U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Decreased glucose-6-phosphate dehydrogenase level in tissue

MedGen UID:
1633293
•Concept ID:
C4703673
•
Finding
Synonym: Decreased G6PD level in tissue
 
HPO: HP:0410187

Definition

A decrease in the level of glucose-6-phosphate dehydrogenase in tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased glucose-6-phosphate dehydrogenase level in tissue

Professional guidelines

PubMed

Quantitative evaluation of the extent of hepatic enzyme changes in Reye syndrome compared with normal liver or with non-Reye liver disorders: objective criteria for animal models.
Mitchell RA, Arcinue EL, Partin JC, Partin JS, Ram ML, Chang CH, Smialek J, Sarnaik A
Pediatr Res 1985 Jan;19(1):19-22. doi: 10.1203/00006450-198501000-00006. PMID: 3969310

Recent clinical studies

Etiology

Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway.
Xu C, Ye Z, Jiang W, Wang S, Zhang H
Mol Med 2023 Dec 13;29(1):169. doi: 10.1186/s10020-023-00758-8. PMID: 38093197Free PMC Article
The splicing factor 9G8 regulates the expression of NADPH-producing enzyme genes in Drosophila.
Weidman T, Nagengast AA, DiAngelo JR
Biochem Biophys Res Commun 2022 Sep 10;620:92-97. Epub 2022 Jun 24 doi: 10.1016/j.bbrc.2022.06.073. PMID: 35780586
Effects of cinnamaldehyde on glucose-6-phosphate dehydrogenase activity, some biochemical and hematological parameters in diabetic rats.
Çelik R, Mert H, Comba B, Mert N
Biomarkers 2022 May;27(3):270-277. Epub 2022 Feb 21 doi: 10.1080/1354750X.2022.2032351. PMID: 35078379
Protective effect of Argan oil on mitochondrial function and oxidative stress against acrylamide-induced liver and kidney injury in rats.
Er R, Aydın B, Şekeroğlu V, Atlı Şekeroğlu Z
Biomarkers 2020 Sep;25(6):458-467. Epub 2020 Jul 26 doi: 10.1080/1354750X.2020.1797877. PMID: 32683986
Global gene expression analysis in liver of db/db mice treated with catalpol.
Liu J, Zhang HR, Hou YB, Jing XL, Song XY, Shen XP
Chin J Nat Med 2018 Aug;16(8):590-598. doi: 10.1016/S1875-5364(18)30096-7. PMID: 30197124

Diagnosis

Downregulation of glucose‑6‑phosphate dehydrogenase by microRNA‑1 inhibits the growth of pituitary tumor cells.
He C, Yang J, Ding J, Li S, Wu H, Xiong Y, Zhou F, Jiang Y, Teng L, Yang J
Oncol Rep 2018 Dec;40(6):3533-3542. Epub 2018 Oct 1 doi: 10.3892/or.2018.6755. PMID: 30272333
Global gene expression analysis in liver of db/db mice treated with catalpol.
Liu J, Zhang HR, Hou YB, Jing XL, Song XY, Shen XP
Chin J Nat Med 2018 Aug;16(8):590-598. doi: 10.1016/S1875-5364(18)30096-7. PMID: 30197124
Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase.
Mailloux RJ, Harper ME
FASEB J 2010 Jul;24(7):2495-506. Epub 2010 Mar 12 doi: 10.1096/fj.09-151803. PMID: 20228249
Serum transcobalamin II level in glucose-6-phosphate dehydrogenase deficient subjects with typhoid fever.
Areekul S, Paksanond S, Thanomsak W, Vatanavicharn S
J Med Assoc Thai 1996 May;79(5):325-9. PMID: 8708525
Effect of dehydroepiandrosterone on human erythrocytes redox metabolism: inhibition of glucose-6-phosphate dehydrogenase activity in vivo and in vitro.
Niort G, Boccuzzi G, Brignardello E, Bonino L, Bosia A
J Steroid Biochem 1985 Nov;23(5A):657-61. doi: 10.1016/0022-4731(85)90018-4. PMID: 3001411

