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Aggravated Epilepsy

MedGen UID:
163113
Concept ID:
C0852977
Disease or Syndrome

Definition

An increase in the duration or intensity of epileptic symptoms in the setting of chronic epilepsy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAggravated Epilepsy

Professional guidelines

PubMed

Valente KD, Varela MC, Koiffmann CP, Andrade JQ, Grossmann R, Kok F, Marques-Dias MJ
Epilepsy Res 2013 Jul;105(1-2):234-9. Epub 2013 Jan 23 doi: 10.1016/j.eplepsyres.2012.12.005. PMID: 23352739

Recent clinical studies

Etiology

Craiu D, Rener Primec Z, Lagae L, Vigevano F, Trinka E, Specchio N, Bakhtadze S, Cazacu C, Golli T, Zuberi SM
Eur J Paediatr Neurol 2022 Jan;36:57-68. Epub 2021 Dec 3 doi: 10.1016/j.ejpn.2021.11.014. PMID: 34922162
Verrotti A, Moavero R, Panzarino G, Di Paolantonio C, Rizzo R, Curatolo P
Clin Drug Investig 2018 Jan;38(1):1-8. doi: 10.1007/s40261-017-0585-1. PMID: 29071470
Pimentel J, Tojal R, Morgado J
Seizure 2015 Feb;25:87-94. Epub 2014 Oct 14 doi: 10.1016/j.seizure.2014.09.015. PMID: 25458104
Ryvlin P, Nashef L, Lhatoo SD, Bateman LM, Bird J, Bleasel A, Boon P, Crespel A, Dworetzky BA, Høgenhaven H, Lerche H, Maillard L, Malter MP, Marchal C, Murthy JM, Nitsche M, Pataraia E, Rabben T, Rheims S, Sadzot B, Schulze-Bonhage A, Seyal M, So EL, Spitz M, Szucs A, Tan M, Tao JX, Tomson T
Lancet Neurol 2013 Oct;12(10):966-77. Epub 2013 Sep 4 doi: 10.1016/S1474-4422(13)70214-X. PMID: 24012372
Chiron C, Duchowny M
Handb Clin Neurol 2013;111:727-39. doi: 10.1016/B978-0-444-52891-9.00075-0. PMID: 23622220

Diagnosis

Paemeleire K, Vandenbussche N, Stark R
Handb Clin Neurol 2023;198:151-167. doi: 10.1016/B978-0-12-823356-6.00007-X. PMID: 38043959
Borowicz-Reutt K, Czernia J, Krawczyk M
Int J Mol Sci 2023 Nov 14;24(22) doi: 10.3390/ijms242216280. PMID: 38003469Free PMC Article
Crunelli V, Lőrincz ML, McCafferty C, Lambert RC, Leresche N, Di Giovanni G, David F
Brain 2020 Aug 1;143(8):2341-2368. doi: 10.1093/brain/awaa072. PMID: 32437558Free PMC Article
Elger CE, Johnston SA, Hoppe C
Seizure 2017 Jan;44:184-193. Epub 2016 Oct 31 doi: 10.1016/j.seizure.2016.10.018. PMID: 27836391
Chiron C, Duchowny M
Handb Clin Neurol 2013;111:727-39. doi: 10.1016/B978-0-444-52891-9.00075-0. PMID: 23622220

Therapy

Borowicz-Reutt K, Czernia J, Krawczyk M
Int J Mol Sci 2023 Nov 14;24(22) doi: 10.3390/ijms242216280. PMID: 38003469Free PMC Article
Craiu D, Rener Primec Z, Lagae L, Vigevano F, Trinka E, Specchio N, Bakhtadze S, Cazacu C, Golli T, Zuberi SM
Eur J Paediatr Neurol 2022 Jan;36:57-68. Epub 2021 Dec 3 doi: 10.1016/j.ejpn.2021.11.014. PMID: 34922162
Soto-Mota A, Norwitz NG, Clarke K
Biochem Soc Trans 2020 Feb 28;48(1):51-59. doi: 10.1042/BST20190240. PMID: 32096539Free PMC Article
Verrotti A, Moavero R, Panzarino G, Di Paolantonio C, Rizzo R, Curatolo P
Clin Drug Investig 2018 Jan;38(1):1-8. doi: 10.1007/s40261-017-0585-1. PMID: 29071470
Chiron C, Duchowny M
Handb Clin Neurol 2013;111:727-39. doi: 10.1016/B978-0-444-52891-9.00075-0. PMID: 23622220

