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Post-Mastectomy Pain Syndrome

MedGen UID:
1631351
•Concept ID:
C4682758
•
Disease or Syndrome

Definition

Chronic pain following mastectomy or lumpectomy that usually affects the anterior thorax, axilla, and/or medial upper arm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPost-Mastectomy Pain Syndrome

Professional guidelines

PubMed

Interventional Treatment Options for Post-mastectomy Pain.
Murugappan A, Khanna A
Curr Oncol Rep 2023 Oct;25(10):1175-1179. Epub 2023 Aug 30 doi: 10.1007/s11912-023-01435-z. PMID: 37646901
Persistent Post-Mastectomy Pain: Risk Factors and Current Approaches to Treatment.
Tait RC, Zoberi K, Ferguson M, Levenhagen K, Luebbert RA, Rowland K, Salsich GB, Herndon C
J Pain 2018 Dec;19(12):1367-1383. Epub 2018 Jun 30 doi: 10.1016/j.jpain.2018.06.002. PMID: 29966772Free PMC Article
The Post-mastectomy Pain Syndrome-A Systematic Review of the Treatment Modalities.
Larsson IM, Ahm Sørensen J, Bille C
Breast J 2017 May;23(3):338-343. Epub 2017 Jan 30 doi: 10.1111/tbj.12739. PMID: 28133848

Recent clinical studies

Etiology

Exercise Therapy in Oncology.
Baumann FT, Jensen W, Berling-Ernst A, Theurich S, Leitzmann M, Götte M
Dtsch Arztebl Int 2024 May 17;121(10):331-337. doi: 10.3238/arztebl.m2024.0038. PMID: 38509786Free PMC Article
Efficacy of physical therapy interventions on quality of life and upper quadrant pain severity in women with post-mastectomy pain syndrome: a systematic review and meta-analysis.
Kannan P, Lam HY, Ma TK, Lo CN, Mui TY, Tang WY
Qual Life Res 2022 Apr;31(4):951-973. Epub 2021 Jun 29 doi: 10.1007/s11136-021-02926-x. PMID: 34185226Free PMC Article
Persistent Post-Mastectomy Pain: Risk Factors and Current Approaches to Treatment.
Tait RC, Zoberi K, Ferguson M, Levenhagen K, Luebbert RA, Rowland K, Salsich GB, Herndon C
J Pain 2018 Dec;19(12):1367-1383. Epub 2018 Jun 30 doi: 10.1016/j.jpain.2018.06.002. PMID: 29966772Free PMC Article
Post-mastectomy pain syndrome: incidence and risks.
Alves Nogueira Fabro E, Bergmann A, do Amaral E Silva B, Padula Ribeiro AC, de Souza Abrahão K, da Costa Leite Ferreira MG, de Almeida Dias R, Santos Thuler LC
Breast 2012 Jun;21(3):321-5. Epub 2012 Feb 27 doi: 10.1016/j.breast.2012.01.019. PMID: 22377590
Post-mastectomy pain syndrome: the magnitude of the problem.
Couceiro TC, Menezes TC, Valênça MM
Rev Bras Anestesiol 2009 May-Jun;59(3):358-65. doi: 10.1590/s0034-70942009000300012. PMID: 19488550

Diagnosis

Exercise Therapy in Oncology.
Baumann FT, Jensen W, Berling-Ernst A, Theurich S, Leitzmann M, Götte M
Dtsch Arztebl Int 2024 May 17;121(10):331-337. doi: 10.3238/arztebl.m2024.0038. PMID: 38509786Free PMC Article
Stellate Ganglion Destruction With Alcohol Versus Thermal Ablation for Chronic Post-Mastectomy Pain: A Randomized Trial.
Thabet TS, Khedr SA
Pain Physician 2024 Feb;27(2):E231-E238. PMID: 38324788
Interventional Treatment Options for Post-mastectomy Pain.
Murugappan A, Khanna A
Curr Oncol Rep 2023 Oct;25(10):1175-1179. Epub 2023 Aug 30 doi: 10.1007/s11912-023-01435-z. PMID: 37646901
Post-breast surgery pain syndrome: establishing a consensus for the definition of post-mastectomy pain syndrome to provide a standardized clinical and research approach - a review of the literature and discussion.
Waltho D, Rockwell G
Can J Surg 2016 Sep;59(5):342-50. doi: 10.1503/cjs.000716. PMID: 27668333Free PMC Article
Post-mastectomy pain syndrome: the magnitude of the problem.
Couceiro TC, Menezes TC, Valênça MM
Rev Bras Anestesiol 2009 May-Jun;59(3):358-65. doi: 10.1590/s0034-70942009000300012. PMID: 19488550

