U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal coagulation factor V activity

MedGen UID:
1633263
•Concept ID:
C4703602
•
Pathologic Function
Synonym: Abnormal factor V activity
 
HPO: HP:0031899

Definition

Any deviation from the activity of coagulation factor V. [from HPO]

Professional guidelines

PubMed

Diagnostic algorithm for thrombophilia screening.
Margetic S
Clin Chem Lab Med 2010 Dec;48 Suppl 1:S27-39. Epub 2010 Nov 5 doi: 10.1515/CCLM.2010.362. PMID: 21054193
Thrombophilia and venous thromboembolism. International consensus statement. Guidelines according to scientific evidence.
European Genetics Foundation; Cardiovascular Disease Educational and Research Trust; International Union of Angiology; Mediterranean League on Thromboembolism, Nicolaides AN, Breddin HK, Carpenter P, Coccheri S, Conard J, De Stefano V, Elkoofy N, Gerotziafas G, Guermazi S, Haas S, Hull R, kalodiki E, Kristof V, Michiels JJ, Myers K, Pineo G, Prandoni P, Romeo G, Samama MM, Simonian S, Xenophonthos S
Int Angiol 2005 Mar;24(1):1-26. PMID: 15876995
Activated protein C resistance: from phenotype to genotype and clinical practice.
Hillarp A, Dahlbäck B, Zöller B
Blood Rev 1995 Dec;9(4):201-12. doi: 10.1016/s0268-960x(95)90011-x. PMID: 8839395

Recent clinical studies

Etiology

Laboratory Diagnostics in Thrombophilia.
Linnemann B, Hart C
Hamostaseologie 2019 Feb;39(1):49-61. Epub 2019 Jan 31 doi: 10.1055/s-0039-1677840. PMID: 30703819
Hypercoagulability and Migraine.
Tietjen GE, Collins SA
Headache 2018 Jan;58(1):173-183. Epub 2017 Feb 9 doi: 10.1111/head.13044. PMID: 28181217
The relationship between coagulation state and inflammatory bowel disease: current understanding and clinical implications.
Koutroubakis IE
Expert Rev Clin Immunol 2015 Apr;11(4):479-88. Epub 2015 Feb 26 doi: 10.1586/1744666X.2015.1019475. PMID: 25719625
New concepts in coagulation.
Rock G, Wells P
Crit Rev Clin Lab Sci 1997;34(5):475-501. doi: 10.3109/10408369709006423. PMID: 9405896
Factor V Leiden mutation and the risks for thromboembolic disease: a clinical perspective.
Price DT, Ridker PM
Ann Intern Med 1997 Nov 15;127(10):895-903. doi: 10.7326/0003-4819-127-10-199711150-00007. PMID: 9382368

Diagnosis

Laboratory Diagnostics in Thrombophilia.
Linnemann B, Hart C
Hamostaseologie 2019 Feb;39(1):49-61. Epub 2019 Jan 31 doi: 10.1055/s-0039-1677840. PMID: 30703819
Hypercoagulability and Migraine.
Tietjen GE, Collins SA
Headache 2018 Jan;58(1):173-183. Epub 2017 Feb 9 doi: 10.1111/head.13044. PMID: 28181217
Hematologic effects and complications of snake envenoming.
Berling I, Isbister GK
Transfus Med Rev 2015 Apr;29(2):82-9. Epub 2014 Dec 18 doi: 10.1016/j.tmrv.2014.09.005. PMID: 25556574
Hemorrhagic and thrombotic disorders due to factor V deficiencies and abnormalities: an updated classification.
Girolami A, Simioni P, Scarano L, Girolami B, Marchiori A
Blood Rev 1998 Mar;12(1):45-51. doi: 10.1016/s0268-960x(98)90029-7. PMID: 9597197
Factor V Leiden mutation and the risks for thromboembolic disease: a clinical perspective.
Price DT, Ridker PM
Ann Intern Med 1997 Nov 15;127(10):895-903. doi: 10.7326/0003-4819-127-10-199711150-00007. PMID: 9382368

