Stage IV includes: IVA: T4, Any N, M0; IVB: Any T, Any N, M1. T4: Tumor invading the mucosa of the bladder or rectum, and/or extending beyond the true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. M1: Distant metastasis (including peritoneal spread or involvement of the supraclavicular, mediastinal, or distant lymph nodes; lung; liver; or bone). (from AJCC 8th Ed.) [from
NCI]