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Increased circulating troponin T concentration

MedGen UID:
1634809
•Concept ID:
C4703661
•
Finding
Synonym: Increased troponin T level in blood
 
HPO: HP:0410174

Definition

An increased concentration of tropnin T in the blood, which is a cardiac regulatory protein that controls the calcium mediated interaction between actin and myosin. Raised cardiac troponin concentrations are now accepted as the standard biochemical marker for the diagnosis of myocardial infarction. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating troponin T concentration

Professional guidelines

PubMed

Assessment of Risk for Interference by Circulating Biotin in Samples Received for High Sensitivity Troponin-T, Thyrotropin, and for Prostate Specific Antigen Testing by Immunoassays.
Nguyen KQN, Langevin R, Fankhauser K, Hashim IA
Clin Lab 2020 Jan 1;66(1) doi: 10.7754/Clin.Lab.2019.190642. PMID: 32013345

Recent clinical studies

Etiology

Circulating cardiovascular biomarkers during and after preeclampsia: Crosstalk with placental function?
Jacobsen DP, Røysland R, Strand H, Moe K, Sugulle M, Omland T, Staff AC
Pregnancy Hypertens 2022 Dec;30:103-109. Epub 2022 Sep 16 doi: 10.1016/j.preghy.2022.09.003. PMID: 36148698
Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T.
du Fay de Lavallaz J, Prepoudis A, Wendebourg MJ, Kesenheimer E, Kyburz D, Daikeler T, Haaf P, Wanschitz J, Löscher WN, Schreiner B, Katan M, Jung HH, Maurer B, Hammerer-Lercher A, Mayr A, Gualandro DM, Acket A, Puelacher C, Boeddinghaus J, Nestelberger T, Lopez-Ayala P, Glarner N, Shrestha S, Manka R, Gawinecka J, Piscuoglio S, Gallon J, Wiedemann S, Sinnreich M, Mueller C; BASEL XII Investigators
Circulation 2022 Jun 14;145(24):1764-1779. Epub 2022 Apr 7 doi: 10.1161/CIRCULATIONAHA.121.058489. PMID: 35389756Free PMC Article
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Exercise-Induced Cardiac Troponin I Increase and Incident Mortality and Cardiovascular Events.
Aengevaeren VL, Hopman MTE, Thompson PD, Bakker EA, George KP, Thijssen DHJ, Eijsvogels TMH
Circulation 2019 Sep 9;140(10):804-814. Epub 2019 Aug 12 doi: 10.1161/CIRCULATIONAHA.119.041627. PMID: 31401842
Serum cardiac troponin T and effective blood flow in stable extracorporeal dialysis patients.
Grzegorzewska AE, Cieszyński K, Niepolski L, Kaczmarek A, Sowińska A
Int Urol Nephrol 2016 Mar;48(3):419-29. Epub 2015 Nov 24 doi: 10.1007/s11255-015-1165-z. PMID: 26603871Free PMC Article

Diagnosis

Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T.
du Fay de Lavallaz J, Prepoudis A, Wendebourg MJ, Kesenheimer E, Kyburz D, Daikeler T, Haaf P, Wanschitz J, Löscher WN, Schreiner B, Katan M, Jung HH, Maurer B, Hammerer-Lercher A, Mayr A, Gualandro DM, Acket A, Puelacher C, Boeddinghaus J, Nestelberger T, Lopez-Ayala P, Glarner N, Shrestha S, Manka R, Gawinecka J, Piscuoglio S, Gallon J, Wiedemann S, Sinnreich M, Mueller C; BASEL XII Investigators
Circulation 2022 Jun 14;145(24):1764-1779. Epub 2022 Apr 7 doi: 10.1161/CIRCULATIONAHA.121.058489. PMID: 35389756Free PMC Article
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Myocardial Injury and the Release of Troponins I and T in the Blood of Patients.
Katrukha IA, Katrukha AG
Clin Chem 2021 Jan 8;67(1):124-130. doi: 10.1093/clinchem/hvaa281. PMID: 33418589
Exercise-Induced Cardiac Troponin I Increase and Incident Mortality and Cardiovascular Events.
Aengevaeren VL, Hopman MTE, Thompson PD, Bakker EA, George KP, Thijssen DHJ, Eijsvogels TMH
Circulation 2019 Sep 9;140(10):804-814. Epub 2019 Aug 12 doi: 10.1161/CIRCULATIONAHA.119.041627. PMID: 31401842
How is cardiac troponin released from injured myocardium?
Mair J, Lindahl B, Hammarsten O, Müller C, Giannitsis E, Huber K, Möckel M, Plebani M, Thygesen K, Jaffe AS
Eur Heart J Acute Cardiovasc Care 2018 Sep;7(6):553-560. Epub 2017 Dec 27 doi: 10.1177/2048872617748553. PMID: 29278915

