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Retinopathy of prematurity(ROP)

MedGen UID:
48438
•Concept ID:
C0035344
•
Disease or Syndrome
Synonyms: Retrolental fibroplasia; ROP
SNOMED CT: Retinopathy of prematurity (415297005); RLF - Retrolental fibroplasia (415297005); ROP - Retinopathy of prematurity (415297005); Retrolental fibroplasia (415297005); Terry's syndrome (415297005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0500049
Monarch Initiative: MONDO:0006952
OMIM®: 133780; 604579
Orphanet: ORPHA90050

Definition

An avascular or abnormally vascularized retina that occurs in premature infants and can lead to blindness. [from HPO]

Conditions with this feature

Lymphatic malformation 13
MedGen UID:
1840915
•Concept ID:
C5830279
•
Disease or Syndrome
Lymphatic malformation-13 (LMPHM13) is characterized by the presence of nonimmune hydrops fetalis which often resolves with age. Capillary or cavernous hemangiomas are present in most patients, as are cardiac defects, often mild (Abdelrahman et al., 2018). For a discussion of genetic heterogeneity of lymphatic malformation, see 153100.
See: Condition Record
Lymphatic malformation 13

Professional guidelines

PubMed

Neonatal Golden Hour: a review of current best practices and available evidence.
Lamary M, Bertoni CB, Schwabenbauer K, Ibrahim J
Curr Opin Pediatr 2023 Apr 1;35(2):209-217. Epub 2023 Feb 1 doi: 10.1097/MOP.0000000000001224. PMID: 36722754
Update in the Treatment of Retinopathy of Prematurity.
Bancalari A, Schade R
Am J Perinatol 2022 Jan;39(1):22-30. Epub 2020 Jun 16 doi: 10.1055/s-0040-1713181. PMID: 32544962
A review of neovascular glaucoma. Etiopathogenesis and treatment.
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article

Recent clinical studies

Etiology

Retinopathy of prematurity.
Dammann O, Hartnett ME, Stahl A
Dev Med Child Neurol 2023 May;65(5):625-631. Epub 2022 Nov 21 doi: 10.1111/dmcn.15468. PMID: 36408783
Retinopathy of Prematurity: A Global Perspective and Recent Developments.
Sabri K, Ells AL, Lee EY, Dutta S, Vinekar A
Pediatrics 2022 Sep 1;150(3) doi: 10.1542/peds.2021-053924. PMID: 35948728
An Update on Retinopathy of Prematurity (ROP).
Dogra MR, Katoch D, Dogra M
Indian J Pediatr 2017 Dec;84(12):930-936. Epub 2017 Jul 4 doi: 10.1007/s12098-017-2404-3. PMID: 28674824
Retinopathy of Prematurity.
Bashinsky AL
N C Med J 2017 Mar-Apr;78(2):124-128. doi: 10.18043/ncm.78.2.124. PMID: 28420777
The International Classification of Retinopathy of Prematurity revisited.
International Committee for the Classification of Retinopathy of Prematurity
Arch Ophthalmol 2005 Jul;123(7):991-9. doi: 10.1001/archopht.123.7.991. PMID: 16009843

Diagnosis

Retinopathy of prematurity.
Dammann O, Hartnett ME, Stahl A
Dev Med Child Neurol 2023 May;65(5):625-631. Epub 2022 Nov 21 doi: 10.1111/dmcn.15468. PMID: 36408783
Retinopathy of Prematurity: A Global Perspective and Recent Developments.
Sabri K, Ells AL, Lee EY, Dutta S, Vinekar A
Pediatrics 2022 Sep 1;150(3) doi: 10.1542/peds.2021-053924. PMID: 35948728
An Update on Retinopathy of Prematurity (ROP).
Dogra MR, Katoch D, Dogra M
Indian J Pediatr 2017 Dec;84(12):930-936. Epub 2017 Jul 4 doi: 10.1007/s12098-017-2404-3. PMID: 28674824
Retinopathy of Prematurity.
Bashinsky AL
N C Med J 2017 Mar-Apr;78(2):124-128. doi: 10.18043/ncm.78.2.124. PMID: 28420777
The International Classification of Retinopathy of Prematurity revisited.
International Committee for the Classification of Retinopathy of Prematurity
Arch Ophthalmol 2005 Jul;123(7):991-9. doi: 10.1001/archopht.123.7.991. PMID: 16009843

Therapy

Effect of Intravitreal Aflibercept vs Laser Photocoagulation on Treatment Success of Retinopathy of Prematurity: The FIREFLEYE Randomized Clinical Trial.
Stahl A, Sukgen EA, Wu WC, Lepore D, Nakanishi H, Mazela J, Moshfeghi DM, Vitti R, Athanikar A, Chu K, Iveli P, Zhao F, Schmelter T, Leal S, Köfüncü E, Azuma N; FIREFLEYE Study Group
JAMA 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564. PMID: 35881122Free PMC Article
Effect of Enteral Lipid Supplement on Severe Retinopathy of Prematurity: A Randomized Clinical Trial.
Hellström A, Nilsson AK, Wackernagel D, Pivodic A, Vanpee M, Sjöbom U, Hellgren G, Hallberg B, Domellöf M, Klevebro S, Hellström W, Andersson M, Lund AM, Löfqvist C, Elfvin A, Sävman K, Hansen-Pupp I, Hård AL, Smith LEH, Ley D
JAMA Pediatr 2021 Apr 1;175(4):359-367. doi: 10.1001/jamapediatrics.2020.5653. PMID: 33523106Free PMC Article
Retinopathy of Prematurity: Evolving Treatment With Anti-Vascular Endothelial Growth Factor.
Hartnett ME
Am J Ophthalmol 2020 Oct;218:208-213. Epub 2020 May 23 doi: 10.1016/j.ajo.2020.05.025. PMID: 32450064Free PMC Article
Guidelines for feeding very low birth weight infants.
Dutta S, Singh B, Chessell L, Wilson J, Janes M, McDonald K, Shahid S, Gardner VA, Hjartarson A, Purcha M, Watson J, de Boer C, Gaal B, Fusch C
Nutrients 2015 Jan 8;7(1):423-42. doi: 10.3390/nu7010423. PMID: 25580815Free PMC Article
Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity.
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article

