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Abnormal circulating glycerol level

MedGen UID:: 1635771
•Concept ID:: C4703543
•: Finding

HPO:	HP:0031795

Definition

Any deviation from the normal concentration of glycerol in the blood. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal circulating glycerol level

Phenotypic abnormality
- Abnormality of metabolism/homeostasis
  - Abnormal circulating metabolite concentration
    - Abnormal circulating carbohydrate concentration
      - Abnormal circulating glycerol level
        Decreased circulating glycerol level
        Hyperglycerolemia

Recent clinical studies

Etiology

Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy.

Johnson JA, Albu JB, Engelson ES, Fried SK, Inada Y, Ionescu G, Kotler DP
Am J Physiol Endocrinol Metab 2004 Feb;286(2):E261-71. Epub 2003 Oct 7 doi: 10.1152/ajpendo.00056.2003. PMID: 14532165

Effect of insulin on glycerol production in obese adolescents.

Robinson C, Tamborlane WV, Maggs DG, Enoksson S, Sherwin RS, Silver D, Shulman GI, Caprio S
Am J Physiol 1998 Apr;274(4):E737-43. doi: 10.1152/ajpendo.1998.274.4.E737. PMID: 9575836

Metabolic abnormalities in impaired glucose tolerance.

Gerich JE
Metabolism 1997 Dec;46(12 Suppl 1):40-3. doi: 10.1016/s0026-0495(97)90316-4. PMID: 9439558

Red blood cell glycerol lysis and hematologic effects in occupational benzene exposure.

Bogadi-Sare A, Turk R, Karacić V, Zavalić M, Trutin-Ostović K
Toxicol Ind Health 1997 Jul-Aug;13(4):485-94. doi: 10.1177/074823379701300402. PMID: 9249930

Metabolic responses to graded exercise in chronic heart failure.

Riley M, Bell N, Elborn JS, Stanford CF, Buchanan KD, Nicholls DP
Eur Heart J 1993 Nov;14(11):1484-8. doi: 10.1093/eurheartj/14.11.1484. PMID: 8299629

See all (13)

Diagnosis

Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy.

Brown RJ, Valencia A, Startzell M, Cochran E, Walter PJ, Garraffo HM, Cai H, Gharib AM, Ouwerkerk R, Courville AB, Bernstein S, Brychta RJ, Chen KY, Walter M, Auh S, Gorden P
J Clin Invest 2018 Aug 1;128(8):3504-3516. Epub 2018 Jul 16 doi: 10.1172/JCI95476. PMID: 29723161 Free PMC Article

Effect of insulin on glycerol production in obese adolescents.

Robinson C, Tamborlane WV, Maggs DG, Enoksson S, Sherwin RS, Silver D, Shulman GI, Caprio S
Am J Physiol 1998 Apr;274(4):E737-43. doi: 10.1152/ajpendo.1998.274.4.E737. PMID: 9575836

Insulin sensitivity in non-diabetic relatives of patients with non-insulin-dependent diabetes from two ethnic groups.

Gelding SV, Niththyananthan R, Chan SP, Skinner E, Robinson S, Gray IP, Mather H, Johnston DG
Clin Endocrinol (Oxf) 1994 Jan;40(1):55-62. doi: 10.1111/j.1365-2265.1994.tb02443.x. PMID: 8306481

Abnormal action of catecholamines on lipolysis in adipocytes of type I diabetic patients treated with insulin.

Wahrenberg H, Lönnqvist F, Engfeldt P, Arner P
Diabetes 1989 Apr;38(4):524-33. doi: 10.2337/diab.38.4.524. PMID: 2647559

Prolactin secretion and biological activity in females with galactorrhoea and normal circulating prolactin concentrations at rest.

Johnston DG, Haigh J, Prescott RW, Heaton A, Kendall-Taylor P, Baylis P, Alberti KG, Rowe R, Friesen H, Cook D
Clin Endocrinol (Oxf) 1985 May;22(5):661-78. doi: 10.1111/j.1365-2265.1985.tb03003.x. PMID: 3928210

See all (6)

Therapy

Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy.

The role of acetic acid on glucose uptake and blood flow rates in the skeletal muscle in humans with impaired glucose tolerance.

Mitrou P, Petsiou E, Papakonstantinou E, Maratou E, Lambadiari V, Dimitriadis P, Spanoudi F, Raptis SA, Dimitriadis G
Eur J Clin Nutr 2015 Jun;69(6):734-9. Epub 2015 Jan 28 doi: 10.1038/ejcn.2014.289. PMID: 25626409

Red blood cell glycerol lysis and hematologic effects in occupational benzene exposure.

Bogadi-Sare A, Turk R, Karacić V, Zavalić M, Trutin-Ostović K
Toxicol Ind Health 1997 Jul-Aug;13(4):485-94. doi: 10.1177/074823379701300402. PMID: 9249930

Metabolic responses to graded exercise in chronic heart failure.

Riley M, Bell N, Elborn JS, Stanford CF, Buchanan KD, Nicholls DP
Eur Heart J 1993 Nov;14(11):1484-8. doi: 10.1093/eurheartj/14.11.1484. PMID: 8299629

Increased cerebral blood volume in benign intracranial hypertension.

Mathew NT, Meyer JS, Ott EO
Neurology 1975 Jul;25(7):646-9. doi: 10.1212/wnl.25.7.646. PMID: 1171396

See all (9)

Clinical prediction guides

Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy.

Johnson JA, Albu JB, Engelson ES, Fried SK, Inada Y, Ionescu G, Kotler DP
Am J Physiol Endocrinol Metab 2004 Feb;286(2):E261-71. Epub 2003 Oct 7 doi: 10.1152/ajpendo.00056.2003. PMID: 14532165

Metabolic abnormalities in impaired glucose tolerance.

Gerich JE
Metabolism 1997 Dec;46(12 Suppl 1):40-3. doi: 10.1016/s0026-0495(97)90316-4. PMID: 9439558

Impaired glucose tolerance is characterized by multiple abnormalities in the regulation of intermediary metabolism.

Krentz AJ, Singh BM, Nattrass M
Diabet Med 1991 Nov;8(9):848-54. doi: 10.1111/j.1464-5491.1991.tb02123.x. PMID: 1837511

Prolactin secretion and biological activity in females with galactorrhoea and normal circulating prolactin concentrations at rest.

Metabolic parameters in women with metastatic breast cancer.

Carter AC, Lefkon BW, Farlin M, Feldman EB
J Clin Endocrinol Metab 1975 Feb;40(2):260-4. doi: 10.1210/jcem-40-2-260. PMID: 48195

See all (9)