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Female Reproductive System Carcinoma

MedGen UID:
1793311
•Concept ID:
C5556870
•
Neoplastic Process

Definition

A malignant neoplasm that arises from the epithelium of any part of the female reproductive system. Representative examples include ovarian carcinoma, cervical carcinoma, and endometrial carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFemale Reproductive System Carcinoma

Professional guidelines

PubMed

Endometrial biopsy: Indications, techniques and recommendations. An evidence-based guideline for clinical practice.
Vitale SG, Buzzaccarini G, Riemma G, Pacheco LA, Di Spiezio Sardo A, Carugno J, Chiantera V, Török P, Noventa M, Haimovich S, De Franciscis P, Perez-Medina T, Angioni S, Laganà AS
J Gynecol Obstet Hum Reprod 2023 Jun;52(6):102588. Epub 2023 Apr 13 doi: 10.1016/j.jogoh.2023.102588. PMID: 37061093
Endometrial polyps. An evidence-based diagnosis and management guide.
Vitale SG, Haimovich S, Laganà AS, Alonso L, Di Spiezio Sardo A, Carugno J; From the Global Community of Hysteroscopy Guidelines Committee
Eur J Obstet Gynecol Reprod Biol 2021 May;260:70-77. Epub 2021 Mar 13 doi: 10.1016/j.ejogrb.2021.03.017. PMID: 33756339
Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma.
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article

Recent clinical studies

Therapy

Cancer of the Vulva: A Review.
Michalski BM, Pfeifer JD, Mutch D, Council ML
Dermatol Surg 2021 Feb 1;47(2):174-183. doi: 10.1097/DSS.0000000000002584. PMID: 32947298
HER2 Testing in Endometrial Serous Carcinoma: Time for Standardized Pathology Practice to Meet the Clinical Demand.
Buza N
Arch Pathol Lab Med 2021 Jun 1;145(6):687-691. doi: 10.5858/arpa.2020-0207-RA. PMID: 32649220
Low-grade serous ovarian cancer: State of the science.
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
Nout RA, Smit VT, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LC, van der Steen-Banasik EM, Mens JW, Slot A, Kroese MC, van Bunningen BN, Ansink AC, van Putten WL, Creutzberg CL; PORTEC Study Group
Lancet 2010 Mar 6;375(9717):816-23. doi: 10.1016/S0140-6736(09)62163-2. PMID: 20206777

Prognosis

FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
Imaging and staging of neuroendocrine cervical cancer.
Elsherif S, Odisio EGLC, Faria S, Javadi S, Yedururi S, Frumovitz M, Ramalingam P, Bhosale P
Abdom Radiol (NY) 2018 Dec;43(12):3468-3478. doi: 10.1007/s00261-018-1667-0. PMID: 29974177
Primary peritoneal psammocarcinoma.
Arole VC, Deshpande KA, Jadhav DB, Jogi A
J Obstet Gynaecol Res 2017 Aug;43(8):1366-1372. Epub 2017 May 19 doi: 10.1111/jog.13355. PMID: 28544349
Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187
Management of endometrial precancers.
Trimble CL, Method M, Leitao M, Lu K, Ioffe O, Hampton M, Higgins R, Zaino R, Mutter GL; Society of Gynecologic Oncology Clinical Practice Committee
Obstet Gynecol 2012 Nov;120(5):1160-75. doi: 10.1097/aog.0b013e31826bb121. PMID: 23090535Free PMC Article

Clinical prediction guides

Predictive and prognostic biomarkers in female genital tract tumours: an update highlighting their clinical relevance and practical issues.
Wong RW, Cheung ANY
Pathology 2024 Mar;56(2):214-227. Epub 2023 Dec 12 doi: 10.1016/j.pathol.2023.10.013. PMID: 38212229
Cervical Carcinoma: Oncobiology and Biomarkers.
Volkova LV, Pashov AI, Omelchuk NN
Int J Mol Sci 2021 Nov 22;22(22) doi: 10.3390/ijms222212571. PMID: 34830452Free PMC Article
Extramammary Paget Disease.
Marcoval J, Penín RM, Vidal A, Bermejo J
Actas Dermosifiliogr (Engl Ed) 2020 May;111(4):306-312. Epub 2020 Apr 9 doi: 10.1016/j.ad.2019.09.003. PMID: 32278442
Ovarian Endometrioid Carcinoma Misdiagnosed as Mucinous Carcinoma: An Underrecognized Problem.
Woodbeck R, Kelemen LE, Köbel M
Int J Gynecol Pathol 2019 Nov;38(6):568-575. doi: 10.1097/PGP.0000000000000564. PMID: 30480647
Management of endometrial precancers.
Trimble CL, Method M, Leitao M, Lu K, Ioffe O, Hampton M, Higgins R, Zaino R, Mutter GL; Society of Gynecologic Oncology Clinical Practice Committee
Obstet Gynecol 2012 Nov;120(5):1160-75. doi: 10.1097/aog.0b013e31826bb121. PMID: 23090535Free PMC Article

Recent systematic reviews

Efficacy, tolerability, and endometrial safety of ospemifene compared with current therapies for the treatment of vulvovaginal atrophy: a systematic literature review and network meta-analysis.
Simon JA, Ferenczy A, Black D, Castonguay A, Royer C, Marouf R, Beauchemin C
Menopause 2023 Aug 1;30(8):855-866. Epub 2023 Jun 27 doi: 10.1097/GME.0000000000002211. PMID: 37369079Free PMC Article
Clear cell carcinoma of the ovary and venous thromboembolism: a systematic review and meta-analysis.
Didar H, Farzaneh F, Najafiarab H, Namakin K, Gohari K, Sheidaei A, Ramezani S
Curr Med Res Opin 2023 Jun;39(6):901-910. Epub 2023 May 7 doi: 10.1080/03007995.2023.2208488. PMID: 37104696
Pathophysiology, Clinical Manifestations, and Treatment of Lichen Sclerosus: A Systematic Review.
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Mesothelin as a biomarker for ovarian carcinoma: a meta-analysis.
Madeira K, Dondossola ER, Farias BF, Simon CS, Alexandre MC, Silva BR, Rosa MI
An Acad Bras Cienc 2016 May 31;88(2):923-32. doi: 10.1590/0001-3765201620150107. PMID: 27254448

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