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Retinopathy of prematurity plus

MedGen UID:
1634291
Concept ID:
C4703701
Disease or Syndrome
Synonym: ROP plus
 
HPO: HP:0500062

Definition

Venous dilatation and arteriolar tortuosity of the posterior retinal vessels and may later increase in severity to include iris vascular engorgement, poor pupillary dilatation (rigid pupil), and vitreous haze. This definition has been further refined in the later clinical trials in which the diagnosis of plus disease could be made if sufficient vascular dilatation and tortuosity are present in at least 2 quadrants of the eye. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetinopathy of prematurity plus

Professional guidelines

PubMed

Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article
Hartnett ME
Curr Opin Ophthalmol 2017 May;28(3):282-288. doi: 10.1097/ICU.0000000000000360. PMID: 28141765Free PMC Article
Cernichiaro-Espinosa LA, Olguin-Manriquez FJ, Henaine-Berra A, Garcia-Aguirre G, Quiroz-Mercado H, Martinez-Castellanos MA
Int Ophthalmol 2016 Oct;36(5):751-60. Epub 2016 Jan 14 doi: 10.1007/s10792-016-0177-8. PMID: 26767656

Recent clinical studies

Etiology

Wang J, Ying GS, Yu Y, Tomlinson L, Binenbaum G
Ophthalmic Epidemiol 2023 Oct;30(5):523-531. Epub 2023 Jan 16 doi: 10.1080/09286586.2023.2168014. PMID: 36647265Free PMC Article
Stahl A, Sukgen EA, Wu WC, Lepore D, Nakanishi H, Mazela J, Moshfeghi DM, Vitti R, Athanikar A, Chu K, Iveli P, Zhao F, Schmelter T, Leal S, Köfüncü E, Azuma N; FIREFLEYE Study Group
JAMA 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564. PMID: 35881122Free PMC Article
Ghergherehchi L, Kim SJ, Campbell JP, Ostmo S, Chan RVP, Chiang MF
Asia Pac J Ophthalmol (Phila) 2018 May-Jun;7(3):152-155. Epub 2018 May 24 doi: 10.22608/APO.201863. PMID: 29797825Free PMC Article
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article
International Committee for the Classification of Retinopathy of Prematurity
Arch Ophthalmol 2005 Jul;123(7):991-9. doi: 10.1001/archopht.123.7.991. PMID: 16009843

Diagnosis

López-Cañizares A, Fernandez MP, Al-Khersan H, Carletti P, Arroyo MS, Fernandez-Ruiz MC, Berrocal AM
Ophthalmic Genet 2022 Aug;43(4):543-549. Epub 2022 Apr 13 doi: 10.1080/13816810.2022.2051193. PMID: 35416114
Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Paul Chan RV, Berrocal A, Binenbaum G, Blair M, Peter Campbell J, Capone A Jr, Chen Y, Dai S, Ells A, Fleck BW, Good WV, Elizabeth Hartnett M, Holmstrom G, Kusaka S, Kychenthal A, Lepore D, Lorenz B, Martinez-Castellanos MA, Özdek Ş, Ademola-Popoola D, Reynolds JD, Shah PK, Shapiro M, Stahl A, Toth C, Vinekar A, Visser L, Wallace DK, Wu WC, Zhao P, Zin A
Ophthalmology 2021 Oct;128(10):e51-e68. Epub 2021 Jul 8 doi: 10.1016/j.ophtha.2021.05.031. PMID: 34247850Free PMC Article
Scruggs BA, Chan RVP, Kalpathy-Cramer J, Chiang MF, Campbell JP
Transl Vis Sci Technol 2020 Feb 10;9(2):5. doi: 10.1167/tvst.9.2.5. PMID: 32704411Free PMC Article
Cernichiaro-Espinosa LA, Olguin-Manriquez FJ, Henaine-Berra A, Garcia-Aguirre G, Quiroz-Mercado H, Martinez-Castellanos MA
Int Ophthalmol 2016 Oct;36(5):751-60. Epub 2016 Jan 14 doi: 10.1007/s10792-016-0177-8. PMID: 26767656
International Committee for the Classification of Retinopathy of Prematurity
Arch Ophthalmol 2005 Jul;123(7):991-9. doi: 10.1001/archopht.123.7.991. PMID: 16009843