Prognosis

Borowicz-Reutt K, Czernia J, Krawczyk M
Int J Mol Sci 2023 Nov 14;24(22) doi: 10.3390/ijms242216280. PMID: 38003469Free PMC Article
Liu X, Sun X, Sun C, Zou M, Chen Y, Huang J, Wu L, Chen WX
Autism 2022 Jan;26(1):33-50. Epub 2021 Sep 13 doi: 10.1177/13623613211045029. PMID: 34510916
Nilo A, Gelisse P, Crespel A
Rev Neurol (Paris) 2020 Jun;176(6):427-438. Epub 2020 May 15 doi: 10.1016/j.neurol.2020.03.018. PMID: 32423603
De Liso P, Moavero R, Coppola G, Curatolo P, Cusmai R, De Sarro G, Franzoni E, Vigevano F, Verrotti A
Ital J Pediatr 2017 Jun 2;43(1):51. doi: 10.1186/s13052-017-0368-6. PMID: 28577562Free PMC Article
Ryvlin P, Nashef L, Lhatoo SD, Bateman LM, Bird J, Bleasel A, Boon P, Crespel A, Dworetzky BA, Høgenhaven H, Lerche H, Maillard L, Malter MP, Marchal C, Murthy JM, Nitsche M, Pataraia E, Rabben T, Rheims S, Sadzot B, Schulze-Bonhage A, Seyal M, So EL, Spitz M, Szucs A, Tan M, Tao JX, Tomson T
Lancet Neurol 2013 Oct;12(10):966-77. Epub 2013 Sep 4 doi: 10.1016/S1474-4422(13)70214-X. PMID: 24012372

Clinical prediction guides

van Hugte EJH, Lewerissa EI, Wu KM, Scheefhals N, Parodi G, van Voorst TW, Puvogel S, Kogo N, Keller JM, Frega M, Schubert D, Schelhaas HJ, Verhoeven J, Majoie M, van Bokhoven H, Nadif Kasri N
Brain 2023 Dec 1;146(12):5153-5167. doi: 10.1093/brain/awad245. PMID: 37467479Free PMC Article
Lima MC, Gabiatti MP, Moreira JD, Ribeiro LC, Lunardi MDS, Lin K, Venske DK
Nutr Rev 2022 Sep 5;80(10):2064-2075. doi: 10.1093/nutrit/nuac021. PMID: 35535020
Liu X, Sun X, Sun C, Zou M, Chen Y, Huang J, Wu L, Chen WX
Autism 2022 Jan;26(1):33-50. Epub 2021 Sep 13 doi: 10.1177/13623613211045029. PMID: 34510916
Kobayashi Y, Tohyama J, Takahashi Y, Goto T, Haginoya K, Inoue T, Kubota M, Fujita H, Honda R, Ito M, Kishimoto K, Nakamura K, Sakai Y, Takanashi JI, Tanaka M, Tanda K, Tominaga K, Yoshioka S, Kato M, Nakashima M, Saitsu H, Matsumoto N
Brain Dev 2021 Apr;43(4):505-514. Epub 2021 Jan 9 doi: 10.1016/j.braindev.2020.12.006. PMID: 33436160
Van Bogaert P
Epileptic Disord 2016 Sep 1;18(S2):115-119. doi: 10.1684/epd.2016.0856. PMID: 27629772

Recent systematic reviews

Lima MC, Gabiatti MP, Moreira JD, Ribeiro LC, Lunardi MDS, Lin K, Venske DK
Nutr Rev 2022 Sep 5;80(10):2064-2075. doi: 10.1093/nutrit/nuac021. PMID: 35535020
Craiu D, Rener Primec Z, Lagae L, Vigevano F, Trinka E, Specchio N, Bakhtadze S, Cazacu C, Golli T, Zuberi SM
Eur J Paediatr Neurol 2022 Jan;36:57-68. Epub 2021 Dec 3 doi: 10.1016/j.ejpn.2021.11.014. PMID: 34922162
Liu X, Sun X, Sun C, Zou M, Chen Y, Huang J, Wu L, Chen WX
Autism 2022 Jan;26(1):33-50. Epub 2021 Sep 13 doi: 10.1177/13623613211045029. PMID: 34510916
Muhigwa A, Preux PM, Gérard D, Marin B, Boumediène F, Ntamwira C, Tsai CH
Sci Rep 2020 Jun 2;10(1):9015. doi: 10.1038/s41598-020-65768-6. PMID: 32488109Free PMC Article
Ortiz de la Rosa JS, Ladino LD, Rodríguez PJ, Rueda MC, Polanía JP, Castañeda AC
Seizure 2018 Mar;56:34-40. Epub 2018 Feb 8 doi: 10.1016/j.seizure.2018.01.014. PMID: 29428899

Supplemental Content

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    Practice guidelines

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