24798217
Reducing overtreatment.
Bourgeois BF
Epilepsy Res 2002 Nov;52(1):53-60. doi: 10.1016/s0920-1211(02)00185-7. PMID: 12445960
Menstruation: choosing whether...and when.
Kaunitz AM
Contraception 2000 Dec;62(6):277-84. doi: 10.1016/s0010-7824(00)00182-7. PMID: 11239613

Diagnosis

Migraine without aura.
Paemeleire K, Vandenbussche N, Stark R
Handb Clin Neurol 2023;198:151-167. doi: 10.1016/B978-0-12-823356-6.00007-X. PMID: 38043959
Genetic Background of Epilepsy and Antiepileptic Treatments.
Borowicz-Reutt K, Czernia J, Krawczyk M
Int J Mol Sci 2023 Nov 14;24(22) doi: 10.3390/ijms242216280. PMID: 38003469Free PMC Article
Genotypic and phenotypic characteristics of juvenile/adult onset vanishing white matter: a series of 14 Chinese patients.
Ren Y, Yu X, Chen B, Tang H, Niu S, Wang X, Pan H, Zhang Z
Neurol Sci 2022 Aug;43(8):4961-4977. Epub 2022 Apr 7 doi: 10.1007/s10072-022-06011-0. PMID: 35389136
Some treatments cause seizure aggravation in idiopathic epilepsies (especially absence epilepsy).
Somerville ER
Epilepsia 2009 Sep;50 Suppl 8:31-6. doi: 10.1111/j.1528-1167.2009.02233.x. PMID: 19702731
Aggravation of epilepsy by antiepileptic drugs.
Sazgar M, Bourgeois BF
Pediatr Neurol 2005 Oct;33(4):227-34. doi: 10.1016/j.pediatrneurol.2005.03.001. PMID: 16194719

Therapy

Update on pharmacotherapy of myoclonic seizures.
Striano P, Belcastro V
Expert Opin Pharmacother 2017 Feb;18(2):187-193. Epub 2017 Jan 23 doi: 10.1080/14656566.2017.1280459. PMID: 28067060
Pharmacotherapy for tonic-clonic seizures.
Rheims S, Ryvlin P
Expert Opin Pharmacother 2014 Jul;15(10):1417-26. Epub 2014 May 6 doi: 10.1517/14656566.2014.915029. PMID: 24798217
Treatment of juvenile myoclonic epilepsy.
Auvin S
CNS Neurosci Ther 2008 Fall;14(3):227-33. doi: 10.1111/j.1527-3458.2008.00046.x. PMID: 18684236Free PMC Article
Reducing overtreatment.
Bourgeois BF
Epilepsy Res 2002 Nov;52(1):53-60. doi: 10.1016/s0920-1211(02)00185-7. PMID: 12445960
Menstruation: choosing whether...and when.
Kaunitz AM
Contraception 2000 Dec;62(6):277-84. doi: 10.1016/s0010-7824(00)00182-7. PMID: 11239613

Prognosis

Genetic Background of Epilepsy and Antiepileptic Treatments.
Borowicz-Reutt K, Czernia J, Krawczyk M
Int J Mol Sci 2023 Nov 14;24(22) doi: 10.3390/ijms242216280. PMID: 38003469Free PMC Article
SCN1A-deficient excitatory neuronal networks display mutation-specific phenotypes.
van Hugte EJH, Lewerissa EI, Wu KM, Scheefhals N, Parodi G, van Voorst TW, Puvogel S, Kogo N, Keller JM, Frega M, Schubert D, Schelhaas HJ, Verhoeven J, Majoie M, van Bokhoven H, Nadif Kasri N
Brain 2023 Dec 1;146(12):5153-5167. doi: 10.1093/brain/awad245. PMID: 37467479Free PMC Article
Current role of rufinamide in the treatment of childhood epilepsy: literature review and treatment guidelines.
Coppola G, Besag F, Cusmai R, Dulac O, Kluger G, Moavero R, Nabbout R, Nikanorova M, Pisani F, Verrotti A, von Stülpnagel C, Curatolo P
Eur J Paediatr Neurol 2014 Nov;18(6):685-90. Epub 2014 May 28 doi: 10.1016/j.ejpn.2014.05.008. PMID: 24929673
The pharmacological treatment of depression in adults with epilepsy.
Mula M, Schmitz B, Sander JW
Expert Opin Pharmacother 2008 Dec;9(18):3159-68. doi: 10.1517/14656560802587024. PMID: 19040337
Aggravation of epilepsy by anti-epileptic drugs.
Gayatri NA, Livingston JH
Dev Med Child Neurol 2006 May;48(5):394-8. doi: 10.1017/S0012162206000843. PMID: 16608550