Therapy

Schmitz T, Doret-Dion M, Sentilhes L, Parant O, Claris O, Renesme L, Abbal J, Girault A, Torchin H, Houllier M, Le Saché N, Vivanti AJ, De Luca D, Winer N, Flamant C, Thuillier C, Boileau P, Blanc J, Brevaut V, Bouet PE, Gascoin G, Beucher G, Datin-Dorriere V, Bounan S, Bolot P, Poncelet C, Alberti C, Ursino M, Aupiais C, Baud O; BETADOSE trial study group; Groupe de Recherche en Obstétrique et Gynécologie
Lancet 2022 Aug 20;400(10352):592-604. doi: 10.1016/S0140-6736(22)01535-5. PMID: 35988568
Stahl A, Sukgen EA, Wu WC, Lepore D, Nakanishi H, Mazela J, Moshfeghi DM, Vitti R, Athanikar A, Chu K, Iveli P, Zhao F, Schmelter T, Leal S, Köfüncü E, Azuma N; FIREFLEYE Study Group
JAMA 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564. PMID: 35881122Free PMC Article
Cernichiaro-Espinosa LA, Olguin-Manriquez FJ, Henaine-Berra A, Garcia-Aguirre G, Quiroz-Mercado H, Martinez-Castellanos MA
Int Ophthalmol 2016 Oct;36(5):751-60. Epub 2016 Jan 14 doi: 10.1007/s10792-016-0177-8. PMID: 26767656
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article
Davitt BV, Wallace DK
Surv Ophthalmol 2009 Nov-Dec;54(6):663-70. Epub 2009 Aug 8 doi: 10.1016/j.survophthal.2009.02.021. PMID: 19665743

Prognosis

Young BK, Cole ED, Shah PK, Ostmo S, Subramaniam P, Venkatapathy N, Tsai ASH, Coyner AS, Gupta A, Singh P, Chiang MF, Kalpathy-Cramer J, Chan RVP, Campbell JP
JAMA Ophthalmol 2023 Jun 1;141(6):582-588. doi: 10.1001/jamaophthalmol.2023.1466. PMID: 37166816Free PMC Article
Wang J, Ying GS, Yu Y, Tomlinson L, Binenbaum G
Ophthalmic Epidemiol 2023 Oct;30(5):523-531. Epub 2023 Jan 16 doi: 10.1080/09286586.2023.2168014. PMID: 36647265Free PMC Article
Trzcionkowska K, Termote JU, Böhringer S, van Sorge AJ, Schalij-Delfos N
Br J Ophthalmol 2023 May;107(5):712-716. Epub 2021 Dec 10 doi: 10.1136/bjophthalmol-2021-319929. PMID: 34893474Free PMC Article
Kumawat D, Sachan A, Shah P, Chawla R, Chandra P
Eye (Lond) 2021 Apr;35(4):1140-1158. Epub 2021 Jan 29 doi: 10.1038/s41433-021-01392-6. PMID: 33514899Free PMC Article
Ahmad M, Patnaik J, Thevarajah T, Cathcart J, Jung J, Singh J, Braverman R, Lynch A, McCourt E
J AAPOS 2019 Apr;23(2):90.e1-90.e6. Epub 2019 Feb 14 doi: 10.1016/j.jaapos.2018.10.012. PMID: 30772472

Clinical prediction guides

Young BK, Cole ED, Shah PK, Ostmo S, Subramaniam P, Venkatapathy N, Tsai ASH, Coyner AS, Gupta A, Singh P, Chiang MF, Kalpathy-Cramer J, Chan RVP, Campbell JP
JAMA Ophthalmol 2023 Jun 1;141(6):582-588. doi: 10.1001/jamaophthalmol.2023.1466. PMID: 37166816Free PMC Article
Ajayi SO, Morris J, Aleem S, Pease ME, Wang A, Mowes A, Welles SL, Anday EK, Bhandari V
J Matern Fetal Neonatal Med 2022 Dec;35(26):10337-10347. Epub 2022 Oct 4 doi: 10.1080/14767058.2022.2128648. PMID: 36195455
Adhikari S, Bajimaya S, Ranjitkar EP
J AAPOS 2021 Oct;25(5):274.e1-274.e5. Epub 2021 Sep 23 doi: 10.1016/j.jaapos.2021.04.010. PMID: 34563697
Hartnett ME, Toth CA
Ophthalmic Surg Lasers Imaging Retina 2019 Apr 1;50(4):228-234. doi: 10.3928/23258160-20190401-05. PMID: 30998244
International Committee for the Classification of Retinopathy of Prematurity
Arch Ophthalmol 2005 Jul;123(7):991-9. doi: 10.1001/archopht.123.7.991. PMID: 16009843

Recent systematic reviews

Shafique MA, Haseeb A, Uddin MMN, Asghar B, Chaudhry ER, Raqib MA, Ali SMS, Mustafa MS
Am J Ophthalmol 2024 Mar;259:141-150. Epub 2023 Nov 17 doi: 10.1016/j.ajo.2023.11.012. PMID: 37979602
Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article
Sankar MJ, Sankar J, Mehta M, Bhat V, Srinivasan R
Cochrane Database Syst Rev 2016;2:CD009734. Epub 2016 Feb 27 doi: 10.1002/14651858.CD009734.pub2. PMID: 26932750
Cernichiaro-Espinosa LA, Olguin-Manriquez FJ, Henaine-Berra A, Garcia-Aguirre G, Quiroz-Mercado H, Martinez-Castellanos MA
Int Ophthalmol 2016 Oct;36(5):751-60. Epub 2016 Jan 14 doi: 10.1007/s10792-016-0177-8. PMID: 26767656
Kemper AR, Wallace DK, Quinn GE
Pediatrics 2008 Oct;122(4):825-30. doi: 10.1542/peds.2007-3667. PMID: 18829807Free PMC Article

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