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Recurrent Leiomyosarcoma

MedGen UID:
163508
•Concept ID:
C0855058
•
Neoplastic Process
Synonyms: Leiomyosarcoma Recurrent; Relapsed Leiomyosarcoma

Definition

The reemergence of leiomyosarcoma after a period of remission [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Leiomyosarcoma

Professional guidelines

PubMed

Role of surgery in the multimodal treatment of primary and recurrent leiomyosarcoma of the inferior vena cava.
Cananzi FC, Mussi C, Bordoni MG, Marrari A, De Sanctis R, Colombo P, Quagliuolo V
J Surg Oncol 2016 Jul;114(1):44-9. Epub 2016 Apr 6 doi: 10.1002/jso.24244. PMID: 27062161
Phase II trial of etoposide in the management of advanced and recurrent leiomyosarcoma of the uterus: a Gynecologic Oncology Group Study.
Slayton RE, Blessing JA, Angel C, Berman M
Cancer Treat Rep 1987 Dec;71(12):1303-4. PMID: 3690545
Cisplatin as second-line chemotherapy in the treatment of advanced or recurrent leiomyosarcoma of the uterus. A phase II trial of the Gynecologic Oncology Group.
Thigpen JT, Blessing JA, Wilbanks GD
Am J Clin Oncol 1986 Feb;9(1):18-20. doi: 10.1097/00000421-198602000-00005. PMID: 3953489

Recent clinical studies

Etiology

Multidisciplinary Oncovascular Surgery is Safe and Effective in the Treatment of Intra-abdominal and Retroperitoneal Sarcomas: A Retrospective Single Centre Cohort Study and a Comprehensive Literature Review.
Homsy P, Blomqvist C, Heiskanen I, Vikatmaa L, Tukiainen E, Numminen K, Sampo M, Leppäniemi A, Albäck A, Kantonen I, Vikatmaa P
Eur J Vasc Endovasc Surg 2020 Nov;60(5):752-763. Epub 2020 Jul 31 doi: 10.1016/j.ejvs.2020.05.029. PMID: 32741678
Recurrent Leiomyosarcoma of the Small Bowel: A Case Series.
Ferrari C, DI Domenico S, Mascherini M, Santoliquido M, Mastracci L, DE Cian F
Anticancer Res 2020 Jul;40(7):4199-4204. doi: 10.21873/anticanres.14420. PMID: 32620670
Role of surgery in the multimodal treatment of primary and recurrent leiomyosarcoma of the inferior vena cava.
Cananzi FC, Mussi C, Bordoni MG, Marrari A, De Sanctis R, Colombo P, Quagliuolo V
J Surg Oncol 2016 Jul;114(1):44-9. Epub 2016 Apr 6 doi: 10.1002/jso.24244. PMID: 27062161
Phase II trial of etoposide in leiomyosarcoma of the uterus: a Gynecologic Oncology Group study.
Thigpen T, Blessing JA, Yordan E, Valea F, Vaccarello L
Gynecol Oncol 1996 Oct;63(1):120-2. doi: 10.1006/gyno.1996.0289. PMID: 8898180
Primary recurrent leiomyosarcoma of the breast. Case report with ultrastructural and immunohistochemical study and review of the literature.
Arista-Nasr J, Gonzalez-Gomez I, Angeles-Angeles A, Illanes-Baz E, Brandt-Brandt H, Larriva-Sahd J
Am J Clin Pathol 1989 Oct;92(4):500-5. doi: 10.1093/ajcp/92.4.500. PMID: 2679042

Diagnosis

A case report of recurrent leiomyosarcoma with chondrosarcoma differentiation in the abdominal wall and a review of the literature.
Zuo X, Wu WL, Shi P, Liu TM, Yu N, Li L
Pathol Oncol Res 2023;29:1611109. Epub 2023 May 10 doi: 10.3389/pore.2023.1611109. PMID: 37235202Free PMC Article
Multidisciplinary Oncovascular Surgery is Safe and Effective in the Treatment of Intra-abdominal and Retroperitoneal Sarcomas: A Retrospective Single Centre Cohort Study and a Comprehensive Literature Review.
Homsy P, Blomqvist C, Heiskanen I, Vikatmaa L, Tukiainen E, Numminen K, Sampo M, Leppäniemi A, Albäck A, Kantonen I, Vikatmaa P
Eur J Vasc Endovasc Surg 2020 Nov;60(5):752-763. Epub 2020 Jul 31 doi: 10.1016/j.ejvs.2020.05.029. PMID: 32741678
Recurrent Leiomyosarcoma of the Small Bowel: A Case Series.
Ferrari C, DI Domenico S, Mascherini M, Santoliquido M, Mastracci L, DE Cian F
Anticancer Res 2020 Jul;40(7):4199-4204. doi: 10.21873/anticanres.14420. PMID: 32620670
Temozolomide in uterine leiomyosarcomas.
Anderson S, Aghajanian C
Gynecol Oncol 2005 Jul;98(1):99-103. doi: 10.1016/j.ygyno.2005.03.018. PMID: 15916799
Primary recurrent leiomyosarcoma of the breast. Case report with ultrastructural and immunohistochemical study and review of the literature.
Arista-Nasr J, Gonzalez-Gomez I, Angeles-Angeles A, Illanes-Baz E, Brandt-Brandt H, Larriva-Sahd J
Am J Clin Pathol 1989 Oct;92(4):500-5. doi: 10.1093/ajcp/92.4.500. PMID: 2679042