Therapy

Prevention of Post-Mastectomy Pain Syndrome: A Review of Recent Literature on Perioperative Interventions.
Wu RR, Katz S, Wang J, Doan LV
Curr Oncol Rep 2024 Aug;26(8):865-879. Epub 2024 May 30 doi: 10.1007/s11912-024-01553-2. PMID: 38814502
Interventional Treatment Options for Post-mastectomy Pain.
Murugappan A, Khanna A
Curr Oncol Rep 2023 Oct;25(10):1175-1179. Epub 2023 Aug 30 doi: 10.1007/s11912-023-01435-z. PMID: 37646901
Efficacy of physical therapy interventions on quality of life and upper quadrant pain severity in women with post-mastectomy pain syndrome: a systematic review and meta-analysis.
Kannan P, Lam HY, Ma TK, Lo CN, Mui TY, Tang WY
Qual Life Res 2022 Apr;31(4):951-973. Epub 2021 Jun 29 doi: 10.1007/s11136-021-02926-x. PMID: 34185226Free PMC Article
Persistent Post-Mastectomy Pain: Risk Factors and Current Approaches to Treatment.
Tait RC, Zoberi K, Ferguson M, Levenhagen K, Luebbert RA, Rowland K, Salsich GB, Herndon C
J Pain 2018 Dec;19(12):1367-1383. Epub 2018 Jun 30 doi: 10.1016/j.jpain.2018.06.002. PMID: 29966772Free PMC Article
Post-mastectomy pain syndrome: the magnitude of the problem.
Couceiro TC, Menezes TC, Valênça MM
Rev Bras Anestesiol 2009 May-Jun;59(3):358-65. doi: 10.1590/s0034-70942009000300012. PMID: 19488550

Prognosis

Stellate Ganglion Destruction With Alcohol Versus Thermal Ablation for Chronic Post-Mastectomy Pain: A Randomized Trial.
Thabet TS, Khedr SA
Pain Physician 2024 Feb;27(2):E231-E238. PMID: 38324788
Intraoperative infusion of esmolol reduces the incidence and intensity of post-mastectomy pain syndrome.
Mendonça FT, Volpe Júnior JF, Tramontini AJ, DE Carvalho LS, Sposito AC
Minerva Anestesiol 2022 May;88(5):414-415. Epub 2021 Oct 12 doi: 10.23736/S0375-9393.21.16152-8. PMID: 34636226
Single institution analysis of incidence and risk factors for post-mastectomy pain syndrome.
Cui L, Fan P, Qiu C, Hong Y
Sci Rep 2018 Jul 31;8(1):11494. doi: 10.1038/s41598-018-29946-x. PMID: 30065342Free PMC Article
Prevalence of post-mastectomy pain syndrome and associated risk factors: a cross-sectional cohort study.
Couceiro TC, Valença MM, Raposo MC, Orange FA, Amorim MM
Pain Manag Nurs 2014 Dec;15(4):731-7. Epub 2013 Oct 19 doi: 10.1016/j.pmn.2013.07.011. PMID: 24144570
Post-mastectomy pain syndrome: incidence and risks.
Alves Nogueira Fabro E, Bergmann A, do Amaral E Silva B, Padula Ribeiro AC, de Souza Abrahão K, da Costa Leite Ferreira MG, de Almeida Dias R, Santos Thuler LC
Breast 2012 Jun;21(3):321-5. Epub 2012 Feb 27 doi: 10.1016/j.breast.2012.01.019. PMID: 22377590

