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Metastatic Peripheral Primitive Neuroectodermal Tumor of Bone

MedGen UID:
163178
•Concept ID:
C0855008
•
Neoplastic Process
Synonym: Metastatic Peripheral Neuroepithelioma of Bone

Definition

A small round cell tumor of the bone with neural differentiation that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Peripheral Primitive Neuroectodermal Tumor of Bone

Professional guidelines

PubMed

Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
Isolated late CNS relapse in a young adult 10 years after initial treatment for neuroblastoma.
Al-Faraj E, Millar BA, Irwin MS, Gupta A
J Pediatr Hematol Oncol 2015 Jan;37(1):75-7. doi: 10.1097/MPH.0000000000000163. PMID: 24755834
Side effects of treatment with I-131-meta-iodobenzylguanidine (I-131-MIBG) in neuroblastoma patients.
Voûte PA, Hoefnagel CA, de Kraker J, Majoor M
Prog Clin Biol Res 1988;271:679-87. PMID: 3406024

Recent clinical studies

Etiology

Metastatic Dissemination of a Neuroblastoma.
Mota EB, Penna CRR, Marchiori E
J Pediatr 2017 Oct;189:232-232.e1. Epub 2017 Jun 23 doi: 10.1016/j.jpeds.2017.05.069. PMID: 28651799
Spinal Canal Involvement in Neuroblastoma.
Trahair T, Sorrentino S, Russell SJ, Sampaio H, Selek L, Plantaz D, Freycon C, Simon T, Kraal K, Beck-Popovic M, Haupt R, Ash S, De Bernardi B
J Pediatr 2017 Sep;188:294-298. Epub 2017 Jun 20 doi: 10.1016/j.jpeds.2017.05.051. PMID: 28645442
Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology.
Kovalevich J, Langford D
Methods Mol Biol 2013;1078:9-21. doi: 10.1007/978-1-62703-640-5_2. PMID: 23975817Free PMC Article
Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation.
Lonergan GJ, Schwab CM, Suarez ES, Carlson CL
Radiographics 2002 Jul-Aug;22(4):911-34. doi: 10.1148/radiographics.22.4.g02jl15911. PMID: 12110723

Diagnosis

Metastatic Dissemination of a Neuroblastoma.
Mota EB, Penna CRR, Marchiori E
J Pediatr 2017 Oct;189:232-232.e1. Epub 2017 Jun 23 doi: 10.1016/j.jpeds.2017.05.069. PMID: 28651799
Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
Index of suspicion.
Festekjian A, Pierson SB, Zlotkin D
Pediatr Rev 2006 May;27(5):189-94. doi: 10.1542/pir.27-5-189. PMID: 16651276
The many faces of neuroblastoma.
David R, Lamki N, Fan S, Singleton EB, Eftekhari F, Shirkhoda A, Kumar R, Madewell JE
Radiographics 1989 Sep;9(5):859-82. doi: 10.1148/radiographics.9.5.2678295. PMID: 2678295
Imaging of neuroblastoma: an overview.
Bousvaros A, Kirks DR, Grossman H
Pediatr Radiol 1986;16(2):89-106. doi: 10.1007/BF02386629. PMID: 3513113

Therapy

Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis.
Heczey A, Courtney AN, Montalbano A, Robinson S, Liu K, Li M, Ghatwai N, Dakhova O, Liu B, Raveh-Sadka T, Chauvin-Fleurence CN, Xu X, Ngai H, Di Pierro EJ, Savoldo B, Dotti G, Metelitsa LS
Nat Med 2020 Nov;26(11):1686-1690. Epub 2020 Oct 12 doi: 10.1038/s41591-020-1074-2. PMID: 33046868
Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial.
Park JR, Kreissman SG, London WB, Naranjo A, Cohn SL, Hogarty MD, Tenney SC, Haas-Kogan D, Shaw PJ, Kraveka JM, Roberts SS, Geiger JD, Doski JJ, Voss SD, Maris JM, Grupp SA, Diller L
JAMA 2019 Aug 27;322(8):746-755. doi: 10.1001/jama.2019.11642. PMID: 31454045Free PMC Article
Spinal Canal Involvement in Neuroblastoma.
Trahair T, Sorrentino S, Russell SJ, Sampaio H, Selek L, Plantaz D, Freycon C, Simon T, Kraal K, Beck-Popovic M, Haupt R, Ash S, De Bernardi B
J Pediatr 2017 Sep;188:294-298. Epub 2017 Jun 20 doi: 10.1016/j.jpeds.2017.05.051. PMID: 28645442
Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
Advances in neuroblastoma research.
Castel V, Grau E
Clin Transl Oncol 2006 Oct;8(10):701-2. doi: 10.1007/s12094-006-0114-9. PMID: 17074666

