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Increased level of allantoin in serum

MedGen UID:
1631553
•Concept ID:
C4703618
•
Finding
HPO: HP:0410052

Definition

An increase in the level of allantoin in the serum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased level of allantoin in serum

Professional guidelines

PubMed

Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA.
Zhang M, Hussain A, Hu B, Yang H, Li C, Guo S, Han X, Li B, Dai Y, Cao Y, Chi H, Weng Y, Qin CF, Huang Y
Nat Commun 2024 Jul 31;15(1):6463. doi: 10.1038/s41467-024-50752-9. PMID: 39085241Free PMC Article
Serum uric acid increases in patients with systemic autoimmune rheumatic diseases after 3 months of treatment with TNF inhibitors.
Hasikova L, Pavlikova M, Hulejova H, Kozlik P, Kalikova K, Mahajan A, Herrmann M, Stiburkova B, Zavada J
Rheumatol Int 2019 Oct;39(10):1749-1757. Epub 2019 Jul 31 doi: 10.1007/s00296-019-04394-6. PMID: 31363829

Recent clinical studies

Etiology

Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA.
Zhang M, Hussain A, Hu B, Yang H, Li C, Guo S, Han X, Li B, Dai Y, Cao Y, Chi H, Weng Y, Qin CF, Huang Y
Nat Commun 2024 Jul 31;15(1):6463. doi: 10.1038/s41467-024-50752-9. PMID: 39085241Free PMC Article
Serum uric acid: a futile bystander in endothelial function?
De Becker B, Van De Borne P
Blood Press 2023 Dec;32(1):2237123. doi: 10.1080/08037051.2023.2237123. PMID: 37470459
Patients with REM sleep behavior disorder have higher serum levels of allantoin.
Hasíková L, Závada J, Serranová T, Kotačková L, Kozlík P, Kalíková K, Trnka J, Zogala D, Šonka K, Růžička E, Dušek P
Parkinsonism Relat Disord 2021 Sep;90:38-43. Epub 2021 Jul 30 doi: 10.1016/j.parkreldis.2021.07.031. PMID: 34352609
The role of uric acid in inflammasome-mediated kidney injury.
Braga TT, Foresto-Neto O, Camara NOS
Curr Opin Nephrol Hypertens 2020 Jul;29(4):423-431. doi: 10.1097/MNH.0000000000000619. PMID: 32452918
Pharmacological urate-lowering approaches in chronic kidney disease.
Li X, Liu J, Ma L, Fu P
Eur J Med Chem 2019 Mar 15;166:186-196. Epub 2019 Jan 23 doi: 10.1016/j.ejmech.2019.01.043. PMID: 30769179

Diagnosis

Serum uric acid increases in patients with systemic autoimmune rheumatic diseases after 3 months of treatment with TNF inhibitors.
Hasikova L, Pavlikova M, Hulejova H, Kozlik P, Kalikova K, Mahajan A, Herrmann M, Stiburkova B, Zavada J
Rheumatol Int 2019 Oct;39(10):1749-1757. Epub 2019 Jul 31 doi: 10.1007/s00296-019-04394-6. PMID: 31363829
Serum allantoin and aminothiols as biomarkers of chronic heart failure.
Caussé E, Fournier P, Roncalli J, Salvayre R, Galinier M
Acta Cardiol 2017 Aug;72(4):397-403. Epub 2017 Jul 14 doi: 10.1080/00015385.2017.1335104. PMID: 28705092
Evaluation of allantoin levels as a new marker of oxidative stress in Behçet's disease.
Yardim-Akaydin S, Sepici A, Ozkan Y, Simşek B, Sepici V
Scand J Rheumatol 2006 Jan-Feb;35(1):61-4. doi: 10.1080/03009740510026878. PMID: 16467045
In vivo evidence for increased oxidation of circulating LDL in impaired glucose tolerance.
Kopprasch S, Pietzsch J, Kuhlisch E, Fuecker K, Temelkova-Kurktschiev T, Hanefeld M, Kühne H, Julius U, Graessler J
Diabetes 2002 Oct;51(10):3102-6. doi: 10.2337/diabetes.51.10.3102. PMID: 12351454
Is allantoin in serum and urine a useful indicator of exercise-induced oxidative stress in humans?
Mikami T, Kita K, Tomita S, Qu GJ, Tasaki Y, Ito A
Free Radic Res 2000 Mar;32(3):235-44. doi: 10.1080/10715760000300241. PMID: 10730822