Prognosis

Trends in Mortality and Morbidities for Infants Born 24 to 28 Weeks in the US: 1997-2021.
Horbar JD, Greenberg LT, Buzas JS, Ehret DEY, Soll RF, Edwards EM
Pediatrics 2024 Jan 1;153(1) doi: 10.1542/peds.2023-064153. PMID: 38053449
Epidemiology of Retinopathy of Prematurity in the US From 2003 to 2019.
Bhatnagar A, Skrehot HC, Bhatt A, Herce H, Weng CY
JAMA Ophthalmol 2023 May 1;141(5):479-485. doi: 10.1001/jamaophthalmol.2023.0809. PMID: 37052930Free PMC Article
Screening Examination of Premature Infants for Retinopathy of Prematurity.
Fierson WM; AMERICAN ACADEMY OF PEDIATRICS Section on Ophthalmology; AMERICAN ACADEMY OF OPHTHALMOLOGY; AMERICAN ASSOCIATION FOR PEDIATRIC OPHTHALMOLOGY AND STRABISMUS; AMERICAN ASSOCIATION OF CERTIFIED ORTHOPTISTS
Pediatrics 2018 Dec;142(6) doi: 10.1542/peds.2018-3061. PMID: 30478242
An Update on Retinopathy of Prematurity (ROP).
Dogra MR, Katoch D, Dogra M
Indian J Pediatr 2017 Dec;84(12):930-936. Epub 2017 Jul 4 doi: 10.1007/s12098-017-2404-3. PMID: 28674824
Retinopathy of prematurity.
Jordan CO
Pediatr Clin North Am 2014 Jun;61(3):567-77. Epub 2014 Mar 26 doi: 10.1016/j.pcl.2014.03.003. PMID: 24852153

Clinical prediction guides

Fundus fluorescein angiography imaging of retinopathy of prematurity in infants: A review.
Kvopka M, Chan W, Lake SR, Durkin S, Taranath D
Surv Ophthalmol 2023 Sep-Oct;68(5):849-860. Epub 2023 May 19 doi: 10.1016/j.survophthal.2023.05.004. PMID: 37211096
Analgesia for retinopathy of prematurity screening: A systematic review.
Thirunavukarasu AJ, Hassan R, Savant SV, Hamilton DL
Pain Pract 2022 Sep;22(7):642-651. Epub 2022 Jun 27 doi: 10.1111/papr.13138. PMID: 35703418Free PMC Article
Postnatal weight gain and retinopathy of prematurity.
Lin L, Binenbaum G
Semin Perinatol 2019 Oct;43(6):352-359. Epub 2019 May 10 doi: 10.1053/j.semperi.2019.05.008. PMID: 31221520
Retinopathy of prematurity.
Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV
Indian J Pediatr 2012 Apr;79(4):501-9. Epub 2010 Oct 27 doi: 10.1007/s12098-010-0279-7. PMID: 20978871
The International Classification of Retinopathy of Prematurity revisited.
International Committee for the Classification of Retinopathy of Prematurity
Arch Ophthalmol 2005 Jul;123(7):991-9. doi: 10.1001/archopht.123.7.991. PMID: 16009843

Recent systematic reviews

Analgesia for retinopathy of prematurity screening: A systematic review.
Thirunavukarasu AJ, Hassan R, Savant SV, Hamilton DL
Pain Pract 2022 Sep;22(7):642-651. Epub 2022 Jun 27 doi: 10.1111/papr.13138. PMID: 35703418Free PMC Article
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
A Systematic Review and Meta-Analysis of Human Milk Feeding and Morbidity in Very Low Birth Weight Infants.
Miller J, Tonkin E, Damarell RA, McPhee AJ, Suganuma M, Suganuma H, Middleton PF, Makrides M, Collins CT
Nutrients 2018 May 31;10(6) doi: 10.3390/nu10060707. PMID: 29857555Free PMC Article
Interventions to prevent hypothermia at birth in preterm and/or low birth weight infants.
McCall EM, Alderdice F, Halliday HL, Vohra S, Johnston L
Cochrane Database Syst Rev 2018 Feb 12;2(2):CD004210. doi: 10.1002/14651858.CD004210.pub5. PMID: 29431872Free PMC Article
Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis.
Fogarty M, Osborn DA, Askie L, Seidler AL, Hunter K, Lui K, Simes J, Tarnow-Mordi W
Am J Obstet Gynecol 2018 Jan;218(1):1-18. Epub 2017 Oct 30 doi: 10.1016/j.ajog.2017.10.231. PMID: 29097178

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