Clinical prediction guides

Stellate Ganglion Destruction With Alcohol Versus Thermal Ablation for Chronic Post-Mastectomy Pain: A Randomized Trial.
Thabet TS, Khedr SA
Pain Physician 2024 Feb;27(2):E231-E238. PMID: 38324788
Post mastectomy pain syndrome at an Indian tertiary cancer centre and its impact on quality of life.
Kakati B, Nair N, Chatterjee A
Indian J Cancer 2023 Apr-Jun;60(2):275-281. doi: 10.4103/ijc.ijc_861_21. PMID: 37530253
Postmastectomy pain syndrome after preoperative stellate ganglion block: a randomized controlled trial.
Salman AS, Abbas DN, Elrawas MM, Kamel MA, Mohammed AM, Abouel Soud AH, Abdelgalil AS
Minerva Anestesiol 2021 Jul;87(7):786-793. Epub 2021 May 3 doi: 10.23736/S0375-9393.21.15112-0. PMID: 33938674
Radiofrequency Thoracic Sympathectomy for Sympathetically Maintained Chronic Post-Mastectomy Pain, a Preliminary Report: 6-Month Results.
Hetta DF, Mohamed AA, Hetta HF, Abd El-Hakeem EE, Boshra MM, El-Barody MM, Fattah Mohammad MA
Pain Pract 2021 Jan;21(1):54-63. Epub 2020 Aug 4 doi: 10.1111/papr.12933. PMID: 32629535
Prevalence of post-mastectomy pain syndrome and associated risk factors: a cross-sectional cohort study.
Couceiro TC, Valença MM, Raposo MC, Orange FA, Amorim MM
Pain Manag Nurs 2014 Dec;15(4):731-7. Epub 2013 Oct 19 doi: 10.1016/j.pmn.2013.07.011. PMID: 24144570

Recent systematic reviews

The Efficacy of Fat Grafting on Treating Post-Mastectomy Pain with and without Breast Reconstruction: A Systematic Review and Meta-Analysis.
Chen J, Alghamdi AA, Wong CY, Alnaim MF, Kuper G, Zhang J
Curr Oncol 2024 Apr 4;31(4):2057-2066. doi: 10.3390/curroncol31040152. PMID: 38668055Free PMC Article
Novel Prevention Approaches of Breast Cancer Surgery Related Complications: Systematic Review and Network Meta-Analysis.
Dzhantemirova N, Ahmedin D, Khasenov D, Khakimova G, Khakimova S, Bekisheva A, Mauletbaev M, Makishev A
Asian Pac J Cancer Prev 2024 Jan 1;25(1):9-23. doi: 10.31557/APJCP.2024.25.1.9. PMID: 38285764Free PMC Article
Efficacy of physical therapy interventions on quality of life and upper quadrant pain severity in women with post-mastectomy pain syndrome: a systematic review and meta-analysis.
Kannan P, Lam HY, Ma TK, Lo CN, Mui TY, Tang WY
Qual Life Res 2022 Apr;31(4):951-973. Epub 2021 Jun 29 doi: 10.1007/s11136-021-02926-x. PMID: 34185226Free PMC Article
Prevalence of pain in patients with breast cancer post-treatment: A systematic review.
Wang K, Yee C, Tam S, Drost L, Chan S, Zaki P, Rico V, Ariello K, Dasios M, Lam H, DeAngelis C, Chow E
Breast 2018 Dec;42:113-127. Epub 2018 Sep 4 doi: 10.1016/j.breast.2018.08.105. PMID: 30243159
The Post-mastectomy Pain Syndrome-A Systematic Review of the Treatment Modalities.
Larsson IM, Ahm Sørensen J, Bille C
Breast J 2017 May;23(3):338-343. Epub 2017 Jan 30 doi: 10.1111/tbj.12739. PMID: 28133848

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