Clinical prediction guides

SCN1A-deficient excitatory neuronal networks display mutation-specific phenotypes.
van Hugte EJH, Lewerissa EI, Wu KM, Scheefhals N, Parodi G, van Voorst TW, Puvogel S, Kogo N, Keller JM, Frega M, Schubert D, Schelhaas HJ, Verhoeven J, Majoie M, van Bokhoven H, Nadif Kasri N
Brain 2023 Dec 1;146(12):5153-5167. doi: 10.1093/brain/awad245. PMID: 37467479Free PMC Article
Genotypic and phenotypic characteristics of juvenile/adult onset vanishing white matter: a series of 14 Chinese patients.
Ren Y, Yu X, Chen B, Tang H, Niu S, Wang X, Pan H, Zhang Z
Neurol Sci 2022 Aug;43(8):4961-4977. Epub 2022 Apr 7 doi: 10.1007/s10072-022-06011-0. PMID: 35389136
KCTD7-related progressive myoclonus epilepsy.
Van Bogaert P
Epileptic Disord 2016 Sep 1;18(S2):115-119. doi: 10.1684/epd.2016.0856. PMID: 27629772
Current role of rufinamide in the treatment of childhood epilepsy: literature review and treatment guidelines.
Coppola G, Besag F, Cusmai R, Dulac O, Kluger G, Moavero R, Nabbout R, Nikanorova M, Pisani F, Verrotti A, von Stülpnagel C, Curatolo P
Eur J Paediatr Neurol 2014 Nov;18(6):685-90. Epub 2014 May 28 doi: 10.1016/j.ejpn.2014.05.008. PMID: 24929673
Aggravation of epilepsy by anti-epileptic drugs.
Gayatri NA, Livingston JH
Dev Med Child Neurol 2006 May;48(5):394-8. doi: 10.1017/S0012162206000843. PMID: 16608550

Recent systematic reviews

Association of seizure with COVID-19 vaccines in persons with epilepsy: A systematic review and meta-analysis.
Rafati A, Jameie M, Amanollahi M, Jameie M, Pasebani Y, Sakhaei D, Ilkhani S, Rashedi S, Pasebani MY, Azadi M, Rahimlou M, Kwon CS
J Med Virol 2023 Sep;95(9):e29118. doi: 10.1002/jmv.29118. PMID: 37732629
Ketogenic diet, epilepsy and cognition: what do we know so far? A systematic review.
Lima MC, Gabiatti MP, Moreira JD, Ribeiro LC, Lunardi MDS, Lin K, Venske DK
Nutr Rev 2022 Sep 5;80(10):2064-2075. doi: 10.1093/nutrit/nuac021. PMID: 35535020
Vaccination and childhood epilepsies.
Craiu D, Rener Primec Z, Lagae L, Vigevano F, Trinka E, Specchio N, Bakhtadze S, Cazacu C, Golli T, Zuberi SM
Eur J Paediatr Neurol 2022 Jan;36:57-68. Epub 2021 Dec 3 doi: 10.1016/j.ejpn.2021.11.014. PMID: 34922162
Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis.
Liu X, Sun X, Sun C, Zou M, Chen Y, Huang J, Wu L, Chen WX
Autism 2022 Jan;26(1):33-50. Epub 2021 Sep 13 doi: 10.1177/13623613211045029. PMID: 34510916
Efficacy of lacosamide in children and adolescents with drug-resistant epilepsy and refractory status epilepticus: A systematic review.
Ortiz de la Rosa JS, Ladino LD, Rodríguez PJ, Rueda MC, Polanía JP, Castañeda AC
Seizure 2018 Mar;56:34-40. Epub 2018 Feb 8 doi: 10.1016/j.seizure.2018.01.014. PMID: 29428899

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