Therapy

Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway.
Xu C, Ye Z, Jiang W, Wang S, Zhang H
Mol Med 2023 Dec 13;29(1):169. doi: 10.1186/s10020-023-00758-8. PMID: 38093197Free PMC Article
G6PD, bond by miR-24, regulates mitochondrial dysfunction and oxidative stress in phenylephrine-induced hypertrophic cardiomyocytes.
Li B, Wang X, Yu M, Yang P, Wang W
Life Sci 2020 Nov 1;260:118378. Epub 2020 Sep 6 doi: 10.1016/j.lfs.2020.118378. PMID: 32898528
Global gene expression analysis in liver of db/db mice treated with catalpol.
Liu J, Zhang HR, Hou YB, Jing XL, Song XY, Shen XP
Chin J Nat Med 2018 Aug;16(8):590-598. doi: 10.1016/S1875-5364(18)30096-7. PMID: 30197124
Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart.
Gupte SA, Levine RJ, Gupte RS, Young ME, Lionetti V, Labinskyy V, Floyd BC, Ojaimi C, Bellomo M, Wolin MS, Recchia FA
J Mol Cell Cardiol 2006 Aug;41(2):340-9. Epub 2006 Jul 7 doi: 10.1016/j.yjmcc.2006.05.003. PMID: 16828794
Calcium oxalate stone disease: role of lipid peroxidation and antioxidants.
Selvam R
Urol Res 2002 Mar;30(1):35-47. doi: 10.1007/s00240-001-0228-z. PMID: 11942324

Prognosis

Proteomic Profile Analysis of Synovial Fluid in Patients With Anterior Cruciate Ligament Tears.
Brophy RH, Cai L, Zhang Q, Townsend RR, Rai MF
Am J Sports Med 2022 Sep;50(11):2935-2943. Epub 2022 Aug 15 doi: 10.1177/03635465221112652. PMID: 35969389
NeuroD1 promotes tumor cell proliferation and tumorigenesis by directly activating the pentose phosphate pathway in colorectal carcinoma.
Li Z, He Y, Li Y, Li J, Zhao H, Song G, Miyagishi M, Wu S, Kasim V
Oncogene 2021 Dec;40(50):6736-6747. Epub 2021 Oct 16 doi: 10.1038/s41388-021-02063-2. PMID: 34657129
Glucose-6-phosphate dehydrogenase correlates with tumor immune activity and programmed death ligand-1 expression in Merkel cell carcinoma.
Nakamura M, Nagase K, Yoshimitsu M, Magara T, Nojiri Y, Kato H, Kobayashi T, Teramoto Y, Yasuda M, Wada H, Ozawa T, Umemori Y, Ogata D, Morita A
J Immunother Cancer 2020 Dec;8(2) doi: 10.1136/jitc-2020-001679. PMID: 33361404Free PMC Article
Downregulation of glucose‑6‑phosphate dehydrogenase by microRNA‑1 inhibits the growth of pituitary tumor cells.
He C, Yang J, Ding J, Li S, Wu H, Xiong Y, Zhou F, Jiang Y, Teng L, Yang J
Oncol Rep 2018 Dec;40(6):3533-3542. Epub 2018 Oct 1 doi: 10.3892/or.2018.6755. PMID: 30272333
Upregulation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase activity increases oxidative stress in failing human heart.
Gupte RS, Vijay V, Marks B, Levine RJ, Sabbah HN, Wolin MS, Recchia FA, Gupte SA
J Card Fail 2007 Aug;13(6):497-506. doi: 10.1016/j.cardfail.2007.04.003. PMID: 17675065

Clinical prediction guides

Proteomic Profile Analysis of Synovial Fluid in Patients With Anterior Cruciate Ligament Tears.
Brophy RH, Cai L, Zhang Q, Townsend RR, Rai MF
Am J Sports Med 2022 Sep;50(11):2935-2943. Epub 2022 Aug 15 doi: 10.1177/03635465221112652. PMID: 35969389
Glucose-6-phosphate dehydrogenase correlates with tumor immune activity and programmed death ligand-1 expression in Merkel cell carcinoma.
Nakamura M, Nagase K, Yoshimitsu M, Magara T, Nojiri Y, Kato H, Kobayashi T, Teramoto Y, Yasuda M, Wada H, Ozawa T, Umemori Y, Ogata D, Morita A
J Immunother Cancer 2020 Dec;8(2) doi: 10.1136/jitc-2020-001679. PMID: 33361404Free PMC Article
A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats.
Lindquist C, Bjørndal B, Bakke HG, Slettom G, Karoliussen M, Rustan AC, Thoresen GH, Skorve J, Nygård OK, Berge RK
PLoS One 2019;14(9):e0222558. Epub 2019 Sep 24 doi: 10.1371/journal.pone.0222558. PMID: 31550253Free PMC Article
Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity.
Leopold JA, Dam A, Maron BA, Scribner AW, Liao R, Handy DE, Stanton RC, Pitt B, Loscalzo J
Nat Med 2007 Feb;13(2):189-97. Epub 2007 Feb 4 doi: 10.1038/nm1545. PMID: 17273168Free PMC Article
Calcium oxalate stone disease: role of lipid peroxidation and antioxidants.
Selvam R
Urol Res 2002 Mar;30(1):35-47. doi: 10.1007/s00240-001-0228-z. PMID: 11942324

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...