Therapy

Serum uric acid increases in patients with systemic autoimmune rheumatic diseases after 3 months of treatment with TNF inhibitors.
Hasikova L, Pavlikova M, Hulejova H, Kozlik P, Kalikova K, Mahajan A, Herrmann M, Stiburkova B, Zavada J
Rheumatol Int 2019 Oct;39(10):1749-1757. Epub 2019 Jul 31 doi: 10.1007/s00296-019-04394-6. PMID: 31363829
Pharmacological urate-lowering approaches in chronic kidney disease.
Li X, Liu J, Ma L, Fu P
Eur J Med Chem 2019 Mar 15;166:186-196. Epub 2019 Jan 23 doi: 10.1016/j.ejmech.2019.01.043. PMID: 30769179
Relationship between serum allantoin and urate in healthy subjects and effects of benzbromarone in gout patients.
Kurajoh M, Koyama H, Shoji T, Sumida C, Yamamoto A, Tsutsumi Z, Moriwaki Y, Yamamoto T, Koga M
Int J Clin Pharmacol Ther 2012 Apr;50(4):265-71. doi: 10.5414/cp201582. PMID: 22456297
Rasburicase therapy in acute hyperuricemia and renal dysfunction.
Ronco C, Inguaggiato P, Bordoni V, De Cal M, Bonello M, Andrikos E, Assuman Y, Rattanarat R, Bellomo R
Contrib Nephrol 2005;147:115-123. doi: 10.1159/000082549. PMID: 15604611
Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies.
Doehner W, Schoene N, Rauchhaus M, Leyva-Leon F, Pavitt DV, Reaveley DA, Schuler G, Coats AJ, Anker SD, Hambrecht R
Circulation 2002 Jun 4;105(22):2619-24. doi: 10.1161/01.cir.0000017502.58595.ed. PMID: 12045167

Prognosis

Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA.
Zhang M, Hussain A, Hu B, Yang H, Li C, Guo S, Han X, Li B, Dai Y, Cao Y, Chi H, Weng Y, Qin CF, Huang Y
Nat Commun 2024 Jul 31;15(1):6463. doi: 10.1038/s41467-024-50752-9. PMID: 39085241Free PMC Article
Serum uric acid increases in patients with systemic autoimmune rheumatic diseases after 3 months of treatment with TNF inhibitors.
Hasikova L, Pavlikova M, Hulejova H, Kozlik P, Kalikova K, Mahajan A, Herrmann M, Stiburkova B, Zavada J
Rheumatol Int 2019 Oct;39(10):1749-1757. Epub 2019 Jul 31 doi: 10.1007/s00296-019-04394-6. PMID: 31363829
Influence of recanalization on uric acid patterns in acute ischemic stroke.
Hong JM, Bang OY, Chung CS, Joo IS, Gwag BJ, Ovbiagele B
Cerebrovasc Dis 2010;29(5):431-9. Epub 2010 Mar 4 doi: 10.1159/000289346. PMID: 20203485
In vivo evidence for increased oxidation of circulating LDL in impaired glucose tolerance.
Kopprasch S, Pietzsch J, Kuhlisch E, Fuecker K, Temelkova-Kurktschiev T, Hanefeld M, Kühne H, Julius U, Graessler J
Diabetes 2002 Oct;51(10):3102-6. doi: 10.2337/diabetes.51.10.3102. PMID: 12351454

Clinical prediction guides

Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA.
Zhang M, Hussain A, Hu B, Yang H, Li C, Guo S, Han X, Li B, Dai Y, Cao Y, Chi H, Weng Y, Qin CF, Huang Y
Nat Commun 2024 Jul 31;15(1):6463. doi: 10.1038/s41467-024-50752-9. PMID: 39085241Free PMC Article
Patients with REM sleep behavior disorder have higher serum levels of allantoin.
Hasíková L, Závada J, Serranová T, Kotačková L, Kozlík P, Kalíková K, Trnka J, Zogala D, Šonka K, Růžička E, Dušek P
Parkinsonism Relat Disord 2021 Sep;90:38-43. Epub 2021 Jul 30 doi: 10.1016/j.parkreldis.2021.07.031. PMID: 34352609
Serum uric acid increases in patients with systemic autoimmune rheumatic diseases after 3 months of treatment with TNF inhibitors.
Hasikova L, Pavlikova M, Hulejova H, Kozlik P, Kalikova K, Mahajan A, Herrmann M, Stiburkova B, Zavada J
Rheumatol Int 2019 Oct;39(10):1749-1757. Epub 2019 Jul 31 doi: 10.1007/s00296-019-04394-6. PMID: 31363829
In vivo evidence for increased oxidation of circulating LDL in impaired glucose tolerance.
Kopprasch S, Pietzsch J, Kuhlisch E, Fuecker K, Temelkova-Kurktschiev T, Hanefeld M, Kühne H, Julius U, Graessler J
Diabetes 2002 Oct;51(10):3102-6. doi: 10.2337/diabetes.51.10.3102. PMID: 12351454
Is allantoin in serum and urine a useful indicator of exercise-induced oxidative stress in humans?
Mikami T, Kita K, Tomita S, Qu GJ, Tasaki Y, Ito A
Free Radic Res 2000 Mar;32(3):235-44. doi: 10.1080/10715760000300241. PMID: 10730822

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