Therapy

Doxorubicin combined with Trabectedin in systemic first-line M+/recurrent leiomyosarcoma patients.
Turinetto M, Meeus P, Ray-Coquard I
Curr Opin Oncol 2023 Jul 1;35(4):288-291. Epub 2023 May 18 doi: 10.1097/CCO.0000000000000961. PMID: 37222199
Multidisciplinary Oncovascular Surgery is Safe and Effective in the Treatment of Intra-abdominal and Retroperitoneal Sarcomas: A Retrospective Single Centre Cohort Study and a Comprehensive Literature Review.
Homsy P, Blomqvist C, Heiskanen I, Vikatmaa L, Tukiainen E, Numminen K, Sampo M, Leppäniemi A, Albäck A, Kantonen I, Vikatmaa P
Eur J Vasc Endovasc Surg 2020 Nov;60(5):752-763. Epub 2020 Jul 31 doi: 10.1016/j.ejvs.2020.05.029. PMID: 32741678
A patient-derived orthotopic xenograft (PDOX) nude-mouse model precisely identifies effective and ineffective therapies for recurrent leiomyosarcoma.
Zhang Z, Hu K, Kiyuna T, Miyake K, Kawaguchi K, Igarashi K, Nelson SD, Li Y, Singh SR, Hoffman RM
Pharmacol Res 2019 Apr;142:169-175. Epub 2019 Feb 23 doi: 10.1016/j.phrs.2019.02.021. PMID: 30807865
Role of surgery in the multimodal treatment of primary and recurrent leiomyosarcoma of the inferior vena cava.
Cananzi FC, Mussi C, Bordoni MG, Marrari A, De Sanctis R, Colombo P, Quagliuolo V
J Surg Oncol 2016 Jul;114(1):44-9. Epub 2016 Apr 6 doi: 10.1002/jso.24244. PMID: 27062161
Temozolomide in uterine leiomyosarcomas.
Anderson S, Aghajanian C
Gynecol Oncol 2005 Jul;98(1):99-103. doi: 10.1016/j.ygyno.2005.03.018. PMID: 15916799

Prognosis

Clinically Aggressive Uterine Epithelioid Leiomyosarcoma with Rhabdomyoblastic Differentiation and High Proliferation Rate: A Case Report.
Kim JY, Kim B
Am J Case Rep 2023 May 16;24:e939349. doi: 10.12659/AJCR.939349. PMID: 37190674Free PMC Article
Multidisciplinary Oncovascular Surgery is Safe and Effective in the Treatment of Intra-abdominal and Retroperitoneal Sarcomas: A Retrospective Single Centre Cohort Study and a Comprehensive Literature Review.
Homsy P, Blomqvist C, Heiskanen I, Vikatmaa L, Tukiainen E, Numminen K, Sampo M, Leppäniemi A, Albäck A, Kantonen I, Vikatmaa P
Eur J Vasc Endovasc Surg 2020 Nov;60(5):752-763. Epub 2020 Jul 31 doi: 10.1016/j.ejvs.2020.05.029. PMID: 32741678
Role of surgery in the multimodal treatment of primary and recurrent leiomyosarcoma of the inferior vena cava.
Cananzi FC, Mussi C, Bordoni MG, Marrari A, De Sanctis R, Colombo P, Quagliuolo V
J Surg Oncol 2016 Jul;114(1):44-9. Epub 2016 Apr 6 doi: 10.1002/jso.24244. PMID: 27062161
Phase II trial of etoposide in leiomyosarcoma of the uterus: a Gynecologic Oncology Group study.
Thigpen T, Blessing JA, Yordan E, Valea F, Vaccarello L
Gynecol Oncol 1996 Oct;63(1):120-2. doi: 10.1006/gyno.1996.0289. PMID: 8898180
Primary recurrent leiomyosarcoma of the breast. Case report with ultrastructural and immunohistochemical study and review of the literature.
Arista-Nasr J, Gonzalez-Gomez I, Angeles-Angeles A, Illanes-Baz E, Brandt-Brandt H, Larriva-Sahd J
Am J Clin Pathol 1989 Oct;92(4):500-5. doi: 10.1093/ajcp/92.4.500. PMID: 2679042

Clinical prediction guides

Role of surgery in the multimodal treatment of primary and recurrent leiomyosarcoma of the inferior vena cava.
Cananzi FC, Mussi C, Bordoni MG, Marrari A, De Sanctis R, Colombo P, Quagliuolo V
J Surg Oncol 2016 Jul;114(1):44-9. Epub 2016 Apr 6 doi: 10.1002/jso.24244. PMID: 27062161
A phase II trial of thalidomide in patients with refractory leiomyosarcoma of the uterus and correlation with biomarkers of angiogenesis: a gynecologic oncology group study.
McMeekin DS, Sill MW, Darcy KM, Stearns-Kurosawa DJ, Webster K, Waggoner S, Benbrook D
Gynecol Oncol 2007 Sep;106(3):596-603. Epub 2007 Jun 27 doi: 10.1016/j.ygyno.2007.05.013. PMID: 17597196
Benefits of endorectal ultrasound for management of smooth-muscle tumor of the rectum: report of three cases.
Hsieh JS, Huang CJ, Wang JY, Huang TJ
Dis Colon Rectum 1999 Aug;42(8):1085-8. doi: 10.1007/BF02236709. PMID: 10458136
Phase II trial of etoposide in leiomyosarcoma of the uterus: a Gynecologic Oncology Group study.
Thigpen T, Blessing JA, Yordan E, Valea F, Vaccarello L
Gynecol Oncol 1996 Oct;63(1):120-2. doi: 10.1006/gyno.1996.0289. PMID: 8898180
Phase II trial of ifosfamide and mesna in leiomyosarcoma of the uterus: a Gynecologic Oncology Group study.
Sutton GP, Blessing JA, Barrett RJ, McGehee R
Am J Obstet Gynecol 1992 Feb;166(2):556-9. doi: 10.1016/0002-9378(92)91671-v. PMID: 1536229

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