Therapy

Thrombin generation abnormalities in Quebec platelet disorder.
Brunet JG, Sharma T, Tasneem S, Liang M, Wilson MD, Rivard GE, Hayward CPM
Int J Lab Hematol 2020 Dec;42(6):801-809. Epub 2020 Aug 6 doi: 10.1111/ijlh.13302. PMID: 32761872Free PMC Article
Laboratory Diagnostics in Thrombophilia.
Linnemann B, Hart C
Hamostaseologie 2019 Feb;39(1):49-61. Epub 2019 Jan 31 doi: 10.1055/s-0039-1677840. PMID: 30703819
Hypercoagulability and Migraine.
Tietjen GE, Collins SA
Headache 2018 Jan;58(1):173-183. Epub 2017 Feb 9 doi: 10.1111/head.13044. PMID: 28181217
Hematologic effects and complications of snake envenoming.
Berling I, Isbister GK
Transfus Med Rev 2015 Apr;29(2):82-9. Epub 2014 Dec 18 doi: 10.1016/j.tmrv.2014.09.005. PMID: 25556574
Factor V Leiden mutation and the risks for thromboembolic disease: a clinical perspective.
Price DT, Ridker PM
Ann Intern Med 1997 Nov 15;127(10):895-903. doi: 10.7326/0003-4819-127-10-199711150-00007. PMID: 9382368

Prognosis

Diagnostic approach to hypercoagulable states.
Remkova A
Bratisl Lek Listy 2006;107(8):292-5. PMID: 17125064
Assessment of hemostatic risk factors in predicting arterial thrombotic events.
Feinbloom D, Bauer KA
Arterioscler Thromb Vasc Biol 2005 Oct;25(10):2043-53. Epub 2005 Aug 11 doi: 10.1161/01.ATV.0000181762.31694.da. PMID: 16100033
Hemorrhagic and thrombotic disorders due to factor V deficiencies and abnormalities: an updated classification.
Girolami A, Simioni P, Scarano L, Girolami B, Marchiori A
Blood Rev 1998 Mar;12(1):45-51. doi: 10.1016/s0268-960x(98)90029-7. PMID: 9597197
Thromboembolic diseases: biochemical mechanisms and new possibilities of biological diagnosis.
Amiral J, Fareed J
Semin Thromb Hemost 1996;22 Suppl 1:41-8. PMID: 8807728
Activated protein C resistance: from phenotype to genotype and clinical practice.
Hillarp A, Dahlbäck B, Zöller B
Blood Rev 1995 Dec;9(4):201-12. doi: 10.1016/s0268-960x(95)90011-x. PMID: 8839395

Clinical prediction guides

Clinical Phenotype and Genetic Analysis of Twins With Congenital Coagulation Factor V Deficiency.
Wei Y, He Y, Guo X
J Pediatr Hematol Oncol 2022 Mar 1;44(2):e482-e486. doi: 10.1097/MPH.0000000000002261. PMID: 34387626Free PMC Article
Thrombin generation abnormalities in Quebec platelet disorder.
Brunet JG, Sharma T, Tasneem S, Liang M, Wilson MD, Rivard GE, Hayward CPM
Int J Lab Hematol 2020 Dec;42(6):801-809. Epub 2020 Aug 6 doi: 10.1111/ijlh.13302. PMID: 32761872Free PMC Article
Inherited thrombophilia and pregnancy loss. Study of an Argentinian cohort.
Perés Wingeyer S, Aranda F, Udry S, Latino J, de Larrañaga G
Med Clin (Barc) 2019 Apr 5;152(7):249-254. Epub 2018 Mar 6 doi: 10.1016/j.medcli.2017.12.019. PMID: 29523337
Hematologic effects and complications of snake envenoming.
Berling I, Isbister GK
Transfus Med Rev 2015 Apr;29(2):82-9. Epub 2014 Dec 18 doi: 10.1016/j.tmrv.2014.09.005. PMID: 25556574
Natural anticoagulants and the liver.
Castelino DJ, Salem HH
J Gastroenterol Hepatol 1997 Jan;12(1):77-83. doi: 10.1111/j.1440-1746.1997.tb00351.x. PMID: 9076629

Recent systematic reviews

The risk of recurrent venous thromboembolism among heterozygous carriers of factor V Leiden or prothrombin G20210A mutation. A systematic review of prospective studies.
Marchiori A, Mosena L, Prins MH, Prandoni P
Haematologica 2007 Aug;92(8):1107-14. doi: 10.3324/haematol.10234. PMID: 17650440

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...