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Abnormal glucose-6-phosphate dehydrogenase level in tissue

MedGen UID:
1641774
•Concept ID:
C4703671
•
Finding
Synonym: Abnormal G6PD level in tissue
 
HPO: HP:0410185

Definition

An anomaly in the level of glucose-6-phosphate dehydrogenase in tissue. [from HPO]

Professional guidelines

PubMed

Quantitative evaluation of the extent of hepatic enzyme changes in Reye syndrome compared with normal liver or with non-Reye liver disorders: objective criteria for animal models.
Mitchell RA, Arcinue EL, Partin JC, Partin JS, Ram ML, Chang CH, Smialek J, Sarnaik A
Pediatr Res 1985 Jan;19(1):19-22. doi: 10.1203/00006450-198501000-00006. PMID: 3969310

Recent clinical studies

Etiology

Hemolytic anemias due to erythrocyte enzyme deficiencies.
Jacobasch G, Rapoport SM
Mol Aspects Med 1996 Apr;17(2):143-70. doi: 10.1016/0098-2997(96)88345-2. PMID: 8813716
Quantitative evaluation of the extent of hepatic enzyme changes in Reye syndrome compared with normal liver or with non-Reye liver disorders: objective criteria for animal models.
Mitchell RA, Arcinue EL, Partin JC, Partin JS, Ram ML, Chang CH, Smialek J, Sarnaik A
Pediatr Res 1985 Jan;19(1):19-22. doi: 10.1203/00006450-198501000-00006. PMID: 3969310

Diagnosis

Macrophage glucose-6-phosphate dehydrogenase stimulates proinflammatory responses with oxidative stress.
Ham M, Lee JW, Choi AH, Jang H, Choi G, Park J, Kozuka C, Sears DD, Masuzaki H, Kim JB
Mol Cell Biol 2013 Jun;33(12):2425-35. Epub 2013 Apr 9 doi: 10.1128/MCB.01260-12. PMID: 23572562Free PMC Article
Endogenous control genes in prostate cells: evaluation of gene expression using 'real-time' quantitative polymerase chain reaction.
Nna E, Tothill IE, Ludeman L, Bailey T
Med Princ Pract 2010;19(6):433-9. Epub 2010 Sep 28 doi: 10.1159/000320300. PMID: 20881409
Some characteristics of hyperoxia-adapted HeLa cells. A tissue culture model for cellular oxygen tolerance.
Joenje H, Gille JJ, Oostra AB, Van der Valk P
Lab Invest 1985 Apr;52(4):420-8. PMID: 2984461

Therapy

Endogenous control genes in prostate cells: evaluation of gene expression using 'real-time' quantitative polymerase chain reaction.
Nna E, Tothill IE, Ludeman L, Bailey T
Med Princ Pract 2010;19(6):433-9. Epub 2010 Sep 28 doi: 10.1159/000320300. PMID: 20881409
The effects of an aromatic retinoid (etretinate) on epidermal cell production and metabolism in normal and ichthyotic patients.
Pearse AD, Gaskell SA, Marks R
Br J Dermatol 1986 Mar;114(3):285-94. doi: 10.1111/j.1365-2133.1986.tb02819.x. PMID: 3954950
Peripheral insensitivity to thyroid hormones in a euthyroid girl with goitre.
Mäenpää J, Liewendahl K
Arch Dis Child 1980 Mar;55(3):207-12. doi: 10.1136/adc.55.3.207. PMID: 6247978Free PMC Article

Prognosis

Overexpression of G6PD is associated with poor clinical outcome in gastric cancer.
Wang J, Yuan W, Chen Z, Wu S, Chen J, Ge J, Hou F, Chen Z
Tumour Biol 2012 Feb;33(1):95-101. Epub 2011 Oct 20 doi: 10.1007/s13277-011-0251-9. PMID: 22012600
Hemolytic anemias due to erythrocyte enzyme deficiencies.
Jacobasch G, Rapoport SM
Mol Aspects Med 1996 Apr;17(2):143-70. doi: 10.1016/0098-2997(96)88345-2. PMID: 8813716

Clinical prediction guides

Overexpression of G6PD is associated with poor clinical outcome in gastric cancer.
Wang J, Yuan W, Chen Z, Wu S, Chen J, Ge J, Hou F, Chen Z
Tumour Biol 2012 Feb;33(1):95-101. Epub 2011 Oct 20 doi: 10.1007/s13277-011-0251-9. PMID: 22012600
Hemolytic anemias due to erythrocyte enzyme deficiencies.
Jacobasch G, Rapoport SM
Mol Aspects Med 1996 Apr;17(2):143-70. doi: 10.1016/0098-2997(96)88345-2. PMID: 8813716
Some characteristics of hyperoxia-adapted HeLa cells. A tissue culture model for cellular oxygen tolerance.
Joenje H, Gille JJ, Oostra AB, Van der Valk P
Lab Invest 1985 Apr;52(4):420-8. PMID: 2984461

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