Prognosis

Metastatic Dissemination of a Neuroblastoma.
Mota EB, Penna CRR, Marchiori E
J Pediatr 2017 Oct;189:232-232.e1. Epub 2017 Jun 23 doi: 10.1016/j.jpeds.2017.05.069. PMID: 28651799
Spinal Canal Involvement in Neuroblastoma.
Trahair T, Sorrentino S, Russell SJ, Sampaio H, Selek L, Plantaz D, Freycon C, Simon T, Kraal K, Beck-Popovic M, Haupt R, Ash S, De Bernardi B
J Pediatr 2017 Sep;188:294-298. Epub 2017 Jun 20 doi: 10.1016/j.jpeds.2017.05.051. PMID: 28645442
Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation.
Lonergan GJ, Schwab CM, Suarez ES, Carlson CL
Radiographics 2002 Jul-Aug;22(4):911-34. doi: 10.1148/radiographics.22.4.g02jl15911. PMID: 12110723
Imaging of neuroblastoma: an overview.
Bousvaros A, Kirks DR, Grossman H
Pediatr Radiol 1986;16(2):89-106. doi: 10.1007/BF02386629. PMID: 3513113
Neuroblastoma.
López-Ibor B, Schwartz AD
Pediatr Clin North Am 1985 Jun;32(3):755-78. doi: 10.1016/s0031-3955(16)34835-0. PMID: 3889804

Clinical prediction guides

Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature.
Mei S, Alchahin AM, Embaie BT, Gavriliuc IM, Verhoeven BM, Zhao T, Li X, Jeffries NE, Pepich A, Sarkar H, Olsen TK, Wickström M, Stenman J, Reina-Bedoya O, Kharchenko PV, Saylor PJ, Johnsen JI, Sykes DB, Kogner P, Baryawno N
JCI Insight 2024 Feb 15;9(6) doi: 10.1172/jci.insight.173337. PMID: 38358826Free PMC Article
Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis.
Heczey A, Courtney AN, Montalbano A, Robinson S, Liu K, Li M, Ghatwai N, Dakhova O, Liu B, Raveh-Sadka T, Chauvin-Fleurence CN, Xu X, Ngai H, Di Pierro EJ, Savoldo B, Dotti G, Metelitsa LS
Nat Med 2020 Nov;26(11):1686-1690. Epub 2020 Oct 12 doi: 10.1038/s41591-020-1074-2. PMID: 33046868
Cabozantinib for relapsed neuroblastoma: Single institution case series.
Perisa MP, Storey M, Streby KA, Ranalli MA, Skeens M, Shah N
Pediatr Blood Cancer 2020 Jul;67(7):e28317. Epub 2020 Apr 28 doi: 10.1002/pbc.28317. PMID: 32343886
Tandem high-dose chemotherapy with thiotepa and busulfan-melphalan and autologous stem cell transplantation in very high-risk neuroblastoma patients.
Pasqualini C, Dufour C, Goma G, Raquin MA, Lapierre V, Valteau-Couanet D
Bone Marrow Transplant 2016 Feb;51(2):227-31. Epub 2015 Nov 2 doi: 10.1038/bmt.2015.264. PMID: 26524264
CT whole-body scanning in pediatric radiology.
Pedersen KD, Jensen J, Hertz H
Pediatr Radiol 1978 Feb 28;6(4):222-9. doi: 10.1007/BF00975541. PMID: 643351

Recent systematic reviews

(18) F-FDG PET and PET/CT as a diagnostic method for Ewing sarcoma: A systematic review and meta-analysis.
Seth N, Seth I, Bulloch G, Siu AHY, Guo A, Chatterjee R, MacManus M, Donnan L
Pediatr Blood Cancer 2022 Mar;69(3):e29415. Epub 2021 Oct 28 doi: 10.1002/pbc.29415. PMID: 34709700
Diagnostic Value of Seven Different Imaging Modalities for Patients with Neuroblastic Tumors: A Network Meta-Analysis.
Wang Y, Xu Y, Kan Y, Wang W, Yang J
Contrast Media Mol Imaging 2021;2021:5333366. Epub 2021 Sep 1 doi: 10.1155/2021/5333366. PMID: 34548851Free PMC Article
Iodine-131-meta-iodobenzylguanidine therapy for patients with newly diagnosed high-risk neuroblastoma.
Kraal KC, van Dalen EC, Tytgat GA, Van Eck-Smit BL
Cochrane Database Syst Rev 2017 Apr 21;4(4):CD010349. doi: 10.1002/14651858.CD010349.pub2. PMID: 28429876Free PMC Article
High-dose chemotherapy and autologous haematopoietic stem cell rescue for children with high-risk neuroblastoma.
Yalçin B, Kremer LC, van Dalen EC
Cochrane Database Syst Rev 2015 Oct 5;2015(10):CD006301. doi: 10.1002/14651858.CD006301.pub4. PMID: 26436598Free PMC Article
High-dose chemotherapy and autologous haematopoietic stem cell rescue for children with high-risk neuroblastoma.
Yalçin B, Kremer LC, Caron HN, van Dalen EC
Cochrane Database Syst Rev 2010 May 12;(5):CD006301. doi: 10.1002/14651858.CD006301.pub2. PMID: 20464740

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