Therapy

Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction.
Koppen E, Omland T, Larsen AI, Karlsen T, Linke A, Prescott E, Halle M, Dalen H, Delagardelle C, Hole T, van Craenenbroeck EM, Beckers P, Ellingsen Ø, Feiereisen P, Valborgland T, Videm V; SMARTEX-HF Study Group
ESC Heart Fail 2021 Jun;8(3):2183-2192. Epub 2021 Mar 23 doi: 10.1002/ehf2.13310. PMID: 33754453Free PMC Article
Increased serum level of high sensitivity troponin T even prior to surgery can predict adverse events during carotid endarterectomy.
Nagy B, Engblom E, Matas M, Maróti P, Kőszegi T, Menyhei G, Lantos J, Szabó P, Molnár T
Vascular 2021 Dec;29(6):938-944. Epub 2021 Jan 11 doi: 10.1177/1708538120986297. PMID: 33427096
Cardiac Troponin T and I Release After a 30-km Run.
Klinkenberg LJ, Luyten P, van der Linden N, Urgel K, Snijders DP, Knackstedt C, Dennert R, Kietselaer BL, Mingels AM, Cardinaels EP, Peeters FE, van Suijlen JD, Ten Kate J, Marsch E, Theelen TL, Sluimer JC, Wouters K, Bekers O, Bekkers SC, van Loon LJ, van Dieijen-Visser MP, Meex SJ
Am J Cardiol 2016 Jul 15;118(2):281-7. Epub 2016 May 4 doi: 10.1016/j.amjcard.2016.04.030. PMID: 27282835
High-sensitivity cardiac troponin T levels are increased in stable COPD.
Neukamm AM, Høiseth AD, Hagve TA, Søyseth V, Omland T
Heart 2013 Mar;99(6):382-7. Epub 2013 Jan 12 doi: 10.1136/heartjnl-2012-303429. PMID: 23315609Free PMC Article

Prognosis

Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Increased serum level of high sensitivity troponin T even prior to surgery can predict adverse events during carotid endarterectomy.
Nagy B, Engblom E, Matas M, Maróti P, Kőszegi T, Menyhei G, Lantos J, Szabó P, Molnár T
Vascular 2021 Dec;29(6):938-944. Epub 2021 Jan 11 doi: 10.1177/1708538120986297. PMID: 33427096
Exercise-Induced Cardiac Troponin I Increase and Incident Mortality and Cardiovascular Events.
Aengevaeren VL, Hopman MTE, Thompson PD, Bakker EA, George KP, Thijssen DHJ, Eijsvogels TMH
Circulation 2019 Sep 9;140(10):804-814. Epub 2019 Aug 12 doi: 10.1161/CIRCULATIONAHA.119.041627. PMID: 31401842
Serum cardiac troponin T and effective blood flow in stable extracorporeal dialysis patients.
Grzegorzewska AE, Cieszyński K, Niepolski L, Kaczmarek A, Sowińska A
Int Urol Nephrol 2016 Mar;48(3):419-29. Epub 2015 Nov 24 doi: 10.1007/s11255-015-1165-z. PMID: 26603871Free PMC Article
Measurement of circulating concentrations of cardiac troponin I and T in healthy subjects: a tool for monitoring myocardial tissue renewal?
Giannoni A, Giovannini S, Clerico A
Clin Chem Lab Med 2009;47(10):1167-77. doi: 10.1515/CCLM.2009.320. PMID: 19803806

Clinical prediction guides

Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T.
du Fay de Lavallaz J, Prepoudis A, Wendebourg MJ, Kesenheimer E, Kyburz D, Daikeler T, Haaf P, Wanschitz J, Löscher WN, Schreiner B, Katan M, Jung HH, Maurer B, Hammerer-Lercher A, Mayr A, Gualandro DM, Acket A, Puelacher C, Boeddinghaus J, Nestelberger T, Lopez-Ayala P, Glarner N, Shrestha S, Manka R, Gawinecka J, Piscuoglio S, Gallon J, Wiedemann S, Sinnreich M, Mueller C; BASEL XII Investigators
Circulation 2022 Jun 14;145(24):1764-1779. Epub 2022 Apr 7 doi: 10.1161/CIRCULATIONAHA.121.058489. PMID: 35389756Free PMC Article
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Increased serum level of high sensitivity troponin T even prior to surgery can predict adverse events during carotid endarterectomy.
Nagy B, Engblom E, Matas M, Maróti P, Kőszegi T, Menyhei G, Lantos J, Szabó P, Molnár T
Vascular 2021 Dec;29(6):938-944. Epub 2021 Jan 11 doi: 10.1177/1708538120986297. PMID: 33427096
Exercise-Induced Cardiac Troponin I Increase and Incident Mortality and Cardiovascular Events.
Aengevaeren VL, Hopman MTE, Thompson PD, Bakker EA, George KP, Thijssen DHJ, Eijsvogels TMH
Circulation 2019 Sep 9;140(10):804-814. Epub 2019 Aug 12 doi: 10.1161/CIRCULATIONAHA.119.041627. PMID: 31401842
Serum cardiac troponin T and effective blood flow in stable extracorporeal dialysis patients.
Grzegorzewska AE, Cieszyński K, Niepolski L, Kaczmarek A, Sowińska A
Int Urol Nephrol 2016 Mar;48(3):419-29. Epub 2015 Nov 24 doi: 10.1007/s11255-015-1165-z. PMID: 26603871Free PMC Article

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